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Patent code US9427440

Compile Data Set for Download or QSAR
Found 69 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243470
PNG
(US9427440, 18)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O5S/c1-34-15-7-8-16-35(2)42(39,40)33-31(37)22-11-13-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)12-14-26(23)30(36)29(27)21-9-5-4-6-10-21/h11-14,17-19,21H,4-10,15-16,20H2,1-3H3,(H,33,37)
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US Patent
n/an/a 26n/an/an/an/an/a25



Janssen Sciences Ireland UC

US Patent


Assay Description
IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243471
PNG
(US9427440, 19)
Show SMILES CN1CCOCCN(C)S(=O)(=O)NC(=O)c2ccc3c(C4CCCCC4)c4-c5ccc(F)cc5C=C(Cn4c3c2)C1=O |c:36|
Show InChI InChI=1S/C31H35FN4O5S/c1-34-12-14-41-15-13-35(2)42(39,40)33-30(37)21-8-10-26-27(18-21)36-19-23(31(34)38)16-22-17-24(32)9-11-25(22)29(36)28(26)20-6-4-3-5-7-20/h8-11,16-18,20H,3-7,12-15,19H2,1-2H3,(H,33,37)
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Janssen Sciences Ireland UC

US Patent


Assay Description
IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
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Janssen Sciences Ireland UC

US Patent


Assay Description
IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243472
PNG
(US9427440, 20)
Show SMILES CN1CCOCCN(C)S(=O)(=O)NC(=O)c2ccc3c(C4CCCCC4)c4-c5ccc(F)cc5C(C)=C(Cn4c3c2)C1=O |c:37|
Show InChI InChI=1S/C32H37FN4O5S/c1-20-26-18-23(33)10-12-24(26)30-29(21-7-5-4-6-8-21)25-11-9-22-17-28(25)37(30)19-27(20)32(39)35(2)13-15-42-16-14-36(3)43(40,41)34-31(22)38/h9-12,17-18,21H,4-8,13-16,19H2,1-3H3,(H,34,38)
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Janssen Sciences Ireland UC

US Patent


Assay Description
IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243468
PNG
(US9427440, 16)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=C(C)c2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |t:25|
Show InChI InChI=1S/C33H40N4O6S/c1-21-27-19-24(42-4)11-13-25(27)31-30(22-8-6-5-7-9-22)26-12-10-23-18-29(26)37(31)20-28(21)33(39)35(2)14-16-43-17-15-36(3)44(40,41)34-32(23)38/h10-13,18-19,22H,5-9,14-17,20H2,1-4H3,(H,34,38)
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Janssen Sciences Ireland UC

US Patent


Assay Description
IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243461
PNG
(US9427440, 13)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)NC\C=C\CN(C)S(=O)(=O)NC5=O |c:25,t:35|
Show InChI InChI=1S/C31H34N4O5S/c1-34-15-7-6-14-32-30(36)23-16-22-17-24(40-2)11-13-25(22)29-28(20-8-4-3-5-9-20)26-12-10-21(18-27(26)35(29)19-23)31(37)33-41(34,38)39/h6-7,10-13,16-18,20H,3-5,8-9,14-15,19H2,1-2H3,(H,32,36)(H,33,37)/b7-6+
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Janssen Sciences Ireland UC

US Patent


Assay Description
Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243457
PNG
(US9427440, 11)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC3(CC3c2c1)C(=O)N1CCN(CC1)CCN(C)S(=O)(=O)NC5=O |(8.09,-.74,;7,-1.83,;5.51,-1.43,;4.5,-2.59,;2.99,-2.3,;2.49,-.84,;.95,-.84,;.05,-2.09,;.44,-3.57,;-.64,-4.66,;-.25,-6.15,;1.24,-6.55,;2.33,-5.46,;1.93,-3.97,;-1.42,-1.61,;-2.75,-2.38,;-4.09,-1.61,;-4.09,-.07,;-2.75,.7,;-1.42,-.07,;.05,.41,;.46,1.96,;1.87,2.57,;3.23,3.52,;3.23,1.84,;3.5,.32,;5.01,.02,;.78,3.65,;-.71,3.26,;1.25,4.55,;-.09,5.32,;-1.42,4.55,;-2.75,5.32,;-1.21,5.32,;.25,6.55,;-4.09,4.55,;-5.42,5.32,;-6.75,4.55,;-8.09,5.32,;-6.75,3.01,;-8.09,2.24,;-5.42,3.78,;-5.42,2.24,;-5.42,.7,;-6.75,-.07,)|
Show InChI InChI=1S/C34H41N5O5S/c1-36-12-13-37-14-16-38(17-15-37)33(41)34-20-28(34)27-19-24(44-2)9-11-25(27)31-30(22-6-4-3-5-7-22)26-10-8-23(18-29(26)39(31)21-34)32(40)35-45(36,42)43/h8-11,18-19,22,28H,3-7,12-17,20-21H2,1-2H3,(H,35,40)
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Janssen Sciences Ireland UC

US Patent


Assay Description
Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
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Janssen Sciences Ireland UC

US Patent


Assay Description
Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243460
PNG
(US9427440, 10)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC3(CC3c2c1)C(=O)NCCCCN(C)S(=O)(=O)NC5=O
Show InChI InChI=1S/C32H38N4O5S/c1-35-15-7-6-14-33-31(38)32-18-26(32)25-17-22(41-2)11-13-23(25)29-28(20-8-4-3-5-9-20)24-12-10-21(16-27(24)36(29)19-32)30(37)34-42(35,39)40/h10-13,16-17,20,26H,3-9,14-15,18-19H2,1-2H3,(H,33,38)(H,34,37)
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Janssen Sciences Ireland UC

US Patent


Assay Description
Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243458
PNG
(US9427440, 5)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)NCCN1CCN(CC1)S(=O)(=O)NC5=O |c:25,(8.09,-.48,;7,-1.57,;5.51,-1.17,;4.5,-2.33,;2.99,-2.03,;2.49,-.57,;.95,-.57,;.05,-1.82,;.44,-3.31,;-.64,-4.4,;-.25,-5.88,;1.24,-6.28,;2.33,-5.19,;1.93,-3.71,;-1.42,-1.34,;-2.75,-2.11,;-4.09,-1.34,;-4.09,.2,;-2.75,.97,;-1.42,.2,;.05,.67,;.46,2.22,;1.87,2.83,;3.23,2.1,;3.5,.59,;5.01,.29,;.78,3.92,;-.71,3.52,;1.25,4.82,;-.09,5.59,;-1.42,4.82,;-2.75,5.59,;-4.09,4.82,;-5.42,5.59,;-6.75,4.82,;-5.31,6.28,;-4.29,5.59,;-6.75,3.28,;-8.09,2.51,;-5.42,4.05,;-5.42,2.51,;-5.42,.97,;-6.75,.2,)|
Show InChI InChI=1S/C32H37N5O5S/c1-42-25-8-10-26-23(18-25)17-24-20-37-28-19-22(7-9-27(28)29(30(26)37)21-5-3-2-4-6-21)32(39)34-43(40,41)36-15-13-35(14-16-36)12-11-33-31(24)38/h7-10,17-19,21H,2-6,11-16,20H2,1H3,(H,33,38)(H,34,39)
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Janssen Sciences Ireland UC

US Patent


Assay Description
Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243455
PNG
(US9427440, 2)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O
Show InChI InChI=1S/C32H40N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,18-19,21,24H,4-8,13-17,20H2,1-3H3,(H,33,37)
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Janssen Sciences Ireland UC

US Patent


Assay Description
Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243462
PNG
(US9427440, 3)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3C[C@@H](Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |r|
Show InChI InChI=1S/C32H40N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,18-19,21,24H,4-8,13-17,20H2,1-3H3,(H,33,37)/t24-/m1/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243459
PNG
(US9427440, 12)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC3(CC3c2c1)C(=O)NCC\C=C\CN(C)S(=O)(=O)NC5=O |t:38|
Show InChI InChI=1S/C33H38N4O5S/c1-36-16-8-4-7-15-34-32(39)33-19-27(33)26-18-23(42-2)12-14-24(26)30-29(21-9-5-3-6-10-21)25-13-11-22(17-28(25)37(30)20-33)31(38)35-43(36,40)41/h4,8,11-14,17-18,21,27H,3,5-7,9-10,15-16,19-20H2,1-2H3,(H,34,39)(H,35,38)/b8-4+
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Janssen Sciences Ireland UC

US Patent


Assay Description
Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243463
PNG
(US9427440, 4)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3C[C@H](Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |r|
Show InChI InChI=1S/C32H40N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,18-19,21,24H,4-8,13-17,20H2,1-3H3,(H,33,37)/t24-/m0/s1
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n/an/a 2.42E+3n/an/an/an/an/a25



Janssen Sciences Ireland UC

US Patent


Assay Description
IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
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Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243457
PNG
(US9427440, 11)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC3(CC3c2c1)C(=O)N1CCN(CC1)CCN(C)S(=O)(=O)NC5=O |(8.09,-.74,;7,-1.83,;5.51,-1.43,;4.5,-2.59,;2.99,-2.3,;2.49,-.84,;.95,-.84,;.05,-2.09,;.44,-3.57,;-.64,-4.66,;-.25,-6.15,;1.24,-6.55,;2.33,-5.46,;1.93,-3.97,;-1.42,-1.61,;-2.75,-2.38,;-4.09,-1.61,;-4.09,-.07,;-2.75,.7,;-1.42,-.07,;.05,.41,;.46,1.96,;1.87,2.57,;3.23,3.52,;3.23,1.84,;3.5,.32,;5.01,.02,;.78,3.65,;-.71,3.26,;1.25,4.55,;-.09,5.32,;-1.42,4.55,;-2.75,5.32,;-1.21,5.32,;.25,6.55,;-4.09,4.55,;-5.42,5.32,;-6.75,4.55,;-8.09,5.32,;-6.75,3.01,;-8.09,2.24,;-5.42,3.78,;-5.42,2.24,;-5.42,.7,;-6.75,-.07,)|
Show InChI InChI=1S/C34H41N5O5S/c1-36-12-13-37-14-16-38(17-15-37)33(41)34-20-28(34)27-19-24(44-2)9-11-25(27)31-30(22-6-4-3-5-7-22)26-10-8-23(18-29(26)39(31)21-34)32(40)35-45(36,42)43/h8-11,18-19,22,28H,3-7,12-17,20-21H2,1-2H3,(H,35,40)
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Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243460
PNG
(US9427440, 10)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC3(CC3c2c1)C(=O)NCCCCN(C)S(=O)(=O)NC5=O
Show InChI InChI=1S/C32H38N4O5S/c1-35-15-7-6-14-33-31(38)32-18-26(32)25-17-22(41-2)11-13-23(25)29-28(20-8-4-3-5-9-20)24-12-10-21(16-27(24)36(29)19-32)30(37)34-42(35,39)40/h10-13,16-17,20,26H,3-9,14-15,18-19H2,1-2H3,(H,33,38)(H,34,37)
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Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243467
PNG
(US9427440, 15)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N1CCN(CC1)CCN(C)S(=O)(=O)NC5=O |c:25,(9.03,-.65,;7.94,-1.74,;6.45,-1.34,;5.44,-2.5,;3.93,-2.2,;3.43,-.75,;1.89,-.75,;.99,-1.99,;1.39,-3.48,;.3,-4.57,;.69,-6.06,;2.18,-6.46,;3.27,-5.37,;2.87,-3.88,;-.48,-1.52,;-1.81,-2.29,;-3.15,-1.52,;-3.15,.02,;-1.81,.79,;-.48,.02,;.99,.5,;1.4,2.05,;2.81,2.66,;4.17,1.93,;4.44,.41,;5.95,.12,;2.81,4.2,;4.15,4.97,;.3,5.37,;-.1,3.88,;-1.59,3.48,;-2.68,4.57,;-2.28,6.06,;-.79,6.46,;-4.16,4.17,;-5.25,5.26,;-6.74,4.86,;-7.83,5.95,;-7.54,2.13,;-7.94,.64,;-9.03,2.53,;-5.25,2.13,;-4.48,.79,;-5.81,.02,)|
Show InChI InChI=1S/C33H39N5O5S/c1-35-12-13-36-14-16-37(17-15-36)33(40)25-18-24-19-26(43-2)9-11-27(24)31-30(22-6-4-3-5-7-22)28-10-8-23(20-29(28)38(31)21-25)32(39)34-44(35,41)42/h8-11,18-20,22H,3-7,12-17,21H2,1-2H3,(H,34,39)
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Janssen Sciences Ireland UC

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Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243470
PNG
(US9427440, 18)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O5S/c1-34-15-7-8-16-35(2)42(39,40)33-31(37)22-11-13-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)12-14-26(23)30(36)29(27)21-9-5-4-6-10-21/h11-14,17-19,21H,4-10,15-16,20H2,1-3H3,(H,33,37)
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n/an/an/an/an/a 0.0000480 2.00E+47.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
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n/an/an/an/an/a 0.0000900 2.00E+47.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243477
PNG
(US9427440, 25)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCNS(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C31H36N4O5S/c1-34-15-7-6-14-32-41(38,39)33-30(36)21-10-12-26-27(18-21)35-19-23(31(34)37)16-22-17-24(40-2)11-13-25(22)29(35)28(26)20-8-4-3-5-9-20/h10-13,16-18,20,32H,3-9,14-15,19H2,1-2H3,(H,33,36)
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n/an/an/an/an/a 0.000310 2.90E+47.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010,L2811I]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
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n/an/an/a 5.50E+3n/a 0.000970 1.80E+47.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243455
PNG
(US9427440, 2)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O
Show InChI InChI=1S/C32H40N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,18-19,21,24H,4-8,13-17,20H2,1-3H3,(H,33,37)
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Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243458
PNG
(US9427440, 5)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)NCCN1CCN(CC1)S(=O)(=O)NC5=O |c:25,(8.09,-.48,;7,-1.57,;5.51,-1.17,;4.5,-2.33,;2.99,-2.03,;2.49,-.57,;.95,-.57,;.05,-1.82,;.44,-3.31,;-.64,-4.4,;-.25,-5.88,;1.24,-6.28,;2.33,-5.19,;1.93,-3.71,;-1.42,-1.34,;-2.75,-2.11,;-4.09,-1.34,;-4.09,.2,;-2.75,.97,;-1.42,.2,;.05,.67,;.46,2.22,;1.87,2.83,;3.23,2.1,;3.5,.59,;5.01,.29,;.78,3.92,;-.71,3.52,;1.25,4.82,;-.09,5.59,;-1.42,4.82,;-2.75,5.59,;-4.09,4.82,;-5.42,5.59,;-6.75,4.82,;-5.31,6.28,;-4.29,5.59,;-6.75,3.28,;-8.09,2.51,;-5.42,4.05,;-5.42,2.51,;-5.42,.97,;-6.75,.2,)|
Show InChI InChI=1S/C32H37N5O5S/c1-42-25-8-10-26-23(18-25)17-24-20-37-28-19-22(7-9-27(28)29(30(26)37)21-5-3-2-4-6-21)32(39)34-43(40,41)36-15-13-35(14-16-36)12-11-33-31(24)38/h7-10,17-19,21H,2-6,11-16,20H2,1H3,(H,33,38)(H,34,39)
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Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243463
PNG
(US9427440, 4)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3C[C@H](Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |r|
Show InChI InChI=1S/C32H40N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,18-19,21,24H,4-8,13-17,20H2,1-3H3,(H,33,37)/t24-/m0/s1
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n/an/an/an/a 3.83E+3n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243469
PNG
(US9427440, 17)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=C(C)c2c1)C(=O)N(C)CCCCN(C)S(=O)(=O)NC5=O |t:25|
Show InChI InChI=1S/C33H40N4O5S/c1-21-27-19-24(42-4)13-15-25(27)31-30(22-10-6-5-7-11-22)26-14-12-23-18-29(26)37(31)20-28(21)33(39)35(2)16-8-9-17-36(3)43(40,41)34-32(23)38/h12-15,18-19,22H,5-11,16-17,20H2,1-4H3,(H,34,38)
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n/an/an/an/a 170n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243480
PNG
(US9427440, 28)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCN(C(C)C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C34H42N4O5S/c1-22(2)38-17-9-8-16-36(3)34(40)26-18-25-19-27(43-4)13-15-28(25)32-31(23-10-6-5-7-11-23)29-14-12-24(20-30(29)37(32)21-26)33(39)35-44(38,41)42/h12-15,18-20,22-23H,5-11,16-17,21H2,1-4H3,(H,35,39)
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n/an/an/a 9n/an/an/a7.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243479
PNG
(US9427440, 27)
Show SMILES CN1CCCCCNC(=O)C2=Cc3ccc(Cl)cc3-c3c(C4CCCCC4)c4ccc(cc4n3C2)C(=O)NS1(=O)=O |t:10|
Show InChI InChI=1S/C31H35ClN4O4S/c1-35-15-7-3-6-14-33-30(37)23-16-21-10-12-24(32)18-26(21)29-28(20-8-4-2-5-9-20)25-13-11-22(17-27(25)36(29)19-23)31(38)34-41(35,39)40/h10-13,16-18,20H,2-9,14-15,19H2,1H3,(H,33,37)(H,34,38)
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n/an/an/a 400n/an/an/a7.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243476
PNG
(US9427440, 24)
Show SMILES CN1CCCCN(C)S(=O)(=O)NC(=O)c2ccc3c(C4CCCCC4)c4-c5cc(Cl)ccc5C=C(Cn4c3c2)C1=O |c:35|
Show InChI InChI=1S/C31H35ClN4O4S/c1-34-14-6-7-15-35(2)41(39,40)33-30(37)22-11-13-25-27(17-22)36-19-23(31(34)38)16-21-10-12-24(32)18-26(21)29(36)28(25)20-8-4-3-5-9-20/h10-13,16-18,20H,3-9,14-15,19H2,1-2H3,(H,33,37)
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Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
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n/an/an/a 5.20n/a 0.000100 2.00E+47.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010,P2914L]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
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n/an/an/a 3.80E+3n/a 0.0220 5.90E+37.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010,V2913A]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
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n/an/an/a 1.50E+3n/a 0.000840 5.50E+47.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243459
PNG
(US9427440, 12)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC3(CC3c2c1)C(=O)NCC\C=C\CN(C)S(=O)(=O)NC5=O |t:38|
Show InChI InChI=1S/C33H38N4O5S/c1-36-16-8-4-7-15-34-32(39)33-19-27(33)26-18-23(42-2)12-14-24(26)30-29(21-9-5-3-6-10-21)25-13-11-22(17-28(25)37(30)20-33)31(38)35-43(36,40)41/h4,8,11-14,17-18,21,27H,3,5-7,9-10,15-16,19-20H2,1-2H3,(H,34,39)(H,35,38)/b8-4+
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n/an/an/an/a 290n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243465
PNG
(US9427440, 8)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3C[C@]3(C[C@H]3c2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |r|
Show InChI InChI=1S/C33H40N4O6S/c1-35-13-15-43-16-14-36(2)44(40,41)34-31(38)22-9-11-25-28(17-22)37-20-33(32(35)39)19-27(33)26-18-23(42-3)10-12-24(26)30(37)29(25)21-7-5-4-6-8-21/h9-12,17-18,21,27H,4-8,13-16,19-20H2,1-3H3,(H,34,38)/t27-,33-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243479
PNG
(US9427440, 27)
Show SMILES CN1CCCCCNC(=O)C2=Cc3ccc(Cl)cc3-c3c(C4CCCCC4)c4ccc(cc4n3C2)C(=O)NS1(=O)=O |t:10|
Show InChI InChI=1S/C31H35ClN4O4S/c1-35-15-7-3-6-14-33-30(37)23-16-21-10-12-24(32)18-26(21)29-28(20-8-4-2-5-9-20)25-13-11-22(17-27(25)36(29)19-23)31(38)34-41(35,39)40/h10-13,16-18,20H,2-9,14-15,19H2,1H3,(H,33,37)(H,34,38)
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n/an/an/an/a 1.02E+4n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243480
PNG
(US9427440, 28)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCN(C(C)C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C34H42N4O5S/c1-22(2)38-17-9-8-16-36(3)34(40)26-18-25-19-27(43-4)13-15-28(25)32-31(23-10-6-5-7-11-23)29-14-12-24(20-30(29)37(32)21-26)33(39)35-44(38,41)42/h12-15,18-20,22-23H,5-11,16-17,21H2,1-4H3,(H,35,39)
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Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243480
PNG
(US9427440, 28)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCN(C(C)C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C34H42N4O5S/c1-22(2)38-17-9-8-16-36(3)34(40)26-18-25-19-27(43-4)13-15-28(25)32-31(23-10-6-5-7-11-23)29-14-12-24(20-30(29)37(32)21-26)33(39)35-44(38,41)42/h12-15,18-20,22-23H,5-11,16-17,21H2,1-4H3,(H,35,39)
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n/an/an/an/an/a 0.0000660 7.30E+37.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243469
PNG
(US9427440, 17)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=C(C)c2c1)C(=O)N(C)CCCCN(C)S(=O)(=O)NC5=O |t:25|
Show InChI InChI=1S/C33H40N4O5S/c1-21-27-19-24(42-4)13-15-25(27)31-30(22-10-6-5-7-11-22)26-14-12-23-18-29(26)37(31)20-28(21)33(39)35(2)16-8-9-17-36(3)43(40,41)34-32(23)38/h12-15,18-19,22H,5-11,16-17,20H2,1-4H3,(H,34,38)
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n/an/an/an/an/a 0.000160 8.70E+37.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
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n/an/an/a 4.40n/a 0.0000900 2.00E+47.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243468
PNG
(US9427440, 16)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=C(C)c2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |t:25|
Show InChI InChI=1S/C33H40N4O6S/c1-21-27-19-24(42-4)11-13-25(27)31-30(22-8-6-5-7-9-22)26-12-10-23-18-29(26)37(31)20-28(21)33(39)35(2)14-16-43-17-15-36(3)44(40,41)34-32(23)38/h10-13,18-19,22H,5-9,14-17,20H2,1-4H3,(H,34,38)
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n/an/an/an/a 78n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243476
PNG
(US9427440, 24)
Show SMILES CN1CCCCN(C)S(=O)(=O)NC(=O)c2ccc3c(C4CCCCC4)c4-c5cc(Cl)ccc5C=C(Cn4c3c2)C1=O |c:35|
Show InChI InChI=1S/C31H35ClN4O4S/c1-34-14-6-7-15-35(2)41(39,40)33-30(37)22-11-13-25-27(17-22)36-19-23(31(34)38)16-21-10-12-24(32)18-26(21)29(36)28(25)20-8-4-3-5-9-20/h10-13,16-18,20H,3-9,14-15,19H2,1-2H3,(H,33,37)
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n/an/an/an/a 1.45E+4n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243481
PNG
(US9427440, 38)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)NCCCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C31H36N4O5S/c1-34-15-7-6-14-32-30(36)23-16-22-17-24(40-2)11-13-25(22)29-28(20-8-4-3-5-9-20)26-12-10-21(18-27(26)35(29)19-23)31(37)33-41(34,38)39/h10-13,16-18,20H,3-9,14-15,19H2,1-2H3,(H,32,36)(H,33,37)
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n/an/an/an/a 912n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243468
PNG
(US9427440, 16)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=C(C)c2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |t:25|
Show InChI InChI=1S/C33H40N4O6S/c1-21-27-19-24(42-4)11-13-25(27)31-30(22-8-6-5-7-9-22)26-12-10-23-18-29(26)37(31)20-28(21)33(39)35(2)14-16-43-17-15-36(3)44(40,41)34-32(23)38/h10-13,18-19,22H,5-9,14-17,20H2,1-4H3,(H,34,38)
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n/an/an/a 1.60n/an/an/a7.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
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n/an/an/a 4.40n/an/an/a7.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243477
PNG
(US9427440, 25)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCNS(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C31H36N4O5S/c1-34-15-7-6-14-32-41(38,39)33-30(36)21-10-12-26-27(18-21)35-19-23(31(34)37)16-22-17-24(40-2)11-13-25(22)29(35)28(26)20-8-4-3-5-9-20/h10-13,16-18,20,32H,3-9,14-15,19H2,1-2H3,(H,33,36)
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n/an/an/a 11n/an/an/a7.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010,S2701T]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
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n/an/an/a 3.90n/a 0.000130 3.40E+47.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010,C2735L]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
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n/an/an/a 2.20n/a 0.0000760 3.50E+47.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243472
PNG
(US9427440, 20)
Show SMILES CN1CCOCCN(C)S(=O)(=O)NC(=O)c2ccc3c(C4CCCCC4)c4-c5ccc(F)cc5C(C)=C(Cn4c3c2)C1=O |c:37|
Show InChI InChI=1S/C32H37FN4O5S/c1-20-26-18-23(33)10-12-24(26)30-29(21-7-5-4-6-8-21)25-11-9-22-17-28(25)37(30)19-27(20)32(39)35(2)13-15-42-16-14-36(3)43(40,41)34-31(22)38/h9-12,17-18,21H,4-8,13-16,19H2,1-3H3,(H,34,38)
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n/an/an/an/a 81n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243474
PNG
(US9427440, 22)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C34H42N4O5S/c1-36-17-9-4-5-10-18-37(2)44(41,42)35-33(39)24-13-15-29-30(21-24)38-22-26(34(36)40)19-25-20-27(43-3)14-16-28(25)32(38)31(29)23-11-7-6-8-12-23/h13-16,19-21,23H,4-12,17-18,22H2,1-3H3,(H,35,39)
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n/an/an/an/a 160n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243481
PNG
(US9427440, 38)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)NCCCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C31H36N4O5S/c1-34-15-7-6-14-32-30(36)23-16-22-17-24(40-2)11-13-25(22)29-28(20-8-4-3-5-9-20)26-12-10-21(18-27(26)35(29)19-23)31(37)33-41(34,38)39/h10-13,16-18,20H,3-9,14-15,19H2,1-2H3,(H,32,36)(H,33,37)
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n/an/an/an/an/a 0.0000410 5.30E+37.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243473
PNG
(US9427440, 21)
Show SMILES CN1CCOCCN(C)S(=O)(=O)NC(=O)c2ccc3c(C4CCCCC4)c4-c5ccc(Cl)cc5C=C(Cn4c3c2)C1=O |c:36|
Show InChI InChI=1S/C31H35ClN4O5S/c1-34-12-14-41-15-13-35(2)42(39,40)33-30(37)21-8-10-26-27(18-21)36-19-23(31(34)38)16-22-17-24(32)9-11-25(22)29(36)28(26)20-6-4-3-5-7-20/h8-11,16-18,20H,3-7,12-15,19H2,1-2H3,(H,33,37)
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Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243470
PNG
(US9427440, 18)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O5S/c1-34-15-7-8-16-35(2)42(39,40)33-31(37)22-11-13-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)12-14-26(23)30(36)29(27)21-9-5-4-6-10-21/h11-14,17-19,21H,4-10,15-16,20H2,1-3H3,(H,33,37)
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n/an/an/a 2.40n/an/an/a7.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243461
PNG
(US9427440, 13)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)NC\C=C\CN(C)S(=O)(=O)NC5=O |c:25,t:35|
Show InChI InChI=1S/C31H34N4O5S/c1-34-15-7-6-14-32-30(36)23-16-22-17-24(40-2)11-13-25(22)29-28(20-8-4-3-5-9-20)26-12-10-21(18-27(26)35(29)19-23)31(37)33-41(34,38)39/h6-7,10-13,16-18,20H,3-5,8-9,14-15,19H2,1-2H3,(H,32,36)(H,33,37)/b7-6+
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Janssen Sciences Ireland UC

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Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243462
PNG
(US9427440, 3)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3C[C@@H](Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |r|
Show InChI InChI=1S/C32H40N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,18-19,21,24H,4-8,13-17,20H2,1-3H3,(H,33,37)/t24-/m1/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243464
PNG
(US9427440, 6)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)NCCN(C)CCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H39N5O5S/c1-35-14-13-33-31(38)24-17-23-18-25(42-3)10-12-26(23)30-29(21-7-5-4-6-8-21)27-11-9-22(19-28(27)37(30)20-24)32(39)34-43(40,41)36(2)16-15-35/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,38)(H,34,39)
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Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243475
PNG
(US9427440, 23)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)NCCN(C)CCNS(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C31H37N5O5S/c1-35-14-12-32-30(37)23-16-22-17-24(41-2)9-11-25(22)29-28(20-6-4-3-5-7-20)26-10-8-21(18-27(26)36(29)19-23)31(38)34-42(39,40)33-13-15-35/h8-11,16-18,20,33H,3-7,12-15,19H2,1-2H3,(H,32,37)(H,34,38)
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Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243477
PNG
(US9427440, 25)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCNS(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C31H36N4O5S/c1-34-15-7-6-14-32-41(38,39)33-30(36)21-10-12-26-27(18-21)35-19-23(31(34)37)16-22-17-24(40-2)11-13-25(22)29(35)28(26)20-8-4-3-5-9-20/h10-13,16-18,20,32H,3-9,14-15,19H2,1-2H3,(H,33,36)
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Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010,M2833T]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
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n/an/an/a 5.90n/a 0.000150 2.60E+47.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243466
PNG
(US9427440, 9)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3C[C@@]3(C[C@@H]3c2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |r|
Show InChI InChI=1S/C33H40N4O6S/c1-35-13-15-43-16-14-36(2)44(40,41)34-31(38)22-9-11-25-28(17-22)37-20-33(32(35)39)19-27(33)26-18-23(42-3)10-12-24(26)30(37)29(25)21-7-5-4-6-8-21/h9-12,17-18,21,27H,4-8,13-16,19-20H2,1-3H3,(H,34,38)/t27-,33-/m1/s1
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n/an/an/an/a 800n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243470
PNG
(US9427440, 18)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O5S/c1-34-15-7-8-16-35(2)42(39,40)33-31(37)22-11-13-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)12-14-26(23)30(36)29(27)21-9-5-4-6-10-21/h11-14,17-19,21H,4-10,15-16,20H2,1-3H3,(H,33,37)
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n/an/an/an/a 79n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243471
PNG
(US9427440, 19)
Show SMILES CN1CCOCCN(C)S(=O)(=O)NC(=O)c2ccc3c(C4CCCCC4)c4-c5ccc(F)cc5C=C(Cn4c3c2)C1=O |c:36|
Show InChI InChI=1S/C31H35FN4O5S/c1-34-12-14-41-15-13-35(2)42(39,40)33-30(37)21-8-10-26-27(18-21)36-19-23(31(34)38)16-22-17-24(32)9-11-25(22)29(36)28(26)20-6-4-3-5-7-20/h8-11,16-18,20H,3-7,12-15,19H2,1-2H3,(H,33,37)
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Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243478
PNG
(US9427440, 26)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)NCCCCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O5S/c1-35-16-8-4-7-15-33-31(37)24-17-23-18-25(41-2)12-14-26(23)30-29(21-9-5-3-6-10-21)27-13-11-22(19-28(27)36(30)20-24)32(38)34-42(35,39)40/h11-14,17-19,21H,3-10,15-16,20H2,1-2H3,(H,33,37)(H,34,38)
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n/an/an/an/a 130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243469
PNG
(US9427440, 17)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=C(C)c2c1)C(=O)N(C)CCCCN(C)S(=O)(=O)NC5=O |t:25|
Show InChI InChI=1S/C33H40N4O5S/c1-21-27-19-24(42-4)13-15-25(27)31-30(22-10-6-5-7-11-22)26-14-12-23-18-29(26)37(31)20-28(21)33(39)35(2)16-8-9-17-36(3)43(40,41)34-32(23)38/h12-15,18-19,22H,5-11,16-17,20H2,1-4H3,(H,34,38)
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n/an/an/a 18n/an/an/a7.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243481
PNG
(US9427440, 38)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)NCCCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C31H36N4O5S/c1-34-15-7-6-14-32-30(36)23-16-22-17-24(40-2)11-13-25(22)29-28(20-8-4-3-5-9-20)26-12-10-21(18-27(26)35(29)19-23)31(37)33-41(34,38)39/h10-13,16-18,20H,3-9,14-15,19H2,1-2H3,(H,32,36)(H,33,37)
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n/an/an/a 7.70n/an/an/a7.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243468
PNG
(US9427440, 16)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=C(C)c2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |t:25|
Show InChI InChI=1S/C33H40N4O6S/c1-21-27-19-24(42-4)11-13-25(27)31-30(22-8-6-5-7-9-22)26-12-10-23-18-29(26)37(31)20-28(21)33(39)35(2)14-16-43-17-15-36(3)44(40,41)34-32(23)38/h10-13,18-19,22H,5-9,14-17,20H2,1-4H3,(H,34,38)
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n/an/an/an/an/a 0.0000360 2.20E+47.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243479
PNG
(US9427440, 27)
Show SMILES CN1CCCCCNC(=O)C2=Cc3ccc(Cl)cc3-c3c(C4CCCCC4)c4ccc(cc4n3C2)C(=O)NS1(=O)=O |t:10|
Show InChI InChI=1S/C31H35ClN4O4S/c1-35-15-7-3-6-14-33-30(37)23-16-21-10-12-24(32)18-26(21)29-28(20-8-4-2-5-9-20)25-13-11-22(17-27(25)36(29)19-23)31(38)34-41(35,39)40/h10-13,16-18,20H,2-9,14-15,19H2,1H3,(H,33,37)(H,34,38)
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n/an/an/an/an/a 0.00380 9.50E+37.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243476
PNG
(US9427440, 24)
Show SMILES CN1CCCCN(C)S(=O)(=O)NC(=O)c2ccc3c(C4CCCCC4)c4-c5cc(Cl)ccc5C=C(Cn4c3c2)C1=O |c:35|
Show InChI InChI=1S/C31H35ClN4O4S/c1-34-14-6-7-15-35(2)41(39,40)33-30(37)22-11-13-25-27(17-22)36-19-23(31(34)38)16-21-10-12-24(32)18-26(21)29(36)28(25)20-8-4-3-5-9-20/h10-13,16-18,20H,3-9,14-15,19H2,1-2H3,(H,33,37)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/an/a 0.00370 4.80E+37.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010,P2914L]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
PDB

UniProtKB/SwissProt

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MCE
PC cid
PC sid
UniChem
US Patent
n/an/an/a 6.40E+3n/a 0.0220 3.40E+37.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010,M2842T]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))		BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
US Patent
n/an/an/a 6.30n/a 0.000150 2.50E+47.425



Janssen Sciences Ireland UC

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...

US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%