BindingDB logo
myBDB logout

Patent code US9012443

Compile Data Set for Download or QSAR

Found 827 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154037
PNG
(US9012443, 30)
Show SMILES COc1cc(Cl)ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H14ClN3O3S2/c1-26-18-10-13(20)5-7-17(18)16-4-2-3-12-9-14(6-8-15(12)16)28(24,25)23-19-21-11-22-27-19/h2-11H,1H3,(H,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154247
PNG
(US9012443, 263)
Show SMILES COc1cc(ccc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ncc(F)s1)C(F)(F)F
Show InChI InChI=1S/C19H12F4N4O3S2/c1-30-15-6-10(19(21,22)23)2-4-13(15)17-12-5-3-11(7-14(12)25-9-26-17)32(28,29)27-18-24-8-16(20)31-18/h2-9H,1H3,(H,24,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154131
PNG
(US9012443, 139)
Show SMILES COc1ccc(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)C(F)(F)F
Show InChI InChI=1S/C21H15F3N4O3S/c1-31-18-5-2-14(21(22,23)24)11-17(18)20-16-4-3-15(10-13(16)6-9-26-20)32(29,30)28-19-7-8-25-12-27-19/h2-12H,1H3,(H,25,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154251
PNG
(US9012443, 267)
Show SMILES COc1cc(Cl)ccc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H13ClN4O3S2/c1-26-16-8-11(19)2-4-14(16)17-13-5-3-12(9-15(13)21-10-22-17)28(24,25)23-18-20-6-7-27-18/h2-10H,1H3,(H,20,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154267
PNG
(US9012443, 283)
Show SMILES COc1cc(ccc1-c1c(N)cnc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F |(2,.77,;.67,,;.67,-1.54,;2,-2.31,;2.05,-3.88,;.67,-4.62,;-.67,-3.85,;-.67,-2.31,;-2,-1.54,;-3.33,-2.31,;-3.33,-3.85,;-4.67,-1.54,;-4.67,,;-3.33,.77,;-3.33,2.31,;-2,3.08,;-.67,2.31,;-.67,.77,;-2,,;-2,4.62,;-2.77,5.95,;-3.54,4.62,;-.67,5.39,;.67,4.62,;1.14,3.16,;2.68,3.16,;3.16,4.62,;1.91,5.53,;3.38,-4.65,;4.72,-5.42,;2.61,-5.98,;4.15,-3.31,)|
Show InChI InChI=1S/C20H15F3N4O3S2/c1-30-17-8-11(20(21,22)23)2-4-14(17)18-13-5-3-12(9-16(13)26-10-15(18)24)32(28,29)27-19-25-6-7-31-19/h2-10H,24H2,1H3,(H,25,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154019
PNG
(US9012443, 12)
Show SMILES COc1cc(ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F
Show InChI InChI=1S/C20H14F3N3O3S2/c1-29-18-10-13(20(21,22)23)5-7-17(18)16-4-2-3-12-9-14(6-8-15(12)16)31(27,28)26-19-24-11-25-30-19/h2-11H,1H3,(H,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154079
PNG
(US9012443, 83)
Show SMILES O=S(=O)(Nc1ncns1)c1ccc2c(cccc2c1)N1CCCC1c1ccccc1
Show InChI InChI=1S/C22H20N4O2S2/c27-30(28,25-22-23-15-24-29-22)18-11-12-19-17(14-18)8-4-9-21(19)26-13-5-10-20(26)16-6-2-1-3-7-16/h1-4,6-9,11-12,14-15,20H,5,10,13H2,(H,23,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154245
PNG
(US9012443, 261)
Show SMILES COc1cc(ccc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C19H13F3N4O3S2/c1-29-16-8-11(19(20,21)22)2-4-14(16)17-13-5-3-12(9-15(13)24-10-25-17)31(27,28)26-18-23-6-7-30-18/h2-10H,1H3,(H,23,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154250
PNG
(US9012443, 266)
Show SMILES COc1cc(ccc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)F
Show InChI InChI=1S/C19H14F2N4O3S2/c1-28-16-8-11(18(20)21)2-4-14(16)17-13-5-3-12(9-15(13)23-10-24-17)30(26,27)25-19-22-6-7-29-19/h2-10,18H,1H3,(H,22,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154186
PNG
(US9012443, 195)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F
Show InChI InChI=1S/C19H13F3N4O3S2/c1-29-16-9-12(19(20,21)22)2-4-15(16)17-14-5-3-13(8-11(14)6-7-23-17)31(27,28)26-18-24-10-25-30-18/h2-10H,1H3,(H,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154088
PNG
(US9012443, 94)
Show SMILES COc1ccccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H15N3O3S2/c1-25-18-8-3-2-6-17(18)16-7-4-5-13-11-14(9-10-15(13)16)27(23,24)22-19-20-12-21-26-19/h2-12H,1H3,(H,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154200
PNG
(US9012443, 213)
Show SMILES COc1cc(F)ccc1-c1ncc(F)c2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H13F2N3O3S2/c1-27-17-8-11(20)2-4-14(17)18-13-5-3-12(9-15(13)16(21)10-23-18)29(25,26)24-19-22-6-7-28-19/h2-10H,1H3,(H,22,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154187
PNG
(US9012443, 196)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C20H14F3N3O3S2/c1-29-17-11-13(20(21,22)23)2-4-16(17)18-15-5-3-14(10-12(15)6-7-24-18)31(27,28)26-19-25-8-9-30-19/h2-11H,1H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154081
PNG
(US9012443, 85)
Show SMILES O=S(=O)(Nc1ncns1)c1ccc2c(cccc2c1)N1CCCC1c1cccnc1
Show InChI InChI=1S/C21H19N5O2S2/c27-30(28,25-21-23-14-24-29-21)17-8-9-18-15(12-17)4-1-6-20(18)26-11-3-7-19(26)16-5-2-10-22-13-16/h1-2,4-6,8-10,12-14,19H,3,7,11H2,(H,23,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154215
PNG
(US9012443, 229)
Show SMILES FC(F)(F)c1ccc(c(c1)-n1ccnc1)-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C22H14F3N5O2S2/c23-22(24,25)15-1-3-18(19(12-15)30-9-7-26-13-30)20-17-4-2-16(11-14(17)5-6-27-20)34(31,32)29-21-28-8-10-33-21/h1-13H,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154198
PNG
(US9012443, 211)
Show SMILES COc1ccccc1-c1ncc(F)c2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H14FN3O3S2/c1-26-17-5-3-2-4-14(17)18-13-7-6-12(10-15(13)16(20)11-22-18)28(24,25)23-19-21-8-9-27-19/h2-11H,1H3,(H,21,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154113
PNG
(US9012443, 120)
Show SMILES FC(F)(F)c1ccc(c(c1)C1CCNCC1)-c1cccc2cc(ccc12)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C26H23F3N4O2S/c27-26(28,29)19-4-6-23(24(15-19)17-8-11-30-12-9-17)22-3-1-2-18-14-20(5-7-21(18)22)36(34,35)33-25-10-13-31-16-32-25/h1-7,10,13-17,30H,8-9,11-12H2,(H,31,32,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154059
PNG
(US9012443, 55)
Show SMILES FC(F)(F)c1ccc(c(c1)-c1cn[nH]c1)-c1nccc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H13F3N6O2S2/c22-21(23,24)14-1-3-17(18(8-14)13-9-27-28-10-13)19-16-4-2-15(7-12(16)5-6-25-19)34(31,32)30-20-26-11-29-33-20/h1-11H,(H,27,28)(H,26,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154185
PNG
(US9012443, 194)
Show SMILES COc1ccccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C18H14N4O3S2/c1-25-16-5-3-2-4-15(16)17-14-7-6-13(10-12(14)8-9-19-17)27(23,24)22-18-20-11-21-26-18/h2-11H,1H3,(H,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154069
PNG
(US9012443, 70 | US9012443, 72)
Show SMILES FC(F)(F)c1ccc(c(c1)C1=CCNCC1)-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1 |t:11|
Show InChI InChI=1S/C24H19F3N4O2S2/c25-24(26,27)17-1-3-20(21(14-17)15-5-8-28-9-6-15)22-19-4-2-18(13-16(19)7-10-29-22)35(32,33)31-23-30-11-12-34-23/h1-5,7,10-14,28H,6,8-9H2,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154456
PNG
(US9012443, 521)
Show SMILES COc1cc(c(Cl)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ncns1)-c1cccc(F)c1
Show InChI InChI=1S/C23H15ClFN5O3S2/c1-33-21-10-17(13-3-2-4-14(25)7-13)19(24)9-18(21)22-16-6-5-15(8-20(16)26-11-27-22)35(31,32)30-23-28-12-29-34-23/h2-12H,1H3,(H,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 19n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154028
PNG
(US9012443, 21)
Show SMILES FC(F)(F)c1ccc(c(c1)-c1cn[nH]c1)-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C22H14F3N5O2S2/c23-22(24,25)15-4-6-19(20(9-15)14-10-27-28-11-14)18-3-1-2-13-8-16(5-7-17(13)18)34(31,32)30-21-26-12-29-33-21/h1-12H,(H,27,28)(H,26,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154034
PNG
(US9012443, 27)
Show SMILES Clc1ccc(c(c1)-c1cn[nH]c1)-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H14ClN5O2S2/c22-15-4-6-19(20(9-15)14-10-24-25-11-14)18-3-1-2-13-8-16(5-7-17(13)18)31(28,29)27-21-23-12-26-30-21/h1-12H,(H,24,25)(H,23,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154201
PNG
(US9012443, 214)
Show SMILES COc1cc(ccc1-c1ncc(F)c2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N
Show InChI InChI=1S/C20H13FN4O3S2/c1-28-18-8-12(10-22)2-4-15(18)19-14-5-3-13(9-16(14)17(21)11-24-19)30(26,27)25-20-23-6-7-29-20/h2-9,11H,1H3,(H,23,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154083
PNG
(US9012443, 88)
Show SMILES O=S(=O)(Nc1ncns1)c1ccc2c(cccc2c1)N1CCCC1c1ccncc1
Show InChI InChI=1S/C21H19N5O2S2/c27-30(28,25-21-23-14-24-29-21)17-6-7-18-16(13-17)3-1-4-20(18)26-12-2-5-19(26)15-8-10-22-11-9-15/h1,3-4,6-11,13-14,19H,2,5,12H2,(H,23,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154153
PNG
(US9012443, 161)
Show SMILES COc1cc(Cl)c(Cl)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H14Cl2N4O3S/c1-29-18-10-17(22)16(21)9-15(18)20-14-3-2-13(8-12(14)4-7-24-20)30(27,28)26-19-5-6-23-11-25-19/h2-11H,1H3,(H,23,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154190
PNG
(US9012443, 199)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1cccc(F)c1
Show InChI InChI=1S/C26H19FN4O3S/c1-34-24-15-18(17-3-2-4-20(27)13-17)5-7-23(24)26-22-8-6-21(14-19(22)9-12-29-26)35(32,33)31-25-10-11-28-16-30-25/h2-16H,1H3,(H,28,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154209
PNG
(US9012443, 222)
Show SMILES CNc1cc2cc(ccc2c(n1)-c1ccc(cc1OC)C(F)(F)F)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C21H17F3N4O3S2/c1-25-18-10-12-9-14(33(29,30)28-20-26-7-8-32-20)4-6-15(12)19(27-18)16-5-3-13(21(22,23)24)11-17(16)31-2/h3-11H,1-2H3,(H,25,27)(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154152
PNG
(US9012443, 160)
Show SMILES COc1cc(Cl)ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H15ClN4O3S/c1-28-18-11-14(21)2-4-17(18)20-16-5-3-15(10-13(16)6-9-23-20)29(26,27)25-19-7-8-22-12-24-19/h2-12H,1H3,(H,22,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154477
PNG
(US9012443, 205)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N
Show InChI InChI=1S/C20H14N4O3S2/c1-27-18-10-13(12-21)2-4-17(18)19-16-5-3-15(11-14(16)6-7-22-19)29(25,26)24-20-23-8-9-28-20/h2-11H,1H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154202
PNG
(US9012443, 215)
Show SMILES COc1cc(Cl)ccc1-c1ncc(F)c2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H13ClFN3O3S2/c1-27-17-8-11(20)2-4-14(17)18-13-5-3-12(9-15(13)16(21)10-23-18)29(25,26)24-19-22-6-7-28-19/h2-10H,1H3,(H,22,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154237
PNG
(US9012443, 253)
Show SMILES COc1cc(ccc1-c1nncc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C19H13F3N4O3S2/c1-29-16-9-12(19(20,21)22)2-4-15(16)17-14-5-3-13(8-11(14)10-24-25-17)31(27,28)26-18-23-6-7-30-18/h2-10H,1H3,(H,23,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154249
PNG
(US9012443, 265)
Show SMILES COc1cc(ccc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F
Show InChI InChI=1S/C18H12F3N5O3S2/c1-29-15-6-10(18(19,20)21)2-4-13(15)16-12-5-3-11(7-14(12)22-8-23-16)31(27,28)26-17-24-9-25-30-17/h2-9H,1H3,(H,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154257
PNG
(US9012443, 273)
Show SMILES COc1cc(ccc1-c1ccnc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N
Show InChI InChI=1S/C20H14N4O3S2/c1-27-19-10-13(12-21)2-4-17(19)15-6-7-22-18-11-14(3-5-16(15)18)29(25,26)24-20-23-8-9-28-20/h2-11H,1H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154070
PNG
(US9012443, 71)
Show SMILES FC(F)(F)c1ccc(c(c1)-c1ccncc1)-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C24H15F3N4O2S2/c25-24(26,27)17-1-3-20(21(14-17)15-5-8-28-9-6-15)22-19-4-2-18(13-16(19)7-10-29-22)35(32,33)31-23-30-11-12-34-23/h1-14H,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154145
PNG
(US9012443, 153)
Show SMILES COc1cc(OC(F)(F)F)ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H15F3N4O4S/c1-31-18-11-14(32-21(22,23)24)2-4-17(18)20-16-5-3-15(10-13(16)6-9-26-20)33(29,30)28-19-7-8-25-12-27-19/h2-12H,1H3,(H,25,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154239
PNG
(US9012443, 255)
Show SMILES COc1cc(ccc1-c1nncc2cc(ccc12)S(=O)(=O)Nc1ncc(F)s1)C(F)(F)F
Show InChI InChI=1S/C19H12F4N4O3S2/c1-30-15-7-11(19(21,22)23)2-4-14(15)17-13-5-3-12(6-10(13)8-25-26-17)32(28,29)27-18-24-9-16(20)31-18/h2-9H,1H3,(H,24,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154033
PNG
(US9012443, 26)
Show SMILES Clc1ccc(c(c1)C1=CCNCC1)-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1 |t:8|
Show InChI InChI=1S/C23H19ClN4O2S2/c24-17-4-6-21(22(13-17)15-8-10-25-11-9-15)20-3-1-2-16-12-18(5-7-19(16)20)32(29,30)28-23-26-14-27-31-23/h1-8,12-14,25H,9-11H2,(H,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154192
PNG
(US9012443, 201)
Show SMILES COc1cc(Cl)ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H14ClN3O3S2/c1-26-17-11-13(20)2-4-16(17)18-15-5-3-14(10-12(15)6-7-21-18)28(24,25)23-19-22-8-9-27-19/h2-11H,1H3,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154112
PNG
(US9012443, 119)
Show SMILES FC(F)(F)c1ccc(c(c1)C1=CCNC1)-c1cccc2cc(ccc12)S(=O)(=O)Nc1ccncn1 |t:11|
Show InChI InChI=1S/C25H19F3N4O2S/c26-25(27,28)18-4-6-22(23(13-18)17-8-10-29-14-17)21-3-1-2-16-12-19(5-7-20(16)21)35(33,34)32-24-9-11-30-15-31-24/h1-9,11-13,15,29H,10,14H2,(H,30,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154211
PNG
(US9012443, 224)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)F
Show InChI InChI=1S/C20H15F2N3O3S2/c1-28-17-11-13(19(21)22)2-4-16(17)18-15-5-3-14(10-12(15)6-7-23-18)30(26,27)25-20-24-8-9-29-20/h2-11,19H,1H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154253
PNG
(US9012443, 269)
Show SMILES COc1cc(ccc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N
Show InChI InChI=1S/C19H13N5O3S2/c1-27-17-8-12(10-20)2-4-15(17)18-14-5-3-13(9-16(14)22-11-23-18)29(25,26)24-19-21-6-7-28-19/h2-9,11H,1H3,(H,21,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154311
PNG
(US9012443, 331)
Show SMILES COc1cc(c(Cl)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ncns1)-c1cccc(F)c1
Show InChI InChI=1S/C24H16ClFN4O3S2/c1-33-22-12-19(14-3-2-4-16(26)9-14)21(25)11-20(22)23-18-6-5-17(10-15(18)7-8-27-23)35(31,32)30-24-28-13-29-34-24/h2-13H,1H3,(H,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 23n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154312
PNG
(US9012443, 332)
Show SMILES COc1cc(c(Cl)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)-c1cccc(F)c1
Show InChI InChI=1S/C24H16ClFN4O3S2/c1-33-22-12-19(14-3-2-4-16(26)9-14)21(25)11-20(22)23-18-6-5-17(10-15(18)7-8-27-23)35(31,32)30-24-29-28-13-34-24/h2-13H,1H3,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 28n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154318
PNG
(US9012443, 338)
Show SMILES COc1cc(-c2cc(F)cc(F)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)C#N
Show InChI InChI=1S/C25H15F2N5O3S2/c1-35-23-11-21(15-6-17(26)10-18(27)7-15)16(12-28)9-22(23)24-20-3-2-19(8-14(20)4-5-29-24)37(33,34)32-25-31-30-13-36-25/h2-11,13H,1H3,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 29n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154216
PNG
(US9012443, 230)
Show SMILES OCC(O)Cc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C22H18F3N3O4S2/c23-22(24,25)15-1-3-19(14(9-15)10-16(30)12-29)20-18-4-2-17(11-13(18)5-6-26-20)34(31,32)28-21-27-7-8-33-21/h1-9,11,16,29-30H,10,12H2,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154212
PNG
(US9012443, 225)
Show SMILES COCc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C21H16F3N3O3S2/c1-30-12-14-10-15(21(22,23)24)2-4-18(14)19-17-5-3-16(11-13(17)6-7-25-19)32(28,29)27-20-26-8-9-31-20/h2-11H,12H2,1H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 30n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154258
PNG
(US9012443, 274)
Show SMILES COc1cc(F)ccc1-c1ccnc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H14FN3O3S2/c1-26-18-10-12(20)2-4-16(18)14-6-7-21-17-11-13(3-5-15(14)17)28(24,25)23-19-22-8-9-27-19/h2-11H,1H3,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 30n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154008
PNG
(US9012443, 1)
Show SMILES Cn1nccc1-c1cc(ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F
Show InChI InChI=1S/C23H16F3N5O2S2/c1-31-21(9-10-28-31)20-12-15(23(24,25)26)5-7-19(20)18-4-2-3-14-11-16(6-8-17(14)18)35(32,33)30-22-27-13-29-34-22/h2-13H,1H3,(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 30n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154055
PNG
(US9012443, 48)
Show SMILES FC(F)(F)c1ccc(c(c1)C1=CCNCC1)-c1cccc2cc(ccc12)S(=O)(=O)Nc1ccncn1 |t:11|
Show InChI InChI=1S/C26H21F3N4O2S/c27-26(28,29)19-4-6-23(24(15-19)17-8-11-30-12-9-17)22-3-1-2-18-14-20(5-7-21(18)22)36(34,35)33-25-10-13-31-16-32-25/h1-8,10,13-16,30H,9,11-12H2,(H,31,32,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 30n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 827 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%