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Patent code US8742138

Compile Data Set for Download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123039
PNG
(US8742138, 24)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H11Cl2NO6/c19-11-5-4-8(6-12(11)20)9-2-1-3-10-14(9)15(18(26)27-17(10)25)16(24)21-7-13(22)23/h1-6,25H,7H2,(H,21,24)(H,22,23)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123045
PNG
(US8742138, 30)
Show SMILES Cc1ccc(cc1)-c1cccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c12
Show InChI InChI=1S/C19H15NO6/c1-10-5-7-11(8-6-10)12-3-2-4-13-15(12)16(19(25)26-18(13)24)17(23)20-9-14(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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n/an/a 80n/an/an/an/an/a25



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123043
PNG
(US8742138, 28)
Show SMILES COc1ccc(cc1)-c1cccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c12
Show InChI InChI=1S/C19H15NO7/c1-26-11-7-5-10(6-8-11)12-3-2-4-13-15(12)16(19(25)27-18(13)24)17(23)20-9-14(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123033
PNG
(US8742138, 18)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H12ClNO6/c19-10-4-1-3-9(7-10)11-5-2-6-12-14(11)15(18(25)26-17(12)24)16(23)20-8-13(21)22/h1-7,24H,8H2,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123036
PNG
(US8742138, 21)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H12F3NO6/c20-19(21,22)10-6-4-9(5-7-10)11-2-1-3-12-14(11)15(18(28)29-17(12)27)16(26)23-8-13(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123037
PNG
(US8742138, 22)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H12F3NO7/c20-19(21,22)30-10-4-1-3-9(7-10)11-5-2-6-12-14(11)15(18(28)29-17(12)27)16(26)23-8-13(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123035
PNG
(US8742138, 20)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C19H12F3NO6/c20-19(21,22)10-4-1-3-9(7-10)11-5-2-6-12-14(11)15(18(28)29-17(12)27)16(26)23-8-13(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123042
PNG
(US8742138, 27)
Show SMILES COc1cccc(c1)-c1cccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c12
Show InChI InChI=1S/C19H15NO7/c1-26-11-5-2-4-10(8-11)12-6-3-7-13-15(12)16(19(25)27-18(13)24)17(23)20-9-14(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123044
PNG
(US8742138, 29)
Show SMILES Cc1cccc(c1)-c1cccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c12
Show InChI InChI=1S/C19H15NO6/c1-10-4-2-5-11(8-10)12-6-3-7-13-15(12)16(19(25)26-18(13)24)17(23)20-9-14(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123019
PNG
(US8742138, 4)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H12ClNO6/c19-11-4-1-9(2-5-11)10-3-6-12-13(7-10)15(18(25)26-17(12)24)16(23)20-8-14(21)22/h1-7,24H,8H2,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123021
PNG
(US8742138, 6)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H12F3NO6/c20-19(21,22)11-4-1-9(2-5-11)10-3-6-12-13(7-10)15(18(28)29-17(12)27)16(26)23-8-14(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123022
PNG
(US8742138, 7)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H12F3NO7/c20-19(21,22)30-11-3-1-2-9(6-11)10-4-5-12-13(7-10)15(18(28)29-17(12)27)16(26)23-8-14(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123030
PNG
(US8742138, 15)
Show SMILES Cc1ccc(cc1)-c1ccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c2c1
Show InChI InChI=1S/C19H15NO6/c1-10-2-4-11(5-3-10)12-6-7-13-14(8-12)16(19(25)26-18(13)24)17(23)20-9-15(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123038
PNG
(US8742138, 23)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C19H12F3NO7/c20-19(21,22)30-10-6-4-9(5-7-10)11-2-1-3-12-14(11)15(18(28)29-17(12)27)16(26)23-8-13(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123023
PNG
(US8742138, 8)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C19H12F3NO7/c20-19(21,22)30-11-4-1-9(2-5-11)10-3-6-12-13(7-10)15(18(28)29-17(12)27)16(26)23-8-14(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123020
PNG
(US8742138, 5)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C19H12F3NO6/c20-19(21,22)11-3-1-2-9(6-11)10-4-5-12-13(7-10)15(18(28)29-17(12)27)16(26)23-8-14(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123024
PNG
(US8742138, 9)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H11Cl2NO6/c19-12-4-2-9(6-13(12)20)8-1-3-10-11(5-8)15(18(26)27-17(10)25)16(24)21-7-14(22)23/h1-6,25H,7H2,(H,21,24)(H,22,23)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123028
PNG
(US8742138, 13)
Show SMILES COc1ccc(cc1)-c1ccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c2c1
Show InChI InChI=1S/C19H15NO7/c1-26-12-5-2-10(3-6-12)11-4-7-13-14(8-11)16(19(25)27-18(13)24)17(23)20-9-15(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123017
PNG
(US8742138, 2)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1ccccc1Cl
Show InChI InChI=1S/C18H12ClNO6/c19-13-4-2-1-3-10(13)9-5-6-11-12(7-9)15(18(25)26-17(11)24)16(23)20-8-14(21)22/h1-7,24H,8H2,(H,20,23)(H,21,22)
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n/an/a 150n/an/an/an/an/a25



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123016
PNG
(US8742138, 1 | US8742138, 34)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1ccccc1
Show InChI InChI=1S/C18H13NO6/c20-14(21)9-19-16(22)15-13-8-11(10-4-2-1-3-5-10)6-7-12(13)17(23)25-18(15)24/h1-8,23H,9H2,(H,19,22)(H,20,21)
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n/an/a 150n/an/an/an/an/a25



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123026
PNG
(US8742138, 11)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C18H10F3NO6/c19-11-4-8(5-12(20)15(11)21)7-1-2-9-10(3-7)14(18(27)28-17(9)26)16(25)22-6-13(23)24/h1-5,26H,6H2,(H,22,25)(H,23,24)
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n/an/a 150n/an/an/an/an/a25



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123027
PNG
(US8742138, 12)
Show SMILES COc1cccc(c1)-c1ccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c2c1
Show InChI InChI=1S/C19H15NO7/c1-26-12-4-2-3-10(7-12)11-5-6-13-14(8-11)16(19(25)27-18(13)24)17(23)20-9-15(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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n/an/a 150n/an/an/an/an/a25



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123040
PNG
(US8742138, 25)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C18H11F2NO6/c19-11-5-4-8(6-12(11)20)9-2-1-3-10-14(9)15(18(26)27-17(10)25)16(24)21-7-13(22)23/h1-6,25H,7H2,(H,21,24)(H,22,23)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123034
PNG
(US8742138, 19)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H12ClNO6/c19-10-6-4-9(5-7-10)11-2-1-3-12-14(11)15(18(25)26-17(12)24)16(23)20-8-13(21)22/h1-7,24H,8H2,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123025
PNG
(US8742138, 10)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C18H11F2NO6/c19-12-4-2-9(6-13(12)20)8-1-3-10-11(5-8)15(18(26)27-17(10)25)16(24)21-7-14(22)23/h1-6,25H,7H2,(H,21,24)(H,22,23)
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n/an/a 150n/an/an/an/an/a25



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123050
PNG
(US8742138, 35)
Show SMILES OC(=O)CNC(=O)c1c2cc(Br)ccc2c(O)oc1=O
Show InChI InChI=1S/C12H8BrNO6/c13-5-1-2-6-7(3-5)9(12(19)20-11(6)18)10(17)14-4-8(15)16/h1-3,18H,4H2,(H,14,17)(H,15,16)
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n/an/a 150n/an/an/an/an/a25



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123041
PNG
(US8742138, 26)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C18H10F3NO6/c19-10-4-7(5-11(20)15(10)21)8-2-1-3-9-13(8)14(18(27)28-17(9)26)16(25)22-6-12(23)24/h1-5,26H,6H2,(H,22,25)(H,23,24)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123018
PNG
(US8742138, 3)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H12ClNO6/c19-11-3-1-2-9(6-11)10-4-5-12-13(7-10)15(18(25)26-17(12)24)16(23)20-8-14(21)22/h1-7,24H,8H2,(H,20,23)(H,21,22)
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n/an/a 150n/an/an/an/an/a25



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123048
PNG
(US8742138, 33)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1cccnc1
Show InChI InChI=1S/C17H12N2O6/c20-13(21)8-19-15(22)14-12-6-9(10-2-1-5-18-7-10)3-4-11(12)16(23)25-17(14)24/h1-7,23H,8H2,(H,19,22)(H,20,21)
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n/an/a 200n/an/an/an/an/a25



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123032
PNG
(US8742138, 17)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccccc1Cl
Show InChI InChI=1S/C18H12ClNO6/c19-12-7-2-1-4-9(12)10-5-3-6-11-14(10)15(18(25)26-17(11)24)16(23)20-8-13(21)22/h1-7,24H,8H2,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123016
PNG
(US8742138, 1 | US8742138, 34)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1ccccc1
Show InChI InChI=1S/C18H13NO6/c20-14(21)9-19-16(22)15-13-8-11(10-4-2-1-3-5-10)6-7-12(13)17(23)25-18(15)24/h1-8,23H,9H2,(H,19,22)(H,20,21)
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n/an/a 250n/an/an/an/an/a25



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123051
PNG
(US8742138, 36)
Show SMILES OC(=O)CNC(=O)c1c2c(Br)cccc2c(O)oc1=O
Show InChI InChI=1S/C12H8BrNO6/c13-6-3-1-2-5-8(6)9(12(19)20-11(5)18)10(17)14-4-7(15)16/h1-3,18H,4H2,(H,14,17)(H,15,16)
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n/an/a 300n/an/an/an/an/a25



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123029
PNG
(US8742138, 14)
Show SMILES Cc1cccc(c1)-c1ccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c2c1
Show InChI InChI=1S/C19H15NO6/c1-10-3-2-4-11(7-10)12-5-6-13-14(8-12)16(19(25)26-18(13)24)17(23)20-9-15(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123031
PNG
(US8742138, 16)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccccc1
Show InChI InChI=1S/C18H13NO6/c20-13(21)9-19-16(22)15-14-11(10-5-2-1-3-6-10)7-4-8-12(14)17(23)25-18(15)24/h1-8,23H,9H2,(H,19,22)(H,20,21)
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n/an/a 350n/an/an/an/an/a25



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Rattus norvegicus (Rat))		BDBM123009
PNG
(US8742138, 37 | US8742158, EX 21)
Show SMILES OC(=O)CNC(=O)c1c2ccc(Br)cc2c(O)oc1=O
Show InChI InChI=1S/C12H8BrNO6/c13-5-1-2-6-7(3-5)11(18)20-12(19)9(6)10(17)14-4-8(15)16/h1-3,18H,4H2,(H,14,17)(H,15,16)
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n/an/a 700n/an/an/an/an/a25



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...

US Patent US8742138 (2014)


BindingDB Entry DOI: 10.7270/Q23R0RJD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%