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Patent code US9447114

Compile Data Set for Download or QSAR
Found 29 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246445
PNG
(US9447114, 1)
Show SMILES Cn1c2sc(Oc3cccc(OC(F)(F)F)c3)c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O
Show InChI InChI=1S/C24H20ClF3N2O5S/c1-29-21-19(20(32)30(23(29)33)10-3-11-31)18(12-14-6-8-15(25)9-7-14)22(36-21)34-16-4-2-5-17(13-16)35-24(26,27)28/h2,4-9,13,31H,3,10-12H2,1H3
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US Patent
n/an/a<1n/an/an/an/a7.2n/a



Hydra Biosciences, Inc.

US Patent


Assay Description
TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246446
PNG
(US9447114, 2)
Show SMILES Cn1c2sc(Oc3cccc(Cl)c3)c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O
Show InChI InChI=1S/C23H20Cl2N2O4S/c1-26-21-19(20(29)27(23(26)30)10-3-11-28)18(12-14-6-8-15(24)9-7-14)22(32-21)31-17-5-2-4-16(25)13-17/h2,4-9,13,28H,3,10-12H2,1H3
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US Patent
n/an/a<1n/an/an/an/a7.2n/a



Hydra Biosciences, Inc.

US Patent


Assay Description
TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246466
PNG
(US9447114, 27)
Show SMILES Cn1c2oc(c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C23H20Cl2N2O4/c1-26-22-19(21(29)27(23(26)30)10-3-11-28)18(12-14-6-8-16(24)9-7-14)20(31-22)15-4-2-5-17(25)13-15/h2,4-9,13,28H,3,10-12H2,1H3
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n/an/a<1n/an/an/an/a7.2n/a



Hydra Biosciences, Inc.

US Patent


Assay Description
TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246465
PNG
(US9447114, 26)
Show SMILES Cn1c2sc(c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H20ClF3N2O4S/c1-29-22-19(21(32)30(23(29)33)10-3-11-31)18(12-14-6-8-16(25)9-7-14)20(35-22)15-4-2-5-17(13-15)34-24(26,27)28/h2,4-9,13,31H,3,10-12H2,1H3
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n/an/a<1n/an/an/an/a7.2n/a



Hydra Biosciences, Inc.

US Patent


Assay Description
TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246463
PNG
(US9447114, 24)
Show SMILES Cn1c2sc(c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20Cl2N2O3S/c1-26-22-19(21(29)27(23(26)30)11-2-12-28)18(13-14-3-7-16(24)8-4-14)20(31-22)15-5-9-17(25)10-6-15/h3-10,28H,2,11-13H2,1H3
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n/an/a 1.84n/an/an/an/a7.2n/a



Hydra Biosciences, Inc.

US Patent


Assay Description
TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246465
PNG
(US9447114, 26)
Show SMILES Cn1c2sc(c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H20ClF3N2O4S/c1-29-22-19(21(32)30(23(29)33)10-3-11-31)18(12-14-6-8-16(25)9-7-14)20(35-22)15-4-2-5-17(13-15)34-24(26,27)28/h2,4-9,13,31H,3,10-12H2,1H3
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n/an/a 1.91n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246464
PNG
(US9447114, 25)
Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H17ClN2O3S/c1-10-13-15(22)20(8-3-9-21)17(23)19(2)16(13)24-14(10)11-4-6-12(18)7-5-11/h4-7,21H,3,8-9H2,1-2H3
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US Patent
n/an/a 15.7n/an/an/an/a7.2n/a



Hydra Biosciences, Inc.

US Patent


Assay Description
TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246453
PNG
(US9447114, 13)
Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C18H17F3N2O4S/c1-10-13-15(25)23(8-5-9-24)17(26)22(2)16(13)28-14(10)11-6-3-4-7-12(11)27-18(19,20)21/h3-4,6-7,24H,5,8-9H2,1-2H3
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n/an/a<21n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246458
PNG
(US9447114, 18)
Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1cccc(F)c1
Show InChI InChI=1S/C17H17FN2O3S/c1-10-13-15(22)20(7-4-8-21)17(23)19(2)16(13)24-14(10)11-5-3-6-12(18)9-11/h3,5-6,9,21H,4,7-8H2,1-2H3
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n/an/a 27n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246449
PNG
(US9447114, 5)
Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H16Cl2N2O3S/c1-9-13-15(23)21(6-3-7-22)17(24)20(2)16(13)25-14(9)10-4-5-11(18)12(19)8-10/h4-5,8,22H,3,6-7H2,1-2H3
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n/an/a<27n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246456
PNG
(US9447114, 16)
Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1ccccc1Cl
Show InChI InChI=1S/C17H17ClN2O3S/c1-10-13-15(22)20(8-5-9-21)17(23)19(2)16(13)24-14(10)11-6-3-4-7-12(11)18/h3-4,6-7,21H,5,8-9H2,1-2H3
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n/an/a 27n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246462
PNG
(US9447114, 23)
Show SMILES Cn1c2sc(c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C23H20Cl2N2O3S/c1-26-22-19(21(29)27(23(26)30)10-3-11-28)18(12-14-6-8-16(24)9-7-14)20(31-22)15-4-2-5-17(25)13-15/h2,4-9,13,28H,3,10-12H2,1H3
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n/an/a 27n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246450
PNG
(US9447114, 6)
Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C18H16F4N2O3S/c1-9-13-15(26)24(6-3-7-25)17(27)23(2)16(13)28-14(9)10-4-5-12(19)11(8-10)18(20,21)22/h4-5,8,25H,3,6-7H2,1-2H3
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n/an/a<27n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246457
PNG
(US9447114, 17)
Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C17H16Cl2N2O3S/c1-9-12-15(23)21(7-4-8-22)17(24)20(2)16(12)25-14(9)10-5-3-6-11(18)13(10)19/h3,5-6,22H,4,7-8H2,1-2H3
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n/an/a 31.6n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246451
PNG
(US9447114, 7)
Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1ccc2ccccc2c1
Show InChI InChI=1S/C21H20N2O3S/c1-13-17-19(25)23(10-5-11-24)21(26)22(2)20(17)27-18(13)16-9-8-14-6-3-4-7-15(14)12-16/h3-4,6-9,12,24H,5,10-11H2,1-2H3
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n/an/a 34.9n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246448
PNG
(US9447114, 4)
Show SMILES Cn1c2sc(c(C(O)c3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C23H20Cl2N2O4S/c1-26-22-18(21(30)27(23(26)31)10-3-11-28)17(19(29)13-6-8-15(24)9-7-13)20(32-22)14-4-2-5-16(25)12-14/h2,4-9,12,19,28-29H,3,10-11H2,1H3
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n/an/a 55n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246454
PNG
(US9447114, 14)
Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C18H17F3N2O4S/c1-10-13-15(25)23(7-4-8-24)17(26)22(2)16(13)28-14(10)11-5-3-6-12(9-11)27-18(19,20)21/h3,5-6,9,24H,4,7-8H2,1-2H3
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n/an/a 82.2n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246455
PNG
(US9447114, 15)
Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C17H16F2N2O3S/c1-9-13-15(23)21(6-3-7-22)17(24)20(2)16(13)25-14(9)10-4-5-11(18)12(19)8-10/h4-5,8,22H,3,6-7H2,1-2H3
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n/an/a 112n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246446
PNG
(US9447114, 2)
Show SMILES Cn1c2sc(Oc3cccc(Cl)c3)c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O
Show InChI InChI=1S/C23H20Cl2N2O4S/c1-26-21-19(20(29)27(23(26)30)10-3-11-28)18(12-14-6-8-15(24)9-7-14)22(32-21)31-17-5-2-4-16(25)13-17/h2,4-9,13,28H,3,10-12H2,1H3
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n/an/a 117n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246466
PNG
(US9447114, 27)
Show SMILES Cn1c2oc(c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C23H20Cl2N2O4/c1-26-22-19(21(29)27(23(26)30)10-3-11-28)18(12-14-6-8-16(24)9-7-14)20(31-22)15-4-2-5-17(25)13-15/h2,4-9,13,28H,3,10-12H2,1H3
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n/an/a 134n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246464
PNG
(US9447114, 25)
Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H17ClN2O3S/c1-10-13-15(22)20(8-3-9-21)17(23)19(2)16(13)24-14(10)11-4-6-12(18)7-5-11/h4-7,21H,3,8-9H2,1-2H3
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n/an/a 168n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246460
PNG
(US9447114, 21)
Show SMILES Cn1c2sc(Oc3cccc(OC(F)(F)F)c3)c(C(O)c3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O
Show InChI InChI=1S/C24H20ClF3N2O6S/c1-29-21-18(20(33)30(23(29)34)10-3-11-31)17(19(32)13-6-8-14(25)9-7-13)22(37-21)35-15-4-2-5-16(12-15)36-24(26,27)28/h2,4-9,12,19,31-32H,3,10-11H2,1H3
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n/an/a 194n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246459
PNG
(US9447114, 19)
Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1cccc(Cl)c1
Show InChI InChI=1S/C17H17ClN2O3S/c1-10-13-15(22)20(7-4-8-21)17(23)19(2)16(13)24-14(10)11-5-3-6-12(18)9-11/h3,5-6,9,21H,4,7-8H2,1-2H3
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 226n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246463
PNG
(US9447114, 24)
Show SMILES Cn1c2sc(c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20Cl2N2O3S/c1-26-22-19(21(29)27(23(26)30)11-2-12-28)18(13-14-3-7-16(24)8-4-14)20(31-22)15-5-9-17(25)10-6-15/h3-10,28H,2,11-13H2,1H3
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US Patent
n/an/a 242n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246447
PNG
(US9447114, 3)
Show SMILES CC(C)CCc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H25F3N2O4S/c1-13(2)8-9-16-17-19(29)27(10-5-11-28)21(30)26(3)20(17)32-18(16)14-6-4-7-15(12-14)31-22(23,24)25/h4,6-7,12-13,28H,5,8-11H2,1-3H3
PDB

UniProtKB/SwissProt

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n/an/a 340n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246461
PNG
(US9447114, 22)
Show SMILES CC(C)CC(O)c1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H25F3N2O5S/c1-12(2)10-15(29)16-17-19(30)27(8-5-9-28)21(31)26(3)20(17)33-18(16)13-6-4-7-14(11-13)32-22(23,24)25/h4,6-7,11-12,15,28-29H,5,8-10H2,1-3H3
PDB

UniProtKB/SwissProt

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UniChem
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n/an/a 369n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246445
PNG
(US9447114, 1)
Show SMILES Cn1c2sc(Oc3cccc(OC(F)(F)F)c3)c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O
Show InChI InChI=1S/C24H20ClF3N2O5S/c1-29-21-19(20(32)30(23(29)33)10-3-11-31)18(12-14-6-8-15(25)9-7-14)22(36-21)34-16-4-2-5-17(13-16)35-24(26,27)28/h2,4-9,13,31H,3,10-12H2,1H3
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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 584n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246452
PNG
(US9447114, 8)
Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1cncc(Cl)c1
Show InChI InChI=1S/C16H16ClN3O3S/c1-9-12-14(22)20(4-3-5-21)16(23)19(2)15(12)24-13(9)10-6-11(17)8-18-7-10/h6-8,21H,3-5H2,1-2H3
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 1.70E+3n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
Short transient receptor potential channel 5


(Homo sapiens (Human))		BDBM246467
PNG
(US9447114, 28)
Show SMILES OCCCn1c2oc(c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C25H24Cl2N2O5/c26-18-8-6-16(7-9-18)14-20-21-23(32)28(10-2-12-30)25(33)29(11-3-13-31)24(21)34-22(20)17-4-1-5-19(27)15-17/h1,4-9,15,30-31H,2-3,10-14H2
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 4.33E+3n/an/an/an/a7.425



Hydra Biosciences, Inc.

US Patent


Assay Description
The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...

US Patent US9447114 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NRD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%