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Patent code US9334278

Compile Data Set for Download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227529
PNG
(US9334278, I-18)
Show SMILES Cc1cc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)sn1
Show InChI InChI=1S/C15H18N6OS/c1-8-5-11(23-21-8)18-10-7-17-13-12(19-10)9(6-16-13)14(22)20-15(2,3)4/h5-7H,1-4H3,(H,16,17)(H,18,19)(H,20,22)
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US Patent
n/an/a 2n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227523
PNG
(US9334278, I-12)
Show SMILES Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cc1
Show InChI InChI=1S/C18H21N5O/c1-11-5-7-12(8-6-11)21-14-10-20-16-15(22-14)13(9-19-16)17(24)23-18(2,3)4/h5-10H,1-4H3,(H,19,20)(H,21,22)(H,23,24)
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n/an/a 3.20n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227549
PNG
(US9334278, I-37)
Show SMILES Cc1nc2[nH]cc(C(=O)NC(C)(C)C)c2nc1Nc1ccccc1
Show InChI InChI=1S/C18H21N5O/c1-11-15(21-12-8-6-5-7-9-12)22-14-13(10-19-16(14)20-11)17(24)23-18(2,3)4/h5-10H,1-4H3,(H,19,20)(H,21,22)(H,23,24)
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n/an/a 4.80n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227537
PNG
(US9334278, I-26)
Show SMILES CC(C)(CO)NC(=O)c1c[nH]c2ncc(Nc3cccnc3)nc12
Show InChI InChI=1S/C16H18N6O2/c1-16(2,9-23)22-15(24)11-7-18-14-13(11)21-12(8-19-14)20-10-4-3-5-17-6-10/h3-8,23H,9H2,1-2H3,(H,18,19)(H,20,21)(H,22,24)
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n/an/a 5.60n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227535
PNG
(US9334278, I-24)
Show SMILES CC(O)c1cccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c1
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n/an/a 5.90n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227512
PNG
(US9334278, I-1)
Show SMILES Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)nc1
Show InChI InChI=1S/C17H20N6O/c1-10-5-6-12(18-7-10)21-13-9-20-15-14(22-13)11(8-19-15)16(24)23-17(2,3)4/h5-9H,1-4H3,(H,19,20)(H,23,24)(H,18,21,22)
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n/an/a 8.5n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227522
PNG
(US9334278, I-11)
Show SMILES Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c(F)c1
Show InChI InChI=1S/C18H20FN5O/c1-10-5-6-13(12(19)7-10)22-14-9-21-16-15(23-14)11(8-20-16)17(25)24-18(2,3)4/h5-9H,1-4H3,(H,20,21)(H,22,23)(H,24,25)
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n/an/a 10.9n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227524
PNG
(US9334278, I-13)
Show SMILES CC(C)(C)NC(=O)c1c[nH]c2ncc(Nc3cccc(c3)S(C)(=O)=O)nc12
Show InChI InChI=1S/C18H21N5O3S/c1-18(2,3)23-17(24)13-9-19-16-15(13)22-14(10-20-16)21-11-6-5-7-12(8-11)27(4,25)26/h5-10H,1-4H3,(H,19,20)(H,21,22)(H,23,24)
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n/an/a 12.8n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227516
PNG
(US9334278, I-5)
Show SMILES Cn1cc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cn1
Show InChI InChI=1S/C15H19N7O/c1-15(2,3)21-14(23)10-6-16-13-12(10)20-11(7-17-13)19-9-5-18-22(4)8-9/h5-8H,1-4H3,(H,16,17)(H,19,20)(H,21,23)
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n/an/a 13.7n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227520
PNG
(US9334278, I-9)
Show SMILES Cc1cc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)[nH]n1
Show InChI InChI=1S/C15H19N7O/c1-8-5-10(22-21-8)18-11-7-17-13-12(19-11)9(6-16-13)14(23)20-15(2,3)4/h5-7H,1-4H3,(H,16,17)(H,20,23)(H2,18,19,21,22)
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n/an/a 15.5n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227521
PNG
(US9334278, I-10)
Show SMILES CC(C)(C)NC(=O)c1c[nH]c2ncc(Nc3cccnc3)nc12
Show InChI InChI=1S/C16H18N6O/c1-16(2,3)22-15(23)11-8-18-14-13(11)21-12(9-19-14)20-10-5-4-6-17-7-10/h4-9H,1-3H3,(H,18,19)(H,20,21)(H,22,23)
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n/an/a 16.3n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227517
PNG
(US9334278, I-6)
Show SMILES Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cn1
Show InChI InChI=1S/C17H20N6O/c1-10-5-6-11(7-18-10)21-13-9-20-15-14(22-13)12(8-19-15)16(24)23-17(2,3)4/h5-9H,1-4H3,(H,19,20)(H,21,22)(H,23,24)
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n/an/a 17.1n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227542
PNG
(US9334278, I-31)
Show SMILES Cc1nsc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)n1
Show InChI InChI=1S/C14H17N7OS/c1-7-17-13(23-21-7)19-9-6-16-11-10(18-9)8(5-15-11)12(22)20-14(2,3)4/h5-6H,1-4H3,(H,15,16)(H,20,22)(H,17,18,19,21)
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n/an/a 17.8n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227538
PNG
(US9334278, I-27)
Show SMILES CC(N)c1cccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c1
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n/an/a 18.8n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227514
PNG
(US9334278, I-3)
Show SMILES Cn1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)n1
Show InChI InChI=1S/C15H19N7O/c1-15(2,3)20-14(23)9-7-16-13-12(9)19-11(8-17-13)18-10-5-6-22(4)21-10/h5-8H,1-4H3,(H,16,17)(H,20,23)(H,18,19,21)
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n/an/a 21.1n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227533
PNG
(US9334278, I-22)
Show SMILES Cc1cc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)on1
Show InChI InChI=1S/C15H18N6O2/c1-8-5-11(23-21-8)18-10-7-17-13-12(19-10)9(6-16-13)14(22)20-15(2,3)4/h5-7H,1-4H3,(H,16,17)(H,18,19)(H,20,22)
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US Patent
n/an/a 25.1n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227513
PNG
(US9334278, I-2)
Show SMILES Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)CO)c3n2)nc1
Show InChI InChI=1S/C17H20N6O2/c1-10-4-5-12(18-6-10)21-13-8-20-15-14(22-13)11(7-19-15)16(25)23-17(2,3)9-24/h4-8,24H,9H2,1-3H3,(H,19,20)(H,23,25)(H,18,21,22)
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n/an/a 27.4n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227531
PNG
(US9334278, I-20)
Show SMILES CC(C)(C)NC(=O)c1c[nH]c2ncc(Nc3ccc(cc3)S(C)(=O)=O)nc12
Show InChI InChI=1S/C18H21N5O3S/c1-18(2,3)23-17(24)13-9-19-16-15(13)22-14(10-20-16)21-11-5-7-12(8-6-11)27(4,25)26/h5-10H,1-4H3,(H,19,20)(H,21,22)(H,23,24)
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n/an/a 30n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227525
PNG
(US9334278, I-14)
Show SMILES CCn1cc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cn1
Show InChI InChI=1S/C16H21N7O/c1-5-23-9-10(6-19-23)20-12-8-18-14-13(21-12)11(7-17-14)15(24)22-16(2,3)4/h6-9H,5H2,1-4H3,(H,17,18)(H,20,21)(H,22,24)
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n/an/a 35.9n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227515
PNG
(US9334278, I-4)
Show SMILES CC(C)NC(=O)c1c[nH]c2ncc(Nc3ccc(C)cn3)nc12
Show InChI InChI=1S/C16H18N6O/c1-9(2)20-16(23)11-7-18-15-14(11)22-13(8-19-15)21-12-5-4-10(3)6-17-12/h4-9H,1-3H3,(H,18,19)(H,20,23)(H,17,21,22)
PDB

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n/an/a 42.8n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227543
PNG
(US9334278, I-32)
Show SMILES Cn1cc2N(CCCc2n1)c1cnc2[nH]cc(C(=O)NC(C)(C)C)c2n1
Show InChI InChI=1S/C18H23N7O/c1-18(2,3)22-17(26)11-8-19-16-15(11)21-14(9-20-16)25-7-5-6-12-13(25)10-24(4)23-12/h8-10H,5-7H2,1-4H3,(H,19,20)(H,22,26)
PDB

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US Patent
n/an/a 43.7n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227528
PNG
(US9334278, I-17)
Show SMILES Cn1cc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)CO)c3n2)cn1
Show InChI InChI=1S/C15H19N7O2/c1-15(2,8-23)21-14(24)10-5-16-13-12(10)20-11(6-17-13)19-9-4-18-22(3)7-9/h4-7,23H,8H2,1-3H3,(H,16,17)(H,19,20)(H,21,24)
PDB

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US Patent
n/an/a 49.9n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227519
PNG
(US9334278, I-8)
Show SMILES Cc1cnc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cn1
Show InChI InChI=1S/C16H19N7O/c1-9-5-18-11(7-17-9)21-12-8-20-14-13(22-12)10(6-19-14)15(24)23-16(2,3)4/h5-8H,1-4H3,(H,19,20)(H,23,24)(H,18,21,22)
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n/an/a 51.3n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227536
PNG
(US9334278, I-25)
Show SMILES COc1ncc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cn1
Show InChI InChI=1S/C16H19N7O2/c1-16(2,3)23-14(24)10-7-17-13-12(10)22-11(8-18-13)21-9-5-19-15(25-4)20-6-9/h5-8H,1-4H3,(H,17,18)(H,21,22)(H,23,24)
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n/an/a 71.2n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227527
PNG
(US9334278, I-16)
Show SMILES Cc1c(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cnn1C
Show InChI InChI=1S/C16H21N7O/c1-9-11(7-19-23(9)5)20-12-8-18-14-13(21-12)10(6-17-14)15(24)22-16(2,3)4/h6-8H,1-5H3,(H,17,18)(H,20,21)(H,22,24)
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n/an/a 92.4n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227541
PNG
(US9334278, I-30)
Show SMILES Cc1nn(C)cc1Nc1cnc2[nH]cc(C(=O)NC(C)(C)C)c2n1
Show InChI InChI=1S/C16H21N7O/c1-9-11(8-23(5)22-9)19-12-7-18-14-13(20-12)10(6-17-14)15(24)21-16(2,3)4/h6-8H,1-5H3,(H,17,18)(H,19,20)(H,21,24)
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n/an/a 97.5n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227534
PNG
(US9334278, I-23)
Show SMILES CC(C)(C)NC(=O)c1c[nH]c2ncc(Nc3ccc(nc3)S(C)(=O)=O)nc12
Show InChI InChI=1S/C17H20N6O3S/c1-17(2,3)23-16(24)11-8-19-15-14(11)22-12(9-20-15)21-10-5-6-13(18-7-10)27(4,25)26/h5-9H,1-4H3,(H,19,20)(H,21,22)(H,23,24)
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n/an/a 117n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227530
PNG
(US9334278, I-19)
Show SMILES Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c(C)c1
Show InChI InChI=1S/C19H23N5O/c1-11-6-7-14(12(2)8-11)22-15-10-21-17-16(23-15)13(9-20-17)18(25)24-19(3,4)5/h6-10H,1-5H3,(H,20,21)(H,22,23)(H,24,25)
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n/an/a 117n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227539
PNG
(US9334278, I-28)
Show SMILES CC(C)(C)NC(=O)c1c[nH]c2ncc(Nc3ccnc(c3)S(C)(=O)=O)nc12
Show InChI InChI=1S/C17H20N6O3S/c1-17(2,3)23-16(24)11-8-19-15-14(11)22-12(9-20-15)21-10-5-6-18-13(7-10)27(4,25)26/h5-9H,1-4H3,(H,19,20)(H,23,24)(H,18,21,22)
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n/an/a 121n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227518
PNG
(US9334278, I-7)
Show SMILES Cc1ncc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)cn1
Show InChI InChI=1S/C16H19N7O/c1-9-17-5-10(6-18-9)21-12-8-20-14-13(22-12)11(7-19-14)15(24)23-16(2,3)4/h5-8H,1-4H3,(H,19,20)(H,21,22)(H,23,24)
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n/an/a 164n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227544
PNG
(US9334278, I-33)
Show SMILES Cn1ncc2N(CCCc12)c1cnc2[nH]cc(C(=O)NC(C)(C)C)c2n1
Show InChI InChI=1S/C18H23N7O/c1-18(2,3)23-17(26)11-8-19-16-15(11)22-14(10-20-16)25-7-5-6-12-13(25)9-21-24(12)4/h8-10H,5-7H2,1-4H3,(H,19,20)(H,23,26)
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n/an/a 167n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227540
PNG
(US9334278, I-29)
Show SMILES CC(C)(C)NC(=O)c1c[nH]c2ncc(Nc3cncc(c3)S(C)(=O)=O)nc12
Show InChI InChI=1S/C17H20N6O3S/c1-17(2,3)23-16(24)12-8-19-15-14(12)22-13(9-20-15)21-10-5-11(7-18-6-10)27(4,25)26/h5-9H,1-4H3,(H,19,20)(H,21,22)(H,23,24)
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n/an/a 228n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227547
PNG
(US9334278, I-36)
Show SMILES Cc1cc(Nc2nc3c(c[nH]c3nc2C)C(=O)NC(C)(C)C)sn1
Show InChI InChI=1S/C16H20N6OS/c1-8-6-11(24-22-8)19-13-9(2)18-14-12(20-13)10(7-17-14)15(23)21-16(3,4)5/h6-7H,1-5H3,(H,17,18)(H,19,20)(H,21,23)
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n/an/a 251n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227548
PNG
(US9334278, I-38)
Show SMILES Cc1cc(Nc2nc3c(c[nH]c3nc2Cl)C(=O)NC(C)(C)C)sn1
Show InChI InChI=1S/C15H17ClN6OS/c1-7-5-9(24-22-7)18-13-11(16)20-12-10(19-13)8(6-17-12)14(23)21-15(2,3)4/h5-6H,1-4H3,(H,17,20)(H,18,19)(H,21,23)
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n/an/a 640n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227526
PNG
(US9334278, I-15)
Show SMILES CN(C)C(=O)c1ccccc1Nc1cnc2[nH]cc(C(=O)NC(C)(C)C)c2n1
Show InChI InChI=1S/C20H24N6O2/c1-20(2,3)25-18(27)13-10-21-17-16(13)24-15(11-22-17)23-14-9-7-6-8-12(14)19(28)26(4)5/h6-11H,1-5H3,(H,21,22)(H,23,24)(H,25,27)
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n/an/a 934n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227545
PNG
(US9334278, I-34)
Show SMILES Cc1nc2[nH]cc(C(=O)NC(C)(C)C)c2nc1Nc1cnn(C)c1
Show InChI InChI=1S/C16H21N7O/c1-9-13(20-10-6-18-23(5)8-10)21-12-11(7-17-14(12)19-9)15(24)22-16(2,3)4/h6-8H,1-5H3,(H,17,19)(H,20,21)(H,22,24)
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n/an/a 1.07E+3n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227532
PNG
(US9334278, I-21)
Show SMILES CN(c1cccnc1)c1cnc2[nH]cc(C(=O)NC(C)(C)C)c2n1
Show InChI InChI=1S/C17H20N6O/c1-17(2,3)22-16(24)12-9-19-15-14(12)21-13(10-20-15)23(4)11-6-5-7-18-8-11/h5-10H,1-4H3,(H,19,20)(H,22,24)
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n/an/a 1.90E+3n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK [360-635]


(Homo sapiens (Human))		BDBM227546
PNG
(US9334278, I-35)
Show SMILES Cc1nc2[nH]cc(C(=O)NC(C)(C)C)c2nc1Nc1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C19H23N5O3S/c1-11-16(22-12-7-6-8-13(9-12)28(5,26)27)23-15-14(10-20-17(15)21-11)18(25)24-19(2,3)4/h6-10H,1-5H3,(H,20,21)(H,22,23)(H,24,25)
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n/an/a 2.94E+3n/an/an/an/an/a30



Hoffmann-La Roche Inc.

US Patent


Assay Description
Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...

US Patent US9334278 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VN3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%