Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium channel protein type 9 subunit alpha | ||
| Ligand | BDBM154268 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | In Vitro PX Assay | ||
| IC50 | 320±n/a nM | ||
| Citation |  Boezio, C; Bregman, H; Coats, JR; Dimauro, EF; Dineen, T; Du, B; Graceffa, R; Kreiman, C; La, D; Marx, IE; Chakka, N; Nguyen, HN; Peterson, EA; Weiss, M; Copeland, KW; Deak, HL; Boezio, A Bicyclic aryl and heteroaryl sodium channel inhibitors US Patent US9012443 Publication Date 4/21/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium channel protein type 9 subunit alpha | |||
| Name: | Sodium channel protein type 9 subunit alpha | ||
| Synonyms: | NENA | Neuroendocrine sodium channel | Peripheral sodium channel 1 | SCN9A | SCN9A_HUMAN | Sodium channel protein type IX alpha subunit | Voltage-gated sodium channel subunit Nav1.7 | Voltage-gated sodium channel subunit alpha Nav1.7 | hNE-Na | ||
| Type: | Protein | ||
| Mol. Mass.: | 226375.97 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15858 | ||
| Residue: | 1988 | ||
| Sequence: |
| ||
| BDBM154268 | |||
| n/a | |||
| Name | BDBM154268 | ||
| Synonyms: | US9012443, 284 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H13F3N4O3S2 | ||
| Mol. Mass. | 490.478 | ||
| SMILES | COc1cc(ccc1-c1c(cnc2cc(ccc12)S(=O)(=O)Nc1nccs1)C#N)C(F)(F)F |(2,.77,;.67,,;.67,-1.54,;2,-2.31,;2.05,-3.88,;.67,-4.62,;-.67,-3.85,;-.67,-2.31,;-2,-1.54,;-3.33,-2.31,;-4.67,-1.54,;-4.67,,;-3.33,.77,;-3.33,2.31,;-2,3.08,;-.67,2.31,;-.67,.77,;-2,,;-2,4.62,;-2.77,5.95,;-3.54,4.62,;-.67,5.39,;.67,4.62,;1.14,3.16,;2.68,3.16,;3.16,4.62,;1.91,5.53,;-3.33,-3.85,;-3.33,-5.39,;3.38,-4.65,;4.72,-5.42,;2.61,-5.98,;4.15,-3.31,)| | ||
| Structure | 
| ||