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Patent code US8815854

Compile Data Set for Download or QSAR
Found 24 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130225
PNG
(US8815854, 14)
Show SMILES Nc1nccnc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C26H23N7/c27-23-22(29-15-16-30-23)25-32-21-12-11-20(17-5-2-1-3-6-17)31-24(21)33(25)19-9-7-18(8-10-19)26(28)13-4-14-26/h1-3,5-12,15-16H,4,13-14,28H2,(H2,27,30)
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n/an/a 1.69n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130222
PNG
(US8815854, 11)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(nc12)-c1cccc(c1)N1CCOCC1)C1CC1
Show InChI InChI=1S/C29H31N5O/c30-29(13-2-14-29)22-7-9-23(10-8-22)34-27(20-5-6-20)32-26-12-11-25(31-28(26)34)21-3-1-4-24(19-21)33-15-17-35-18-16-33/h1,3-4,7-12,19-20H,2,5-6,13-18,30H2
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n/an/a 1.99n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130221
PNG
(US8815854, 9)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(nc12)-c1cccc(c1)N1CCOCC1)C1CCCCC1
Show InChI InChI=1S/C32H37N5O/c33-32(16-5-17-32)25-10-12-26(13-11-25)37-30(23-6-2-1-3-7-23)35-29-15-14-28(34-31(29)37)24-8-4-9-27(22-24)36-18-20-38-21-19-36/h4,8-15,22-23H,1-3,5-7,16-21,33H2
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n/an/a 3.47n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130249
PNG
(US8815854, 47)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(Nc3ccccc3)nc12)-c1ccccc1
Show InChI InChI=1S/C28H25N5/c29-28(18-7-19-28)21-12-14-23(15-13-21)33-26(20-8-3-1-4-9-20)31-24-16-17-25(32-27(24)33)30-22-10-5-2-6-11-22/h1-6,8-17H,7,18-19,29H2,(H,30,32)
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n/an/a 4.13n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130241
PNG
(US8815854, 42)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1ccc2nc(-c3ccccc3)n(-c3ccc(cc3)C3(N)CCC3)c2n1
Show InChI InChI=1S/C31H29N5O/c1-35(2)30(37)23-11-6-10-22(20-23)26-16-17-27-29(33-26)36(28(34-27)21-8-4-3-5-9-21)25-14-12-24(13-15-25)31(32)18-7-19-31/h3-6,8-17,20H,7,18-19,32H2,1-2H3
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n/an/a 4.27n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130226
PNG
(US8815854, 15)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(nc12)-c1ccccc1)-c1cccnc1
Show InChI InChI=1S/C27H23N5/c28-27(15-5-16-27)21-9-11-22(12-10-21)32-25(20-8-4-17-29-18-20)31-24-14-13-23(30-26(24)32)19-6-2-1-3-7-19/h1-4,6-14,17-18H,5,15-16,28H2
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n/an/a 4.30n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130233
PNG
(US8815854, 26)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(nc12)-c1cccc(c1)N1CCOCC1)-c1cccc(O)c1
Show InChI InChI=1S/C32H31N5O2/c33-32(14-3-15-32)24-8-10-25(11-9-24)37-30(23-5-2-7-27(38)21-23)35-29-13-12-28(34-31(29)37)22-4-1-6-26(20-22)36-16-18-39-19-17-36/h1-2,4-13,20-21,38H,3,14-19,33H2
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n/an/a 4.42n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130228
PNG
(US8815854, 17)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(nc12)-c1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C28H24N4O/c29-28(17-6-18-28)20-11-13-21(14-12-20)32-26(22-9-4-5-10-25(22)33)31-24-16-15-23(30-27(24)32)19-7-2-1-3-8-19/h1-5,7-16,33H,6,17-18,29H2
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n/an/a 4.74n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130234
PNG
(US8815854, 30)
Show SMILES COc1ccc(cc1)-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C33H33N5O2/c1-39-28-12-6-23(7-13-28)31-36-30-15-14-29(24-4-2-5-27(22-24)37-18-20-40-21-19-37)35-32(30)38(31)26-10-8-25(9-11-26)33(34)16-3-17-33/h2,4-15,22H,3,16-21,34H2,1H3
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n/an/a 4.78n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130239
PNG
(US8815854, 37)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(nc12)-c1cccc(c1)N1CCOCC1)-c1ccnnc1
Show InChI InChI=1S/C30H29N7O/c31-30(12-2-13-30)23-5-7-24(8-6-23)37-28(22-11-14-32-33-20-22)35-27-10-9-26(34-29(27)37)21-3-1-4-25(19-21)36-15-17-38-18-16-36/h1,3-11,14,19-20H,2,12-13,15-18,31H2
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n/an/a 4.96n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130230
PNG
(US8815854, 19)
Show SMILES Nc1ccccc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C28H25N5/c29-23-10-5-4-9-22(23)26-32-25-16-15-24(19-7-2-1-3-8-19)31-27(25)33(26)21-13-11-20(12-14-21)28(30)17-6-18-28/h1-5,7-16H,6,17-18,29-30H2
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n/an/a 5.67n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130238
PNG
(US8815854, 36)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(nc12)-c1cccc(c1)N1CCOCC1)-c1ncccn1
Show InChI InChI=1S/C30H29N7O/c31-30(12-2-13-30)22-6-8-23(9-7-22)37-28-26(35-29(37)27-32-14-3-15-33-27)11-10-25(34-28)21-4-1-5-24(20-21)36-16-18-38-19-17-36/h1,3-11,14-15,20H,2,12-13,16-19,31H2
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n/an/a 5.71n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130224
PNG
(US8815854, 13)
Show SMILES Cn1cc(c(N)n1)-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C26H25N7/c1-32-16-20(23(27)31-32)24-30-22-13-12-21(17-6-3-2-4-7-17)29-25(22)33(24)19-10-8-18(9-11-19)26(28)14-5-15-26/h2-4,6-13,16H,5,14-15,28H2,1H3,(H2,27,31)
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n/an/a 5.78n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130236
PNG
(US8815854, 34)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(nc12)-c1cccc(c1)N1CCOCC1)-c1cccc(Cl)c1
Show InChI InChI=1S/C32H30ClN5O/c33-25-6-1-5-23(20-25)30-36-29-13-12-28(22-4-2-7-27(21-22)37-16-18-39-19-17-37)35-31(29)38(30)26-10-8-24(9-11-26)32(34)14-3-15-32/h1-2,4-13,20-21H,3,14-19,34H2
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n/an/a 5.90n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130237
PNG
(US8815854, 35)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(nc12)-c1cccc(c1)N1CCOCC1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C32H30ClN5O/c33-25-9-5-22(6-10-25)30-36-29-14-13-28(23-3-1-4-27(21-23)37-17-19-39-20-18-37)35-31(29)38(30)26-11-7-24(8-12-26)32(34)15-2-16-32/h1,3-14,21H,2,15-20,34H2
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n/an/a 6.27n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130223
PNG
(US8815854, 12)
Show SMILES Nc1ncnc(Cl)c1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1ccccc1 |(6.97,-2.37,;7.74,-3.71,;9.28,-3.71,;10.05,-5.04,;9.28,-6.38,;7.74,-6.38,;6.97,-7.71,;6.97,-5.04,;5.43,-5.04,;4.52,-3.8,;3.06,-4.27,;1.72,-3.5,;.39,-4.27,;.39,-5.81,;1.72,-6.58,;3.06,-5.81,;4.52,-6.29,;4.52,-7.83,;5.86,-8.6,;5.86,-10.14,;4.52,-10.91,;3.19,-10.14,;3.19,-8.6,;4.52,-12.45,;3.19,-13.22,;5.29,-13.78,;6.63,-13.01,;5.86,-11.68,;-.94,-6.58,;-2.28,-5.81,;-3.61,-6.58,;-3.61,-8.12,;-2.28,-8.89,;-.94,-8.12,)|
Show InChI InChI=1S/C26H22ClN7/c27-22-21(23(28)31-15-30-22)25-33-20-12-11-19(16-5-2-1-3-6-16)32-24(20)34(25)18-9-7-17(8-10-18)26(29)13-4-14-26/h1-3,5-12,15H,4,13-14,29H2,(H2,28,30,31)
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n/an/a 7.17n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130229
PNG
(US8815854, 18)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(nc12)-c1ccccc1)-c1cccnc1F
Show InChI InChI=1S/C27H22FN5/c28-24-21(8-4-17-30-24)25-32-23-14-13-22(18-6-2-1-3-7-18)31-26(23)33(25)20-11-9-19(10-12-20)27(29)15-5-16-27/h1-4,6-14,17H,5,15-16,29H2
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n/an/a 7.27n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130227
PNG
(US8815854, 16)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(nc12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C28H24N4/c29-28(18-7-19-28)22-12-14-23(15-13-22)32-26(21-10-5-2-6-11-21)31-25-17-16-24(30-27(25)32)20-8-3-1-4-9-20/h1-6,8-17H,7,18-19,29H2
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n/an/a 7.75n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130220
PNG
(US8815854, 7)
Show SMILES Cc1ccccc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C33H33N5O/c1-23-6-2-3-9-28(23)31-36-30-15-14-29(24-7-4-8-27(22-24)37-18-20-39-21-19-37)35-32(30)38(31)26-12-10-25(11-13-26)33(34)16-5-17-33/h2-4,6-15,22H,5,16-21,34H2,1H3
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n/an/a 11.5n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130219
PNG
(US8815854, 5)
Show SMILES COC(=O)c1ccccc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C34H33N5O3/c1-41-33(40)28-9-3-2-8-27(28)31-37-30-15-14-29(23-6-4-7-26(22-23)38-18-20-42-21-19-38)36-32(30)39(31)25-12-10-24(11-13-25)34(35)16-5-17-34/h2-4,6-15,22H,5,16-21,35H2,1H3
PDB

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n/an/a 12.6n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130235
PNG
(US8815854, 31)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(nc12)-c1cccc(c1)N1CCOCC1)-c1cccc(F)c1
Show InChI InChI=1S/C32H30FN5O/c33-25-6-1-5-23(20-25)30-36-29-13-12-28(22-4-2-7-27(21-22)37-16-18-39-19-17-37)35-31(29)38(30)26-10-8-24(9-11-26)32(34)14-3-15-32/h1-2,4-13,20-21H,3,14-19,34H2
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n/an/a 35.5n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130242
PNG
(US8815854, 44)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(NCc3ccccc3)nc12)-c1ccccc1
Show InChI InChI=1S/C29H27N5/c30-29(18-7-19-29)23-12-14-24(15-13-23)34-27(22-10-5-2-6-11-22)32-25-16-17-26(33-28(25)34)31-20-21-8-3-1-4-9-21/h1-6,8-17H,7,18-20,30H2,(H,31,33)
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n/an/a 871n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130232
PNG
(US8815854, 24)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(nc12)-c1cccc(c1)N1CCOCC1)-c1cc[nH]n1
Show InChI InChI=1S/C29H29N7O/c30-29(12-2-13-29)21-5-7-22(8-6-21)36-27-25(33-28(36)26-11-14-31-34-26)10-9-24(32-27)20-3-1-4-23(19-20)35-15-17-37-18-16-35/h1,3-11,14,19H,2,12-13,15-18,30H2,(H,31,34)
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n/an/a 1.16E+3n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM130231
PNG
(US8815854, 20)
Show SMILES NC1(CCC1)c1ccc(cc1)-n1c(nc2ccc(nc12)-c1cccc(c1)N1CCOCC1)-c1ccccn1
Show InChI InChI=1S/C31H30N6O/c32-31(14-4-15-31)23-8-10-24(11-9-23)37-29(27-7-1-2-16-33-27)35-28-13-12-26(34-30(28)37)22-5-3-6-25(21-22)36-17-19-38-20-18-36/h1-3,5-13,16,21H,4,14-15,17-20,32H2
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n/an/a 5.26E+3n/an/an/an/a8.0n/a



ArQule, Inc.

US Patent


Assay Description
AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...

US Patent US8815854 (2014)


BindingDB Entry DOI: 10.7270/Q2J67FMR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%