Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50262685 (6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM36356 (DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 26.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM160333 (US9040694, 5) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 40.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM36355 (4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 42.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM36354 (4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50262685 (6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB US Patent | n/a | n/a | 148 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM160333 (US9040694, 5) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 215 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM5410 (4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 235 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase subunit beta-1 (Homo sapiens (Human)) | BDBM50262685 (6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 318 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase subunit beta-1 (Homo sapiens (Human)) | BDBM36355 (4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 527 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM160333 (US9040694, 5) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 565 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM36356 (DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 999 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase subunit beta-1 (Homo sapiens (Human)) | BDBM160333 (US9040694, 5) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM36355 (4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase subunit beta-1 (Homo sapiens (Human)) | BDBM36356 (DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM36356 (DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM36355 (4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM5410 (4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase subunit beta-1 (Homo sapiens (Human)) | BDBM5410 (4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50262685 (6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se... | US Patent US9040694 (2015) BindingDB Entry DOI: 10.7270/Q2X065SN | |||||||||||
More data for this Ligand-Target Pair |