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Patent code US9206199

Compile Data Set for Download or QSAR

Found 217 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195932
PNG
(US9206199, 37)
Show SMILES Fc1ccc(cc1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C22H21FN8O2/c1-24-19-9-16(3-4-18(19)23)20-12-29-6-7-30(11-17(29)13-33-20)22(32)8-15-2-5-21(25-10-15)31-14-26-27-28-31/h2-5,9-10,14,17,20H,6-8,11-13H2/t17-,20-/m0/s1
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n/an/a 20n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196105
PNG
(US9206199, 13 | US9206199, 14 | US9206199, 9)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])C1CN2CCN(CC2CO1)C(=O)Cc1cnc(nc1)-n1cnnn1
Show InChI InChI=1S/C22H22FN9O2/c1-14-17(3-4-18(23)21(14)24-2)19-11-30-5-6-31(10-16(30)12-34-19)20(33)7-15-8-25-22(26-9-15)32-13-27-28-29-32/h3-4,8-9,13,16,19H,5-7,10-12H2,1H3
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n/an/a 30n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196031
PNG
(US9206199, 136)
Show SMILES Fc1ccc([C@@H]2CN3CCN(C[C@H]3CO2)C(=O)Cc2cnc(nc2)-n2cnnn2)c(Cl)c1[N+]#[C-] |r|
Show InChI InChI=1S/C21H19ClFN9O2/c1-24-20-16(23)3-2-15(19(20)22)17-10-30-4-5-31(9-14(30)11-34-17)18(33)6-13-7-25-21(26-8-13)32-12-27-28-29-32/h2-3,7-8,12,14,17H,4-6,9-11H2/t14-,17-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195913
PNG
(US9206199, 6)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1cnc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C22H22FN9O2/c1-14-17(3-4-18(23)21(14)24-2)19-11-30-5-6-31(10-16(30)12-34-19)20(33)7-15-8-25-22(26-9-15)32-13-27-28-29-32/h3-4,8-9,13,16,19H,5-7,10-12H2,1H3/t16-,19+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195922
PNG
(US9206199, 25)
Show SMILES O=C(Cc1ccc(nc1)-n1cnnn1)N1CCN2C[C@H](OC[C@@H]2C1)c1ccc2C(=O)OCc2c1 |r|
Show InChI InChI=1S/C23H23N7O4/c31-22(7-15-1-4-21(24-9-15)30-14-25-26-27-30)29-6-5-28-11-20(33-13-18(28)10-29)16-2-3-19-17(8-16)12-34-23(19)32/h1-4,8-9,14,18,20H,5-7,10-13H2/t18-,20-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195912
PNG
(US9206199, 4 | US9206199, 5)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H23FN8O2/c1-15-18(4-5-19(24)23(15)25-2)20-12-30-7-8-31(11-17(30)13-34-20)22(33)9-16-3-6-21(26-10-16)32-14-27-28-29-32/h3-6,10,14,17,20H,7-9,11-13H2,1H3/t17-,20+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195963
PNG
(US9206199, 68)
Show SMILES Cc1c(csc1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C21H22N8O2S/c1-14-17(12-32-21(14)22-2)18-10-27-5-6-28(9-16(27)11-31-18)20(30)7-15-3-4-19(23-8-15)29-13-24-25-26-29/h3-4,8,12-13,16,18H,5-7,9-11H2,1H3/t16-,18-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196103
PNG
(US9206199, 7 | US9206199, 8)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])C1CN2CCN(CC2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1
Show InChI InChI=1S/C23H23FN8O2/c1-15-18(4-5-19(24)23(15)25-2)20-12-30-7-8-31(11-17(30)13-34-20)22(33)9-16-3-6-21(26-10-16)32-14-27-28-29-32/h3-6,10,14,17,20H,7-9,11-13H2,1H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195946
PNG
(US9206199, 51)
Show SMILES Fc1ccc([C@@H]2CN3CCN(C[C@H]3CO2)C(=O)Cc2ccc(nc2)-n2cnnn2)c(Cl)c1[N+]#[C-] |r|
Show InChI InChI=1S/C22H20ClFN8O2/c1-25-22-17(24)4-3-16(21(22)23)18-11-30-6-7-31(10-15(30)12-34-18)20(33)8-14-2-5-19(26-9-14)32-13-27-28-29-32/h2-5,9,13,15,18H,6-8,10-12H2/t15-,18-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195912
PNG
(US9206199, 4 | US9206199, 5)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H23FN8O2/c1-15-18(4-5-19(24)23(15)25-2)20-12-30-7-8-31(11-17(30)13-34-20)22(33)9-16-3-6-21(26-10-16)32-14-27-28-29-32/h3-6,10,14,17,20H,7-9,11-13H2,1H3/t17-,20+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196089
PNG
(US9206199, 194)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CN1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H24FN9O/c1-15-18(4-5-19(24)23(15)25-2)20-13-31-7-8-32(12-17(31)11-26-20)22(34)9-16-3-6-21(27-10-16)33-14-28-29-30-33/h3-6,10,14,17,20,26H,7-9,11-13H2,1H3/t17-,20+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195986
PNG
(US9206199, 91)
Show SMILES Cc1c(cccc1[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1)[N+]#[C-] |r|
Show InChI InChI=1S/C23H24N8O2/c1-16-19(4-3-5-20(16)24-2)21-13-29-8-9-30(12-18(29)14-33-21)23(32)10-17-6-7-22(25-11-17)31-15-26-27-28-31/h3-7,11,15,18,21H,8-10,12-14H2,1H3/t18-,21-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195948
PNG
(US9206199, 53)
Show SMILES Fc1ccc([C@@H]2CN3CCN(C[C@H]3CO2)C(=O)Cc2ccc(cn2)-n2cnnn2)c(Cl)c1[N+]#[C-] |r|
Show InChI InChI=1S/C22H20ClFN8O2/c1-25-22-18(24)5-4-17(21(22)23)19-11-30-6-7-31(10-16(30)12-34-19)20(33)8-14-2-3-15(9-26-14)32-13-27-28-29-32/h2-5,9,13,16,19H,6-8,10-12H2/t16-,19-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196032
PNG
(US9206199, 137)
Show SMILES Fc1ccc([C@H]2CN3CCN(C[C@H]3CO2)C(=O)Cc2cnc(nc2)-n2cnnn2)c(Cl)c1[N+]#[C-] |r|
Show InChI InChI=1S/C21H19ClFN9O2/c1-24-20-16(23)3-2-15(19(20)22)17-10-30-4-5-31(9-14(30)11-34-17)18(33)6-13-7-25-21(26-8-13)32-12-27-28-29-32/h2-3,7-8,12,14,17H,4-6,9-11H2/t14-,17+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195909
PNG
(US9206199, 1)
Show SMILES O=C(Cc1ccc(nc1)-n1cnnn1)N1CCN2C[C@H](OC[C@@H]2C1)c1ccc2C(=O)OCCc2c1 |r|
Show InChI InChI=1S/C24H25N7O4/c32-23(9-16-1-4-22(25-11-16)31-15-26-27-28-31)30-7-6-29-13-21(35-14-19(29)12-30)18-2-3-20-17(10-18)5-8-34-24(20)33/h1-4,10-11,15,19,21H,5-9,12-14H2/t19-,21-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196089
PNG
(US9206199, 194)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CN1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H24FN9O/c1-15-18(4-5-19(24)23(15)25-2)20-13-31-7-8-32(12-17(31)11-26-20)22(34)9-16-3-6-21(27-10-16)33-14-28-29-30-33/h3-6,10,14,17,20,26H,7-9,11-13H2,1H3/t17-,20+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195923
PNG
(US9206199, 26)
Show SMILES O=C(Cc1ccc(nc1)-n1cnnn1)N1CCN2C[C@@H](OC[C@@H]2C1)c1ccc2C(=O)OCc2c1 |r|
Show InChI InChI=1S/C23H23N7O4/c31-22(7-15-1-4-21(24-9-15)30-14-25-26-27-30)29-6-5-28-11-20(33-13-18(28)10-29)16-2-3-19-17(8-16)12-34-23(19)32/h1-4,8-9,14,18,20H,5-7,10-13H2/t18-,20+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196020
PNG
(US9206199, 125)
Show SMILES Fc1ccc([C@@H]2CN3CCN(C[C@@H]3CO2)C(=O)Cc2cnc(nc2)-n2cnnn2)c(Cl)c1[N+]#[C-] |r|
Show InChI InChI=1S/C21H19ClFN9O2/c1-24-20-16(23)3-2-15(19(20)22)17-10-30-4-5-31(9-14(30)11-34-17)18(33)6-13-7-25-21(26-8-13)32-12-27-28-29-32/h2-3,7-8,12,14,17H,4-6,9-11H2/t14-,17+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195956
PNG
(US9206199, 61)
Show SMILES COc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H23FN8O3/c1-25-22-18(24)5-4-17(23(22)34-2)19-12-30-7-8-31(11-16(30)13-35-19)21(33)9-15-3-6-20(26-10-15)32-14-27-28-29-32/h3-6,10,14,16,19H,7-9,11-13H2,2H3/t16-,19+/m0/s1
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n/an/a 70n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195912
PNG
(US9206199, 4 | US9206199, 5)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H23FN8O2/c1-15-18(4-5-19(24)23(15)25-2)20-12-30-7-8-31(11-17(30)13-34-20)22(33)9-16-3-6-21(26-10-16)32-14-27-28-29-32/h3-6,10,14,17,20H,7-9,11-13H2,1H3/t17-,20+/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196103
PNG
(US9206199, 7 | US9206199, 8)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])C1CN2CCN(CC2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1
Show InChI InChI=1S/C23H23FN8O2/c1-15-18(4-5-19(24)23(15)25-2)20-12-30-7-8-31(11-17(30)13-34-20)22(33)9-16-3-6-21(26-10-16)32-14-27-28-29-32/h3-6,10,14,17,20H,7-9,11-13H2,1H3
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n/an/a 70n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195910
PNG
(US9206199, 2)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(cn1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H23FN8O2/c1-15-19(5-6-20(24)23(15)25-2)21-12-30-7-8-31(11-18(30)13-34-21)22(33)9-16-3-4-17(10-26-16)32-14-27-28-29-32/h3-6,10,14,18,21H,7-9,11-13H2,1H3/t18-,21-/m0/s1
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n/an/a 70n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195935
PNG
(US9206199, 40)
Show SMILES COc1cc(ccc1[N+]#[C-])[C@@H]1CN2CCN(C[C@@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H24N8O3/c1-24-19-5-4-17(10-20(19)33-2)21-13-29-7-8-30(12-18(29)14-34-21)23(32)9-16-3-6-22(25-11-16)31-15-26-27-28-31/h3-6,10-11,15,18,21H,7-9,12-14H2,2H3/t18-,21+/m1/s1
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n/an/a 70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195984
PNG
(US9206199, 89)
Show SMILES Cc1nc(ccc1CC(=O)N1CCN2C[C@@H](OC[C@@H]2C1)c1ccc(F)c([N+]#[C-])c1F)-n1cnnn1 |r|
Show InChI InChI=1S/C23H22F2N8O2/c1-14-15(3-6-20(28-14)33-13-27-29-30-33)9-21(34)32-8-7-31-11-19(35-12-16(31)10-32)17-4-5-18(24)23(26-2)22(17)25/h3-6,13,16,19H,7-12H2,1H3/t16-,19+/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196087
PNG
(US9206199, 192)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CN1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H24FN9O/c1-15-18(4-5-19(24)23(15)25-2)20-13-31-7-8-32(12-17(31)11-26-20)22(34)9-16-3-6-21(27-10-16)33-14-28-29-30-33/h3-6,10,14,17,20,26H,7-9,11-13H2,1H3/t17-,20-/m1/s1
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n/an/a 70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195920
PNG
(US9206199, 23)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H]1CN2CCN(C[C@@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C24H25N7O4/c1-15-18(3-4-19-20(15)13-35-24(19)33)21-11-29-6-7-30(10-17(29)12-34-21)23(32)8-16-2-5-22(25-9-16)31-14-26-27-28-31/h2-5,9,14,17,21H,6-8,10-13H2,1H3/t17-,21+/m1/s1
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n/an/a 70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196113
PNG
(US9206199, 35)
Show SMILES C[C@@H]1Cc2cc(ccc2C(=O)O1)[C@H]1CN2CCN(CC2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C25H27N7O4/c1-16-8-19-10-18(3-4-21(19)25(34)36-16)22-13-30-6-7-31(12-20(30)14-35-22)24(33)9-17-2-5-23(26-11-17)32-15-27-28-29-32/h2-5,10-11,15-16,20,22H,6-9,12-14H2,1H3/t16-,20?,22-/m1/s1
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n/an/a 70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195962
PNG
(US9206199, 67)
Show SMILES Fc1cc(ccc1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C22H21FN8O2/c1-24-19-4-3-16(9-18(19)23)20-12-29-6-7-30(11-17(29)13-33-20)22(32)8-15-2-5-21(25-10-15)31-14-26-27-28-31/h2-5,9-10,14,17,20H,6-8,11-13H2/t17-,20+/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195914
PNG
(US9206199, 10)
Show SMILES Fc1ccc([C@H]2CN3CCN(C[C@H]3CO2)C(=O)Cc2ccc(nc2)-n2cnnn2)c(Cl)c1[N+]#[C-] |r|
Show InChI InChI=1S/C22H20ClFN8O2/c1-25-22-17(24)4-3-16(21(22)23)18-11-30-6-7-31(10-15(30)12-34-18)20(33)8-14-2-5-19(26-9-14)32-13-27-28-29-32/h2-5,9,13,15,18H,6-8,10-12H2/t15-,18+/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195928
PNG
(US9206199, 32)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@@H]2CO1)C(=O)Cc1ccc(cn1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H23FN8O2/c1-15-19(5-6-20(24)23(15)25-2)21-12-30-7-8-31(11-18(30)13-34-21)22(33)9-16-3-4-17(10-26-16)32-14-27-28-29-32/h3-6,10,14,18,21H,7-9,11-13H2,1H3/t18-,21+/m1/s1
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n/an/a 80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195909
PNG
(US9206199, 1)
Show SMILES O=C(Cc1ccc(nc1)-n1cnnn1)N1CCN2C[C@H](OC[C@@H]2C1)c1ccc2C(=O)OCCc2c1 |r|
Show InChI InChI=1S/C24H25N7O4/c32-23(9-16-1-4-22(25-11-16)31-15-26-27-28-31)30-7-6-29-13-21(35-14-19(29)12-30)18-2-3-20-17(10-18)5-8-34-24(20)33/h1-4,10-11,15,19,21H,5-9,12-14H2/t19-,21-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195929
PNG
(US9206199, 33)
Show SMILES C[C@H]1Cc2cc(ccc2C(=O)O1)[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C25H27N7O4/c1-16-8-19-10-18(3-4-21(19)25(34)36-16)22-13-30-6-7-31(12-20(30)14-35-22)24(33)9-17-2-5-23(26-11-17)32-15-27-28-29-32/h2-5,10-11,15-16,20,22H,6-9,12-14H2,1H3/t16-,20-,22-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195945
PNG
(US9206199, 50)
Show SMILES COc1ccc([C@@H]2CN3CCN(C[C@H]3CO2)C(=O)Cc2ccc(nc2)-n2cnnn2)c(C)c1[N+]#[C-] |r|
Show InChI InChI=1S/C24H26N8O3/c1-16-19(5-6-20(34-3)24(16)25-2)21-13-30-8-9-31(12-18(30)14-35-21)23(33)10-17-4-7-22(26-11-17)32-15-27-28-29-32/h4-7,11,15,18,21H,8-10,12-14H2,1,3H3/t18-,21-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196105
PNG
(US9206199, 13 | US9206199, 14 | US9206199, 9)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])C1CN2CCN(CC2CO1)C(=O)Cc1cnc(nc1)-n1cnnn1
Show InChI InChI=1S/C22H22FN9O2/c1-14-17(3-4-18(23)21(14)24-2)19-11-30-5-6-31(10-16(30)12-34-19)20(33)7-15-8-25-22(26-9-15)32-13-27-28-29-32/h3-4,8-9,13,16,19H,5-7,10-12H2,1H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196043
PNG
(US9206199, 148)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1cnc(c(F)c1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H22F2N8O2/c1-14-17(3-4-18(24)22(14)26-2)20-11-31-5-6-32(10-16(31)12-35-20)21(34)8-15-7-19(25)23(27-9-15)33-13-28-29-30-33/h3-4,7,9,13,16,20H,5-6,8,10-12H2,1H3/t16-,20-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195929
PNG
(US9206199, 33)
Show SMILES C[C@H]1Cc2cc(ccc2C(=O)O1)[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C25H27N7O4/c1-16-8-19-10-18(3-4-21(19)25(34)36-16)22-13-30-6-7-31(12-20(30)14-35-22)24(33)9-17-2-5-23(26-11-17)32-15-27-28-29-32/h2-5,10-11,15-16,20,22H,6-9,12-14H2,1H3/t16-,20-,22-/m0/s1
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n/an/a 80n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195983
PNG
(US9206199, 88)
Show SMILES Fc1ccc([C@@H]2CN3CCN(C[C@@H]3CO2)C(=O)Cc2ccc(nc2)-n2cnnn2)c(F)c1[N+]#[C-] |r|
Show InChI InChI=1S/C22H20F2N8O2/c1-25-22-17(23)4-3-16(21(22)24)18-11-30-6-7-31(10-15(30)12-34-18)20(33)8-14-2-5-19(26-9-14)32-13-27-28-29-32/h2-5,9,13,15,18H,6-8,10-12H2/t15-,18+/m1/s1
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n/an/a 90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196016
PNG
(US9206199, 121)
Show SMILES Cc1nc(ncc1CC(=O)N1CCN2C[C@@H](OC[C@@H]2C1)c1ccc(F)c([N+]#[C-])c1C)-n1cnnn1 |r|
Show InChI InChI=1S/C23H24FN9O2/c1-14-18(4-5-19(24)22(14)25-3)20-11-31-6-7-32(10-17(31)12-35-20)21(34)8-16-9-26-23(28-15(16)2)33-13-27-29-30-33/h4-5,9,13,17,20H,6-8,10-12H2,1-2H3/t17-,20+/m0/s1
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n/an/a 90n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195942
PNG
(US9206199, 47)
Show SMILES Clc1c2COC(=O)c2ccc1[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H22ClN7O4/c24-22-17(3-2-16-18(22)12-35-23(16)33)19-10-29-5-6-30(9-15(29)11-34-19)21(32)7-14-1-4-20(25-8-14)31-13-26-27-28-31/h1-4,8,13,15,19H,5-7,9-12H2/t15-,19+/m0/s1
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n/an/a 90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195911
PNG
(US9206199, 3)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(cn1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H23FN8O2/c1-15-19(5-6-20(24)23(15)25-2)21-12-30-7-8-31(11-18(30)13-34-21)22(33)9-16-3-4-17(10-26-16)32-14-27-28-29-32/h3-6,10,14,18,21H,7-9,11-13H2,1H3/t18-,21+/m0/s1
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n/an/a 90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195938
PNG
(US9206199, 43)
Show SMILES Cc1cc(ncc1CC(=O)N1CCN2C[C@@H](OC[C@@H]2C1)c1ccc(F)c([N+]#[C-])c1C)-n1cnnn1 |r|
Show InChI InChI=1S/C24H25FN8O2/c1-15-8-22(33-14-28-29-30-33)27-10-17(15)9-23(34)32-7-6-31-12-21(35-13-18(31)11-32)19-4-5-20(25)24(26-3)16(19)2/h4-5,8,10,14,18,21H,6-7,9,11-13H2,1-2H3/t18-,21+/m0/s1
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n/an/a 90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196106
PNG
(US9206199, 11)
Show SMILES Fc1ccc(C2CN3CCN(CC3CO2)C(=O)Cc2ccc(nc2)-n2cnnn2)c(F)c1[N+]#[C-]
Show InChI InChI=1S/C22H20F2N8O2/c1-25-22-17(23)4-3-16(21(22)24)18-11-30-6-7-31(10-15(30)12-34-18)20(33)8-14-2-5-19(26-9-14)32-13-27-28-29-32/h2-5,9,13,15,18H,6-8,10-12H2
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n/an/a 90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196022
PNG
(US9206199, 127)
Show SMILES Cc1nc(CC(=O)N2CCN3C[C@@H](OC[C@@H]3C2)c2ccc(F)c([N+]#[C-])c2C)ccc1-n1cnnn1 |r|
Show InChI InChI=1S/C24H25FN8O2/c1-15-19(5-6-20(25)24(15)26-3)22-12-31-8-9-32(11-18(31)13-35-22)23(34)10-17-4-7-21(16(2)28-17)33-14-27-29-30-33/h4-7,14,18,22H,8-13H2,1-2H3/t18-,22+/m0/s1
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n/an/a 90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196041
PNG
(US9206199, 146)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@@H]2CO1)C(=O)Cc1cnc(c(F)c1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H22F2N8O2/c1-14-17(3-4-18(24)22(14)26-2)20-11-31-5-6-32(10-16(31)12-35-20)21(34)8-15-7-19(25)23(27-9-15)33-13-28-29-30-33/h3-4,7,9,13,16,20H,5-6,8,10-12H2,1H3/t16-,20+/m1/s1
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n/an/a 90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195913
PNG
(US9206199, 6)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1cnc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C22H22FN9O2/c1-14-17(3-4-18(23)21(14)24-2)19-11-30-5-6-31(10-16(30)12-34-19)20(33)7-15-8-25-22(26-9-15)32-13-27-28-29-32/h3-4,8-9,13,16,19H,5-7,10-12H2,1H3/t16-,19+/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195918
PNG
(US9206199, 21)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C24H25N7O4/c1-15-18(3-4-19-20(15)13-35-24(19)33)21-11-29-6-7-30(10-17(29)12-34-21)23(32)8-16-2-5-22(25-9-16)31-14-26-27-28-31/h2-5,9,14,17,21H,6-8,10-13H2,1H3/t17-,21+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195911
PNG
(US9206199, 3)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(cn1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H23FN8O2/c1-15-19(5-6-20(24)23(15)25-2)21-12-30-7-8-31(11-18(30)13-34-21)22(33)9-16-3-4-17(10-26-16)32-14-27-28-29-32/h3-6,10,14,18,21H,7-9,11-13H2,1H3/t18-,21+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196088
PNG
(US9206199, 193)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CN1)C(=O)Cc1cnc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C22H23FN10O/c1-14-17(3-4-18(23)21(14)24-2)19-12-31-5-6-32(11-16(31)10-25-19)20(34)7-15-8-26-22(27-9-15)33-13-28-29-30-33/h3-4,8-9,13,16,19,25H,5-7,10-12H2,1H3/t16-,19+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195949
PNG
(US9206199, 54)
Show SMILES Fc1ccc([C@@H]2CN3CCN(C[C@H]3CO2)C(=O)Cc2ccc(cn2)-n2cnnn2)c(F)c1[N+]#[C-] |r|
Show InChI InChI=1S/C22H20F2N8O2/c1-25-22-18(23)5-4-17(21(22)24)19-11-30-6-7-31(10-16(30)12-34-19)20(33)8-14-2-3-15(9-26-14)32-13-27-28-29-32/h2-5,9,13,16,19H,6-8,10-12H2/t16-,19-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196037
PNG
(US9206199, 142)
Show SMILES Fc1ccc(cc1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1cnc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C21H20FN9O2/c1-23-18-7-15(2-3-17(18)22)19-11-29-4-5-30(10-16(29)12-33-19)20(32)6-14-8-24-21(25-9-14)31-13-26-27-28-31/h2-3,7-9,13,16,19H,4-6,10-12H2/t16-,19-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 217 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%