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Patent code US9688710

Compile Data Set for Download or QSAR

Found 328 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176402
PNG
(US9688710, 1 (E)-3-(4-(2-methyl-5-((2S,3R,4R,5S,6R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\C(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C28H36N2O5S/c1-18-4-10-21(27-25(33)24(32)26(34)28(35-27)36-3)17-22(18)16-20-7-5-19(6-8-20)9-11-23(31)30-14-12-29(2)13-15-30/h4-11,17,24-28,32-34H,12-16H2,1-3H3/b11-9+/t24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176409
PNG
(US9688710, 8 N-(1,3-dihydroxy-2-(hydroxymethyl)pro...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(CO)(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C28H39NO8S/c1-17-6-11-20(26-24(35)23(34)25(36)27(37-26)38-2)13-21(17)12-19-9-7-18(8-10-19)4-3-5-22(33)29-28(14-30,15-31)16-32/h6-11,13,23-27,30-32,34-36H,3-5,12,14-16H2,1-2H3,(H,29,33)/t23-,24-,25+,26+,27-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176434
PNG
(US9688710, 33 N-(1-amino-2-methyl-1-oxopropan-2-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C28H38N2O7S/c1-16-7-10-18(25-23(33)22(32)24(34)26(37-25)38-4)15-19(16)14-17-8-11-20(12-9-17)36-13-5-6-21(31)30-28(2,3)27(29)35/h7-12,15,22-26,32-34H,5-6,13-14H2,1-4H3,(H2,29,35)(H,30,31)/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176452
PNG
(US9688710, 51 N-(1-amino-2-methyl-1-oxopropan-2-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C30H42N2O6S/c1-18-10-15-21(27-25(35)24(34)26(36)28(38-27)39-4)17-22(18)16-20-13-11-19(12-14-20)8-6-5-7-9-23(33)32-30(2,3)29(31)37/h10-15,17,24-28,34-36H,5-9,16H2,1-4H3,(H2,31,37)(H,32,33)/t24-,25-,26+,27+,28-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176455
PNG
(US9688710, 54 1-(4-(4-(2-methyl-5-((2S,3R,4R,5S,6R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(=O)C3CCCC3)cc2)c1 |r|
Show InChI InChI=1S/C30H39NO7S/c1-18-9-12-21(28-26(34)25(33)27(35)30(38-28)39-2)17-22(18)16-19-10-13-23(14-11-19)37-15-5-8-24(32)31-29(36)20-6-3-4-7-20/h9-14,17,20,25-28,30,33-35H,3-8,15-16H2,1-2H3,(H,31,32,36)/t25-,26-,27+,28+,30-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176521
PNG
(US9688710, 86 N-ethyl-4-(4-(2-methyl-5-((2S,3R,4R,...)
Show SMILES CCNC(=O)CCCOc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C26H35NO6S/c1-4-27-21(28)6-5-13-32-20-11-8-17(9-12-20)14-19-15-18(10-7-16(19)2)25-23(30)22(29)24(31)26(33-25)34-3/h7-12,15,22-26,29-31H,4-6,13-14H2,1-3H3,(H,27,28)/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176528
PNG
(US9688710, 91 2-methyl-2-(3-(4-(4-(2-methyl-5-((2S...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCNC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C29H41N3O6S/c1-17-8-13-20(25-23(34)22(33)24(35)26(38-25)39-4)16-21(17)15-19-11-9-18(10-12-19)7-5-6-14-31-28(37)32-29(2,3)27(30)36/h8-13,16,22-26,33-35H,5-7,14-15H2,1-4H3,(H2,30,36)(H2,31,32,37)/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176688
PNG
(US9688710, 111 2-methyl-2-(4-(4-(2-methyl-5-((2S,3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C28H37NO7S/c1-16-8-13-19(25-23(32)22(31)24(33)26(36-25)37-4)15-20(16)14-18-11-9-17(10-12-18)6-5-7-21(30)29-28(2,3)27(34)35/h8-13,15,22-26,31-33H,5-7,14H2,1-4H3,(H,29,30)(H,34,35)/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176698
PNG
(US9688710, 121 tert-butyl (1-(2-methyl-2-(4-(4-(2-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N3CCC(CC3)NC(=O)OC(C)(C)C)cc2)c1 |r|
Show InChI InChI=1S/C38H55N3O8S/c1-23-11-16-26(33-31(44)30(43)32(45)34(48-33)50-7)22-27(23)21-25-14-12-24(13-15-25)9-8-10-29(42)40-38(5,6)35(46)41-19-17-28(18-20-41)39-36(47)49-37(2,3)4/h11-16,22,28,30-34,43-45H,8-10,17-21H2,1-7H3,(H,39,47)(H,40,42)/t30-,31-,32+,33+,34-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176699
PNG
(US9688710, 122 tert-butyl4-(2-methyl-2-(4-(4-(2-me...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)NC3CCN(CC3)C(=O)OC(C)(C)C)cc2)c1 |r|
Show InChI InChI=1S/C38H55N3O8S/c1-23-11-16-26(33-31(44)30(43)32(45)34(48-33)50-7)22-27(23)21-25-14-12-24(13-15-25)9-8-10-29(42)40-38(5,6)35(46)39-28-17-19-41(20-18-28)36(47)49-37(2,3)4/h11-16,22,28,30-34,43-45H,8-10,17-21H2,1-7H3,(H,39,46)(H,40,42)/t30-,31-,32+,33+,34-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176711
PNG
(US9688710, 134 2,2-dimethyl-3-((3-(4-(2-methyl-5-(...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCNCC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C28H40N2O6S/c1-17-6-9-19(25-23(32)22(31)24(33)26(36-25)37-4)15-20(17)14-18-7-10-21(11-8-18)35-13-5-12-30-16-28(2,3)27(29)34/h6-11,15,22-26,30-33H,5,12-14,16H2,1-4H3,(H2,29,34)/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176724
PNG
(US9688710, 146 (3R,4R,5S,6R)-2-(3-(4-(3-((3-(dimet...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCNCC(C)(C)CN(C)C)cc2)c1 |r|
Show InChI InChI=1S/C30H46N2O5S/c1-20-8-11-22(28-26(34)25(33)27(35)29(37-28)38-6)17-23(20)16-21-9-12-24(13-10-21)36-15-7-14-31-18-30(2,3)19-32(4)5/h8-13,17,25-29,31,33-35H,7,14-16,18-19H2,1-6H3/t25-,26-,27+,28+,29-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176737
PNG
(US9688710, 158 (3R,4R,5S,6R)-2-(3-(4-(3-((1,3-dihy...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCNC(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C26H37NO7S/c1-16-4-7-18(25-23(31)22(30)24(32)26(34-25)35-2)13-19(16)12-17-5-8-21(9-6-17)33-11-3-10-27-20(14-28)15-29/h4-9,13,20,22-32H,3,10-12,14-15H2,1-2H3/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176739
PNG
(US9688710, 160 2-methyl-2-(4-(4-(2-methyl-5-((2S,3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(C)(C)C(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C28H37NO8S/c1-16-7-10-18(25-23(32)22(31)24(33)26(37-25)38-4)15-19(16)14-17-8-11-20(12-9-17)36-13-5-6-21(30)29-28(2,3)27(34)35/h7-12,15,22-26,31-33H,5-6,13-14H2,1-4H3,(H,29,30)(H,34,35)/t22-,23-,24+,25+,26-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176403
PNG
(US9688710, 2 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C23H27ClO7S/c1-32-23-21(29)19(27)20(28)22(31-23)14-6-9-17(24)15(12-14)11-13-4-7-16(8-5-13)30-10-2-3-18(25)26/h4-9,12,19-23,27-29H,2-3,10-11H2,1H3,(H,25,26)/t19-,20-,21+,22+,23-/m1/s1
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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176405
PNG
(US9688710, 4 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCC(O)CO)cc2)c1 |r|
Show InChI InChI=1S/C23H30O7S/c1-13-3-6-15(22-20(27)19(26)21(28)23(30-22)31-2)10-16(13)9-14-4-7-18(8-5-14)29-12-17(25)11-24/h3-8,10,17,19-28H,9,11-12H2,1-2H3/t17?,19-,20-,21+,22+,23-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176406
PNG
(US9688710, 5 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-...)
Show SMILES COCCOCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C24H31ClO7S/c1-29-9-10-30-11-12-31-18-6-3-15(4-7-18)13-17-14-16(5-8-19(17)25)23-21(27)20(26)22(28)24(32-23)33-2/h3-8,14,20-24,26-28H,9-13H2,1-2H3/t20-,21-,22+,23+,24-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176408
PNG
(US9688710, 7 (S,E)-2-amino-5-(4-(2-methyl-5-((2S,3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\CC(N)C(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C25H31NO6S/c1-14-6-11-17(23-21(28)20(27)22(29)25(32-23)33-2)13-18(14)12-16-9-7-15(8-10-16)4-3-5-19(26)24(30)31/h3-4,6-11,13,19-23,25,27-29H,5,12,26H2,1-2H3,(H,30,31)/b4-3+/t19?,20-,21-,22+,23+,25-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176415
PNG
(US9688710, 14 2-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCC(=O)NC(CO)(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C25H32ClNO9S/c1-37-24-22(34)20(32)21(33)23(36-24)15-4-7-18(26)16(9-15)8-14-2-5-17(6-3-14)35-10-19(31)27-25(11-28,12-29)13-30/h2-7,9,20-24,28-30,32-34H,8,10-13H2,1H3,(H,27,31)/t20-,21-,22+,23+,24-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176417
PNG
(US9688710, 16 (S)-2-amino-6-(4-(4-(2-methyl-5-((2S...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NCCCC[C@H](N)C(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C30H42N2O7S/c1-18-9-14-21(28-26(35)25(34)27(36)30(39-28)40-2)17-22(18)16-20-12-10-19(11-13-20)6-5-8-24(33)32-15-4-3-7-23(31)29(37)38/h9-14,17,23,25-28,30,34-36H,3-8,15-16,31H2,1-2H3,(H,32,33)(H,37,38)/t23-,25+,26+,27-,28-,30+/m0/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176426
PNG
(US9688710, 25 5-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C30H42N2O5S/c1-20-8-13-23(29-27(35)26(34)28(36)30(37-29)38-3)19-24(20)18-22-11-9-21(10-12-22)6-4-5-7-25(33)32-16-14-31(2)15-17-32/h8-13,19,26-30,34-36H,4-7,14-18H2,1-3H3/t26-,27-,28+,29+,30-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176427
PNG
(US9688710, 26 N-(2-methyl-1-(4-methylpiperazin-1-y...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)C(=O)N3CCNCC3)cc2)c1 |r|
Show InChI InChI=1S/C33H47N3O6S/c1-21-9-14-24(30-28(39)27(38)29(40)31(42-30)43-4)20-25(21)19-23-12-10-22(11-13-23)7-5-6-8-26(37)35-33(2,3)32(41)36-17-15-34-16-18-36/h9-14,20,27-31,34,38-40H,5-8,15-19H2,1-4H3,(H,35,37)/t27-,28-,29+,30+,31-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176428
PNG
(US9688710, 27 N-(1-hydroxy-2-methylpropan-2-yl)-5-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C29H41NO6S/c1-18-9-14-21(27-25(34)24(33)26(35)28(36-27)37-4)16-22(18)15-20-12-10-19(11-13-20)7-5-6-8-23(32)30-29(2,3)17-31/h9-14,16,24-28,31,33-35H,5-8,15,17H2,1-4H3,(H,30,32)/t24-,25-,26+,27+,28-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176440
PNG
(US9688710, 39 N-(1-amino-2-methyl-1-oxopropan-2-yl...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C27H36N2O7S/c1-15-6-9-18(25-23(32)22(31)24(33)27(36-25)37-3)14-19(15)13-17-7-10-20(11-8-17)35-12-4-5-21(30)29-16(2)26(28)34/h6-11,14,16,22-25,27,31-33H,4-5,12-13H2,1-3H3,(H2,28,34)(H,29,30)/t16?,22-,23-,24+,25+,27-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176441
PNG
(US9688710, 40 N-(1-hydroxy-2-methylpropan-2-yl)-4-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C27H37NO7S/c1-16-6-9-19(26-24(32)23(31)25(33)27(35-26)36-3)14-20(16)13-18-7-10-21(11-8-18)34-12-4-5-22(30)28-17(2)15-29/h6-11,14,17,23-27,29,31-33H,4-5,12-13,15H2,1-3H3,(H,28,30)/t17?,23-,24-,25+,26+,27-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176446
PNG
(US9688710, 45 N-(2-methyl-1-(4-methylpiperazin-1-y...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C33H47N3O7S/c1-21-8-11-23(30-28(39)27(38)29(40)31(43-30)44-5)20-24(21)19-22-9-12-25(13-10-22)42-18-6-7-26(37)34-33(2,3)32(41)36-16-14-35(4)15-17-36/h8-13,20,27-31,38-40H,6-7,14-19H2,1-5H3,(H,34,37)/t27-,28-,29+,30+,31-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176449
PNG
(US9688710, 48 N-((S)-1-amino-3-hydroxy-1-oxopropan...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)N[C@@](C)(CO)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C28H38N2O8S/c1-16-6-9-18(25-23(34)22(33)24(35)26(38-25)39-3)14-19(16)13-17-7-10-20(11-8-17)37-12-4-5-21(32)30-28(2,15-31)27(29)36/h6-11,14,22-26,31,33-35H,4-5,12-13,15H2,1-3H3,(H2,29,36)(H,30,32)/t22-,23-,24+,25+,26-,28+/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176453
PNG
(US9688710, 52 N-(3-amino-2,2-dimethyl-3-oxopropyl)...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NCC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C29H40N2O7S/c1-17-7-10-19(26-24(34)23(33)25(35)27(38-26)39-4)15-20(17)14-18-8-11-21(12-9-18)37-13-5-6-22(32)31-16-29(2,3)28(30)36/h7-12,15,23-27,33-35H,5-6,13-14,16H2,1-4H3,(H2,30,36)(H,31,32)/t23-,24-,25+,26+,27-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176487
PNG
(US9688710, 68 (2S,3R,4R,5S,6R)-2-(3-(4-(2-(2-metho...)
Show SMILES COCCOCCOc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C25H34O7S/c1-16-4-7-18(24-22(27)21(26)23(28)25(32-24)33-3)15-19(16)14-17-5-8-20(9-6-17)31-13-12-30-11-10-29-2/h4-9,15,21-28H,10-14H2,1-3H3/t21-,22-,23+,24+,25-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176491
PNG
(US9688710, 72 (2S,3R,4R,5S,6R)-2-(3-(4-(2-aminoeth...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCN)cc2)c1 |r|
Show InChI InChI=1S/C21H26ClNO5S/c1-29-21-19(26)17(24)18(25)20(28-21)13-4-7-16(22)14(11-13)10-12-2-5-15(6-3-12)27-9-8-23/h2-7,11,17-21,24-26H,8-10,23H2,1H3/t17-,18-,19+,20+,21-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176496
PNG
(US9688710, 77 N-(2-hydroxyethyl)-4-(4-(2-methyl-5-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NCCO)cc2)c1 |r|
Show InChI InChI=1S/C26H35NO7S/c1-16-5-8-18(25-23(31)22(30)24(32)26(34-25)35-2)15-19(16)14-17-6-9-20(10-7-17)33-13-3-4-21(29)27-11-12-28/h5-10,15,22-26,28,30-32H,3-4,11-14H2,1-2H3,(H,27,29)/t22-,23-,24+,25+,26-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176524
PNG
(US9688710, 89 4-methyl-N-(4-(4-(2-methyl-5-((2S,3R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCNC(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C27H36ClN3O6S/c1-30-10-12-31(13-11-30)27(35)29-9-14-36-20-6-3-17(4-7-20)15-19-16-18(5-8-21(19)28)25-23(33)22(32)24(34)26(37-25)38-2/h3-8,16,22-26,32-34H,9-15H2,1-2H3,(H,29,35)/t22-,23-,24+,25+,26-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176531
PNG
(US9688710, 94 (2S,3R,4R,5S,6R)-2-(3-(4-(4-((2,3-di...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCNCC(O)CO)cc2)c1 |r|
Show InChI InChI=1S/C27H39NO6S/c1-17-6-11-20(26-24(32)23(31)25(33)27(34-26)35-2)14-21(17)13-19-9-7-18(8-10-19)5-3-4-12-28-15-22(30)16-29/h6-11,14,22-33H,3-5,12-13,15-16H2,1-2H3/t22?,23-,24-,25+,26+,27-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176533
PNG
(US9688710, 96 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2...)
Show SMILES CCN(CC)CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C25H34ClNO5S/c1-4-27(5-2)12-13-31-19-9-6-16(7-10-19)14-18-15-17(8-11-20(18)26)24-22(29)21(28)23(30)25(32-24)33-3/h6-11,15,21-25,28-30H,4-5,12-14H2,1-3H3/t21-,22-,23+,24+,25-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176540
PNG
(US9688710, 100 (3R,4R,5S,6R)-2-(3-(4-(4-((1-hydrox...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCNC(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C28H41NO5S/c1-18-8-13-21(26-24(32)23(31)25(33)27(34-26)35-4)16-22(18)15-20-11-9-19(10-12-20)7-5-6-14-29-28(2,3)17-30/h8-13,16,23-27,29-33H,5-7,14-15,17H2,1-4H3/t23-,24-,25+,26+,27-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176543
PNG
(US9688710, 103 1-((4-(4-(2-methyl-5-((3R,4R,5S,6R)...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCNC(=O)C3CCCC3)cc2)c1 |r|
Show InChI InChI=1S/C30H41NO5S/c1-19-10-15-23(28-26(33)25(32)27(34)30(36-28)37-2)18-24(19)17-21-13-11-20(12-14-21)7-5-6-16-31-29(35)22-8-3-4-9-22/h10-15,18,22,25-28,30,32-34H,3-9,16-17H2,1-2H3,(H,31,35)/t25-,26-,27+,28+,30-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176544
PNG
(US9688710, 104 2,2-dimethyl-3-((4-(4-(2-methyl-5-(...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCNCC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C29H42N2O5S/c1-18-8-13-21(26-24(33)23(32)25(34)27(36-26)37-4)16-22(18)15-20-11-9-19(10-12-20)7-5-6-14-31-17-29(2,3)28(30)35/h8-13,16,23-27,31-34H,5-7,14-15,17H2,1-4H3,(H2,30,35)/t23-,24-,25+,26+,27-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176627
PNG
(US9688710, 107 2-(3-(3-(4-(2-chloro-5-((2S,3R,4R,5...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCNC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C27H36ClN3O7S/c1-27(2,25(29)35)31-26(36)30-11-4-12-37-18-8-5-15(6-9-18)13-17-14-16(7-10-19(17)28)23-21(33)20(32)22(34)24(38-23)39-3/h5-10,14,20-24,32-34H,4,11-13H2,1-3H3,(H2,29,35)(H2,30,31,36)/t20-,21-,22+,23+,24-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176681
PNG
(US9688710, 108 N-(3-(4-(2-chloro-5-((2S,3R,4R,5S,6...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCNC(=O)C(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C27H36ClNO7S/c1-27(2,15-30)26(34)29-11-4-12-35-19-8-5-16(6-9-19)13-18-14-17(7-10-20(18)28)24-22(32)21(31)23(33)25(36-24)37-3/h5-10,14,21-25,30-33H,4,11-13,15H2,1-3H3,(H,29,34)/t21-,22-,23+,24+,25-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176689
PNG
(US9688710, 112 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCNC3CCNCC3)cc2)c1 |r|
Show InChI InChI=1S/C26H35ClN2O5S/c1-35-26-24(32)22(30)23(31)25(34-26)17-4-7-21(27)18(15-17)14-16-2-5-20(6-3-16)33-13-12-29-19-8-10-28-11-9-19/h2-7,15,19,22-26,28-32H,8-14H2,1H3/t22-,23-,24+,25+,26-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176693
PNG
(US9688710, 116 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC3(CC3)C(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C33H45N3O6S/c1-21-7-12-24(30-28(39)27(38)29(40)31(42-30)43-3)20-25(21)19-23-10-8-22(9-11-23)5-4-6-26(37)34-33(13-14-33)32(41)36-17-15-35(2)16-18-36/h7-12,20,27-31,38-40H,4-6,13-19H2,1-3H3,(H,34,37)/t27-,28-,29+,30+,31-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176695
PNG
(US9688710, 118 tert-butyl 4-(2-methyl-2-(4-(4-(2-m...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N3CCN(CC3)C(=O)OC(C)(C)C)cc2)c1 |r|
Show InChI InChI=1S/C37H53N3O8S/c1-23-11-16-26(32-30(43)29(42)31(44)33(47-32)49-7)22-27(23)21-25-14-12-24(13-15-25)9-8-10-28(41)38-37(5,6)34(45)39-17-19-40(20-18-39)35(46)48-36(2,3)4/h11-16,22,29-33,42-44H,8-10,17-21H2,1-7H3,(H,38,41)/t29-,30-,31+,32+,33-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176697
PNG
(US9688710, 120 N-(2-methyl-1-(4-methylpiperidin-1-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N3CCC(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C34H48N2O6S/c1-21-15-17-36(18-16-21)33(41)34(3,4)35-27(37)8-6-7-23-10-12-24(13-11-23)19-26-20-25(14-9-22(26)2)31-29(39)28(38)30(40)32(42-31)43-5/h9-14,20-21,28-32,38-40H,6-8,15-19H2,1-5H3,(H,35,37)/t28-,29-,30+,31+,32-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176699
PNG
(US9688710, 122 tert-butyl4-(2-methyl-2-(4-(4-(2-me...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)NC3CCN(CC3)C(=O)OC(C)(C)C)cc2)c1 |r|
Show InChI InChI=1S/C38H55N3O8S/c1-23-11-16-26(33-31(44)30(43)32(45)34(48-33)50-7)22-27(23)21-25-14-12-24(13-15-25)9-8-10-29(42)40-38(5,6)35(46)39-28-17-19-41(20-18-28)36(47)49-37(2,3)4/h11-16,22,28,30-34,43-45H,8-10,17-21H2,1-7H3,(H,39,46)(H,40,42)/t30-,31-,32+,33+,34-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176702
PNG
(US9688710, 125 2,2-dimethyl-3-((2-(4-(2-methyl-5-(...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCNCC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C27H38N2O6S/c1-16-5-8-18(24-22(31)21(30)23(32)25(35-24)36-4)14-19(16)13-17-6-9-20(10-7-17)34-12-11-29-15-27(2,3)26(28)33/h5-10,14,21-25,29-32H,11-13,15H2,1-4H3,(H2,28,33)/t21-,22-,23+,24+,25-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176704
PNG
(US9688710, 127 N-(2,2-dimethyl-3-(4-methylpiperazi...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NCC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C34H49N3O6S/c1-22-9-14-25(31-29(40)28(39)30(41)32(43-31)44-5)20-26(22)19-24-12-10-23(11-13-24)7-6-8-27(38)35-21-34(2,3)33(42)37-17-15-36(4)16-18-37/h9-14,20,28-32,39-41H,6-8,15-19,21H2,1-5H3,(H,35,38)/t28-,29-,30+,31+,32-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176705
PNG
(US9688710, 128 2,2-dimethyl-3-((4-(4-(2-methyl-5-(...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCNCC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C34H51N3O5S/c1-23-9-14-26(31-29(39)28(38)30(40)32(42-31)43-5)21-27(23)20-25-12-10-24(11-13-25)8-6-7-15-35-22-34(2,3)33(41)37-18-16-36(4)17-19-37/h9-14,21,28-32,35,38-40H,6-8,15-20,22H2,1-5H3/t28-,29-,30+,31+,32-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176706
PNG
(US9688710, 129 2-methyl-2-((4-(4-(2-methyl-5-((2S,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCNC(C)(C)C(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C33H49N3O5S/c1-22-9-14-25(30-28(38)27(37)29(39)31(41-30)42-5)21-26(22)20-24-12-10-23(11-13-24)8-6-7-15-34-33(2,3)32(40)36-18-16-35(4)17-19-36/h9-14,21,27-31,34,37-39H,6-8,15-20H2,1-5H3/t27-,28-,29+,30+,31-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176709
PNG
(US9688710, 132 N-(1-((2-(dimethylamino)ethyl)(meth...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)N(C)CCN(C)C)cc2)c1 |r|
Show InChI InChI=1S/C33H49N3O6S/c1-21-11-16-24(30-28(39)27(38)29(40)31(42-30)43-7)20-25(21)19-23-14-12-22(13-15-23)9-8-10-26(37)34-33(2,3)32(41)36(6)18-17-35(4)5/h11-16,20,27-31,38-40H,8-10,17-19H2,1-7H3,(H,34,37)/t27-,28-,29+,30+,31-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176714
PNG
(US9688710, 136 N-(1-((2-(dimethylamino)ethyl)amino...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(=O)NCCN(C)C)cc2)c1 |r|
Show InChI InChI=1S/C32H47N3O6S/c1-20-10-15-23(29-27(38)26(37)28(39)30(41-29)42-6)19-24(20)18-22-13-11-21(12-14-22)8-7-9-25(36)34-32(2,3)31(40)33-16-17-35(4)5/h10-15,19,26-30,37-39H,7-9,16-18H2,1-6H3,(H,33,40)(H,34,36)/t26-,27-,28+,29+,30-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
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