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Patent code US9012443

Compile Data Set for Download or QSAR

Found 827 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154254
PNG
(US9012443, 270)
Show SMILES COc1cc(C(F)F)c(Cl)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H13ClF2N4O3S2/c1-29-16-8-12(18(21)22)14(20)7-13(16)17-11-3-2-10(6-15(11)24-9-25-17)31(27,28)26-19-23-4-5-30-19/h2-9,18H,1H3,(H,23,26)
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n/an/a 150n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154268
PNG
(US9012443, 284)
Show SMILES COc1cc(ccc1-c1c(cnc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N)C(F)(F)F |(2,.77,;.67,,;.67,-1.54,;2,-2.31,;2.05,-3.88,;.67,-4.62,;-.67,-3.85,;-.67,-2.31,;-2,-1.54,;-3.33,-2.31,;-4.67,-1.54,;-4.67,,;-3.33,.77,;-3.33,2.31,;-2,3.08,;-.67,2.31,;-.67,.77,;-2,,;-2,4.62,;-2.77,5.95,;-3.54,4.62,;-.67,5.39,;.67,4.62,;1.14,3.16,;2.68,3.16,;3.16,4.62,;1.91,5.53,;-3.33,-3.85,;-3.33,-5.39,;3.38,-4.65,;4.72,-5.42,;2.61,-5.98,;4.15,-3.31,)|
Show InChI InChI=1S/C21H13F3N4O3S2/c1-31-18-8-13(21(22,23)24)2-4-16(18)19-12(10-25)11-27-17-9-14(3-5-15(17)19)33(29,30)28-20-26-6-7-32-20/h2-9,11H,1H3,(H,26,28)
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n/an/a 320n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154499
PNG
(US9012443, 328)
Show SMILES COc1cc(ccc1-c1ccnc2c(C)c(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C21H16F3N3O3S2/c1-12-18(32(28,29)27-20-26-9-10-31-20)6-5-16-14(7-8-25-19(12)16)15-4-3-13(21(22,23)24)11-17(15)30-2/h3-11H,1-2H3,(H,26,27)
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n/an/a 6.87E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154311
PNG
(US9012443, 331)
Show SMILES COc1cc(c(Cl)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ncns1)-c1cccc(F)c1
Show InChI InChI=1S/C24H16ClFN4O3S2/c1-33-22-12-19(14-3-2-4-16(26)9-14)21(25)11-20(22)23-18-6-5-17(10-15(18)7-8-27-23)35(31,32)30-24-28-13-29-34-24/h2-13H,1H3,(H,28,29,30)
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n/an/a 23n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154313
PNG
(US9012443, 333)
Show SMILES COc1cc(c(Cl)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1cccc(F)c1
Show InChI InChI=1S/C26H18ClFN4O3S/c1-35-24-14-21(16-3-2-4-18(28)11-16)23(27)13-22(24)26-20-6-5-19(12-17(20)7-10-30-26)36(33,34)32-25-8-9-29-15-31-25/h2-15H,1H3,(H,29,31,32)
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n/an/a 75n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154315
PNG
(US9012443, 335)
Show SMILES COc1cc(c(Cl)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(F)c1
Show InChI InChI=1S/C25H17ClFN3O4S/c1-33-23-14-20(15-3-2-4-17(27)11-15)22(26)13-21(23)25-19-6-5-18(12-16(19)7-9-28-25)35(31,32)30-24-8-10-34-29-24/h2-14H,1H3,(H,29,30)
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n/an/a 52n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154317
PNG
(US9012443, 337)
Show SMILES COc1cc(Cl)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)C#N
Show InChI InChI=1S/C19H12ClN5O3S2/c1-28-17-8-16(20)12(9-21)7-15(17)18-14-3-2-13(6-11(14)4-5-22-18)30(26,27)25-19-24-23-10-29-19/h2-8,10H,1H3,(H,24,25)
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n/an/a 388n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154320
PNG
(US9012443, 340)
Show SMILES COc1cc(-c2cccc(F)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ncns1)C#N
Show InChI InChI=1S/C25H16FN5O3S2/c1-34-23-12-21(15-3-2-4-18(26)9-15)17(13-27)11-22(23)24-20-6-5-19(10-16(20)7-8-28-24)36(32,33)31-25-29-14-30-35-25/h2-12,14H,1H3,(H,29,30,31)
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n/an/a 56n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154335
PNG
(US9012443, 355)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H16F2N4O3S2/c1-33-22-11-14(16-8-17(25)12-18(26)9-16)2-4-21(22)23-20-5-3-19(10-15(20)6-7-27-23)35(31,32)30-24-29-28-13-34-24/h2-13H,1H3,(H,29,30)
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n/an/a 48n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154374
PNG
(US9012443, 413)
Show SMILES FC(F)Oc1ccc(F)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H12F3N3O3S2/c20-12-1-4-16(28-18(21)22)15(10-12)17-14-3-2-13(9-11(14)5-6-23-17)30(26,27)25-19-24-7-8-29-19/h1-10,18H,(H,24,25)
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n/an/a 830n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154377
PNG
(US9012443, 416)
Show SMILES FC(Oc1cc(F)ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1)[N+]#[C-]
Show InChI InChI=1S/C20H12F2N4O3S2/c1-23-19(22)29-17-11-13(21)2-4-16(17)18-15-5-3-14(10-12(15)6-7-24-18)31(27,28)26-20-25-8-9-30-20/h2-11,19H,(H,25,26)
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n/an/a 1.22E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154378
PNG
(US9012443, 417)
Show SMILES NC(=O)COc1cc(F)ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H15FN4O4S2/c21-13-1-3-16(17(10-13)29-11-18(22)26)19-15-4-2-14(9-12(15)5-6-23-19)31(27,28)25-20-24-7-8-30-20/h1-10H,11H2,(H2,22,26)(H,24,25)
PDB

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n/an/a 1.23E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154381
PNG
(US9012443, 421)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nc(cs1)C#N)C(F)(F)F
Show InChI InChI=1S/C21H13F3N4O3S2/c1-31-18-9-13(21(22,23)24)2-4-17(18)19-16-5-3-15(8-12(16)6-7-26-19)33(29,30)28-20-27-14(10-25)11-32-20/h2-9,11H,1H3,(H,27,28)
PDB

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n/an/a 786n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154382
PNG
(US9012443, 422)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1cc(Cl)ncn1)C(F)(F)F
Show InChI InChI=1S/C21H14ClF3N4O3S/c1-32-17-9-13(21(23,24)25)2-4-16(17)20-15-5-3-14(8-12(15)6-7-26-20)33(30,31)29-19-10-18(22)27-11-28-19/h2-11H,1H3,(H,27,28,29)
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n/an/a 835n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154383
PNG
(US9012443, 423)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1)C(F)(F)F
Show InChI InChI=1S/C20H14F3N3O4S/c1-29-17-11-13(20(21,22)23)2-4-16(17)19-15-5-3-14(10-12(15)6-8-24-19)31(27,28)26-18-7-9-30-25-18/h2-11H,1H3,(H,25,26)
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n/an/a 1.34E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154399
PNG
(US9012443, 449)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C26H18F2N4O3S/c1-35-24-13-16(18-10-19(27)14-20(28)11-18)2-4-23(24)26-22-5-3-21(12-17(22)6-9-30-26)36(33,34)32-25-7-8-29-15-31-25/h2-15H,1H3,(H,29,31,32)
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n/an/a 34n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154404
PNG
(US9012443, 456)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1nccs1
Show InChI InChI=1S/C23H17N5O3S2/c1-31-20-13-16(23-26-10-11-32-23)2-4-19(20)22-18-5-3-17(12-15(18)6-9-25-22)33(29,30)28-21-7-8-24-14-27-21/h2-14H,1H3,(H,24,27,28)
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n/an/a 4.70E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154408
PNG
(US9012443, 461)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1ccc(C)o1
Show InChI InChI=1S/C25H20N4O4S/c1-16-3-8-22(33-16)18-4-6-21(23(14-18)32-2)25-20-7-5-19(13-17(20)9-12-27-25)34(30,31)29-24-10-11-26-15-28-24/h3-15H,1-2H3,(H,26,28,29)
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n/an/a 1.78E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154413
PNG
(US9012443, 467)
Show SMILES COc1cccc(c1)-c1ccc(c(OC)c1)-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C27H22N4O4S/c1-34-21-5-3-4-18(14-21)19-6-8-24(25(16-19)35-2)27-23-9-7-22(15-20(23)10-13-29-27)36(32,33)31-26-11-12-28-17-30-26/h3-17H,1-2H3,(H,28,30,31)
PDB

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n/an/a 204n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154417
PNG
(US9012443, 471)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1ccc(C)c(F)c1
Show InChI InChI=1S/C27H21FN4O3S/c1-17-3-4-18(14-24(17)28)19-5-7-23(25(15-19)35-2)27-22-8-6-21(13-20(22)9-12-30-27)36(33,34)32-26-10-11-29-16-31-26/h3-16H,1-2H3,(H,29,31,32)
PDB

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n/an/a 56n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154423
PNG
(US9012443, 477)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1ccc(C)nc1
Show InChI InChI=1S/C26H21N5O3S/c1-17-3-4-20(15-29-17)18-5-7-23(24(14-18)34-2)26-22-8-6-21(13-19(22)9-12-28-26)35(32,33)31-25-10-11-27-16-30-25/h3-16H,1-2H3,(H,27,30,31)
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US Patent
n/an/a 4.04E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154425
PNG
(US9012443, 480)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1c(C)ccnc1F
Show InChI InChI=1S/C26H20FN5O3S/c1-16-7-11-30-26(27)24(16)18-3-5-21(22(14-18)35-2)25-20-6-4-19(13-17(20)8-12-29-25)36(33,34)32-23-9-10-28-15-31-23/h3-15H,1-2H3,(H,28,31,32)
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n/an/a 2.77E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154428
PNG
(US9012443, 483)
Show SMILES COc1ccc(cn1)-c1ccc(c(OC)c1)-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C26H21N5O4S/c1-34-23-14-17(19-4-8-25(35-2)29-15-19)3-6-22(23)26-21-7-5-20(13-18(21)9-12-28-26)36(32,33)31-24-10-11-27-16-30-24/h3-16H,1-2H3,(H,27,30,31)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154433
PNG
(US9012443, 488)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C27H21FN4O3S/c1-17-13-18(4-8-24(17)28)19-3-6-23(25(15-19)35-2)27-22-7-5-21(14-20(22)9-12-30-27)36(33,34)32-26-10-11-29-16-31-26/h3-16H,1-2H3,(H,29,31,32)
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n/an/a 99n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154436
PNG
(US9012443, 491)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C26H18ClFN4O3S/c1-35-24-13-16(18-10-19(27)14-20(28)11-18)2-4-23(24)26-22-5-3-21(12-17(22)6-9-30-26)36(33,34)32-25-7-8-29-15-31-25/h2-15H,1H3,(H,29,31,32)
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n/an/a 101n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154454
PNG
(US9012443, 517)
Show SMILES COc1cc(ccc1-c1nc(C)nc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N
Show InChI InChI=1S/C20H15N5O3S2/c1-12-23-17-10-14(30(26,27)25-20-22-7-8-29-20)4-6-15(17)19(24-12)16-5-3-13(11-21)9-18(16)28-2/h3-10H,1-2H3,(H,22,25)
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n/an/a 1.28E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154457
PNG
(US9012443, 522)
Show SMILES COc1cc(c(Cl)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1nncs1)-c1cccc(F)c1
Show InChI InChI=1S/C23H15ClFN5O3S2/c1-33-21-10-17(13-3-2-4-14(25)7-13)19(24)9-18(21)22-16-6-5-15(8-20(16)26-11-27-22)35(31,32)30-23-29-28-12-34-23/h2-12H,1H3,(H,29,30)
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n/an/a 34n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154514
PNG
(US9012443, 533)
Show SMILES Oc1cc(ccc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C18H11F3N4O3S2/c19-18(20,21)10-1-3-13(15(26)7-10)16-12-4-2-11(8-14(12)23-9-24-16)30(27,28)25-17-22-5-6-29-17/h1-9,26H,(H,22,25)
PDB

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n/an/a 4.09E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM154167
PNG
(US9012443, 175)
Show SMILES COc1cc(C)ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H17N3O3S2/c1-13-3-5-17(18(11-13)26-2)19-16-6-4-15(12-14(16)7-8-21-19)28(24,25)23-20-22-9-10-27-20/h3-12H,1-2H3,(H,22,23)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM154169
PNG
(US9012443, 177)
Show SMILES COc1cc(Cl)c(Cl)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C19H13Cl2N3O3S2/c1-27-17-10-16(21)15(20)9-14(17)18-13-3-2-12(8-11(13)4-5-22-18)29(25,26)24-19-23-6-7-28-19/h2-10H,1H3,(H,23,24)
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM154497
PNG
(US9012443, 293)
Show SMILES COc1cc(ccc1-c1n[nH]c(=O)c2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F
Show InChI InChI=1S/C19H13F3N4O4S2/c1-30-15-8-10(19(20,21)22)2-4-13(15)16-12-5-3-11(9-14(12)17(27)25-24-16)32(28,29)26-18-23-6-7-31-18/h2-9H,1H3,(H,23,26)(H,25,27)
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM154320
PNG
(US9012443, 340)
Show SMILES COc1cc(-c2cccc(F)c2)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ncns1)C#N
Show InChI InChI=1S/C25H16FN5O3S2/c1-34-23-12-21(15-3-2-4-18(26)9-15)17(13-27)11-22(23)24-20-6-5-19(10-16(20)7-8-28-24)36(32,33)31-25-29-14-30-35-25/h2-12,14H,1H3,(H,29,30,31)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM154324
PNG
(US9012443, 344)
Show SMILES COc1ccc(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H17F3N4O3S2/c1-35-22-8-5-16(15-3-2-4-18(11-15)25(26,27)28)13-21(22)23-20-7-6-19(12-17(20)9-10-29-23)37(33,34)32-24-31-30-14-36-24/h2-14H,1H3,(H,31,32)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM154328
PNG
(US9012443, 348)
Show SMILES COc1ccc(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1cccc(F)c1
Show InChI InChI=1S/C26H19FN4O3S/c1-34-24-8-5-18(17-3-2-4-20(27)13-17)15-23(24)26-22-7-6-21(14-19(22)9-12-29-26)35(32,33)31-25-10-11-28-16-30-25/h2-16H,1H3,(H,28,30,31)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM154342
PNG
(US9012443, 363)
Show SMILES COc1nc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1cccc(F)c1
Show InChI InChI=1S/C25H18FN5O3S/c1-34-25-21(7-8-22(30-25)17-3-2-4-18(26)13-17)24-20-6-5-19(14-16(20)9-12-28-24)35(32,33)31-23-10-11-27-15-29-23/h2-15H,1H3,(H,27,29,31)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM154344
PNG
(US9012443, 365)
Show SMILES COc1cc(c(F)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1nncs1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C24H15F3N4O3S2/c1-34-22-11-17(13-2-5-19(25)21(27)9-13)20(26)10-18(22)23-16-4-3-15(8-14(16)6-7-28-23)36(32,33)31-24-30-29-12-35-24/h2-12H,1H3,(H,30,31)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM154394
PNG
(US9012443, 444)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1cccc(F)c1F
Show InChI InChI=1S/C26H18F2N4O3S/c1-35-23-14-16(19-3-2-4-22(27)25(19)28)5-7-21(23)26-20-8-6-18(13-17(20)9-12-30-26)36(33,34)32-24-10-11-29-15-31-24/h2-15H,1H3,(H,29,31,32)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM154397
PNG
(US9012443, 447)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1c(F)cccc1F
Show InChI InChI=1S/C26H18F2N4O3S/c1-35-23-14-17(25-21(27)3-2-4-22(25)28)5-7-20(23)26-19-8-6-18(13-16(19)9-12-30-26)36(33,34)32-24-10-11-29-15-31-24/h2-15H,1H3,(H,29,31,32)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM154437
PNG
(US9012443, 492)
Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C26H18ClFN4O3S/c1-35-24-14-17(16-3-7-22(27)23(28)13-16)2-5-21(24)26-20-6-4-19(12-18(20)8-11-30-26)36(33,34)32-25-9-10-29-15-31-25/h2-15H,1H3,(H,29,31,32)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM154451
PNG
(US9012443, 514)
Show SMILES COc1cc(C(F)F)c(F)cc1-c1nc(C)nc2cc(ccc12)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C20H15F3N4O3S2/c1-10-25-16-7-11(32(28,29)27-20-24-5-6-31-20)3-4-12(16)18(26-10)14-8-15(21)13(19(22)23)9-17(14)30-2/h3-9,19H,1-2H3,(H,24,27)
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))		BDBM154452
PNG
(US9012443, 515)
Show SMILES COc1cc(ccc1-c1nc(C)nc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)F
Show InChI InChI=1S/C20H16F2N4O3S2/c1-11-24-16-10-13(31(27,28)26-20-23-7-8-30-20)4-6-14(16)18(25-11)15-5-3-12(19(21)22)9-17(15)29-2/h3-10,19H,1-2H3,(H,23,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154021
PNG
(US9012443, 14 (isomer 1) | US9012443, 14 (isomer 2...)
Show SMILES O=S(=O)(Nc1ncns1)c1ccc2c(cccc2c1)N1CCOC(C1)c1ccccc1
Show InChI InChI=1S/C22H20N4O3S2/c27-31(28,25-22-23-15-24-30-22)18-9-10-19-17(13-18)7-4-8-20(19)26-11-12-29-21(14-26)16-5-2-1-3-6-16/h1-10,13,15,21H,11-12,14H2,(H,23,24,25)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154022
PNG
(US9012443, 15)
Show SMILES CC1(CN(CCO1)c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1)c1ccccc1
Show InChI InChI=1S/C23H22N4O3S2/c1-23(18-7-3-2-4-8-18)15-27(12-13-30-23)21-9-5-6-17-14-19(10-11-20(17)21)32(28,29)26-22-24-16-25-31-22/h2-11,14,16H,12-13,15H2,1H3,(H,24,25,26)
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n/an/a 1.29E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154025
PNG
(US9012443, 18)
Show SMILES CCC1CN(CCO1)c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C18H20N4O3S2/c1-2-14-11-22(8-9-25-14)17-5-3-4-13-10-15(6-7-16(13)17)27(23,24)21-18-19-12-20-26-18/h3-7,10,12,14H,2,8-9,11H2,1H3,(H,19,20,21)
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n/an/a 710n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154040
PNG
(US9012443, 33)
Show SMILES Cc1cc(Cl)ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H14ClN3O2S2/c1-12-9-14(20)5-7-16(12)18-4-2-3-13-10-15(6-8-17(13)18)27(24,25)23-19-21-11-22-26-19/h2-11H,1H3,(H,21,22,23)
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n/an/a 190n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154042
PNG
(US9012443, 35)
Show SMILES Fc1cc(Cl)ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C18H11ClFN3O2S2/c19-12-4-6-16(17(20)9-12)15-3-1-2-11-8-13(5-7-14(11)15)27(24,25)23-18-21-10-22-26-18/h1-10H,(H,21,22,23)
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n/an/a 210n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154045
PNG
(US9012443, 38)
Show SMILES Oc1cc(ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1)C(F)(F)F
Show InChI InChI=1S/C19H12F3N3O3S2/c20-19(21,22)12-4-6-16(17(26)9-12)15-3-1-2-11-8-13(5-7-14(11)15)30(27,28)25-18-23-10-24-29-18/h1-10,26H,(H,23,24,25)
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n/an/a 490n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154046
PNG
(US9012443, 39)
Show SMILES FC(F)(F)c1cc(Cl)ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H11ClF3N3O2S2/c20-12-4-6-16(17(9-12)19(21,22)23)15-3-1-2-11-8-13(5-7-14(11)15)30(27,28)26-18-24-10-25-29-18/h1-10H,(H,24,25,26)
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n/an/a 1.54E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154047
PNG
(US9012443, 40)
Show SMILES Clc1ccc(c(Cl)c1)-c1cccc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C18H11Cl2N3O2S2/c19-12-4-6-16(17(20)9-12)15-3-1-2-11-8-13(5-7-14(11)15)27(24,25)23-18-21-10-22-26-18/h1-10H,(H,21,22,23)
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n/an/a 1.97E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM154063
PNG
(US9012443, 59)
Show SMILES COc1ccc(c(OC)c1)-c1nccc2cc(ccc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H16N4O4S2/c1-26-13-3-5-16(17(10-13)27-2)18-15-6-4-14(9-12(15)7-8-20-18)29(24,25)23-19-21-11-22-28-19/h3-11H,1-2H3,(H,21,22,23)
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n/an/a 60n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...

US Patent US9012443 (2015)


BindingDB Entry DOI: 10.7270/Q2N0158J
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%