Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM106968 (US8592457, 1-5) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.720 | -54.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Assay methodology using FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). | US Patent US8592457 (2013) BindingDB Entry DOI: 10.7270/Q2251GTW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM106970 (US8592457, 1-16) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.910 | -53.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Assay methodology using FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). | US Patent US8592457 (2013) BindingDB Entry DOI: 10.7270/Q2251GTW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM106971 (US8592457, 7-5) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | 0.950 | -53.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Assay methodology using FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). | US Patent US8592457 (2013) BindingDB Entry DOI: 10.7270/Q2251GTW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM106972 (US8592457, 7-7) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.970 | -53.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Assay methodology using FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). | US Patent US8592457 (2013) BindingDB Entry DOI: 10.7270/Q2251GTW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM106969 (US8592457, 1-13) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 4.5 | -49.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Assay methodology using FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). | US Patent US8592457 (2013) BindingDB Entry DOI: 10.7270/Q2251GTW | |||||||||||
More data for this Ligand-Target Pair |