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Patent code US9475795

Compile Data Set for Download or QSAR
Found 111 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250600
PNG
(US10167273, Example 79 | US10544126, Example 79 | ...)
Show SMILES COc1cc(Cl)ccc1CC1CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C19H26ClN3O3S/c1-13-19(14(2)22(3)21-13)27(24,25)23-9-7-15(8-10-23)11-16-5-6-17(20)12-18(16)26-4/h5-6,12,15H,7-11H2,1-4H3
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n/an/a 50n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250620
PNG
(US10167273, Example 99 | US10544126, Example 99 | ...)
Show SMILES COC(C1CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H26ClN3O3S/c1-13-19(14(2)22(3)21-13)27(24,25)23-11-9-16(10-12-23)18(26-4)15-5-7-17(20)8-6-15/h5-8,16,18H,9-12H2,1-4H3
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n/an/a 60n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250599
PNG
(US10167273, Example 78 | US10544126, Example 78 | ...)
Show SMILES COc1cc(Cl)ccc1CC1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C18H24ClN3O3S/c1-12-18(13(2)21-20-12)26(23,24)22-8-6-14(7-9-22)10-15-4-5-16(19)11-17(15)25-3/h4-5,11,14H,6-10H2,1-3H3,(H,20,21)
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n/an/a 70n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250617
PNG
(US10167273, Example 98 | US10544126, Example 96 | ...)
Show SMILES COC(C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1
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n/an/a 80n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250612
PNG
(US10167273, Example 91 | US10544126, Example 91 | ...)
Show SMILES COc1cc(Cl)ccc1CC1(F)CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C19H25ClFN3O3S/c1-13-18(14(2)23(3)22-13)28(25,26)24-9-7-19(21,8-10-24)12-15-5-6-16(20)11-17(15)27-4/h5-6,11H,7-10,12H2,1-4H3
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n/an/a 140n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250617
PNG
(US10167273, Example 98 | US10544126, Example 96 | ...)
Show SMILES COC(C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1
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n/an/a 160n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250611
PNG
(US10167273, Example 90 | US10544126, Example 90 | ...)
Show SMILES COc1cc(Cl)ccc1CC1(F)CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C18H23ClFN3O3S/c1-12-17(13(2)22-21-12)27(24,25)23-8-6-18(20,7-9-23)11-14-4-5-15(19)10-16(14)26-3/h4-5,10H,6-9,11H2,1-3H3,(H,21,22)
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n/an/a 170n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250595
PNG
(US10167273, Example 74 | US10544126, Example 74 | ...)
Show SMILES COc1cc(Cl)ccc1OC1CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C18H24ClN3O4S/c1-12-18(13(2)21(3)20-12)27(23,24)22-9-7-15(8-10-22)26-16-6-5-14(19)11-17(16)25-4/h5-6,11,15H,7-10H2,1-4H3
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n/an/a 170n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250594
PNG
(US10167273, Example 73 | US10544126, Example 73 | ...)
Show SMILES COc1cc(Cl)ccc1OC1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C17H22ClN3O4S/c1-11-17(12(2)20-19-11)26(22,23)21-8-6-14(7-9-21)25-15-5-4-13(18)10-16(15)24-3/h4-5,10,14H,6-9H2,1-3H3,(H,19,20)
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n/an/a 200n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250609
PNG
(US10167273, Example 88 | US10544126, Example 88 | ...)
Show SMILES COc1cc(Cl)ccc1CC1(O)CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C19H26ClN3O4S/c1-13-18(14(2)22(3)21-13)28(25,26)23-9-7-19(24,8-10-23)12-15-5-6-16(20)11-17(15)27-4/h5-6,11,24H,7-10,12H2,1-4H3
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n/an/a 200n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250561
PNG
(US10167273, Example 40 | US10544126, Example 40 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C17H19ClF3N3O3S/c1-10-16(11(2)23-22-10)28(25,26)24-7-5-13(6-8-24)27-15-4-3-12(18)9-14(15)17(19,20)21/h3-4,9,13H,5-8H2,1-2H3,(H,22,23)
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n/an/a 210n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250560
PNG
(US10167273, Example 39 | US10544126, Example 39 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C18H21ClF3N3O3S/c1-11-17(12(2)24(3)23-11)29(26,27)25-8-6-14(7-9-25)28-16-5-4-13(19)10-15(16)18(20,21)22/h4-5,10,14H,6-9H2,1-3H3
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n/an/a 210n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250544
PNG
(US10167273, Example 23 | US10544126, Example 23 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc2ccccc2c1
Show InChI InChI=1S/C21H25N3O3S/c1-15-21(16(2)23(3)22-15)28(25,26)24-12-10-19(11-13-24)27-20-9-8-17-6-4-5-7-18(17)14-20/h4-9,14,19H,10-13H2,1-3H3
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n/an/a 220n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250555
PNG
(US10167273, Example 34 | US10544126, Example 34 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1C#N
Show InChI InChI=1S/C17H19ClN4O3S/c1-11-17(12(2)21-20-11)26(23,24)22-7-5-15(6-8-22)25-16-4-3-14(18)9-13(16)10-19/h3-4,9,15H,5-8H2,1-2H3,(H,20,21)
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n/an/a 240n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250626
PNG
(US10167273, Example 107 | US10544126, Example 107 ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(F)c1ccc(Cl)cc1
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n/an/a 310n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250552
PNG
(US10167273, Example 31 | US10544126, Example 31 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1C#N
Show InChI InChI=1S/C18H21ClN4O3S/c1-12-18(13(2)22(3)21-12)27(24,25)23-8-6-16(7-9-23)26-17-5-4-15(19)10-14(17)11-20/h4-5,10,16H,6-9H2,1-3H3
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n/an/a 310n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250549
PNG
(US10167273, Example 28 | US10544126, Example 28 | ...)
Show SMILES CCc1nn(C)c(CC)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H25Cl2N3O3S/c1-4-16-19(17(5-2)23(3)22-16)28(25,26)24-10-8-14(9-11-24)27-18-7-6-13(20)12-15(18)21/h6-7,12,14H,4-5,8-11H2,1-3H3
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n/an/a 320n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250632
PNG
(US10167273, Example 111 | US10544126, Example 111 ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(C(F)F)c1ccc(Cl)cc1
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n/an/a 340n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250626
PNG
(US10167273, Example 107 | US10544126, Example 107 ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(F)c1ccc(Cl)cc1
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n/an/a 410n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250610
PNG
(US10167273, Example 89 | US10544126, Example 89 | ...)
Show SMILES COc1cc(Cl)ccc1CC1(O)CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C18H24ClN3O4S/c1-12-17(13(2)21-20-12)27(24,25)22-8-6-18(23,7-9-22)11-14-4-5-15(19)10-16(14)26-3/h4-5,10,23H,6-9,11H2,1-3H3,(H,20,21)
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n/an/a 410n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250554
PNG
(US10167273, Example 33 | US10544126, Example 33 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc2ccccc2c1
Show InChI InChI=1S/C20H23N3O3S/c1-14-20(15(2)22-21-14)27(24,25)23-11-9-18(10-12-23)26-19-8-7-16-5-3-4-6-17(16)13-19/h3-8,13,18H,9-12H2,1-2H3,(H,21,22)
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n/an/a 440n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250593
PNG
(US10167273, Example 72 | US10544126, Example 72 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)c(F)c2)CC1
Show InChI InChI=1S/C18H23ClFN3O2S/c1-12-18(13(2)22(3)21-12)26(24,25)23-8-6-14(7-9-23)10-15-4-5-16(19)17(20)11-15/h4-5,11,14H,6-10H2,1-3H3
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n/an/a 440n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250535
PNG
(US10167273, Example 14 | US10544126, Example 14 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Br)cc1F
Show InChI InChI=1S/C17H21BrFN3O3S/c1-11-17(12(2)21(3)20-11)26(23,24)22-8-6-14(7-9-22)25-16-5-4-13(18)10-15(16)19/h4-5,10,14H,6-9H2,1-3H3
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n/an/a 470n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250623
PNG
(US10167273, Example 102 | US10544126, Example 102 ...)
Show SMILES CC(C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1
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n/an/a 470n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250551
PNG
(US10167273, Example 30 | US10544126, Example 30 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1F
Show InChI InChI=1S/C17H21ClFN3O3S/c1-11-17(12(2)21(3)20-11)26(23,24)22-8-6-14(7-9-22)25-16-5-4-13(18)10-15(16)19/h4-5,10,14H,6-9H2,1-3H3
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n/an/a 510n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250576
PNG
(US10167273, Example 55 | US10544126, Example 55 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C18H24ClN3O2S/c1-13-18(14(2)21(3)20-13)25(23,24)22-10-8-16(9-11-22)12-15-4-6-17(19)7-5-15/h4-7,16H,8-12H2,1-3H3
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n/an/a 520n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250588
PNG
(US10167273, Example 67 | US10544126, Example 67 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C17H22ClN3O2S/c1-12-17(13(2)20-19-12)24(22,23)21-9-7-15(8-10-21)11-14-3-5-16(18)6-4-14/h3-6,15H,7-11H2,1-2H3,(H,19,20)
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n/an/a 520n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250526
PNG
(US10167273, Example 5 | US10544126, Example 5 | US...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C17H22ClN3O3S/c1-12-17(13(2)20(3)19-12)25(22,23)21-10-8-16(9-11-21)24-15-6-4-14(18)5-7-15/h4-7,16H,8-11H2,1-3H3
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n/an/a 530n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250614
PNG
(US10167273, Example 93 | US10544126, Example 93 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(C#N)c1ccc(Cl)cc1
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n/an/a 610n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250584
PNG
(US10167273, Example 63 | US10544126, Example 63 | ...)
Show SMILES CCOC(=O)C1(Cc2ccc(Br)cc2)CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C21H28BrN3O4S/c1-5-29-20(26)21(14-17-6-8-18(22)9-7-17)10-12-25(13-11-21)30(27,28)19-15(2)23-24(4)16(19)3/h6-9H,5,10-14H2,1-4H3
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n/an/a 640n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250602
PNG
(US10167273, Example 81 | US10544126, Example 81 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(F)(Cc2ccc(Cl)cc2F)CC1
Show InChI InChI=1S/C18H22ClF2N3O2S/c1-12-17(13(2)23(3)22-12)27(25,26)24-8-6-18(21,7-9-24)11-14-4-5-15(19)10-16(14)20/h4-5,10H,6-9,11H2,1-3H3
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n/an/a 670n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250583
PNG
(US10167273, Example 62 | US10544126, Example 62 | ...)
Show SMILES CCOC(=O)C1(Cc2ccc(Br)cc2)CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C20H26BrN3O4S/c1-4-28-19(25)20(13-16-5-7-17(21)8-6-16)9-11-24(12-10-20)29(26,27)18-14(2)22-23-15(18)3/h5-8H,4,9-13H2,1-3H3,(H,22,23)
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n/an/a 680n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250616
PNG
(US10167273, Example 95 | US10544126, Example 95 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)C(O)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H24ClN3O3S/c1-12-18(13(2)21(3)20-12)26(24,25)22-10-8-15(9-11-22)17(23)14-4-6-16(19)7-5-14/h4-7,15,17,23H,8-11H2,1-3H3
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n/an/a 710n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250625
PNG
(US10167273, Example 104 | US10544126, Example 104 ...)
Show SMILES CCOC(C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1
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n/an/a 720n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250605
PNG
(US10167273, Example 84 | US10544126, Example 84 | ...)
Show SMILES COc1cc(Cl)cnc1OC1CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C17H23ClN4O4S/c1-11-16(12(2)21(3)20-11)27(23,24)22-7-5-14(6-8-22)26-17-15(25-4)9-13(18)10-19-17/h9-10,14H,5-8H2,1-4H3
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n/an/a 720n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250604
PNG
(US10167273, Example 83 | US10544126, Example 83 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2F)CC1
Show InChI InChI=1S/C18H23ClFN3O2S/c1-12-18(13(2)22(3)21-12)26(24,25)23-8-6-14(7-9-23)10-15-4-5-16(19)11-17(15)20/h4-5,11,14H,6-10H2,1-3H3
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n/an/a 730n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250592
PNG
(US10167273, Example 71 | US10544126, Example 71 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)c(F)c2)CC1
Show InChI InChI=1S/C17H21ClFN3O2S/c1-11-17(12(2)21-20-11)25(23,24)22-7-5-13(6-8-22)9-14-3-4-15(18)16(19)10-14/h3-4,10,13H,5-9H2,1-2H3,(H,20,21)
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n/an/a 780n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250534
PNG
(US10167273, Example 13 | US10544126, Example 13 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C17H21Cl2N3O3S/c1-11-17(12(2)21(3)20-11)26(23,24)22-8-6-14(7-9-22)25-16-5-4-13(18)10-15(16)19/h4-5,10,14H,6-9H2,1-3H3
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n/an/a 790n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250601
PNG
(US10167273, Example 80 | US10544126, Example 80 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(F)(Cc2ccc(Cl)cc2F)CC1
Show InChI InChI=1S/C17H20ClF2N3O2S/c1-11-16(12(2)22-21-11)26(24,25)23-7-5-17(20,6-8-23)10-13-3-4-14(18)9-15(13)19/h3-4,9H,5-8,10H2,1-2H3,(H,21,22)
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n/an/a 810n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250525
PNG
(US10167273, Example 4 | US10544126, Example 4 | US...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(C)cc1
Show InChI InChI=1S/C18H25N3O3S/c1-13-5-7-16(8-6-13)24-17-9-11-21(12-10-17)25(22,23)18-14(2)19-20(4)15(18)3/h5-8,17H,9-12H2,1-4H3
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n/an/a 820n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250532
PNG
(US10167273, Example 11 | US10544126, Example 11 | ...)
Show SMILES Cc1nn(C)c(Cl)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(C)cc1
Show InChI InChI=1S/C17H22ClN3O3S/c1-12-4-6-14(7-5-12)24-15-8-10-21(11-9-15)25(22,23)16-13(2)19-20(3)17(16)18/h4-7,15H,8-11H2,1-3H3
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n/an/a 860n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250585
PNG
(US10167273, Example 64 | US10544126, Example 64 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2)(CC1)C#N
Show InChI InChI=1S/C18H21ClN4O2S/c1-13-17(14(2)22-21-13)26(24,25)23-9-7-18(12-20,8-10-23)11-15-3-5-16(19)6-4-15/h3-6H,7-11H2,1-2H3,(H,21,22)
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n/an/a 890n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250581
PNG
(US10167273, Example 60 | US10544126, Example 60 | ...)
Show SMILES COCC1(Cc2ccc(Cl)cc2)CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C20H28ClN3O3S/c1-15-19(16(2)23(3)22-15)28(25,26)24-11-9-20(10-12-24,14-27-4)13-17-5-7-18(21)8-6-17/h5-8H,9-14H2,1-4H3
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n/an/a 900n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250574
PNG
(US10167273, Example 53 | US10544126, Example 53 | ...)
Show SMILES CN(C1CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H25ClN4O2S/c1-13-18(14(2)22(4)20-13)26(24,25)23-11-9-17(10-12-23)21(3)16-7-5-15(19)6-8-16/h5-8,17H,9-12H2,1-4H3
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n/an/a 900n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250586
PNG
(US10167273, Example 65 | US10544126, Example 65 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2Cl)(CC1)C#N
Show InChI InChI=1S/C18H20Cl2N4O2S/c1-12-17(13(2)23-22-12)27(25,26)24-7-5-18(11-21,6-8-24)10-14-3-4-15(19)9-16(14)20/h3-4,9H,5-8,10H2,1-2H3,(H,22,23)
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n/an/a 940n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250577
PNG
(US10167273, Example 56 | US10544126, Example 56 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)c(Cl)c2)CC1
Show InChI InChI=1S/C18H23Cl2N3O2S/c1-12-18(13(2)22(3)21-12)26(24,25)23-8-6-14(7-9-23)10-15-4-5-16(19)17(20)11-15/h4-5,11,14H,6-10H2,1-3H3
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n/an/a 950n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250523
PNG
(US10167273, Example 2 | US10544126, Example 2 | US...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H19Cl2N3O3S/c1-10-16(11(2)20-19-10)25(22,23)21-7-5-12(6-8-21)24-13-3-4-14(17)15(18)9-13/h3-4,9,12H,5-8H2,1-2H3,(H,19,20)
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n/an/a 1.00E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250570
PNG
(US10167273, Example 49 | US10544126, Example 49 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H22ClN3O3S/c1-12-18(13(2)21(3)20-12)26(24,25)22-10-8-15(9-11-22)17(23)14-4-6-16(19)7-5-14/h4-7,15H,8-11H2,1-3H3
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n/an/a 1.00E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250567
PNG
(US10167273, Example 46 | US10544126, Example 46 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1c(F)cc(Cl)cc1F
Show InChI InChI=1S/C17H20ClF2N3O3S/c1-10-17(11(2)22(3)21-10)27(24,25)23-6-4-13(5-7-23)26-16-14(19)8-12(18)9-15(16)20/h8-9,13H,4-7H2,1-3H3
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n/an/a 1.00E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250587
PNG
(US10167273, Example 66 | US10544126, Example 66 | ...)
Show SMILES CCc1n[nH]c(CC)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C19H26ClN3O2S/c1-3-17-19(18(4-2)22-21-17)26(24,25)23-11-9-15(10-12-23)13-14-5-7-16(20)8-6-14/h5-8,15H,3-4,9-13H2,1-2H3,(H,21,22)
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n/an/a 1.01E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250603
PNG
(US10167273, Example 82 | US10544126, Example 82 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2F)CC1
Show InChI InChI=1S/C17H21ClFN3O2S/c1-11-17(12(2)21-20-11)25(23,24)22-7-5-13(6-8-22)9-14-3-4-15(18)10-16(14)19/h3-4,10,13H,5-9H2,1-2H3,(H,20,21)
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n/an/a 1.02E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250582
PNG
(US10167273, Example 61 | US10544126, Example 61 | ...)
Show SMILES CCOC(=O)C1(Cc2ccc(Cl)cc2)CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C21H28ClN3O4S/c1-5-29-20(26)21(14-17-6-8-18(22)9-7-17)10-12-25(13-11-21)30(27,28)19-15(2)23-24(4)16(19)3/h6-9H,5,10-14H2,1-4H3
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n/an/a 1.08E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250550
PNG
(US10167273, Example 29 | US10544126, Example 29 | ...)
Show SMILES Cc1nn(C(F)F)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C17H19Cl2F2N3O3S/c1-10-16(11(2)24(22-10)17(20)21)28(25,26)23-7-5-13(6-8-23)27-15-4-3-12(18)9-14(15)19/h3-4,9,13,17H,5-8H2,1-2H3
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n/an/a 1.10E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250556
PNG
(US10167273, Example 35 | US10544126, Example 35 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1F
Show InChI InChI=1S/C16H19ClFN3O3S/c1-10-16(11(2)20-19-10)25(22,23)21-7-5-13(6-8-21)24-15-4-3-12(17)9-14(15)18/h3-4,9,13H,5-8H2,1-2H3,(H,19,20)
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n/an/a 1.10E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250557
PNG
(US10167273, Example 36 | US10544126, Example 36 | ...)
Show SMILES Cc1cnn(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H19Cl2N3O3S/c1-11-10-19-20(2)16(11)25(22,23)21-7-5-13(6-8-21)24-15-4-3-12(17)9-14(15)18/h3-4,9-10,13H,5-8H2,1-2H3
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n/an/a 1.10E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250543
PNG
(US10167273, Example 22 | US10544126, Example 22 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H19Cl2N3O3S/c1-10-16(11(2)20-19-10)25(22,23)21-7-5-13(6-8-21)24-15-4-3-12(17)9-14(15)18/h3-4,9,13H,5-8H2,1-2H3,(H,19,20)
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n/an/a 1.18E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250606
PNG
(US10167273, Example 85 | US10544126, Example 85 | ...)
Show SMILES COc1cc(Cl)cnc1OC1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C16H21ClN4O4S/c1-10-15(11(2)20-19-10)26(22,23)21-6-4-13(5-7-21)25-16-14(24-3)8-12(17)9-18-16/h8-9,13H,4-7H2,1-3H3,(H,19,20)
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n/an/a 1.23E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250546
PNG
(US10167273, Example 25 | US10544126, Example 25 | ...)
Show SMILES Cc1nn(C)c(Cl)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H18Cl3N3O3S/c1-10-15(16(19)21(2)20-10)26(23,24)22-7-5-12(6-8-22)25-14-4-3-11(17)9-13(14)18/h3-4,9,12H,5-8H2,1-2H3
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n/an/a 1.30E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250522
PNG
(US10167273, Example 1 | US10544126, Example 1 | US...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H21Cl2N3O3S/c1-11-17(12(2)21(3)20-11)26(23,24)22-8-6-13(7-9-22)25-14-4-5-15(18)16(19)10-14/h4-5,10,13H,6-9H2,1-3H3
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n/an/a 1.40E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250566
PNG
(US10167273, Example 45 | US10544126, Example 45 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)c(F)c1
Show InChI InChI=1S/C17H21ClFN3O3S/c1-11-17(12(2)21(3)20-11)26(23,24)22-8-6-13(7-9-22)25-14-4-5-15(18)16(19)10-14/h4-5,10,13H,6-9H2,1-3H3
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n/an/a 1.40E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250524
PNG
(US10167273, Example 3 | US10544126, Example 3 | US...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C18H22F3N3O4S/c1-12-17(13(2)23(3)22-12)29(25,26)24-10-8-15(9-11-24)27-14-4-6-16(7-5-14)28-18(19,20)21/h4-7,15H,8-11H2,1-3H3
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n/an/a 1.40E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250529
PNG
(US10167273, Example 8 | US10544126, Example 8 | US...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C16H20ClN3O3S/c1-11-16(12(2)19-18-11)24(21,22)20-9-7-15(8-10-20)23-14-5-3-13(17)4-6-14/h3-6,15H,7-10H2,1-2H3,(H,18,19)
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n/an/a 1.45E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250572
PNG
(US10167273, Example 51 | US10544126, Example 51 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C17H23ClN4O2S/c1-12-17(13(2)21(3)20-12)25(23,24)22-10-8-16(9-11-22)19-15-6-4-14(18)5-7-15/h4-7,16,19H,8-11H2,1-3H3
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n/an/a 1.50E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250545
PNG
(US10167273, Example 24 | US10544126, Example 24 | ...)
Show SMILES CC1CC(CCN1S(=O)(=O)c1c(C)nn(C)c1C)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C18H24ClN3O3S/c1-12-11-17(25-16-7-5-15(19)6-8-16)9-10-22(12)26(23,24)18-13(2)20-21(4)14(18)3/h5-8,12,17H,9-11H2,1-4H3
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n/an/a 1.50E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250578
PNG
(US10167273, Example 57 | US10544126, Example 57 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(O)(Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C18H24ClN3O3S/c1-13-17(14(2)21(3)20-13)26(24,25)22-10-8-18(23,9-11-22)12-15-4-6-16(19)7-5-15/h4-7,23H,8-12H2,1-3H3
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n/an/a 1.60E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250629
PNG
(US10167273, Example 108 | US10544126, Example 108 ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(O)(Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C17H22ClN3O3S/c1-12-16(13(2)20-19-12)25(23,24)21-9-7-17(22,8-10-21)11-14-3-5-15(18)6-4-14/h3-6,22H,7-11H2,1-2H3,(H,19,20)
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n/an/a 1.64E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250531
PNG
(US10167273, Example 10 | US10544126, Example 10 | ...)
Show SMILES Cc1c(c(nn1C)C(F)(F)F)S(=O)(=O)N1CCC(CC1)Oc1ccc(C)cc1
Show InChI InChI=1S/C18H22F3N3O3S/c1-12-4-6-14(7-5-12)27-15-8-10-24(11-9-15)28(25,26)16-13(2)23(3)22-17(16)18(19,20)21/h4-7,15H,8-11H2,1-3H3
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n/an/a 1.70E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250547
PNG
(US10167273, Example 26 | US10544126, Example 26 | ...)
Show SMILES Cc1c(c(nn1C)C(F)(F)F)S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C17H18Cl2F3N3O3S/c1-10-15(16(17(20,21)22)23-24(10)2)29(26,27)25-7-5-12(6-8-25)28-14-4-3-11(18)9-13(14)19/h3-4,9,12H,5-8H2,1-2H3
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n/an/a 1.70E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250615
PNG
(US10167273, Example 94 | US10544126, Example 94 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(O)c1ccc(Cl)cc1
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n/an/a 1.74E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250624
PNG
(US10167273, Example 103 | US10544126, Example 103 ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C16H21ClN4O2S/c1-11-16(12(2)20-19-11)24(22,23)21-9-7-15(8-10-21)18-14-5-3-13(17)4-6-14/h3-6,15,18H,7-10H2,1-2H3,(H,19,20)
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n/an/a 1.76E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250613
PNG
(US10167273, Example 92 | US11512066, Example 92 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(C#N)c1ccc(Cl)cc1F
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n/an/a 1.85E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250630
PNG
(US10167273, Example 109 | US10544126, Example 109 ...)
Show SMILES COCC(C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1
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n/an/a 1.86E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250568
PNG
(US10167273, Example 47 | US10544126, Example 47 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)c(F)c1
Show InChI InChI=1S/C16H19ClFN3O3S/c1-10-16(11(2)20-19-10)25(22,23)21-7-5-12(6-8-21)24-13-3-4-14(17)15(18)9-13/h3-4,9,12H,5-8H2,1-2H3,(H,19,20)
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n/an/a 1.90E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250589
PNG
(US10167273, Example 68 | US10544126, Example 68 | ...)
Show SMILES Cc1nn(C)c(Cl)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C17H21Cl2N3O2S/c1-12-16(17(19)21(2)20-12)25(23,24)22-9-7-14(8-10-22)11-13-3-5-15(18)6-4-13/h3-6,14H,7-11H2,1-2H3
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n/an/a 2.02E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250571
PNG
(US10167273, Example 50 | US10544126, Example 50 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H21Cl2N3O3S/c1-11-18(12(2)22(3)21-11)27(25,26)23-8-6-13(7-9-23)17(24)14-4-5-15(19)16(20)10-14/h4-5,10,13H,6-9H2,1-3H3
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n/an/a 2.10E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250542
PNG
(US10167273, Example 21 | US10544126, Example 21 | ...)
Show SMILES CC1CN(CCC1Oc1ccc(Cl)cc1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C18H24ClN3O3S/c1-12-11-22(26(23,24)18-13(2)20-21(4)14(18)3)10-9-17(12)25-16-7-5-15(19)6-8-16/h5-8,12,17H,9-11H2,1-4H3
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n/an/a 2.10E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250527
PNG
(US10167273, Example 6 | US10544126, Example 6 | US...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1cccc(Cl)c1
Show InChI InChI=1S/C17H22ClN3O3S/c1-12-17(13(2)20(3)19-12)25(22,23)21-9-7-15(8-10-21)24-16-6-4-5-14(18)11-16/h4-6,11,15H,7-10H2,1-3H3
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n/an/a 2.20E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250530
PNG
(US10167273, Example 9 | US10544126, Example 9 | US...)
Show SMILES CCn1nc(C)c(c1C)S(=O)(=O)N1CCC(CC1)Oc1ccc(C)cc1
Show InChI InChI=1S/C19H27N3O3S/c1-5-22-16(4)19(15(3)20-22)26(23,24)21-12-10-18(11-13-21)25-17-8-6-14(2)7-9-17/h6-9,18H,5,10-13H2,1-4H3
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n/an/a 2.30E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250622
PNG
(US10167273, Example 101 | US10544126, Example 101 ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(C)(O)c1ccc(Cl)cc1
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n/an/a 2.38E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250579
PNG
(US10167273, Example 58 | US10544126, Example 58 | ...)
Show SMILES COC1(Cc2ccc(Cl)cc2)CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C19H26ClN3O3S/c1-14-18(15(2)22(3)21-14)27(24,25)23-11-9-19(26-4,10-12-23)13-16-5-7-17(20)8-6-16/h5-8H,9-13H2,1-4H3
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n/an/a 2.40E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250580
PNG
(US10167273, Example 59 | US10544126, Example 59 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(O)(Cc2ccc(Cl)cc2Cl)CC1
Show InChI InChI=1S/C18H23Cl2N3O3S/c1-12-17(13(2)22(3)21-12)27(25,26)23-8-6-18(24,7-9-23)11-14-4-5-15(19)10-16(14)20/h4-5,10,24H,6-9,11H2,1-3H3
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n/an/a 2.40E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250573
PNG
(US10167273, Example 52 | US10544126, Example 52 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H22Cl2N4O2S/c1-11-17(12(2)22(3)21-11)26(24,25)23-8-6-13(7-9-23)20-14-4-5-15(18)16(19)10-14/h4-5,10,13,20H,6-9H2,1-3H3
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n/an/a 2.70E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250536
PNG
(US10167273, Example 15 | US10544126, Example 15 | ...)
Show SMILES Cc1nn(C)c(Cl)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C16H19Cl2N3O3S/c1-11-15(16(18)20(2)19-11)25(22,23)21-9-7-14(8-10-21)24-13-5-3-12(17)4-6-13/h3-6,14H,7-10H2,1-2H3
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n/an/a 2.90E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250631
PNG
(US10167273, Example 110 | US10544126, Example 110 ...)
Show SMILES COC(C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccccc1
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n/an/a 3.01E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250598
PNG
(US10167273, Example 77 | US10544126, Example 77 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ncc(Cl)cc1F
Show InChI InChI=1S/C16H20ClFN4O3S/c1-10-15(11(2)21(3)20-10)26(23,24)22-6-4-13(5-7-22)25-16-14(18)8-12(17)9-19-16/h8-9,13H,4-7H2,1-3H3
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n/an/a 3.19E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250559
PNG
(US10167273, Example 38 | US10544126, Example 38 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1c(C)cccc1C
Show InChI InChI=1S/C18H25N3O3S/c1-12-6-5-7-13(2)17(12)24-16-8-10-21(11-9-16)25(22,23)18-14(3)19-20-15(18)4/h5-7,16H,8-11H2,1-4H3,(H,19,20)
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n/an/a 3.20E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250553
PNG
(US10167273, Example 32 | US10544126, Example 32 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C17H20F3N3O4S/c1-11-16(12(2)22-21-11)28(24,25)23-9-7-14(8-10-23)26-13-3-5-15(6-4-13)27-17(18,19)20/h3-6,14H,7-10H2,1-2H3,(H,21,22)
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n/an/a 3.40E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250541
PNG
(US10167273, Example 20 | US10544126, Example 20 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(F)cc1
Show InChI InChI=1S/C17H22FN3O3S/c1-12-17(13(2)20(3)19-12)25(22,23)21-10-8-16(9-11-21)24-15-6-4-14(18)5-7-15/h4-7,16H,8-11H2,1-3H3
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n/an/a 3.60E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250538
PNG
(US10167273, Example 17 | US10544126, Example 17 | ...)
Show SMILES COc1cccc(OC2CCN(CC2)S(=O)(=O)c2c(C)nn(C)c2C)c1
Show InChI InChI=1S/C18H25N3O4S/c1-13-18(14(2)20(3)19-13)26(22,23)21-10-8-15(9-11-21)25-17-7-5-6-16(12-17)24-4/h5-7,12,15H,8-11H2,1-4H3
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n/an/a 3.60E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250597
PNG
(US10167273, Example 76 | US10544126, Example 76 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccccc1F
Show InChI InChI=1S/C16H20FN3O3S/c1-11-16(12(2)19-18-11)24(21,22)20-9-7-13(8-10-20)23-15-6-4-3-5-14(15)17/h3-6,13H,7-10H2,1-2H3,(H,18,19)
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n/an/a 3.73E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250569
PNG
(US10167273, Example 48 | US10544126, Example 48 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cn1
Show InChI InChI=1S/C16H21ClN4O3S/c1-11-16(12(2)20(3)19-11)25(22,23)21-8-6-14(7-9-21)24-15-5-4-13(17)10-18-15/h4-5,10,14H,6-9H2,1-3H3
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n/an/a 3.80E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250626
PNG
(US10167273, Example 107 | US10544126, Example 107 ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(F)c1ccc(Cl)cc1
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n/an/a 4.00E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250537
PNG
(US10167273, Example 16 | US10544126, Example 16 | ...)
Show SMILES Cc1c(c(nn1C)C(F)(F)F)S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C17H19ClF3N3O3S/c1-11-15(16(17(19,20)21)22-23(11)2)28(25,26)24-9-7-14(8-10-24)27-13-5-3-12(18)4-6-13/h3-6,14H,7-10H2,1-2H3
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n/an/a 4.60E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250607
PNG
(US10167273, Example 86 | US10544126, Example 86 | ...)
Show SMILES COc1cc(Cl)ccc1CC1(CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)OC
Show InChI InChI=1S/C19H26ClN3O4S/c1-13-18(14(2)22-21-13)28(24,25)23-9-7-19(27-4,8-10-23)12-15-5-6-16(20)11-17(15)26-3/h5-6,11H,7-10,12H2,1-4H3,(H,21,22)
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n/an/a 4.60E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250617
PNG
(US10167273, Example 98 | US10544126, Example 96 | ...)
Show SMILES COC(C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1
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n/an/a 4.62E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250533
PNG
(US10167273, Example 12 | US10544126, Example 12 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H22F3N3O3S/c1-12-17(13(2)23(3)22-12)28(25,26)24-10-8-16(9-11-24)27-15-6-4-14(5-7-15)18(19,20)21/h4-7,16H,8-11H2,1-3H3
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n/an/a 4.70E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250565
PNG
(US10167273, Example 44 | US10544126, Example 44 | ...)
Show SMILES COc1c(F)cc(OC2CCN(CC2)S(=O)(=O)c2c(C)nn(C)c2C)cc1F
Show InChI InChI=1S/C18H23F2N3O4S/c1-11-18(12(2)22(3)21-11)28(24,25)23-7-5-13(6-8-23)27-14-9-15(19)17(26-4)16(20)10-14/h9-10,13H,5-8H2,1-4H3
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n/an/a 5.10E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250575
PNG
(US10167273, Example 54 | US10544126, Example 54 | ...)
Show SMILES CN(C1CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H24Cl2N4O2S/c1-12-18(13(2)23(4)21-12)27(25,26)24-9-7-14(8-10-24)22(3)15-5-6-16(19)17(20)11-15/h5-6,11,14H,7-10H2,1-4H3
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n/an/a 5.20E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250548
PNG
(US10167273, Example 27 | US10544126, Example 27 | ...)
Show SMILES Cc1nn(C)cc1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H19Cl2N3O3S/c1-11-16(10-20(2)19-11)25(22,23)21-7-5-13(6-8-21)24-15-4-3-12(17)9-14(15)18/h3-4,9-10,13H,5-8H2,1-2H3
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n/an/a 5.60E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250540
PNG
(US10167273, Example 19 | US10544126, Example 19 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccccc1
Show InChI InChI=1S/C17H23N3O3S/c1-13-17(14(2)19(3)18-13)24(21,22)20-11-9-16(10-12-20)23-15-7-5-4-6-8-15/h4-8,16H,9-12H2,1-3H3
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n/an/a 5.60E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250608
PNG
(US10167273, Example 87 | US10544126, Example 87 | ...)
Show SMILES COc1cc(Cl)ccc1CC1(CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C)OC
Show InChI InChI=1S/C20H28ClN3O4S/c1-14-19(15(2)23(3)22-14)29(25,26)24-10-8-20(28-5,9-11-24)13-16-6-7-17(21)12-18(16)27-4/h6-7,12H,8-11,13H2,1-5H3
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n/an/a 5.88E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250562
PNG
(US10167273, Example 41 | US10544126, Example 41 | ...)
Show SMILES COc1ccc(OC2CCN(CC2)S(=O)(=O)c2c(C)n[nH]c2C)cc1F
Show InChI InChI=1S/C17H22FN3O4S/c1-11-17(12(2)20-19-11)26(22,23)21-8-6-13(7-9-21)25-14-4-5-16(24-3)15(18)10-14/h4-5,10,13H,6-9H2,1-3H3,(H,19,20)
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n/an/a 5.90E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250563
PNG
(US10167273, Example 42 | US10544126, Example 42 | ...)
Show SMILES COc1c(F)cc(OC2CCN(CC2)S(=O)(=O)c2c(C)n[nH]c2C)cc1F
Show InChI InChI=1S/C17H21F2N3O4S/c1-10-17(11(2)21-20-10)27(23,24)22-6-4-12(5-7-22)26-13-8-14(18)16(25-3)15(19)9-13/h8-9,12H,4-7H2,1-3H3,(H,20,21)
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n/an/a 5.90E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250564
PNG
(US10167273, Example 43 | US10544126, Example 43 | ...)
Show SMILES COc1ccc(OC2CCN(CC2)S(=O)(=O)c2c(C)nn(C)c2C)cc1F
Show InChI InChI=1S/C18H24FN3O4S/c1-12-18(13(2)21(3)20-12)27(23,24)22-9-7-14(8-10-22)26-15-5-6-17(25-4)16(19)11-15/h5-6,11,14H,7-10H2,1-4H3
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n/an/a 6.30E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250590
PNG
(US10167273, Example 69 | US10544126, Example 69 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(O)(Cc2ccc(Cl)c(Cl)c2)CC1
Show InChI InChI=1S/C18H23Cl2N3O3S/c1-12-17(13(2)22(3)21-12)27(25,26)23-8-6-18(24,7-9-23)11-14-4-5-15(19)16(20)10-14/h4-5,10,24H,6-9,11H2,1-3H3
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n/an/a 6.47E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250596
PNG
(US10167273, Example 75 | US10544126, Example 75 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(O)(Cc2ccc(Cl)cc2F)CC1
Show InChI InChI=1S/C17H21ClFN3O3S/c1-11-16(12(2)21-20-11)26(24,25)22-7-5-17(23,6-8-22)10-13-3-4-14(18)9-15(13)19/h3-4,9,23H,5-8,10H2,1-2H3,(H,20,21)
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US Patent
n/an/a 6.98E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250539
PNG
(US10167273, Example 18 | US10544126, Example 18 | ...)
Show SMILES COc1ccc(OC2CCN(CC2)S(=O)(=O)c2c(C)nn(C)c2C)cc1
Show InChI InChI=1S/C18H25N3O4S/c1-13-18(14(2)20(3)19-13)26(22,23)21-11-9-17(10-12-21)25-16-7-5-15(24-4)6-8-16/h5-8,17H,9-12H2,1-4H3
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n/an/a 7.00E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250528
PNG
(US10167273, Example 7 | US10544126, Example 7 | US...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(cc1)C#N
Show InChI InChI=1S/C18H22N4O3S/c1-13-18(14(2)21(3)20-13)26(23,24)22-10-8-17(9-11-22)25-16-6-4-15(12-19)5-7-16/h4-7,17H,8-11H2,1-3H3
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n/an/a 7.30E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250558
PNG
(US10167273, Example 37 | US10544126, Example 37 | ...)
Show SMILES Cc1cnn(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C16H20ClN3O3S/c1-12-11-18-19(2)16(12)24(21,22)20-9-7-15(8-10-20)23-14-5-3-13(17)4-6-14/h3-6,11,15H,7-10H2,1-2H3
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n/an/a 7.40E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250591
PNG
(US10167273, Example 70 | US10544126, Example 70 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(O)(Cc2ccc(Cl)c(Cl)c2)CC1
Show InChI InChI=1S/C17H21Cl2N3O3S/c1-11-16(12(2)21-20-11)26(24,25)22-7-5-17(23,6-8-22)10-13-3-4-14(18)15(19)9-13/h3-4,9,23H,5-8,10H2,1-2H3,(H,20,21)
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n/an/a 8.62E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
Prokineticin receptor 1


(Homo sapiens (Human))		BDBM250621
PNG
(US10167273, Example 100 | US10544126, Example 100 ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(CO)c1ccc(Cl)cc1
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US Patent
n/an/a 9.42E+3n/an/an/an/a7.437



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...

US Patent US9475795 (2016)


BindingDB Entry DOI: 10.7270/Q20Z727W
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%