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Patent code US9233968

Compile Data Set for Download or QSAR
Found 97 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201228
PNG
(US9233968, 31)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2cccc(c2)C#Cc2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C23H18FN5O/c1-14-8-11-18(24)20(12-14)27-23(30)26-17-6-2-4-15(13-17)9-10-16-5-3-7-19-21(16)22(25)29-28-19/h2-8,11-13H,1H3,(H3,25,28,29)(H2,26,27,30)
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US Patent
n/an/a 16n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201201
PNG
(US9233968, 1)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nc(N)cn3n2)c1
Show InChI InChI=1S/C22H18N6O/c1-15-3-2-4-19(13-15)25-22(29)24-17-8-5-16(6-9-17)7-10-18-11-12-21-26-20(23)14-28(21)27-18/h2-6,8-9,11-14H,23H2,1H3,(H2,24,25,29)
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US Patent
n/an/a 20n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201229
PNG
(US9233968, 32)
Show SMILES Nc1n[nH]c2cccc(C#Cc3cccc(NC(=O)Nc4ccccc4)c3)c12
Show InChI InChI=1S/C22H17N5O/c23-21-20-16(7-5-11-19(20)26-27-21)13-12-15-6-4-10-18(14-15)25-22(28)24-17-8-2-1-3-9-17/h1-11,14H,(H3,23,26,27)(H2,24,25,28)
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n/an/a 20n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201228
PNG
(US9233968, 31)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2cccc(c2)C#Cc2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C23H18FN5O/c1-14-8-11-18(24)20(12-14)27-23(30)26-17-6-2-4-15(13-17)9-10-16-5-3-7-19-21(16)22(25)29-28-19/h2-8,11-13H,1H3,(H3,25,28,29)(H2,26,27,30)
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n/an/a 21n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201203
PNG
(US9233968, 3)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)c1
Show InChI InChI=1S/C22H17N5O/c1-16-3-2-4-20(15-16)25-22(28)24-18-8-5-17(6-9-18)7-10-19-11-12-21-23-13-14-27(21)26-19/h2-6,8-9,11-15H,1H3,(H2,24,25,28)
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n/an/a 23n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201224
PNG
(US9233968, 27)
Show SMILES O=C(Nc1cccc(c1)C#Cc1ccc2nccn2n1)c1ccccc1
Show InChI InChI=1S/C21H14N4O/c26-21(17-6-2-1-3-7-17)23-19-8-4-5-16(15-19)9-10-18-11-12-20-22-13-14-25(20)24-18/h1-8,11-15H,(H,23,26)
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n/an/a 27n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201202
PNG
(US9233968, 2)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)c1
Show InChI InChI=1S/C22H14F3N5O/c23-22(24,25)16-2-1-3-19(14-16)28-21(31)27-17-7-4-15(5-8-17)6-9-18-10-11-20-26-12-13-30(20)29-18/h1-5,7-8,10-14H,(H2,27,28,31)
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n/an/a 32n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201201
PNG
(US9233968, 1)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nc(N)cn3n2)c1
Show InChI InChI=1S/C22H18N6O/c1-15-3-2-4-19(13-15)25-22(29)24-17-8-5-16(6-9-17)7-10-18-11-12-21-26-20(23)14-28(21)27-18/h2-6,8-9,11-14H,23H2,1H3,(H2,24,25,29)
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n/an/a 34n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201229
PNG
(US9233968, 32)
Show SMILES Nc1n[nH]c2cccc(C#Cc3cccc(NC(=O)Nc4ccccc4)c3)c12
Show InChI InChI=1S/C22H17N5O/c23-21-20-16(7-5-11-19(20)26-27-21)13-12-15-6-4-10-18(14-15)25-22(28)24-17-8-2-1-3-9-17/h1-11,14H,(H3,23,26,27)(H2,24,25,28)
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n/an/a 41n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201207
PNG
(US9233968, 7)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)ccc1Cl
Show InChI InChI=1S/C22H13ClF3N5O/c23-19-9-7-17(13-18(19)22(24,25)26)29-21(32)28-15-4-1-14(2-5-15)3-6-16-8-10-20-27-11-12-31(20)30-16/h1-2,4-5,7-13H,(H2,28,29,32)
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n/an/a 43n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201202
PNG
(US9233968, 2)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)c1
Show InChI InChI=1S/C22H14F3N5O/c23-22(24,25)16-2-1-3-19(14-16)28-21(31)27-17-7-4-15(5-8-17)6-9-18-10-11-20-26-12-13-30(20)29-18/h1-5,7-8,10-14H,(H2,27,28,31)
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n/an/a 47n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201201
PNG
(US9233968, 1)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nc(N)cn3n2)c1
Show InChI InChI=1S/C22H18N6O/c1-15-3-2-4-19(13-15)25-22(29)24-17-8-5-16(6-9-17)7-10-18-11-12-21-26-20(23)14-28(21)27-18/h2-6,8-9,11-14H,23H2,1H3,(H2,24,25,29)
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n/an/a 51n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201204
PNG
(US9233968, 4)
Show SMILES Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C22H14F4N6O/c23-17-9-4-14(22(24,25)26)11-18(17)29-21(33)28-15-5-1-13(2-6-15)3-7-16-8-10-20-30-19(27)12-32(20)31-16/h1-2,4-6,8-12H,27H2,(H2,28,29,33)
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n/an/a 55n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201213
PNG
(US9233968, 13)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)cc1
Show InChI InChI=1S/C22H17N5O/c1-16-2-7-18(8-3-16)24-22(28)25-19-9-4-17(5-10-19)6-11-20-12-13-21-23-14-15-27(21)26-20/h2-5,7-10,12-15H,1H3,(H2,24,25,28)
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n/an/a 67n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201203
PNG
(US9233968, 3)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)c1
Show InChI InChI=1S/C22H17N5O/c1-16-3-2-4-20(15-16)25-22(28)24-18-8-5-17(6-9-18)7-10-19-11-12-21-23-13-14-27(21)26-19/h2-6,8-9,11-15H,1H3,(H2,24,25,28)
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n/an/a 70n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201204
PNG
(US9233968, 4)
Show SMILES Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C22H14F4N6O/c23-17-9-4-14(22(24,25)26)11-18(17)29-21(33)28-15-5-1-13(2-6-15)3-7-16-8-10-20-30-19(27)12-32(20)31-16/h1-2,4-6,8-12H,27H2,(H2,28,29,33)
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n/an/a 73n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201203
PNG
(US9233968, 3)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)c1
Show InChI InChI=1S/C22H17N5O/c1-16-3-2-4-20(15-16)25-22(28)24-18-8-5-17(6-9-18)7-10-19-11-12-21-23-13-14-27(21)26-19/h2-6,8-9,11-15H,1H3,(H2,24,25,28)
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n/an/a 80n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201218
PNG
(US9233968, 21)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nc(N)cn2n1
Show InChI InChI=1S/C22H16FN5O/c1-14-5-9-19(23)18(11-14)22(29)25-17-4-2-3-15(12-17)6-7-16-8-10-21-26-20(24)13-28(21)27-16/h2-5,8-13H,24H2,1H3,(H,25,29)
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n/an/a 88n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201230
PNG
(US9233968, 33)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)C#Cc2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C23H18FN5O/c1-14-5-12-18(24)20(13-14)27-23(30)26-17-10-7-15(8-11-17)6-9-16-3-2-4-19-21(16)22(25)29-28-19/h2-5,7-8,10-13H,1H3,(H3,25,28,29)(H2,26,27,30)
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n/an/a 90n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201209
PNG
(US9233968, 9)
Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(cc1)C#Cc1ccc2nccn2n1)C(F)(F)F
Show InChI InChI=1S/C22H13F4N5O/c23-18-9-4-15(22(24,25)26)13-19(18)29-21(32)28-16-5-1-14(2-6-16)3-7-17-8-10-20-27-11-12-31(20)30-17/h1-2,4-6,8-13H,(H2,28,29,32)
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UniChem
US Patent
n/an/a 93n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201205
PNG
(US9233968, 5)
Show SMILES Fc1ccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)cc1Cl
Show InChI InChI=1S/C21H13ClFN5O/c22-18-13-17(7-9-19(18)23)26-21(29)25-15-4-1-14(2-5-15)3-6-16-8-10-20-24-11-12-28(20)27-16/h1-2,4-5,7-13H,(H2,25,26,29)
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US Patent
n/an/a 96n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201206
PNG
(US9233968, 6)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)c1
Show InChI InChI=1S/C22H16FN5O/c1-15-2-10-19(23)20(14-15)26-22(29)25-17-6-3-16(4-7-17)5-8-18-9-11-21-24-12-13-28(21)27-18/h2-4,6-7,9-14H,1H3,(H2,25,26,29)
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US Patent
n/an/a 101n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201207
PNG
(US9233968, 7)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)ccc1Cl
Show InChI InChI=1S/C22H13ClF3N5O/c23-19-9-7-17(13-18(19)22(24,25)26)29-21(32)28-15-4-1-14(2-5-15)3-6-16-8-10-20-27-11-12-31(20)30-16/h1-2,4-5,7-13H,(H2,28,29,32)
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US Patent
n/an/a 127n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201203
PNG
(US9233968, 3)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)c1
Show InChI InChI=1S/C22H17N5O/c1-16-3-2-4-20(15-16)25-22(28)24-18-8-5-17(6-9-18)7-10-19-11-12-21-23-13-14-27(21)26-19/h2-6,8-9,11-15H,1H3,(H2,24,25,28)
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US Patent
n/an/a 132n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201230
PNG
(US9233968, 33)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)C#Cc2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C23H18FN5O/c1-14-5-12-18(24)20(13-14)27-23(30)26-17-10-7-15(8-11-17)6-9-16-3-2-4-19-21(16)22(25)29-28-19/h2-5,7-8,10-13H,1H3,(H3,25,28,29)(H2,26,27,30)
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US Patent
n/an/a 162n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201208
PNG
(US9233968, 8)
Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C21H15N5O/c27-21(23-17-4-2-1-3-5-17)24-18-9-6-16(7-10-18)8-11-19-12-13-20-22-14-15-26(20)25-19/h1-7,9-10,12-15H,(H2,23,24,27)
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n/an/a 185n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201201
PNG
(US9233968, 1)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nc(N)cn3n2)c1
Show InChI InChI=1S/C22H18N6O/c1-15-3-2-4-19(13-15)25-22(29)24-17-8-5-16(6-9-17)7-10-18-11-12-21-26-20(23)14-28(21)27-18/h2-6,8-9,11-14H,23H2,1H3,(H2,24,25,29)
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US Patent
n/an/a 227n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201208
PNG
(US9233968, 8)
Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C21H15N5O/c27-21(23-17-4-2-1-3-5-17)24-18-9-6-16(7-10-18)8-11-19-12-13-20-22-14-15-26(20)25-19/h1-7,9-10,12-15H,(H2,23,24,27)
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n/an/a 267n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201219
PNG
(US9233968, 22)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H13F3N4O/c23-22(24,25)17-5-2-4-16(14-17)21(30)27-19-6-1-3-15(13-19)7-8-18-9-10-20-26-11-12-29(20)28-18/h1-6,9-14H,(H,27,30)
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US Patent
n/an/a 279n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201220
PNG
(US9233968, 23)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H16N4O/c1-16-4-2-6-18(14-16)22(27)24-20-7-3-5-17(15-20)8-9-19-10-11-21-23-12-13-26(21)25-19/h2-7,10-15H,1H3,(H,24,27)
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US Patent
n/an/a 295n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201218
PNG
(US9233968, 21)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nc(N)cn2n1
Show InChI InChI=1S/C22H16FN5O/c1-14-5-9-19(23)18(11-14)22(29)25-17-4-2-3-15(12-17)6-7-16-8-10-21-26-20(24)13-28(21)27-16/h2-5,8-13H,24H2,1H3,(H,25,29)
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n/an/a 371n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201204
PNG
(US9233968, 4)
Show SMILES Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C22H14F4N6O/c23-17-9-4-14(22(24,25)26)11-18(17)29-21(33)28-15-5-1-13(2-6-15)3-7-16-8-10-20-30-19(27)12-32(20)31-16/h1-2,4-6,8-12H,27H2,(H2,28,29,33)
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n/an/a 423n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201209
PNG
(US9233968, 9)
Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(cc1)C#Cc1ccc2nccn2n1)C(F)(F)F
Show InChI InChI=1S/C22H13F4N5O/c23-18-9-4-15(22(24,25)26)13-19(18)29-21(32)28-16-5-1-14(2-6-16)3-7-17-8-10-20-27-11-12-31(20)30-17/h1-2,4-6,8-13H,(H2,28,29,32)
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US Patent
n/an/a 448n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201202
PNG
(US9233968, 2)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)c1
Show InChI InChI=1S/C22H14F3N5O/c23-22(24,25)16-2-1-3-19(14-16)28-21(31)27-17-7-4-15(5-8-17)6-9-18-10-11-20-26-12-13-30(20)29-18/h1-5,7-8,10-14H,(H2,27,28,31)
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n/an/a 457n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201221
PNG
(US9233968, 24)
Show SMILES Fc1ccc(cc1Cl)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C21H12ClFN4O/c22-18-13-15(5-8-19(18)23)21(28)25-17-3-1-2-14(12-17)4-6-16-7-9-20-24-10-11-27(20)26-16/h1-3,5,7-13H,(H,25,28)
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US Patent
n/an/a 464n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201204
PNG
(US9233968, 4)
Show SMILES Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C22H14F4N6O/c23-17-9-4-14(22(24,25)26)11-18(17)29-21(33)28-15-5-1-13(2-6-15)3-7-16-8-10-20-30-19(27)12-32(20)31-16/h1-2,4-6,8-12H,27H2,(H2,28,29,33)
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n/an/a 516n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201219
PNG
(US9233968, 22)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H13F3N4O/c23-22(24,25)17-5-2-4-16(14-17)21(30)27-19-6-1-3-15(13-19)7-8-18-9-10-20-26-11-12-29(20)28-18/h1-6,9-14H,(H,27,30)
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n/an/a 628n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201218
PNG
(US9233968, 21)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nc(N)cn2n1
Show InChI InChI=1S/C22H16FN5O/c1-14-5-9-19(23)18(11-14)22(29)25-17-4-2-3-15(12-17)6-7-16-8-10-21-26-20(24)13-28(21)27-16/h2-5,8-13H,24H2,1H3,(H,25,29)
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n/an/a 767n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201220
PNG
(US9233968, 23)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H16N4O/c1-16-4-2-6-18(14-16)22(27)24-20-7-3-5-17(15-20)8-9-19-10-11-21-23-12-13-26(21)25-19/h2-7,10-15H,1H3,(H,24,27)
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n/an/a 862n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201221
PNG
(US9233968, 24)
Show SMILES Fc1ccc(cc1Cl)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C21H12ClFN4O/c22-18-13-15(5-8-19(18)23)21(28)25-17-3-1-2-14(12-17)4-6-16-7-9-20-24-10-11-27(20)26-16/h1-3,5,7-13H,(H,25,28)
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n/an/a 938n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201202
PNG
(US9233968, 2)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)c1
Show InChI InChI=1S/C22H14F3N5O/c23-22(24,25)16-2-1-3-19(14-16)28-21(31)27-17-7-4-15(5-8-17)6-9-18-10-11-20-26-12-13-30(20)29-18/h1-5,7-8,10-14H,(H2,27,28,31)
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n/an/a 962n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201218
PNG
(US9233968, 21)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nc(N)cn2n1
Show InChI InChI=1S/C22H16FN5O/c1-14-5-9-19(23)18(11-14)22(29)25-17-4-2-3-15(12-17)6-7-16-8-10-21-26-20(24)13-28(21)27-16/h2-5,8-13H,24H2,1H3,(H,25,29)
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n/an/a 1.12E+3n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201216
PNG
(US9233968, 19)
Show SMILES Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C21H15N5O/c22-19-14-26-20(24-19)13-12-18(25-26)11-8-15-6-9-17(10-7-15)23-21(27)16-4-2-1-3-5-16/h1-7,9-10,12-14H,22H2,(H,23,27)
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n/an/a 1.25E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201219
PNG
(US9233968, 22)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H13F3N4O/c23-22(24,25)17-5-2-4-16(14-17)21(30)27-19-6-1-3-15(13-19)7-8-18-9-10-20-26-11-12-29(20)28-18/h1-6,9-14H,(H,27,30)
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n/an/a 1.28E+3n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201212
PNG
(US9233968, 12)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nc(NC(=O)C4CC4)cn3n2)c1
Show InChI InChI=1S/C26H22N6O2/c1-17-3-2-4-22(15-17)28-26(34)27-20-10-5-18(6-11-20)7-12-21-13-14-24-29-23(16-32(24)31-21)30-25(33)19-8-9-19/h2-6,10-11,13-16,19H,8-9H2,1H3,(H,30,33)(H2,27,28,34)
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n/an/a 1.31E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201210
PNG
(US9233968, 10)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C30H17F8N7O2/c31-21-10-4-17(29(33,34)35)13-23(21)40-27(46)39-19-6-1-16(2-7-19)3-8-20-9-12-26-42-25(15-45(26)44-20)43-28(47)41-24-14-18(30(36,37)38)5-11-22(24)32/h1-2,4-7,9-15H,(H2,39,40,46)(H2,41,43,47)
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n/an/a 1.43E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201221
PNG
(US9233968, 24)
Show SMILES Fc1ccc(cc1Cl)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C21H12ClFN4O/c22-18-13-15(5-8-19(18)23)21(28)25-17-3-1-2-14(12-17)4-6-16-7-9-20-24-10-11-27(20)26-16/h1-3,5,7-13H,(H,25,28)
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n/an/a 1.46E+3n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201220
PNG
(US9233968, 23)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H16N4O/c1-16-4-2-6-18(14-16)22(27)24-20-7-3-5-17(15-20)8-9-19-10-11-21-23-12-13-26(21)25-19/h2-7,10-15H,1H3,(H,24,27)
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n/an/a 1.53E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201222
PNG
(US9233968, 25)
Show SMILES O=C(Nc1cccc(c1)C#Cc1ccc2nccn2n1)c1cc2ccccc2o1
Show InChI InChI=1S/C23H14N4O2/c28-23(21-15-17-5-1-2-7-20(17)29-21)25-19-6-3-4-16(14-19)8-9-18-10-11-22-24-12-13-27(22)26-18/h1-7,10-15H,(H,25,28)
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n/an/a 1.61E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201223
PNG
(US9233968, 26)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H15FN4O/c1-15-5-9-20(23)19(13-15)22(28)25-18-4-2-3-16(14-18)6-7-17-8-10-21-24-11-12-27(21)26-17/h2-5,8-14H,1H3,(H,25,28)
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n/an/a 1.62E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201219
PNG
(US9233968, 22)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H13F3N4O/c23-22(24,25)17-5-2-4-16(14-17)21(30)27-19-6-1-3-15(13-19)7-8-18-9-10-20-26-11-12-29(20)28-18/h1-6,9-14H,(H,27,30)
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n/an/a 1.63E+3n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201214
PNG
(US9233968, 14)
Show SMILES Nc1ccc(cc1)C#Cc1ccc2nc(NC(=O)Nc3ccc(F)c(Cl)c3)cn2n1
Show InChI InChI=1S/C21H14ClFN6O/c22-17-11-16(7-9-18(17)23)25-21(30)27-19-12-29-20(26-19)10-8-15(28-29)6-3-13-1-4-14(24)5-2-13/h1-2,4-5,7-12H,24H2,(H2,25,27,30)
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n/an/a 1.69E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201227
PNG
(US9233968, 30)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccccc2C#Cc2ccc3nccn3n2)c1
Show InChI InChI=1S/C22H16FN5O/c1-15-6-10-18(23)20(14-15)26-22(29)25-19-5-3-2-4-16(19)7-8-17-9-11-21-24-12-13-28(21)27-17/h2-6,9-14H,1H3,(H2,25,26,29)
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n/an/a 1.81E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201207
PNG
(US9233968, 7)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)ccc1Cl
Show InChI InChI=1S/C22H13ClF3N5O/c23-19-9-7-17(13-18(19)22(24,25)26)29-21(32)28-15-4-1-14(2-5-15)3-6-16-8-10-20-27-11-12-31(20)30-16/h1-2,4-5,7-13H,(H2,28,29,32)
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n/an/a 2.05E+3n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201213
PNG
(US9233968, 13)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)cc1
Show InChI InChI=1S/C22H17N5O/c1-16-2-7-18(8-3-16)24-22(28)25-19-9-4-17(5-10-19)6-11-20-12-13-21-23-14-15-27(21)26-20/h2-5,7-10,12-15H,1H3,(H2,24,25,28)
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n/an/a 2.30E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201224
PNG
(US9233968, 27)
Show SMILES O=C(Nc1cccc(c1)C#Cc1ccc2nccn2n1)c1ccccc1
Show InChI InChI=1S/C21H14N4O/c26-21(17-6-2-1-3-7-17)23-19-8-4-5-16(15-19)9-10-18-11-12-20-22-13-14-25(20)24-18/h1-8,11-15H,(H,23,26)
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n/an/a 2.36E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201221
PNG
(US9233968, 24)
Show SMILES Fc1ccc(cc1Cl)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C21H12ClFN4O/c22-18-13-15(5-8-19(18)23)21(28)25-17-3-1-2-14(12-17)4-6-16-7-9-20-24-10-11-27(20)26-16/h1-3,5,7-13H,(H,25,28)
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n/an/a 2.68E+3n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201222
PNG
(US9233968, 25)
Show SMILES O=C(Nc1cccc(c1)C#Cc1ccc2nccn2n1)c1cc2ccccc2o1
Show InChI InChI=1S/C23H14N4O2/c28-23(21-15-17-5-1-2-7-20(17)29-21)25-19-6-3-4-16(14-19)8-9-18-10-11-22-24-12-13-27(22)26-18/h1-7,10-15H,(H,25,28)
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n/an/a 2.72E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201215
PNG
(US9233968, 15)
Show SMILES Fc1ccc(NC(=O)Nc2cn3nc(ccc3n2)C#Cc2ccc(NC(=O)Nc3ccc(F)c(Cl)c3)cc2)cc1Cl
Show InChI InChI=1S/C28H17Cl2F2N7O2/c29-21-13-19(7-10-23(21)31)34-27(40)33-17-4-1-16(2-5-17)3-6-18-9-12-26-36-25(15-39(26)38-18)37-28(41)35-20-8-11-24(32)22(30)14-20/h1-2,4-5,7-15H,(H2,33,34,40)(H2,35,37,41)
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n/an/a 2.93E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201223
PNG
(US9233968, 26)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H15FN4O/c1-15-5-9-20(23)19(13-15)22(28)25-18-4-2-3-16(14-18)6-7-17-8-10-21-24-11-12-27(21)26-17/h2-5,8-14H,1H3,(H,25,28)
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n/an/a 3.04E+3n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201211
PNG
(US9233968, 11)
Show SMILES CC(=O)Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C24H20N6O2/c1-16-4-3-5-21(14-16)27-24(32)26-19-9-6-18(7-10-19)8-11-20-12-13-23-28-22(25-17(2)31)15-30(23)29-20/h3-7,9-10,12-15H,1-2H3,(H,25,31)(H2,26,27,32)
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n/an/a 3.18E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201225
PNG
(US9233968, 28)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H16N4O/c1-16-5-8-18(9-6-16)22(27)24-20-4-2-3-17(15-20)7-10-19-11-12-21-23-13-14-26(21)25-19/h2-6,8-9,11-15H,1H3,(H,24,27)
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n/an/a 3.24E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201215
PNG
(US9233968, 15)
Show SMILES Fc1ccc(NC(=O)Nc2cn3nc(ccc3n2)C#Cc2ccc(NC(=O)Nc3ccc(F)c(Cl)c3)cc2)cc1Cl
Show InChI InChI=1S/C28H17Cl2F2N7O2/c29-21-13-19(7-10-23(21)31)34-27(40)33-17-4-1-16(2-5-17)3-6-18-9-12-26-36-25(15-39(26)38-18)37-28(41)35-20-8-11-24(32)22(30)14-20/h1-2,4-5,7-15H,(H2,33,34,40)(H2,35,37,41)
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n/an/a 3.61E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201215
PNG
(US9233968, 15)
Show SMILES Fc1ccc(NC(=O)Nc2cn3nc(ccc3n2)C#Cc2ccc(NC(=O)Nc3ccc(F)c(Cl)c3)cc2)cc1Cl
Show InChI InChI=1S/C28H17Cl2F2N7O2/c29-21-13-19(7-10-23(21)31)34-27(40)33-17-4-1-16(2-5-17)3-6-18-9-12-26-36-25(15-39(26)38-18)37-28(41)35-20-8-11-24(32)22(30)14-20/h1-2,4-5,7-15H,(H2,33,34,40)(H2,35,37,41)
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n/an/a 3.63E+3n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201225
PNG
(US9233968, 28)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H16N4O/c1-16-5-8-18(9-6-16)22(27)24-20-4-2-3-17(15-20)7-10-19-11-12-21-23-13-14-26(21)25-19/h2-6,8-9,11-15H,1H3,(H,24,27)
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n/an/a 4.31E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201217
PNG
(US9233968, 20)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1ccc(cc1)C#Cc1ccc2nc(N)cn2n1
Show InChI InChI=1S/C22H16FN5O/c1-14-2-10-19(23)18(12-14)22(29)25-16-6-3-15(4-7-16)5-8-17-9-11-21-26-20(24)13-28(21)27-17/h2-4,6-7,9-13H,24H2,1H3,(H,25,29)
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n/an/a 4.40E+3n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201226
PNG
(US9233968, 29)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2cccc(c2)C#Cc2ccc3nccn3n2)c1
Show InChI InChI=1S/C22H16FN5O/c1-15-5-9-19(23)20(13-15)26-22(29)25-18-4-2-3-16(14-18)6-7-17-8-10-21-24-11-12-28(21)27-17/h2-5,8-14H,1H3,(H2,25,26,29)
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n/an/a 4.70E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201208
PNG
(US9233968, 8)
Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C21H15N5O/c27-21(23-17-4-2-1-3-5-17)24-18-9-6-16(7-10-18)8-11-19-12-13-20-22-14-15-26(20)25-19/h1-7,9-10,12-15H,(H2,23,24,27)
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n/an/a 5.43E+3n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201223
PNG
(US9233968, 26)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H15FN4O/c1-15-5-9-20(23)19(13-15)22(28)25-18-4-2-3-16(14-18)6-7-17-8-10-21-24-11-12-27(21)26-17/h2-5,8-14H,1H3,(H,25,28)
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n/an/a 6.08E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201214
PNG
(US9233968, 14)
Show SMILES Nc1ccc(cc1)C#Cc1ccc2nc(NC(=O)Nc3ccc(F)c(Cl)c3)cn2n1
Show InChI InChI=1S/C21H14ClFN6O/c22-17-11-16(7-9-18(17)23)25-21(30)27-19-12-29-20(26-19)10-8-15(28-29)6-3-13-1-4-14(24)5-2-13/h1-2,4-5,7-12H,24H2,(H2,25,27,30)
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n/an/a 6.57E+3n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201209
PNG
(US9233968, 9)
Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(cc1)C#Cc1ccc2nccn2n1)C(F)(F)F
Show InChI InChI=1S/C22H13F4N5O/c23-18-9-4-15(22(24,25)26)13-19(18)29-21(32)28-16-5-1-14(2-6-16)3-7-17-8-10-20-27-11-12-31(20)30-17/h1-2,4-6,8-13H,(H2,28,29,32)
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n/an/a 8.42E+3n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201222
PNG
(US9233968, 25)
Show SMILES O=C(Nc1cccc(c1)C#Cc1ccc2nccn2n1)c1cc2ccccc2o1
Show InChI InChI=1S/C23H14N4O2/c28-23(21-15-17-5-1-2-7-20(17)29-21)25-19-6-3-4-16(14-19)8-9-18-10-11-22-24-12-13-27(22)26-18/h1-7,10-15H,(H,25,28)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201210
PNG
(US9233968, 10)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C30H17F8N7O2/c31-21-10-4-17(29(33,34)35)13-23(21)40-27(46)39-19-6-1-16(2-7-19)3-8-20-9-12-26-42-25(15-45(26)44-20)43-28(47)41-24-14-18(30(36,37)38)5-11-22(24)32/h1-2,4-7,9-15H,(H2,39,40,46)(H2,41,43,47)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201224
PNG
(US9233968, 27)
Show SMILES O=C(Nc1cccc(c1)C#Cc1ccc2nccn2n1)c1ccccc1
Show InChI InChI=1S/C21H14N4O/c26-21(17-6-2-1-3-7-17)23-19-8-4-5-16(15-19)9-10-18-11-12-20-22-13-14-25(20)24-18/h1-8,11-15H,(H,23,26)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201211
PNG
(US9233968, 11)
Show SMILES CC(=O)Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C24H20N6O2/c1-16-4-3-5-21(14-16)27-24(32)26-19-9-6-18(7-10-19)8-11-20-12-13-23-28-22(25-17(2)31)15-30(23)29-20/h3-7,9-10,12-15H,1-2H3,(H,25,31)(H2,26,27,32)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201217
PNG
(US9233968, 20)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1ccc(cc1)C#Cc1ccc2nc(N)cn2n1
Show InChI InChI=1S/C22H16FN5O/c1-14-2-10-19(23)18(12-14)22(29)25-16-6-3-15(4-7-16)5-8-17-9-11-21-26-20(24)13-28(21)27-17/h2-4,6-7,9-13H,24H2,1H3,(H,25,29)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201217
PNG
(US9233968, 20)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1ccc(cc1)C#Cc1ccc2nc(N)cn2n1
Show InChI InChI=1S/C22H16FN5O/c1-14-2-10-19(23)18(12-14)22(29)25-16-6-3-15(4-7-16)5-8-17-9-11-21-26-20(24)13-28(21)27-17/h2-4,6-7,9-13H,24H2,1H3,(H,25,29)
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n/an/a>1.00E+4n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201227
PNG
(US9233968, 30)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccccc2C#Cc2ccc3nccn3n2)c1
Show InChI InChI=1S/C22H16FN5O/c1-15-6-10-18(23)20(14-15)26-22(29)25-19-5-3-2-4-16(19)7-8-17-9-11-21-24-12-13-28(21)27-17/h2-6,9-14H,1H3,(H2,25,26,29)
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n/an/a>1.00E+4n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201215
PNG
(US9233968, 15)
Show SMILES Fc1ccc(NC(=O)Nc2cn3nc(ccc3n2)C#Cc2ccc(NC(=O)Nc3ccc(F)c(Cl)c3)cc2)cc1Cl
Show InChI InChI=1S/C28H17Cl2F2N7O2/c29-21-13-19(7-10-23(21)31)34-27(40)33-17-4-1-16(2-5-17)3-6-18-9-12-26-36-25(15-39(26)38-18)37-28(41)35-20-8-11-24(32)22(30)14-20/h1-2,4-5,7-15H,(H2,33,34,40)(H2,35,37,41)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201216
PNG
(US9233968, 19)
Show SMILES Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C21H15N5O/c22-19-14-26-20(24-19)13-12-18(25-26)11-8-15-6-9-17(10-7-15)23-21(27)16-4-2-1-3-5-16/h1-7,9-10,12-14H,22H2,(H,23,27)
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n/an/a>1.00E+4n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201217
PNG
(US9233968, 20)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1ccc(cc1)C#Cc1ccc2nc(N)cn2n1
Show InChI InChI=1S/C22H16FN5O/c1-14-2-10-19(23)18(12-14)22(29)25-16-6-3-15(4-7-16)5-8-17-9-11-21-26-20(24)13-28(21)27-17/h2-4,6-7,9-13H,24H2,1H3,(H,25,29)
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n/an/a>1.00E+4n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201226
PNG
(US9233968, 29)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2cccc(c2)C#Cc2ccc3nccn3n2)c1
Show InChI InChI=1S/C22H16FN5O/c1-15-5-9-19(23)20(13-15)26-22(29)25-18-4-2-3-16(14-18)6-7-17-8-10-21-24-11-12-28(21)27-17/h2-5,8-14H,1H3,(H2,25,26,29)
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n/an/a>1.00E+4n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201214
PNG
(US9233968, 14)
Show SMILES Nc1ccc(cc1)C#Cc1ccc2nc(NC(=O)Nc3ccc(F)c(Cl)c3)cn2n1
Show InChI InChI=1S/C21H14ClFN6O/c22-17-11-16(7-9-18(17)23)25-21(30)27-19-12-29-20(26-19)10-8-15(28-29)6-3-13-1-4-14(24)5-2-13/h1-2,4-5,7-12H,24H2,(H2,25,27,30)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201216
PNG
(US9233968, 19)
Show SMILES Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C21H15N5O/c22-19-14-26-20(24-19)13-12-18(25-26)11-8-15-6-9-17(10-7-15)23-21(27)16-4-2-1-3-5-16/h1-7,9-10,12-14H,22H2,(H,23,27)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201212
PNG
(US9233968, 12)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nc(NC(=O)C4CC4)cn3n2)c1
Show InChI InChI=1S/C26H22N6O2/c1-17-3-2-4-22(15-17)28-26(34)27-20-10-5-18(6-11-20)7-12-21-13-14-24-29-23(16-32(24)31-21)30-25(33)19-8-9-19/h2-6,10-11,13-16,19H,8-9H2,1H3,(H,30,33)(H2,27,28,34)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201211
PNG
(US9233968, 11)
Show SMILES CC(=O)Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C24H20N6O2/c1-16-4-3-5-21(14-16)27-24(32)26-19-9-6-18(7-10-19)8-11-20-12-13-23-28-22(25-17(2)31)15-30(23)29-20/h3-7,9-10,12-15H,1-2H3,(H,25,31)(H2,26,27,32)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201216
PNG
(US9233968, 19)
Show SMILES Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C21H15N5O/c22-19-14-26-20(24-19)13-12-18(25-26)11-8-15-6-9-17(10-7-15)23-21(27)16-4-2-1-3-5-16/h1-7,9-10,12-14H,22H2,(H,23,27)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201222
PNG
(US9233968, 25)
Show SMILES O=C(Nc1cccc(c1)C#Cc1ccc2nccn2n1)c1cc2ccccc2o1
Show InChI InChI=1S/C23H14N4O2/c28-23(21-15-17-5-1-2-7-20(17)29-21)25-19-6-3-4-16(14-19)8-9-18-10-11-22-24-12-13-27(22)26-18/h1-7,10-15H,(H,25,28)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201213
PNG
(US9233968, 13)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nccn3n2)cc1
Show InChI InChI=1S/C22H17N5O/c1-16-2-7-18(8-3-16)24-22(28)25-19-9-4-17(5-10-19)6-11-20-12-13-21-23-14-15-27(21)26-20/h2-5,7-10,12-15H,1H3,(H2,24,25,28)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201210
PNG
(US9233968, 10)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C30H17F8N7O2/c31-21-10-4-17(29(33,34)35)13-23(21)40-27(46)39-19-6-1-16(2-7-19)3-8-20-9-12-26-42-25(15-45(26)44-20)43-28(47)41-24-14-18(30(36,37)38)5-11-22(24)32/h1-2,4-7,9-15H,(H2,39,40,46)(H2,41,43,47)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201223
PNG
(US9233968, 26)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H15FN4O/c1-15-5-9-20(23)19(13-15)22(28)25-18-4-2-3-16(14-18)6-7-17-8-10-21-24-11-12-27(21)26-17/h2-5,8-14H,1H3,(H,25,28)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201212
PNG
(US9233968, 12)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)C#Cc2ccc3nc(NC(=O)C4CC4)cn3n2)c1
Show InChI InChI=1S/C26H22N6O2/c1-17-3-2-4-22(15-17)28-26(34)27-20-10-5-18(6-11-20)7-12-21-13-14-24-29-23(16-32(24)31-21)30-25(33)19-8-9-19/h2-6,10-11,13-16,19H,8-9H2,1H3,(H,30,33)(H2,27,28,34)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM201225
PNG
(US9233968, 28)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H16N4O/c1-16-5-8-18(9-6-16)22(27)24-20-4-2-3-17(15-20)7-10-19-11-12-21-23-13-14-26(21)25-19/h2-6,8-9,11-15H,1H3,(H,24,27)
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n/an/a>1.00E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201210
PNG
(US9233968, 10)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cn2nc(ccc2n1)C#Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C30H17F8N7O2/c31-21-10-4-17(29(33,34)35)13-23(21)40-27(46)39-19-6-1-16(2-7-19)3-8-20-9-12-26-42-25(15-45(26)44-20)43-28(47)41-24-14-18(30(36,37)38)5-11-22(24)32/h1-2,4-7,9-15H,(H2,39,40,46)(H2,41,43,47)
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n/an/a>1.00E+4n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201214
PNG
(US9233968, 14)
Show SMILES Nc1ccc(cc1)C#Cc1ccc2nc(NC(=O)Nc3ccc(F)c(Cl)c3)cn2n1
Show InChI InChI=1S/C21H14ClFN6O/c22-17-11-16(7-9-18(17)23)25-21(30)27-19-12-29-20(26-19)10-8-15(28-29)6-3-13-1-4-14(24)5-2-13/h1-2,4-5,7-12H,24H2,(H2,25,27,30)
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n/an/a 1.05E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201224
PNG
(US9233968, 27)
Show SMILES O=C(Nc1cccc(c1)C#Cc1ccc2nccn2n1)c1ccccc1
Show InChI InChI=1S/C21H14N4O/c26-21(17-6-2-1-3-7-17)23-19-8-4-5-16(15-19)9-10-18-11-12-20-22-13-14-25(20)24-18/h1-8,11-15H,(H,23,26)
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n/an/a 1.78E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM201225
PNG
(US9233968, 28)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1
Show InChI InChI=1S/C22H16N4O/c1-16-5-8-18(9-6-16)22(27)24-20-4-2-3-17(15-20)7-10-19-11-12-21-23-13-14-26(21)25-19/h2-6,8-9,11-15H,1H3,(H,24,27)
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n/an/a 2.69E+4n/an/an/an/an/a37



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9233968 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M49
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%