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Patent code US8957059

Compile Data Set for Download or QSAR
Found 66 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM104992
PNG
(US8575364, 1)
Show SMILES COc1ccc(cc1OC1CNC1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C17H16F3NO2/c1-22-15-7-6-11(8-16(15)23-12-9-21-10-12)13-4-2-3-5-14(13)17(18,19)20/h2-8,12,21H,9-10H2,1H3
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 3.79n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105008
PNG
(US8575364, 17)
Show SMILES COc1ccc(cc1OC1CNC1)-c1ccccc1Cl
Show InChI InChI=1S/C16H16ClNO2/c1-19-15-7-6-11(13-4-2-3-5-14(13)17)8-16(15)20-12-9-18-10-12/h2-8,12,18H,9-10H2,1H3
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 4.42n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105034
PNG
(US8575364, 43)
Show SMILES COc1ccc(cc1C1CCNC1)-c1ccccc1C
Show InChI InChI=1S/C18H21NO/c1-13-5-3-4-6-16(13)14-7-8-18(20-2)17(11-14)15-9-10-19-12-15/h3-8,11,15,19H,9-10,12H2,1-2H3
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 5.46n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105038
PNG
(US8575364, 47)
Show SMILES COc1ccc(cc1C1CCNC1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C18H18F3NO/c1-23-17-7-6-12(10-15(17)13-8-9-22-11-13)14-4-2-3-5-16(14)18(19,20)21/h2-7,10,13,22H,8-9,11H2,1H3
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 7.98n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM104997
PNG
(US8575364, 6)
Show SMILES COc1ccc(cc1OC1CNC1)-c1c(C)cccc1C
Show InChI InChI=1S/C18H21NO2/c1-12-5-4-6-13(2)18(12)14-7-8-16(20-3)17(9-14)21-15-10-19-11-15/h4-9,15,19H,10-11H2,1-3H3
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 8.20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105015
PNG
(US8575364, 24)
Show SMILES Clc1ccc(cc1OC1CNC1)-c1ccccc1Cl
Show InChI InChI=1S/C15H13Cl2NO/c16-13-4-2-1-3-12(13)10-5-6-14(17)15(7-10)19-11-8-18-9-11/h1-7,11,18H,8-9H2
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 8.89n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM104998
PNG
(US8575364, 7)
Show SMILES COc1ccc(cc1OC1CNC1)-c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C17H16F3NO3/c1-22-15-7-6-11(8-16(15)23-12-9-21-10-12)13-4-2-3-5-14(13)24-17(18,19)20/h2-8,12,21H,9-10H2,1H3
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 10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105016
PNG
(US8575364, 25)
Show SMILES FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1
Show InChI InChI=1S/C16H13ClF3NO/c17-14-6-5-10(7-15(14)22-11-8-21-9-11)12-3-1-2-4-13(12)16(18,19)20/h1-7,11,21H,8-9H2
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 10.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM104995
PNG
(US8575364, 4)
Show SMILES COc1ccc(cc1OC1CNC1)-c1cccc(C)c1C
Show InChI InChI=1S/C18H21NO2/c1-12-5-4-6-16(13(12)2)14-7-8-17(20-3)18(9-14)21-15-10-19-11-15/h4-9,15,19H,10-11H2,1-3H3
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 11n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM104999
PNG
(US8575364, 8)
Show SMILES COc1ccc(cc1OC1CNC1)-c1ccccc1C
Show InChI InChI=1S/C17H19NO2/c1-12-5-3-4-6-15(12)13-7-8-16(19-2)17(9-13)20-14-10-18-11-14/h3-9,14,18H,10-11H2,1-2H3
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 13.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105017
PNG
(US8575364, 26)
Show SMILES Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1
Show InChI InChI=1S/C16H16ClNO/c1-11-4-2-3-5-14(11)12-6-7-15(17)16(8-12)19-13-9-18-10-13/h2-8,13,18H,9-10H2,1H3
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 15.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105035
PNG
(US8575364, 44)
Show SMILES COc1ccc(cc1C1CCNC1)-c1cccc(F)c1C
Show InChI InChI=1S/C18H20FNO/c1-12-15(4-3-5-17(12)19)13-6-7-18(21-2)16(10-13)14-8-9-20-11-14/h3-7,10,14,20H,8-9,11H2,1-2H3
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 19n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM104996
PNG
(US8575364, 5)
Show SMILES COc1ccc(cc1OC1CNC1)-c1cccc(F)c1C
Show InChI InChI=1S/C17H18FNO2/c1-11-14(4-3-5-15(11)18)12-6-7-16(20-2)17(8-12)21-13-9-19-10-13/h3-8,13,19H,9-10H2,1-2H3
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 19n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105039
PNG
(US8575364, 48)
Show SMILES COc1ccc(cc1C1CCNC1)-c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C18H18F3NO2/c1-23-16-7-6-12(10-15(16)13-8-9-22-11-13)14-4-2-3-5-17(14)24-18(19,20)21/h2-7,10,13,22H,8-9,11H2,1H3
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 19.8n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM104993
PNG
(US8575364, 2)
Show SMILES COc1ccc(cc1OC1CNC1)-c1ccc(F)cc1C
Show InChI InChI=1S/C17H18FNO2/c1-11-7-13(18)4-5-15(11)12-3-6-16(20-2)17(8-12)21-14-9-19-10-14/h3-8,14,19H,9-10H2,1-2H3
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 21n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105011
PNG
(US8575364, 20)
Show SMILES FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1
Show InChI InChI=1S/C16H14F3NO/c17-16(18,19)15-7-2-1-6-14(15)11-4-3-5-12(8-11)21-13-9-20-10-13/h1-8,13,20H,9-10H2
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 25.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM104994
PNG
(US8575364, 3)
Show SMILES COc1ccc(cc1OC1CNC1)-c1ccccc1C#N
Show InChI InChI=1S/C17H16N2O2/c1-20-16-7-6-12(8-17(16)21-14-10-19-11-14)15-5-3-2-4-13(15)9-18/h2-8,14,19H,10-11H2,1H3
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 33.9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105012
PNG
(US8575364, 21)
Show SMILES Clc1ccccc1-c1cccc(OC2CNC2)c1
Show InChI InChI=1S/C15H14ClNO/c16-15-7-2-1-6-14(15)11-4-3-5-12(8-11)18-13-9-17-10-13/h1-8,13,17H,9-10H2
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 34.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105000
PNG
(US8575364, 9)
Show SMILES COc1ccc(cc1OC1CNC1)-c1ccccc1OC
Show InChI InChI=1S/C17H19NO3/c1-19-15-6-4-3-5-14(15)12-7-8-16(20-2)17(9-12)21-13-10-18-11-13/h3-9,13,18H,10-11H2,1-2H3
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 50n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105036
PNG
(US8575364, 45)
Show SMILES COc1ccc(cc1C1CCNC1)-c1cccc(F)c1F
Show InChI InChI=1S/C17H17F2NO/c1-21-16-6-5-11(9-14(16)12-7-8-20-10-12)13-3-2-4-15(18)17(13)19/h2-6,9,12,20H,7-8,10H2,1H3
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 52n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105048
PNG
(US8575364, 57)
Show SMILES Cc1ccc(cc1C)-c1ccccc1C1CCNC1
Show InChI InChI=1S/C18H21N/c1-13-7-8-15(11-14(13)2)17-5-3-4-6-18(17)16-9-10-19-12-16/h3-8,11,16,19H,9-10,12H2,1-2H3
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 55.9n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105060
PNG
(US8575364, 60)
Show SMILES COc1ccc(cc1OC1CCNCC1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C19H20F3NO2/c1-24-17-7-6-13(12-18(17)25-14-8-10-23-11-9-14)15-4-2-3-5-16(15)19(20,21)22/h2-7,12,14,23H,8-11H2,1H3
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 59.0n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105014
PNG
(US8575364, 23)
Show SMILES Cc1ccccc1-c1cccc(OC2CNC2)c1
Show InChI InChI=1S/C16H17NO/c1-12-5-2-3-8-16(12)13-6-4-7-14(9-13)18-15-10-17-11-15/h2-9,15,17H,10-11H2,1H3
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 67n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105043
PNG
(US8575364, 52)
Show SMILES Cc1cccc(c1)-c1ccccc1C1CCNC1
Show InChI InChI=1S/C17H19N/c1-13-5-4-6-14(11-13)16-7-2-3-8-17(16)15-9-10-18-12-15/h2-8,11,15,18H,9-10,12H2,1H3
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 80.2n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105001
PNG
(US8575364, 10)
Show SMILES COc1ccc(cc1OC1CNC1)-c1c(Cl)cccc1C(F)(F)F
Show InChI InChI=1S/C17H15ClF3NO2/c1-23-14-6-5-10(7-15(14)24-11-8-22-9-11)16-12(17(19,20)21)3-2-4-13(16)18/h2-7,11,22H,8-9H2,1H3
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 112n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105007
PNG
(US8575364, 16)
Show SMILES COc1ccc(cc1OC1CNC1)-c1cc(C)ccc1C
Show InChI InChI=1S/C18H21NO2/c1-12-4-5-13(2)16(8-12)14-6-7-17(20-3)18(9-14)21-15-10-19-11-15/h4-9,15,19H,10-11H2,1-3H3
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 114n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105037
PNG
(US8575364, 46)
Show SMILES COc1ccc(cc1C1CCNC1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C18H18F3NO/c1-23-17-6-5-13(10-16(17)14-7-8-22-11-14)12-3-2-4-15(9-12)18(19,20)21/h2-6,9-10,14,22H,7-8,11H2,1H3
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 117n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105045
PNG
(US8575364, 54)
Show SMILES Cc1ccc(cc1)-c1ccccc1C1CCNC1
Show InChI InChI=1S/C17H19N/c1-13-6-8-14(9-7-13)16-4-2-3-5-17(16)15-10-11-18-12-15/h2-9,15,18H,10-12H2,1H3
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 120n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105058
PNG
(US8575364, 67)
Show SMILES Cc1ccc(cc1C)-c1ccc(Cl)cc1C1CCNC1
Show InChI InChI=1S/C18H20ClN/c1-12-3-4-14(9-13(12)2)17-6-5-16(19)10-18(17)15-7-8-20-11-15/h3-6,9-10,15,20H,7-8,11H2,1-2H3
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 120n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105042
PNG
(US8575364, 51)
Show SMILES C1CC(CN1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C16H17N/c1-2-6-13(7-3-1)15-8-4-5-9-16(15)14-10-11-17-12-14/h1-9,14,17H,10-12H2
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 120n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105006
PNG
(US8575364, 15)
Show SMILES COc1ccc(cc1OC1CNC1)-c1ccccc1
Show InChI InChI=1S/C16H17NO2/c1-18-15-8-7-13(12-5-3-2-4-6-12)9-16(15)19-14-10-17-11-14/h2-9,14,17H,10-11H2,1H3
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 120n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105019
PNG
(US8575364, 28)
Show SMILES FC(F)(F)c1ccccc1-c1ccc(C#N)c(OC2CNC2)c1
Show InChI InChI=1S/C17H13F3N2O/c18-17(19,20)15-4-2-1-3-14(15)11-5-6-12(8-21)16(7-11)23-13-9-22-10-13/h1-7,13,22H,9-10H2
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 127n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105056
PNG
(US8575364, 65)
Show SMILES Clc1cccc(c1)-c1ccc(Cl)cc1C1CCNC1
Show InChI InChI=1S/C16H15Cl2N/c17-13-3-1-2-11(8-13)15-5-4-14(18)9-16(15)12-6-7-19-10-12/h1-5,8-9,12,19H,6-7,10H2
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 130n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105040
PNG
(US8575364, 49)
Show SMILES COc1ccc(cc1C1CCNC1)-c1ccccc1
Show InChI InChI=1S/C17H19NO/c1-19-17-8-7-14(13-5-3-2-4-6-13)11-16(17)15-9-10-18-12-15/h2-8,11,15,18H,9-10,12H2,1H3
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 130n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105041
PNG
(US8575364, 50)
Show SMILES COc1ccc(cc1C1CCN(C)C1)-c1ccccc1
Show InChI InChI=1S/C18H21NO/c1-19-11-10-16(13-19)17-12-15(8-9-18(17)20-2)14-6-4-3-5-7-14/h3-9,12,16H,10-11,13H2,1-2H3
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 150n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105049
PNG
(US8575364, 58)
Show SMILES CN1CCC(C1)c1ccccc1-c1ccc(C)c(C)c1
Show InChI InChI=1S/C19H23N/c1-14-8-9-16(12-15(14)2)18-6-4-5-7-19(18)17-10-11-20(3)13-17/h4-9,12,17H,10-11,13H2,1-3H3
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 155n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105047
PNG
(US8575364, 56)
Show SMILES Clc1ccc(cc1)-c1ccccc1C1CCNC1
Show InChI InChI=1S/C16H16ClN/c17-14-7-5-12(6-8-14)15-3-1-2-4-16(15)13-9-10-18-11-13/h1-8,13,18H,9-11H2
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 180n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105029
PNG
(US8575364, 38)
Show SMILES Cc1cccc(c1)-c1ccc(Cl)cc1OC1CNC1
Show InChI InChI=1S/C16H16ClNO/c1-11-3-2-4-12(7-11)15-6-5-13(17)8-16(15)19-14-9-18-10-14/h2-8,14,18H,9-10H2,1H3
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 189n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105050
PNG
(US8575364, 59)
Show SMILES Cc1ccccc1-c1ccccc1C1CCNC1
Show InChI InChI=1S/C17H19N/c1-13-6-2-3-7-15(13)17-9-5-4-8-16(17)14-10-11-18-12-14/h2-9,14,18H,10-12H2,1H3
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 210n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105033
PNG
(US8575364, 42)
Show SMILES Cc1ccc(cc1C)-c1ccc(Cl)cc1OC1CNC1
Show InChI InChI=1S/C17H18ClNO/c1-11-3-4-13(7-12(11)2)16-6-5-14(18)8-17(16)20-15-9-19-10-15/h3-8,15,19H,9-10H2,1-2H3
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 210n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105005
PNG
(US8575364, 14)
Show SMILES COc1ccc(cc1OC1CNC1)-c1ccc(C)c(C)c1
Show InChI InChI=1S/C18H21NO2/c1-12-4-5-14(8-13(12)2)15-6-7-17(20-3)18(9-15)21-16-10-19-11-16/h4-9,16,19H,10-11H2,1-3H3
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 250n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105010
PNG
(US8575364, 19)
Show SMILES COc1ccc(cc1OC1CN(C1)C1CCC1)-c1ccccc1Cl
Show InChI InChI=1S/C20H22ClNO2/c1-23-19-10-9-14(17-7-2-3-8-18(17)21)11-20(19)24-16-12-22(13-16)15-5-4-6-15/h2-3,7-11,15-16H,4-6,12-13H2,1H3
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 300n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105052
PNG
(US8575364, 61)
Show SMILES COc1ccccc1-c1ccccc1C1CCNC1
Show InChI InChI=1S/C17H19NO/c1-19-17-9-5-4-8-16(17)15-7-3-2-6-14(15)13-10-11-18-12-13/h2-9,13,18H,10-12H2,1H3
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 300n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105044
PNG
(US8575364, 53)
Show SMILES CN1CCC(C1)c1ccccc1-c1cccc(C)c1
Show InChI InChI=1S/C18H21N/c1-14-6-5-7-15(12-14)17-8-3-4-9-18(17)16-10-11-19(2)13-16/h3-9,12,16H,10-11,13H2,1-2H3
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 310n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105051
PNG
(US8575364, 60)
Show SMILES CN1CCC(C1)c1ccccc1-c1ccccc1C
Show InChI InChI=1S/C18H21N/c1-14-7-3-4-8-16(14)18-10-6-5-9-17(18)15-11-12-19(2)13-15/h3-10,15H,11-13H2,1-2H3
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 330n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105057
PNG
(US8575364, 66)
Show SMILES Cc1cc(ccc1F)-c1ccc(Cl)cc1C1CCNC1
Show InChI InChI=1S/C17H17ClFN/c1-11-8-12(2-5-17(11)19)15-4-3-14(18)9-16(15)13-6-7-20-10-13/h2-5,8-9,13,20H,6-7,10H2,1H3
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 380n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105018
PNG
(US8575364, 27)
Show SMILES Cc1cccc(c1)-c1ccc(Cl)c(OC2CNC2)c1
Show InChI InChI=1S/C16H16ClNO/c1-11-3-2-4-12(7-11)13-5-6-15(17)16(8-13)19-14-9-18-10-14/h2-8,14,18H,9-10H2,1H3
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 410n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105046
PNG
(US8575364, 55)
Show SMILES CN1CCC(C1)c1ccccc1-c1ccc(C)cc1
Show InChI InChI=1S/C18H21N/c1-14-7-9-15(10-8-14)17-5-3-4-6-18(17)16-11-12-19(2)13-16/h3-10,16H,11-13H2,1-2H3
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 430n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105023
PNG
(US8575364, 32)
Show SMILES CCOc1ccc(cc1OC1CNC1)-c1ccccc1C
Show InChI InChI=1S/C18H21NO2/c1-3-20-17-9-8-14(16-7-5-4-6-13(16)2)10-18(17)21-15-11-19-12-15/h4-10,15,19H,3,11-12H2,1-2H3
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 454n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105032
PNG
(US8575364, 41)
Show SMILES Cc1cc(ccc1F)-c1ccc(Cl)cc1OC1CNC1
Show InChI InChI=1S/C16H15ClFNO/c1-10-6-11(2-5-15(10)18)14-4-3-12(17)7-16(14)20-13-8-19-9-13/h2-7,13,19H,8-9H2,1H3
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 470n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105021
PNG
(US8575364, 30)
Show SMILES Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1
Show InChI InChI=1S/C17H16N2O/c1-12-4-2-3-5-16(12)13-6-7-14(9-18)17(8-13)20-15-10-19-11-15/h2-8,15,19H,10-11H2,1H3
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 508n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105024
PNG
(US8575364, 33)
Show SMILES Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1
Show InChI InChI=1S/C18H18F3NO2/c1-12-4-2-3-5-15(12)13-6-7-16(23-11-18(19,20)21)17(8-13)24-14-9-22-10-14/h2-8,14,22H,9-11H2,1H3
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 525n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105009
PNG
(US8575364, 18)
Show SMILES COc1ccc(cc1OC1CN(C1)C(C)C)-c1ccccc1Cl
Show InChI InChI=1S/C19H22ClNO2/c1-13(2)21-11-15(12-21)23-19-10-14(8-9-18(19)22-3)16-6-4-5-7-17(16)20/h4-10,13,15H,11-12H2,1-3H3
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 533n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105025
PNG
(US8575364, 34)
Show SMILES Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1
Show InChI InChI=1S/C20H23NO2/c1-14-5-2-3-8-18(14)15-9-10-19(22-16-6-4-7-16)20(11-15)23-17-12-21-13-17/h2-3,5,8-11,16-17,21H,4,6-7,12-13H2,1H3
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 667n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105053
PNG
(US8575364, 62)
Show SMILES COc1ccccc1-c1ccccc1C1CCN(C)C1
Show InChI InChI=1S/C18H21NO/c1-19-12-11-14(13-19)15-7-3-4-8-16(15)17-9-5-6-10-18(17)20-2/h3-10,14H,11-13H2,1-2H3
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 730n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105013
PNG
(US8575364, 22)
Show SMILES Cc1cccc(c1)-c1cccc(OC2CNC2)c1
Show InChI InChI=1S/C16H17NO/c1-12-4-2-5-13(8-12)14-6-3-7-15(9-14)18-16-10-17-11-16/h2-9,16-17H,10-11H2,1H3
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 752n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105026
PNG
(US8575364, 35)
Show SMILES Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1
Show InChI InChI=1S/C20H23NO2/c1-14-4-2-3-5-18(14)16-8-9-19(22-13-15-6-7-15)20(10-16)23-17-11-21-12-17/h2-5,8-10,15,17,21H,6-7,11-13H2,1H3
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 755n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105002
PNG
(US8575364, 11)
Show SMILES COc1ccc(cc1OC1CNC1)-c1ccc(C)cc1
Show InChI InChI=1S/C17H19NO2/c1-12-3-5-13(6-4-12)14-7-8-16(19-2)17(9-14)20-15-10-18-11-15/h3-9,15,18H,10-11H2,1-2H3
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 760n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105003
PNG
(US8575364, 12)
Show SMILES COc1ccc(cc1OC1CNC1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C17H18FNO2/c1-11-7-12(3-5-15(11)18)13-4-6-16(20-2)17(8-13)21-14-9-19-10-14/h3-8,14,19H,9-10H2,1-2H3
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 770n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105004
PNG
(US8575364, 13)
Show SMILES COc1ccc(cc1OC1CNC1)-c1cccc(C)c1
Show InChI InChI=1S/C17H19NO2/c1-12-4-3-5-13(8-12)14-6-7-16(19-2)17(9-14)20-15-10-18-11-15/h3-9,15,18H,10-11H2,1-2H3
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Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105059
PNG
(US8575364, 68)
Show SMILES COc1ccc(cc1OC1CCNCC1)-c1ccccc1
Show InChI InChI=1S/C18H21NO2/c1-20-17-8-7-15(14-5-3-2-4-6-14)13-18(17)21-16-9-11-19-12-10-16/h2-8,13,16,19H,9-12H2,1H3
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 1.48E+3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105054
PNG
(US8575364, 63)
Show SMILES COc1ccc(C)cc1-c1ccccc1C1CCNC1
Show InChI InChI=1S/C18H21NO/c1-13-7-8-18(20-2)17(11-13)16-6-4-3-5-15(16)14-9-10-19-12-14/h3-8,11,14,19H,9-10,12H2,1-2H3
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 1.70E+3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105028
PNG
(US8575364, 37)
Show SMILES CCN(CC)C(=O)c1ccc(cc1OC1CNC1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C21H23F3N2O2/c1-3-26(4-2)20(27)17-10-9-14(11-19(17)28-15-12-25-13-15)16-7-5-6-8-18(16)21(22,23)24/h5-11,15,25H,3-4,12-13H2,1-2H3
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 2.27E+3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105022
PNG
(US8575364, 31)
Show SMILES Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1
Show InChI InChI=1S/C17H16N2O/c1-12-7-14(9-18)17(20-15-10-19-11-15)8-16(12)13-5-3-2-4-6-13/h2-8,15,19H,10-11H2,1H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105020
PNG
(US8575364, 29)
Show SMILES N#Cc1ccc(cc1OC1CNC1)-c1ccccc1
Show InChI InChI=1S/C16H14N2O/c17-9-14-7-6-13(12-4-2-1-3-5-12)8-16(14)19-15-10-18-11-15/h1-8,15,18H,10-11H2
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 1.00E+4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM105027
PNG
(US8575364, 36)
Show SMILES CC(C)Oc1ccc(cc1OC1CNC1)-c1ccccc1C
Show InChI InChI=1S/C19H23NO2/c1-13(2)21-18-9-8-15(17-7-5-4-6-14(17)3)10-19(18)22-16-11-20-12-16/h4-10,13,16,20H,11-12H2,1-3H3
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 1.00E+4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...

US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%