BDBM195984 US9206199, 89

SMILES: Cc1nc(ccc1CC(=O)N1CCN2C[C@@H](OC[C@@H]2C1)c1ccc(F)c([N+]#[C-])c1F)-n1cnnn1

InChI Key: InChIKey=UMBGDTWHQRFWRS-QFBILLFUSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 195984   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM195984 (US9206199, 89) Show SMILES Cc1nc(ccc1CC(=O)N1CCN2C[C@@H](OC[C@@H]2C1)c1ccc(F)c([N+]#[C-])c1F)-n1cnnn1 |r| Show InChI InChI=1S/C23H22F2N8O2/c1-14-15(3-6-20(28-14)33-13-27-29-30-33)9-21(34)32-8-7-31-11-19(35-12-16(31)10-32)17-4-5-18(24)23(26-2)22(17)25/h3-6,13,16,19H,7-12H2,1H3/t16-,19+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...				US Patent US9206199 (2015) BindingDB Entry DOI: 10.7270/Q2VH5MND
					More data for this Ligand-Target Pair