Affinity Data by Patent

Patent code US8497277

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM1773 (US10280174, Comparative Compound 1 \| US8476284, 4 ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.4	n/a
Pharmacyclics, Inc. US Patent					Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.				US Patent US8497277 (2013) BindingDB Entry DOI: 10.7270/Q2MW2FR5
Pharmacyclics, Inc. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM97673 (US8476284, 41 \| US8497277, 6) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.520	n/a	n/a	n/a	n/a	7.4	n/a
Pharmacyclics, Inc. US Patent					Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.				US Patent US8497277 (2013) BindingDB Entry DOI: 10.7270/Q2MW2FR5
Pharmacyclics, Inc. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM97678 (US8476284, 9 \| US8497277, 10 \| US8497277, 9 \| US91...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.580	n/a	n/a	n/a	n/a	7.4	n/a
Pharmacyclics, Inc. US Patent					Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.				US Patent US8497277 (2013) BindingDB Entry DOI: 10.7270/Q2MW2FR5
Pharmacyclics, Inc. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM97677 (US8476284, 7 \| US8497277, 7 \| US9133201, 7) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.580	n/a	n/a	n/a	n/a	7.4	n/a
Pharmacyclics, Inc. US Patent					Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.				US Patent US8497277 (2013) BindingDB Entry DOI: 10.7270/Q2MW2FR5
Pharmacyclics, Inc. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM97674 (US8476284, 42 \| US8497277, 8 \| US9133201, 8) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.720	n/a	n/a	n/a	n/a	7.4	n/a
Pharmacyclics, Inc. US Patent					Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.				US Patent US8497277 (2013) BindingDB Entry DOI: 10.7270/Q2MW2FR5
Pharmacyclics, Inc. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM1773 (US10280174, Comparative Compound 1 \| US8476284, 4 ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	0.720	n/a	n/a	n/a	n/a	7.4	n/a
Pharmacyclics, Inc. US Patent					Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.				US Patent US8497277 (2013) BindingDB Entry DOI: 10.7270/Q2MW2FR5
Pharmacyclics, Inc. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM97669 (US8476284, 37 \| US8497277, 14) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.4	n/a
Pharmacyclics, Inc. US Patent					Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.				US Patent US8497277 (2013) BindingDB Entry DOI: 10.7270/Q2MW2FR5
Pharmacyclics, Inc. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM98655 (US8497277, 11 \| US8497277, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.4	n/a
Pharmacyclics, Inc. US Patent					Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.				US Patent US8497277 (2013) BindingDB Entry DOI: 10.7270/Q2MW2FR5
Pharmacyclics, Inc. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM98655 (US8497277, 11 \| US8497277, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.4	n/a
Pharmacyclics, Inc. US Patent					Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.				US Patent US8497277 (2013) BindingDB Entry DOI: 10.7270/Q2MW2FR5
Pharmacyclics, Inc. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM97675 (US8476284, 43 \| US8497277, 15 \| US9133201, 15 \| US...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	7.4	n/a
Pharmacyclics, Inc. US Patent					Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.				US Patent US8497277 (2013) BindingDB Entry DOI: 10.7270/Q2MW2FR5
Pharmacyclics, Inc. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM97678 (US8476284, 9 \| US8497277, 10 \| US8497277, 9 \| US91...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	7.4	n/a
Pharmacyclics, Inc. US Patent					Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.				US Patent US8497277 (2013) BindingDB Entry DOI: 10.7270/Q2MW2FR5
Pharmacyclics, Inc. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM97676 (US8476284, 5 \| US8497277, 5 \| US9133201, 5) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	n/a
Pharmacyclics, Inc. US Patent					Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.				US Patent US8497277 (2013) BindingDB Entry DOI: 10.7270/Q2MW2FR5
Pharmacyclics, Inc. US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%