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SMILES: FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1

InChI Key: InChIKey=RFSNVVNGMLVHOH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 201219   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM201219 (US9233968, 22) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1 Show InChI InChI=1S/C22H13F3N4O/c23-22(24,25)17-5-2-4-16(14-17)21(30)27-19-6-1-3-15(13-19)7-8-18-9-10-20-26-11-12-29(20)28-18/h1-6,9-14H,(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.63E+3	n/a	n/a	n/a	n/a	n/a	37
Allergan, Inc. US Patent					Assay Description Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...				US Patent US9233968 (2016) BindingDB Entry DOI: 10.7270/Q2KH0M49
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM201219 (US9233968, 22) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1 Show InChI InChI=1S/C22H13F3N4O/c23-22(24,25)17-5-2-4-16(14-17)21(30)27-19-6-1-3-15(13-19)7-8-18-9-10-20-26-11-12-29(20)28-18/h1-6,9-14H,(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.28E+3	n/a	n/a	n/a	n/a	n/a	37
Allergan, Inc. US Patent					Assay Description Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...				US Patent US9233968 (2016) BindingDB Entry DOI: 10.7270/Q2KH0M49
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM201219 (US9233968, 22) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1 Show InChI InChI=1S/C22H13F3N4O/c23-22(24,25)17-5-2-4-16(14-17)21(30)27-19-6-1-3-15(13-19)7-8-18-9-10-20-26-11-12-29(20)28-18/h1-6,9-14H,(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	628	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...				US Patent US9233968 (2016) BindingDB Entry DOI: 10.7270/Q2KH0M49
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM201219 (US9233968, 22) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)C#Cc1ccc2nccn2n1 Show InChI InChI=1S/C22H13F3N4O/c23-22(24,25)17-5-2-4-16(14-17)21(30)27-19-6-1-3-15(13-19)7-8-18-9-10-20-26-11-12-29(20)28-18/h1-6,9-14H,(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	279	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...				US Patent US9233968 (2016) BindingDB Entry DOI: 10.7270/Q2KH0M49
					More data for this Ligand-Target Pair