BDBM142681 US8937068, 171

SMILES: CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(Cl)cc1OC

InChI Key: InChIKey=FEWYNEPNJCINKR-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 142681   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM142681 (US8937068, 171) Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(Cl)cc1OC Show InChI InChI=1S/C17H16ClN5O2/c1-3-19-17(24)23-15-7-6-12-16(22-15)21-13(9-20-12)11-5-4-10(18)8-14(11)25-2/h4-9H,3H2,1-2H3,(H2,19,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
Zentaris GmbH US Patent					Assay Description The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...				US Patent US8937068 (2015) BindingDB Entry DOI: 10.7270/Q2H993WP
					More data for this Ligand-Target Pair
Jnk1 & Jnk2 (Homo sapiens (Human))	BDBM142681 (US8937068, 171) Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(Cl)cc1OC Show InChI InChI=1S/C17H16ClN5O2/c1-3-19-17(24)23-15-7-6-12-16(22-15)21-13(9-20-12)11-5-4-10(18)8-14(11)25-2/h4-9H,3H2,1-2H3,(H2,19,21,22,23,24)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Zentaris GmbH US Patent					Assay Description The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...				US Patent US8937068 (2015) BindingDB Entry DOI: 10.7270/Q2H993WP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM142681 (US8937068, 171) Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(Cl)cc1OC Show InChI InChI=1S/C17H16ClN5O2/c1-3-19-17(24)23-15-7-6-12-16(22-15)21-13(9-20-12)11-5-4-10(18)8-14(11)25-2/h4-9H,3H2,1-2H3,(H2,19,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Zentaris GmbH US Patent					Assay Description The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...				US Patent US8937068 (2015) BindingDB Entry DOI: 10.7270/Q2H993WP
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM142681 (US8937068, 171) Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(Cl)cc1OC Show InChI InChI=1S/C17H16ClN5O2/c1-3-19-17(24)23-15-7-6-12-16(22-15)21-13(9-20-12)11-5-4-10(18)8-14(11)25-2/h4-9H,3H2,1-2H3,(H2,19,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Zentaris GmbH US Patent					Assay Description The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...				US Patent US8937068 (2015) BindingDB Entry DOI: 10.7270/Q2H993WP
					More data for this Ligand-Target Pair