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Patent code US9067917

Compile Data Set for Download or QSAR

Found 220 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165186
PNG
(US9067917, 3)
Show SMILES OC(=O)[C@@H]1CCCC[C@@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1 |r|
Show InChI InChI=1S/C31H28BrN3O3/c32-22-12-9-20(10-13-22)18-35-29-16-15-24(38-19-23-14-11-21-5-1-4-8-27(21)33-23)17-28(29)34-30(35)25-6-2-3-7-26(25)31(36)37/h1,4-5,8-17,25-26H,2-3,6-7,18-19H2,(H,36,37)/t25-,26+/m0/s1
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 1.60n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM164981
PNG
(US9067917, 14 | US9682971, 14)
Show SMILES CC1(C)[C@H]([C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1F)C(O)=O |r|
Show InChI InChI=1S/C30H25BrFN3O3/c1-30(2)26(27(30)29(36)37)28-34-24-14-21(38-16-20-10-8-17-5-3-4-6-23(17)33-20)11-12-25(24)35(28)15-18-7-9-19(31)13-22(18)32/h3-14,26-27H,15-16H2,1-2H3,(H,36,37)/t26-,27+/m0/s1
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 2.70n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM164975
PNG
(US9067917, 8 | US9682971, 8)
Show SMILES CC1(C)CCCC1(Cc1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C33H32BrN3O3/c1-32(2)16-5-17-33(32,31(38)39)19-30-36-28-18-26(40-21-25-13-10-23-6-3-4-7-27(23)35-25)14-15-29(28)37(30)20-22-8-11-24(34)12-9-22/h3-4,6-15,18H,5,16-17,19-21H2,1-2H3,(H,38,39)
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 3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165174
PNG
(US9067917, 209 | US9067917, 210 | US9682971, 210)
Show SMILES OC(=O)[C@@H]1CCCC[C@@H]1c1nc2cc(OCc3nc4ccccc4s3)ccc2n1Cc1ccc(Br)cc1 |r|
Show InChI InChI=1S/C29H26BrN3O3S/c30-19-11-9-18(10-12-19)16-33-25-14-13-20(36-17-27-31-23-7-3-4-8-26(23)37-27)15-24(25)32-28(33)21-5-1-2-6-22(21)29(34)35/h3-4,7-15,21-22H,1-2,5-6,16-17H2,(H,34,35)/t21-,22+/m0/s1
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 3.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM164970
PNG
(US9067917, 1 | US9067917, 21 | US9682971, 21)
Show SMILES OC(=O)[C@H]1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1 |r|
Show InChI InChI=1S/C31H28BrN3O3/c32-22-12-9-20(10-13-22)18-35-29-16-15-24(38-19-23-14-11-21-5-1-4-8-27(21)33-23)17-28(29)34-30(35)25-6-2-3-7-26(25)31(36)37/h1,4-5,8-17,25-26H,2-3,6-7,18-19H2,(H,36,37)/t25?,26-/m0/s1
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 3.60n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165154
PNG
(US9067917, 189 | US9682971, 189)
Show SMILES OC(=O)[C@H]1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1cccc(c1)-c1ncccn1 |r|
Show InChI InChI=1S/C35H31N5O3/c41-35(42)29-11-3-2-10-28(29)34-39-31-20-27(43-22-26-14-13-24-8-1-4-12-30(24)38-26)15-16-32(31)40(34)21-23-7-5-9-25(19-23)33-36-17-6-18-37-33/h1,4-9,12-20,28-29H,2-3,10-11,21-22H2,(H,41,42)/t28?,29-/m0/s1
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 4.10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165008
PNG
(US9067917, 41 | US9067917, 43 | US9682971, 42)
Show SMILES OC(=O)[C@H]1CCCC[C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(OC(F)(F)F)cc1F |r|
Show InChI InChI=1S/C32H27F4N3O4/c33-26-15-23(43-32(34,35)36)12-10-20(26)17-39-29-14-13-22(42-18-21-11-9-19-5-1-4-8-27(19)37-21)16-28(29)38-30(39)24-6-2-3-7-25(24)31(40)41/h1,4-5,8-16,24-25H,2-3,6-7,17-18H2,(H,40,41)/t24-,25+/m1/s1
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 4.20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165103
PNG
(US9067917, 138 | US9682971, 138)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cccc(Cn2c(nc3cc(OCc4ccc5ccccc5n4)ccc23)C2CCCC[C@@H]2C(O)=O)c1 |r|
Show InChI InChI=1S/C38H36N4O5S/c1-48(45,46)41-29-16-13-26(14-17-29)28-9-6-7-25(21-28)23-42-36-20-19-31(47-24-30-18-15-27-8-2-5-12-34(27)39-30)22-35(36)40-37(42)32-10-3-4-11-33(32)38(43)44/h2,5-9,12-22,32-33,41H,3-4,10-11,23-24H2,1H3,(H,43,44)/t32?,33-/m0/s1
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 4.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165002
PNG
(US9067917, 35 | US9682971, 35)
Show SMILES OC(=O)[C@@H]1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(cc1)C#N |r|
Show InChI InChI=1S/C32H28N4O3/c33-18-21-9-11-22(12-10-21)19-36-30-16-15-25(39-20-24-14-13-23-5-1-4-8-28(23)34-24)17-29(30)35-31(36)26-6-2-3-7-27(26)32(37)38/h1,4-5,8-17,26-27H,2-3,6-7,19-20H2,(H,37,38)/t26?,27-/m1/s1
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 4.80n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165062
PNG
(US9067917, 97 | US9682971, 97)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cccc(Cn2c(CC3(CCCC3)C(O)=O)nc3cc(OCc4ccc5ccccc5n4)ccc23)c1
Show InChI InChI=1S/C38H36N4O5S/c1-48(45,46)41-30-14-11-27(12-15-30)29-9-6-7-26(21-29)24-42-35-18-17-32(47-25-31-16-13-28-8-2-3-10-33(28)39-31)22-34(35)40-36(42)23-38(37(43)44)19-4-5-20-38/h2-3,6-18,21-22,41H,4-5,19-20,23-25H2,1H3,(H,43,44)
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 5.10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165010
PNG
(US9067917, 45 | US9067917, 46 | US9682971, 46)
Show SMILES OC(=O)[C@H]1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(OC(F)(F)F)cc1 |r|
Show InChI InChI=1S/C32H28F3N3O4/c33-32(34,35)42-23-13-9-20(10-14-23)18-38-29-16-15-24(41-19-22-12-11-21-5-1-4-8-27(21)36-22)17-28(29)37-30(38)25-6-2-3-7-26(25)31(39)40/h1,4-5,8-17,25-26H,2-3,6-7,18-19H2,(H,39,40)/t25?,26-/m0/s1
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 5.60n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165133
PNG
(US9067917, 168 | US9682971, 168)
Show SMILES CC(C)(Cc1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1cccc(c1)-c1ccc(NS(C)(=O)=O)cc1)C(O)=O
Show InChI InChI=1S/C36H34N4O5S/c1-36(2,35(41)42)21-34-38-32-20-30(45-23-29-16-13-26-8-4-5-10-31(26)37-29)17-18-33(32)40(34)22-24-7-6-9-27(19-24)25-11-14-28(15-12-25)39-46(3,43)44/h4-20,39H,21-23H2,1-3H3,(H,41,42)
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 5.60n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165017
PNG
(US9067917, 52 | US9682971, 52)
Show SMILES OC(=O)[C@@H]1CCCC[C@@H]1c1nc2cc(OCc3ccc4cc(F)ccc4n3)ccc2n1Cc1ccc(Br)cc1 |r|
Show InChI InChI=1S/C31H27BrFN3O3/c32-21-8-5-19(6-9-21)17-36-29-14-12-24(39-18-23-11-7-20-15-22(33)10-13-27(20)34-23)16-28(29)35-30(36)25-3-1-2-4-26(25)31(37)38/h5-16,25-26H,1-4,17-18H2,(H,37,38)/t25-,26+/m0/s1
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 5.70n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165005
PNG
(US9067917, 38 | US9682971, 38)
Show SMILES Cc1ccccc1Cn1c(nc2cc(OCc3ccc4ccccc4n3)ccc12)[C@@H]1CCCC[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C32H31N3O3/c1-21-8-2-3-10-23(21)19-35-30-17-16-25(38-20-24-15-14-22-9-4-7-13-28(22)33-24)18-29(30)34-31(35)26-11-5-6-12-27(26)32(36)37/h2-4,7-10,13-18,26-27H,5-6,11-12,19-20H2,1H3,(H,36,37)/t26-,27+/m1/s1
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 5.80n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165008
PNG
(US9067917, 41 | US9067917, 43 | US9682971, 42)
Show SMILES OC(=O)[C@H]1CCCC[C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(OC(F)(F)F)cc1F |r|
Show InChI InChI=1S/C32H27F4N3O4/c33-26-15-23(43-32(34,35)36)12-10-20(26)17-39-29-14-13-22(42-18-21-11-9-19-5-1-4-8-27(19)37-21)16-28(29)38-30(39)24-6-2-3-7-25(24)31(40)41/h1,4-5,8-16,24-25H,2-3,6-7,17-18H2,(H,40,41)/t24-,25+/m1/s1
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 6.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM164982
PNG
(US9067917, 15 | US9682971, 15)
Show SMILES OC(=O)[C@H]1CCCC[C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1F |r|
Show InChI InChI=1S/C31H27BrFN3O3/c32-21-11-9-20(26(33)15-21)17-36-29-14-13-23(39-18-22-12-10-19-5-1-4-8-27(19)34-22)16-28(29)35-30(36)24-6-2-3-7-25(24)31(37)38/h1,4-5,8-16,24-25H,2-3,6-7,17-18H2,(H,37,38)/t24-,25+/m1/s1
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 7n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165064
PNG
(US9067917, 99 | US9682971, 99)
Show SMILES Cn1cc(cn1)-c1cccc(Cn2c(CC3(CCCC3)C(O)=O)nc3cc(OCc4ccc5ccccc5n4)ccc23)c1
Show InChI InChI=1S/C35H33N5O3/c1-39-22-27(20-36-39)26-9-6-7-24(17-26)21-40-32-14-13-29(43-23-28-12-11-25-8-2-3-10-30(25)37-28)18-31(32)38-33(40)19-35(34(41)42)15-4-5-16-35/h2-3,6-14,17-18,20,22H,4-5,15-16,19,21,23H2,1H3,(H,41,42)
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 7.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM164970
PNG
(US9067917, 1 | US9067917, 21 | US9682971, 21)
Show SMILES OC(=O)[C@H]1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1 |r|
Show InChI InChI=1S/C31H28BrN3O3/c32-22-12-9-20(10-13-22)18-35-29-16-15-24(38-19-23-14-11-21-5-1-4-8-27(21)33-23)17-28(29)34-30(35)25-6-2-3-7-26(25)31(36)37/h1,4-5,8-17,25-26H,2-3,6-7,18-19H2,(H,36,37)/t25?,26-/m0/s1
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 7.80n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165009
PNG
(US9067917, 44 | US9682971, 44)
Show SMILES Cc1ccc(Cn2c(nc3cc(OCc4ccc5ccccc5n4)ccc23)C2CCCC[C@H]2C(O)=O)cc1 |r|
Show InChI InChI=1S/C32H31N3O3/c1-21-10-12-22(13-11-21)19-35-30-17-16-25(38-20-24-15-14-23-6-2-5-9-28(23)33-24)18-29(30)34-31(35)26-7-3-4-8-27(26)32(36)37/h2,5-6,9-18,26-27H,3-4,7-8,19-20H2,1H3,(H,36,37)/t26?,27-/m1/s1
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 8.40n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165003
PNG
(US9067917, 36 | US9682971, 36)
Show SMILES OC(=O)[C@H]1CCCC[C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccccc1 |r|
Show InChI InChI=1S/C31H29N3O3/c35-31(36)26-12-6-5-11-25(26)30-33-28-18-24(16-17-29(28)34(30)19-21-8-2-1-3-9-21)37-20-23-15-14-22-10-4-7-13-27(22)32-23/h1-4,7-10,13-18,25-26H,5-6,11-12,19-20H2,(H,35,36)/t25-,26+/m1/s1
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 9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM164984
PNG
(US9067917, 17 | US9682971, 17)
Show SMILES CC1(C)CCC(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2ccc(Br)cc2)(C1)C(O)=O
Show InChI InChI=1S/C33H32BrN3O3/c1-32(2)15-16-33(21-32,31(38)39)18-30-36-28-17-26(40-20-25-12-9-23-5-3-4-6-27(23)35-25)13-14-29(28)37(30)19-22-7-10-24(34)11-8-22/h3-14,17H,15-16,18-21H2,1-2H3,(H,38,39)
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 9.20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165023
PNG
(US9067917, 58 | US9682971, 58)
Show SMILES OC(=O)C1(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2ccc(F)cc2)CCCC1
Show InChI InChI=1S/C31H28FN3O3/c32-23-10-7-21(8-11-23)19-35-28-14-13-25(38-20-24-12-9-22-5-1-2-6-26(22)33-24)17-27(28)34-29(35)18-31(30(36)37)15-3-4-16-31/h1-2,5-14,17H,3-4,15-16,18-20H2,(H,36,37)
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 9.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165028
PNG
(US9067917, 63 | US9682971, 63)
Show SMILES OC(=O)C1(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2ccc(Cl)cc2)CCCC1
Show InChI InChI=1S/C31H28ClN3O3/c32-23-10-7-21(8-11-23)19-35-28-14-13-25(38-20-24-12-9-22-5-1-2-6-26(22)33-24)17-27(28)34-29(35)18-31(30(36)37)15-3-4-16-31/h1-2,5-14,17H,3-4,15-16,18-20H2,(H,36,37)
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 9.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165014
PNG
(US9067917, 49 | US9682971, 49)
Show SMILES Cc1cccc(Cn2c(nc3cc(OCc4ccc5ccccc5n4)ccc23)C2CCCC[C@@H]2C(O)=O)c1 |r|
Show InChI InChI=1S/C32H31N3O3/c1-21-7-6-8-22(17-21)19-35-30-16-15-25(38-20-24-14-13-23-9-2-5-12-28(23)33-24)18-29(30)34-31(35)26-10-3-4-11-27(26)32(36)37/h2,5-9,12-18,26-27H,3-4,10-11,19-20H2,1H3,(H,36,37)/t26?,27-/m0/s1
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 9.70n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM164996
PNG
(US9067917, 29 | US9682971, 29)
Show SMILES OC(=O)C1(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2ccc(Br)cc2)CCCC1
Show InChI InChI=1S/C31H28BrN3O3/c32-23-10-7-21(8-11-23)19-35-28-14-13-25(38-20-24-12-9-22-5-1-2-6-26(22)33-24)17-27(28)34-29(35)18-31(30(36)37)15-3-4-16-31/h1-2,5-14,17H,3-4,15-16,18-20H2,(H,36,37)
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 11n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165010
PNG
(US9067917, 45 | US9067917, 46 | US9682971, 46)
Show SMILES OC(=O)[C@H]1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(OC(F)(F)F)cc1 |r|
Show InChI InChI=1S/C32H28F3N3O4/c33-32(34,35)42-23-13-9-20(10-14-23)18-38-29-16-15-24(41-19-22-12-11-21-5-1-4-8-27(21)36-22)17-28(29)37-30(38)25-6-2-3-7-26(25)31(39)40/h1,4-5,8-17,25-26H,2-3,6-7,18-19H2,(H,39,40)/t25?,26-/m0/s1
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 11n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165059
PNG
(US9067917, 94 | US9682971, 94)
Show SMILES COc1ncc(cn1)-c1cccc(Cn2c(CC3(CCCC3)C(O)=O)nc3cc(OCc4ccc5ccccc5n4)ccc23)c1
Show InChI InChI=1S/C36H33N5O4/c1-44-35-37-20-27(21-38-35)26-9-6-7-24(17-26)22-41-32-14-13-29(45-23-28-12-11-25-8-2-3-10-30(25)39-28)18-31(32)40-33(41)19-36(34(42)43)15-4-5-16-36/h2-3,6-14,17-18,20-21H,4-5,15-16,19,22-23H2,1H3,(H,42,43)
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 12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165107
PNG
(US9067917, 142 | US9682971, 142)
Show SMILES OC(=O)C1(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2cccc(c2)-c2ccn[nH]2)CCCC1
Show InChI InChI=1S/C34H31N5O3/c40-33(41)34(15-3-4-16-34)20-32-37-30-19-27(42-22-26-11-10-24-7-1-2-9-28(24)36-26)12-13-31(30)39(32)21-23-6-5-8-25(18-23)29-14-17-35-38-29/h1-2,5-14,17-19H,3-4,15-16,20-22H2,(H,35,38)(H,40,41)
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 12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM164983
PNG
(US9067917, 16 | US9682971, 16)
Show SMILES OC(=O)[C@@H]1CCCC[C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1F |r|
Show InChI InChI=1S/C31H27BrFN3O3/c32-21-11-9-20(26(33)15-21)17-36-29-14-13-23(39-18-22-12-10-19-5-1-4-8-27(19)34-22)16-28(29)35-30(36)24-6-2-3-7-25(24)31(37)38/h1,4-5,8-16,24-25H,2-3,6-7,17-18H2,(H,37,38)/t24-,25-/m1/s1
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 12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165063
PNG
(US9067917, 98 | US9682971, 98)
Show SMILES OC(=O)C1(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2cccc(c2)-c2cscn2)CCCC1
Show InChI InChI=1S/C34H30N4O3S/c39-33(40)34(14-3-4-15-34)18-32-37-29-17-27(41-20-26-11-10-24-7-1-2-9-28(24)36-26)12-13-31(29)38(32)19-23-6-5-8-25(16-23)30-21-42-22-35-30/h1-2,5-13,16-17,21-22H,3-4,14-15,18-20H2,(H,39,40)
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 13n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165058
PNG
(US9067917, 93 | US9682971, 93)
Show SMILES Cc1ccc(cc1)-c1cccc(Cn2c(CC3(CCCC3)C(O)=O)nc3cc(OCc4ccc5ccccc5n4)ccc23)c1
Show InChI InChI=1S/C38H35N3O3/c1-26-11-13-28(14-12-26)30-9-6-7-27(21-30)24-41-35-18-17-32(44-25-31-16-15-29-8-2-3-10-33(29)39-31)22-34(35)40-36(41)23-38(37(42)43)19-4-5-20-38/h2-3,6-18,21-22H,4-5,19-20,23-25H2,1H3,(H,42,43)
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 13n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165173
PNG
(US9067917, 208 | US9682971, 208)
Show SMILES OC(=O)[C@H]1CCCCC1c1nc2cc(OCc3nc4ccccc4s3)ccc2n1Cc1ccc(Br)cc1 |r|
Show InChI InChI=1S/C29H26BrN3O3S/c30-19-11-9-18(10-12-19)16-33-25-14-13-20(36-17-27-31-23-7-3-4-8-26(23)37-27)15-24(25)32-28(33)21-5-1-2-6-22(21)29(34)35/h3-4,7-15,21-22H,1-2,5-6,16-17H2,(H,34,35)/t21?,22-/m0/s1
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 13n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165177
PNG
(US9067917, 212 | US9682971, 212)
Show SMILES OC(=O)[C@@H]1CCCCC1c1nc2cc(OCc3nc4ccccc4s3)ccc2n1Cc1ccc(Br)cc1 |r|
Show InChI InChI=1S/C29H26BrN3O3S/c30-19-11-9-18(10-12-19)16-33-25-14-13-20(36-17-27-31-23-7-3-4-8-26(23)37-27)15-24(25)32-28(33)21-5-1-2-6-22(21)29(34)35/h3-4,7-15,21-22H,1-2,5-6,16-17H2,(H,34,35)/t21?,22-/m1/s1
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 13n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165056
PNG
(US9067917, 91 | US9682971, 91)
Show SMILES OC(=O)C1(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2cccc(c2)-c2ccccc2)CCCC1
Show InChI InChI=1S/C37H33N3O3/c41-36(42)37(19-6-7-20-37)23-35-39-33-22-31(43-25-30-16-15-28-12-4-5-14-32(28)38-30)17-18-34(33)40(35)24-26-9-8-13-29(21-26)27-10-2-1-3-11-27/h1-5,8-18,21-22H,6-7,19-20,23-25H2,(H,41,42)
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 13n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165164
PNG
(US9067917, 199 | US9682971, 199)
Show SMILES OC(=O)C1(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2cccc(c2)N2CCCC2)CCCC1
Show InChI InChI=1S/C35H36N4O3/c40-34(41)35(16-3-4-17-35)22-33-37-31-21-29(42-24-27-13-12-26-9-1-2-11-30(26)36-27)14-15-32(31)39(33)23-25-8-7-10-28(20-25)38-18-5-6-19-38/h1-2,7-15,20-21H,3-6,16-19,22-24H2,(H,40,41)
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 14n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM164991
PNG
(US9067917, 24 | US9682971, 24)
Show SMILES OC(=O)C1(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2ccc(Br)cc2)Cc2ccccc2C1
Show InChI InChI=1S/C35H28BrN3O3/c36-27-12-9-23(10-13-27)21-39-32-16-15-29(42-22-28-14-11-24-5-3-4-8-30(24)37-28)17-31(32)38-33(39)20-35(34(40)41)18-25-6-1-2-7-26(25)19-35/h1-17H,18-22H2,(H,40,41)
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 14n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165060
PNG
(US9067917, 95 | US9682971, 95)
Show SMILES COc1ccc(cn1)-c1cccc(Cn2c(CC3(CCCC3)C(O)=O)nc3cc(OCc4ccc5ccccc5n4)ccc23)c1
Show InChI InChI=1S/C37H34N4O4/c1-44-35-16-12-28(22-38-35)27-9-6-7-25(19-27)23-41-33-15-14-30(45-24-29-13-11-26-8-2-3-10-31(26)39-29)20-32(33)40-34(41)21-37(36(42)43)17-4-5-18-37/h2-3,6-16,19-20,22H,4-5,17-18,21,23-24H2,1H3,(H,42,43)
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 14n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165054
PNG
(US9067917, 89 | US9682971, 89)
Show SMILES OC(=O)C1(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2cccc(Br)c2)CCCC1
Show InChI InChI=1S/C31H28BrN3O3/c32-23-8-5-6-21(16-23)19-35-28-13-12-25(38-20-24-11-10-22-7-1-2-9-26(22)33-24)17-27(28)34-29(35)18-31(30(36)37)14-3-4-15-31/h1-2,5-13,16-17H,3-4,14-15,18-20H2,(H,36,37)
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 14n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM164990
PNG
(US9067917, 23 | US9682971, 23)
Show SMILES CCC(CC)(Cc1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C31H30BrN3O3/c1-3-31(4-2,30(36)37)18-29-34-27-17-25(38-20-24-14-11-22-7-5-6-8-26(22)33-24)15-16-28(27)35(29)19-21-9-12-23(32)13-10-21/h5-17H,3-4,18-20H2,1-2H3,(H,36,37)
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 14n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165065
PNG
(US9067917, 100 | US9682971, 100)
Show SMILES OC(=O)C1(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2cccc(c2)-c2ccoc2)CCCC1
Show InChI InChI=1S/C35H31N3O4/c39-34(40)35(15-3-4-16-35)20-33-37-31-19-29(42-23-28-11-10-25-7-1-2-9-30(25)36-28)12-13-32(31)38(33)21-24-6-5-8-26(18-24)27-14-17-41-22-27/h1-2,5-14,17-19,22H,3-4,15-16,20-21,23H2,(H,39,40)
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 15n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165130
PNG
(US9067917, 165 | US9682971, 165)
Show SMILES CC(C)(Cc1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1cccc(c1)-c1ccc(cc1)S(N)(=O)=O)C(O)=O
Show InChI InChI=1S/C35H32N4O5S/c1-35(2,34(40)41)20-33-38-31-19-28(44-22-27-13-10-25-7-3-4-9-30(25)37-27)14-17-32(31)39(33)21-23-6-5-8-26(18-23)24-11-15-29(16-12-24)45(36,42)43/h3-19H,20-22H2,1-2H3,(H,40,41)(H2,36,42,43)
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 16n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM164971
PNG
(US9067917, 4 | US9682971, 4)
Show SMILES OC(=O)[C@H]1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1cccc(Br)c1 |r|
Show InChI InChI=1S/C31H28BrN3O3/c32-22-8-5-6-20(16-22)18-35-29-15-14-24(38-19-23-13-12-21-7-1-4-11-27(21)33-23)17-28(29)34-30(35)25-9-2-3-10-26(25)31(36)37/h1,4-8,11-17,25-26H,2-3,9-10,18-19H2,(H,36,37)/t25?,26-/m0/s1
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 16n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM164985
PNG
(US9067917, 18 | US9682971, 18)
Show SMILES Cc1nc(no1)-c1ccc(Cn2c(nc3cc(OCc4ccc5ccccc5n4)ccc23)C2CCCC[C@@H]2C(O)=O)cc1 |r|
Show InChI InChI=1S/C34H31N5O4/c1-21-35-32(38-43-21)24-12-10-22(11-13-24)19-39-31-17-16-26(42-20-25-15-14-23-6-2-5-9-29(23)36-25)18-30(31)37-33(39)27-7-3-4-8-28(27)34(40)41/h2,5-6,9-18,27-28H,3-4,7-8,19-20H2,1H3,(H,40,41)/t27?,28-/m0/s1
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 17n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165025
PNG
(US9067917, 60 | US9682971, 60)
Show SMILES OC(=O)C1(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2ccc(OC(F)(F)F)cc2)CCCC1
Show InChI InChI=1S/C32H28F3N3O4/c33-32(34,35)42-24-11-7-21(8-12-24)19-38-28-14-13-25(41-20-23-10-9-22-5-1-2-6-26(22)36-23)17-27(28)37-29(38)18-31(30(39)40)15-3-4-16-31/h1-2,5-14,17H,3-4,15-16,18-20H2,(H,39,40)
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 17n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165132
PNG
(US9067917, 167 | US9682971, 167)
Show SMILES CC(C)(Cc1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1cccc(c1)-c1cncs1)C(O)=O
Show InChI InChI=1S/C32H28N4O3S/c1-32(2,31(37)38)16-30-35-27-15-25(39-19-24-11-10-22-7-3-4-9-26(22)34-24)12-13-28(27)36(30)18-21-6-5-8-23(14-21)29-17-33-20-40-29/h3-15,17,20H,16,18-19H2,1-2H3,(H,37,38)
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 17n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165105
PNG
(US9067917, 140 | US9682971, 140)
Show SMILES OC(=O)[C@H]1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(cc1F)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C38H31F4N3O3/c39-32-19-25(23-11-14-27(15-12-23)38(40,41)42)9-10-26(32)21-45-35-18-17-29(48-22-28-16-13-24-5-1-4-8-33(24)43-28)20-34(35)44-36(45)30-6-2-3-7-31(30)37(46)47/h1,4-5,8-20,30-31H,2-3,6-7,21-22H2,(H,46,47)/t30?,31-/m0/s1
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 18n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165007
PNG
(US9067917, 40 | US9682971, 40)
Show SMILES OC(=O)[C@H]1CCCC[C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(OC(F)(F)F)c(F)c1 |r|
Show InChI InChI=1S/C32H27F4N3O4/c33-25-15-19(9-14-29(25)43-32(34,35)36)17-39-28-13-12-22(42-18-21-11-10-20-5-1-4-8-26(20)37-21)16-27(28)38-30(39)23-6-2-3-7-24(23)31(40)41/h1,4-5,8-16,23-24H,2-3,6-7,17-18H2,(H,40,41)/t23-,24+/m1/s1
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 19n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165061
PNG
(US9067917, 96 | US9682971, 96)
Show SMILES OC(=O)C1(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2cccc(c2)-c2ccc(F)c(F)c2)CCCC1
Show InChI InChI=1S/C37H31F2N3O3/c38-30-14-11-27(19-31(30)39)26-8-5-6-24(18-26)22-42-34-15-13-29(45-23-28-12-10-25-7-1-2-9-32(25)40-28)20-33(34)41-35(42)21-37(36(43)44)16-3-4-17-37/h1-2,5-15,18-20H,3-4,16-17,21-23H2,(H,43,44)
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 20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM164998
PNG
(US9067917, 31 | US9067917, 32 | US9682971, 32)
Show SMILES CC1(C)[C@H](C1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1)C(O)=O |r|
Show InChI InChI=1S/C30H26BrN3O3/c1-30(2)26(27(30)29(35)36)28-33-24-15-22(37-17-21-12-9-19-5-3-4-6-23(19)32-21)13-14-25(24)34(28)16-18-7-10-20(31)11-8-18/h3-15,26-27H,16-17H2,1-2H3,(H,35,36)/t26?,27-/m1/s1
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 20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM165153
PNG
(US9067917, 188 | US9682971, 188)
Show SMILES OC(=O)[C@H]1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(cc1)-c1ncccn1 |r|
Show InChI InChI=1S/C35H31N5O3/c41-35(42)29-8-3-2-7-28(29)34-39-31-20-27(43-22-26-15-14-24-6-1-4-9-30(24)38-26)16-17-32(31)40(34)21-23-10-12-25(13-11-23)33-36-18-5-19-37-33/h1,4-6,9-20,28-29H,2-3,7-8,21-22H2,(H,41,42)/t28?,29-/m0/s1
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 21n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...

US Patent US9067917 (2015)


BindingDB Entry DOI: 10.7270/Q24748M5
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 220 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%