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Patent code US9206199

Compile Data Set for Download or QSAR

Found 217 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196007
PNG
(US9206199, 112)
Show SMILES COc1cc(cc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H23FN8O3/c1-25-23-18(24)8-16(9-19(23)34-2)20-12-30-5-6-31(11-17(30)13-35-20)22(33)7-15-3-4-21(26-10-15)32-14-27-28-29-32/h3-4,8-10,14,17,20H,5-7,11-13H2,2H3/t17-,20-/m1/s1
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n/an/a 220n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196018
PNG
(US9206199, 123)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H]1CN2CCN(C[C@@H]2CO1)C(=O)Cc1cnc(cn1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H24N8O4/c1-14-17(2-3-18-19(14)12-35-23(18)33)20-10-29-4-5-30(9-16(29)11-34-20)22(32)6-15-7-25-21(8-24-15)31-13-26-27-28-31/h2-3,7-8,13,16,20H,4-6,9-12H2,1H3/t16-,20+/m1/s1
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n/an/a 690n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196021
PNG
(US9206199, 126)
Show SMILES Fc1ccc([C@H]2CN3CCN(C[C@@H]3CO2)C(=O)Cc2cnc(nc2)-n2cnnn2)c(Cl)c1[N+]#[C-] |r|
Show InChI InChI=1S/C21H19ClFN9O2/c1-24-20-16(23)3-2-15(19(20)22)17-10-30-4-5-31(9-14(30)11-34-17)18(33)6-13-7-25-21(26-8-13)32-12-27-28-29-32/h2-3,7-8,12,14,17H,4-6,9-11H2/t14-,17-/m1/s1
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n/an/a 140n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196024
PNG
(US9206199, 129)
Show SMILES Cc1cc(CC(=O)N2CCN3C[C@H](OC[C@H]3C2)c2ccc(F)c([N+]#[C-])c2C)ncc1-n1cnnn1 |r|
Show InChI InChI=1S/C24H25FN8O2/c1-15-8-17(27-10-21(15)33-14-28-29-30-33)9-23(34)32-7-6-31-12-22(35-13-18(31)11-32)19-4-5-20(25)24(26-3)16(19)2/h4-5,8,10,14,18,22H,6-7,9,11-13H2,1-2H3/t18-,22+/m1/s1
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n/an/a 250n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196029
PNG
(US9206199, 134)
Show SMILES Cc1cc(CC(=O)N2CCN3C[C@@H](OC[C@H]3C2)c2ccc(F)c([N+]#[C-])c2C)cnc1-n1cnnn1 |r|
Show InChI InChI=1S/C24H25FN8O2/c1-15-8-17(10-27-24(15)33-14-28-29-30-33)9-22(34)32-7-6-31-12-21(35-13-18(31)11-32)19-4-5-20(25)23(26-3)16(19)2/h4-5,8,10,14,18,21H,6-7,9,11-13H2,1-2H3/t18-,21-/m1/s1
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n/an/a 280n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196033
PNG
(US9206199, 138)
Show SMILES Cc1nc(ncc1CC(=O)N1CCN2C[C@H](OC[C@H]2C1)c1ccc(F)c([N+]#[C-])c1Cl)-n1cnnn1 |r|
Show InChI InChI=1S/C22H21ClFN9O2/c1-13-14(8-26-22(28-13)33-12-27-29-30-33)7-19(34)32-6-5-31-10-18(35-11-15(31)9-32)16-3-4-17(24)21(25-2)20(16)23/h3-4,8,12,15,18H,5-7,9-11H2,1H3/t15-,18+/m1/s1
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n/an/a 140n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196054
PNG
(US9206199, 159)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1cnc(nc1C(F)(F)F)-n1cnnn1 |r|
Show InChI InChI=1S/C23H21F4N9O2/c1-13-16(3-4-17(24)20(13)28-2)18-10-34-5-6-35(9-15(34)11-38-18)19(37)7-14-8-29-22(36-12-30-32-33-36)31-21(14)23(25,26)27/h3-4,8,12,15,18H,5-7,9-11H2,1H3/t15-,18-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196062
PNG
(US9206199, 167)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H]1CN2CCN(C[C@H]2CS1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C24H25N7O3S/c1-15-18(3-4-19-20(15)12-34-24(19)33)21-11-29-6-7-30(10-17(29)13-35-21)23(32)8-16-2-5-22(25-9-16)31-14-26-27-28-31/h2-5,9,14,17,21H,6-8,10-13H2,1H3/t17-,21+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196064
PNG
(US9206199, 169 | US9206199, 170 | US9206199, 171)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])C1CN2CCN(CC2CCO1)C(=O)Cc1ccc(nc1)-n1cnnn1
Show InChI InChI=1S/C24H25FN8O2/c1-16-19(4-5-20(25)24(16)26-2)21-14-31-8-9-32(13-18(31)7-10-35-21)23(34)11-17-3-6-22(27-12-17)33-15-28-29-30-33/h3-6,12,15,18,21H,7-11,13-14H2,1H3
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n/an/a 240n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196070
PNG
(US9206199, 175)
Show SMILES O=C(Cc1cnc(nc1)-n1cnnn1)N1CCN2C[C@H](OC[C@@H]2C1)c1ccc2nonc2c1 |r|
Show InChI InChI=1S/C20H20N10O3/c31-19(5-13-7-21-20(22-8-13)30-12-23-26-27-30)29-4-3-28-10-18(32-11-15(28)9-29)14-1-2-16-17(6-14)25-33-24-16/h1-2,6-8,12,15,18H,3-5,9-11H2/t15-,18-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196088
PNG
(US9206199, 193)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CN1)C(=O)Cc1cnc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C22H23FN10O/c1-14-17(3-4-18(23)21(14)24-2)19-12-31-5-6-32(11-16(31)10-25-19)20(34)7-15-8-26-22(27-9-15)33-13-28-29-30-33/h3-4,8-9,13,16,19,25H,5-7,10-12H2,1H3/t16-,19+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196089
PNG
(US9206199, 194)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CN1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H24FN9O/c1-15-18(4-5-19(24)23(15)25-2)20-13-31-7-8-32(12-17(31)11-26-20)22(34)9-16-3-6-21(27-10-16)33-14-28-29-30-33/h3-6,10,14,17,20,26H,7-9,11-13H2,1H3/t17-,20+/m1/s1
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n/an/a 60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195910
PNG
(US9206199, 2)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(cn1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H23FN8O2/c1-15-19(5-6-20(24)23(15)25-2)21-12-30-7-8-31(11-18(30)13-34-21)22(33)9-16-3-4-17(10-26-16)32-14-27-28-29-32/h3-6,10,14,18,21H,7-9,11-13H2,1H3/t18-,21-/m0/s1
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n/an/a 70n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195933
PNG
(US9206199, 38)
Show SMILES Fc1ccc(cc1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(cn1)-n1cnnn1 |r|
Show InChI InChI=1S/C22H21FN8O2/c1-24-20-8-15(2-5-19(20)23)21-12-29-6-7-30(11-18(29)13-33-21)22(32)9-16-3-4-17(10-25-16)31-14-26-27-28-31/h2-5,8,10,14,18,21H,6-7,9,11-13H2/t18-,21-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195914
PNG
(US9206199, 10)
Show SMILES Fc1ccc([C@H]2CN3CCN(C[C@H]3CO2)C(=O)Cc2ccc(nc2)-n2cnnn2)c(Cl)c1[N+]#[C-] |r|
Show InChI InChI=1S/C22H20ClFN8O2/c1-25-22-17(24)4-3-16(21(22)23)18-11-30-6-7-31(10-15(30)12-34-18)20(33)8-14-2-5-19(26-9-14)32-13-27-28-29-32/h2-5,9,13,15,18H,6-8,10-12H2/t15-,18+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195924
PNG
(US9206199, 27)
Show SMILES O=C(Cc1ccc(cn1)-n1cnnn1)N1CCN2C[C@H](OC[C@@H]2C1)c1ccc2C(=O)OCc2c1 |r|
Show InChI InChI=1S/C23H23N7O4/c31-22(8-17-2-3-18(9-24-17)30-14-25-26-27-30)29-6-5-28-11-21(33-13-19(28)10-29)15-1-4-20-16(7-15)12-34-23(20)32/h1-4,7,9,14,19,21H,5-6,8,10-13H2/t19-,21-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196101
PNG
(US9206199, 30)
Show SMILES Cc1nc(ccc1CC(=O)N1CCN2C[C@@H](OCC2C1)c1ccc2C(=O)OCCc2c1)-n1cnnn1 |r|
Show InChI InChI=1S/C25H27N7O4/c1-16-17(3-5-23(27-16)32-15-26-28-29-32)11-24(33)31-8-7-30-13-22(36-14-20(30)12-31)19-2-4-21-18(10-19)6-9-35-25(21)34/h2-5,10,15,20,22H,6-9,11-14H2,1H3/t20?,22-/m1/s1
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n/an/a 160n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195931
PNG
(US9206199, 35)
Show SMILES C[C@H]1Cc2cc(ccc2C(=O)O1)[C@H]1CN2CCN(C[C@@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C25H27N7O4/c1-16-8-19-10-18(3-4-21(19)25(34)36-16)22-13-30-6-7-31(12-20(30)14-35-22)24(33)9-17-2-5-23(26-11-17)32-15-27-28-29-32/h2-5,10-11,15-16,20,22H,6-9,12-14H2,1H3/t16-,20+,22+/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195942
PNG
(US9206199, 47)
Show SMILES Clc1c2COC(=O)c2ccc1[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H22ClN7O4/c24-22-17(3-2-16-18(22)12-35-23(16)33)19-10-29-5-6-30(9-15(29)11-34-19)21(32)7-14-1-4-20(25-8-14)31-13-26-27-28-31/h1-4,8,13,15,19H,5-7,9-12H2/t15-,19+/m0/s1
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n/an/a 90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195954
PNG
(US9206199, 59)
Show SMILES Cc1cc(ncc1CC(=O)N1CCN2C[C@@H](OC[C@H]2C1)c1ccc(F)c([N+]#[C-])c1C)-n1cnnn1 |r|
Show InChI InChI=1S/C24H25FN8O2/c1-15-8-22(33-14-28-29-30-33)27-10-17(15)9-23(34)32-7-6-31-12-21(35-13-18(31)11-32)19-4-5-20(25)24(26-3)16(19)2/h4-5,8,10,14,18,21H,6-7,9,11-13H2,1-2H3/t18-,21-/m1/s1
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n/an/a 140n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195958
PNG
(US9206199, 63)
Show SMILES COc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(cn1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H23FN8O3/c1-25-22-19(24)6-5-18(23(22)34-2)20-12-30-7-8-31(11-17(30)13-35-20)21(33)9-15-3-4-16(10-26-15)32-14-27-28-29-32/h3-6,10,14,17,20H,7-9,11-13H2,2H3/t17-,20+/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195963
PNG
(US9206199, 68)
Show SMILES Cc1c(csc1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C21H22N8O2S/c1-14-17(12-32-21(14)22-2)18-10-27-5-6-28(9-16(27)11-31-18)20(30)7-15-3-4-19(23-8-15)29-13-24-25-26-29/h3-4,8,12-13,16,18H,5-7,9-11H2,1H3/t16-,18-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195965
PNG
(US9206199, 70)
Show SMILES Cc1c(csc1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(cn1)-n1cnnn1 |r|
Show InChI InChI=1S/C21H22N8O2S/c1-14-18(12-32-21(14)22-2)19-10-27-5-6-28(9-17(27)11-31-19)20(30)7-15-3-4-16(8-23-15)29-13-24-25-26-29/h3-4,8,12-13,17,19H,5-7,9-11H2,1H3/t17-,19-/m0/s1
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n/an/a 270n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195968
PNG
(US9206199, 73)
Show SMILES Cc1cc2C(=O)OCc2cc1[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C24H25N7O4/c1-15-6-20-17(12-35-24(20)33)8-19(15)21-11-29-4-5-30(10-18(29)13-34-21)23(32)7-16-2-3-22(25-9-16)31-14-26-27-28-31/h2-3,6,8-9,14,18,21H,4-5,7,10-13H2,1H3/t18-,21+/m0/s1
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n/an/a 230n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195969
PNG
(US9206199, 74)
Show SMILES Cc1c(cncc1[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1)[N+]#[C-] |r|
Show InChI InChI=1S/C22H23N9O2/c1-15-18(9-24-10-19(15)23-2)20-12-29-5-6-30(11-17(29)13-33-20)22(32)7-16-3-4-21(25-8-16)31-14-26-27-28-31/h3-4,8-10,14,17,20H,5-7,11-13H2,1H3/t17-,20-/m0/s1
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n/an/a 390n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195970
PNG
(US9206199, 75)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1cnc(cn1)-n1cnnn1 |r|
Show InChI InChI=1S/C22H22FN9O2/c1-14-17(3-4-18(23)22(14)24-2)19-11-30-5-6-31(10-16(30)12-34-19)21(33)7-15-8-26-20(9-25-15)32-13-27-28-29-32/h3-4,8-9,13,16,19H,5-7,10-12H2,1H3/t16-,19-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195978
PNG
(US9206199, 83)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1cnc(cn1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H24N8O4/c1-14-17(2-3-18-19(14)12-35-23(18)33)20-10-29-4-5-30(9-16(29)11-34-20)22(32)6-15-7-25-21(8-24-15)31-13-26-27-28-31/h2-3,7-8,13,16,20H,4-6,9-12H2,1H3/t16-,20+/m0/s1
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n/an/a 160n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195980
PNG
(US9206199, 85)
Show SMILES Cc1cc(cnc1CC(=O)N1CCN2C[C@@H](OC[C@@H]2C1)c1ccc(F)c([N+]#[C-])c1C)-n1cnnn1 |r|
Show InChI InChI=1S/C24H25FN8O2/c1-15-8-17(33-14-28-29-30-33)10-27-21(15)9-23(34)32-7-6-31-12-22(35-13-18(31)11-32)19-4-5-20(25)24(26-3)16(19)2/h4-5,8,10,14,18,22H,6-7,9,11-13H2,1-2H3/t18-,22+/m0/s1
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n/an/a 240n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195981
PNG
(US9206199, 86)
Show SMILES Fc1ccc([C@H]2CN3CCN(C[C@H]3CO2)C(=O)Cc2ccc(cn2)-n2cnnn2)c(F)c1[N+]#[C-] |r|
Show InChI InChI=1S/C22H20F2N8O2/c1-25-22-18(23)5-4-17(21(22)24)19-11-30-6-7-31(10-16(30)12-34-19)20(33)8-14-2-3-15(9-26-14)32-13-27-28-29-32/h2-5,9,13,16,19H,6-8,10-12H2/t16-,19+/m0/s1
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n/an/a 290n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195987
PNG
(US9206199, 92)
Show SMILES Cc1nc(ccc1CC(=O)N1CCN2C[C@@H](OC[C@@H]2C1)c1cccc([N+]#[C-])c1C)-n1cnnn1 |r|
Show InChI InChI=1S/C24H26N8O2/c1-16-20(5-4-6-21(16)25-3)22-13-30-9-10-31(12-19(30)14-34-22)24(33)11-18-7-8-23(27-17(18)2)32-15-26-28-29-32/h4-8,15,19,22H,9-14H2,1-2H3/t19-,22+/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195994
PNG
(US9206199, 99)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccnc(c1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H23FN8O2/c1-15-18(3-4-19(24)23(15)25-2)20-12-30-7-8-31(11-17(30)13-34-20)22(33)10-16-5-6-26-21(9-16)32-14-27-28-29-32/h3-6,9,14,17,20H,7-8,10-13H2,1H3/t17-,20-/m0/s1
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n/an/a 340n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196002
PNG
(US9206199, 107)
Show SMILES Fc1cc(cc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@@H]2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C22H20F2N8O2/c1-25-22-17(23)7-15(8-18(22)24)19-11-30-4-5-31(10-16(30)12-34-19)21(33)6-14-2-3-20(26-9-14)32-13-27-28-29-32/h2-3,7-9,13,16,19H,4-6,10-12H2/t16-,19+/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196014
PNG
(US9206199, 119)
Show SMILES Cc1nc(ncc1CC(=O)N1CCN2C[C@@H](OC[C@H]2C1)c1ccc(F)c([N+]#[C-])c1C)-n1cnnn1 |r|
Show InChI InChI=1S/C23H24FN9O2/c1-14-18(4-5-19(24)22(14)25-3)20-11-31-6-7-32(10-17(31)12-35-20)21(34)8-16-9-26-23(28-15(16)2)33-13-27-29-30-33/h4-5,9,13,17,20H,6-8,10-12H2,1-2H3/t17-,20-/m1/s1
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n/an/a 330n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196019
PNG
(US9206199, 124)
Show SMILES COc1cc(cnc1CC(=O)N1CCN2C[C@H](OC[C@H]2C1)c1ccc(F)c([N+]#[C-])c1C)-n1cnnn1 |r|
Show InChI InChI=1S/C24H25FN8O3/c1-15-18(4-5-19(25)24(15)26-2)22-12-31-6-7-32(11-17(31)13-36-22)23(34)9-20-21(35-3)8-16(10-27-20)33-14-28-29-30-33/h4-5,8,10,14,17,22H,6-7,9,11-13H2,1,3H3/t17-,22+/m1/s1
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n/an/a 330n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196040
PNG
(US9206199, 145)
Show SMILES O=C(Cc1cnc(nc1)-n1cnnn1)N1CCN2C[C@H](OC[C@@H]2C1)c1ccc2C(=O)OCCc2c1 |r|
Show InChI InChI=1S/C23H24N8O4/c32-21(7-15-9-24-23(25-10-15)31-14-26-27-28-31)30-5-4-29-12-20(35-13-18(29)11-30)17-1-2-19-16(8-17)3-6-34-22(19)33/h1-2,8-10,14,18,20H,3-7,11-13H2/t18-,20-/m0/s1
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n/an/a 240n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196057
PNG
(US9206199, 162)
Show SMILES Cc1nnnn1-c1ccc(CC(=O)N2CCN3C[C@H](OC[C@@H]3C2)c2ccc(F)c([N+]#[C-])c2C)nc1 |r|
Show InChI InChI=1S/C24H25FN8O2/c1-15-20(6-7-21(25)24(15)26-3)22-13-31-8-9-32(12-19(31)14-35-22)23(34)10-17-4-5-18(11-27-17)33-16(2)28-29-30-33/h4-7,11,19,22H,8-10,12-14H2,1-2H3/t19-,22-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196061
PNG
(US9206199, 166)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H]1CN2CCN(C[C@H]2CS1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C24H25N7O3S/c1-15-18(3-4-19-20(15)12-34-24(19)33)21-11-29-6-7-30(10-17(29)13-35-21)23(32)8-16-2-5-22(25-9-16)31-14-26-27-28-31/h2-5,9,14,17,21H,6-8,10-13H2,1H3/t17-,21-/m0/s1
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n/an/a 380n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196069
PNG
(US9206199, 174)
Show SMILES Cc1cc([C@@H]2CN3CCN(C[C@@H]3CO2)C(=O)Cc2ccc(nc2)-n2cnnn2)c(C)c([N+]#[C-])c1F |r|
Show InChI InChI=1S/C24H25FN8O2/c1-15-8-19(16(2)24(26-3)23(15)25)20-12-31-6-7-32(11-18(31)13-35-20)22(34)9-17-4-5-21(27-10-17)33-14-28-29-30-33/h4-5,8,10,14,18,20H,6-7,9,11-13H2,1-2H3/t18-,20+/m1/s1
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n/an/a 350n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196076
PNG
(US9206199, 181)
Show SMILES Fc1ccc([C@H]2CN3CCN(C[C@H]3CO2)C(=O)Cc2ccc(nc2)-n2cnnn2)c(C2CC2)c1[N+]#[C-] |r|
Show InChI InChI=1S/C25H25FN8O2/c1-27-25-20(26)6-5-19(24(25)17-3-4-17)21-13-32-8-9-33(12-18(32)14-36-21)23(35)10-16-2-7-22(28-11-16)34-15-29-30-31-34/h2,5-7,11,15,17-18,21H,3-4,8-10,12-14H2/t18-,21+/m0/s1
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n/an/a 380n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196077
PNG
(US9206199, 182)
Show SMILES C[C@@H]1Cc2cc(ccc2C(=O)O1)C1CN2CCN(CC2(C)CO1)C(=O)Cc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C26H29N7O4/c1-17-9-20-11-19(4-5-21(20)25(35)37-17)22-13-32-8-7-31(14-26(32,2)15-36-22)24(34)10-18-3-6-23(27-12-18)33-16-28-29-30-33/h3-6,11-12,16-17,22H,7-10,13-15H2,1-2H3/t17-,22?,26?/m1/s1
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n/an/a 320n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196081
PNG
(US9206199, 186)
Show SMILES Cc1c(ccc(F)c1C#N)[C@H]1CN2CCN(C[C@H]2CS1)C(=O)Cc1ccc(cn1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H23FN8OS/c1-15-19(4-5-21(24)20(15)9-25)22-12-30-6-7-31(11-18(30)13-34-22)23(33)8-16-2-3-17(10-26-16)32-14-27-28-29-32/h2-5,10,14,18,22H,6-8,11-13H2,1H3/t18-,22+/m0/s1
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n/an/a 270n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196092
PNG
(US9206199, 197)
Show SMILES Fc1ccc(cc1[N+]#[C-])[C@@H]1CN2CCN(C[C@H]2CN1)C(=O)Cc1cnc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C21H21FN10O/c1-23-18-7-15(2-3-17(18)22)19-12-30-4-5-31(11-16(30)10-24-19)20(33)6-14-8-25-21(26-9-14)32-13-27-28-29-32/h2-3,7-9,13,16,19,24H,4-6,10-12H2/t16-,19+/m1/s1
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n/an/a 240n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196094
PNG
(US9206199, 199)
Show SMILES Cc1c(ccc(F)c1C#N)[C@@H]1CN2CCN(C[C@@H]2CO1)C(=O)Nc1ccc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C22H22FN9O2/c1-14-17(3-4-19(23)18(14)8-24)20-11-30-6-7-31(10-16(30)12-34-20)22(33)27-15-2-5-21(25-9-15)32-13-26-28-29-32/h2-5,9,13,16,20H,6-7,10-12H2,1H3,(H,27,33)/t16-,20+/m1/s1
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n/an/a 140n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195909
PNG
(US9206199, 1)
Show SMILES O=C(Cc1ccc(nc1)-n1cnnn1)N1CCN2C[C@H](OC[C@@H]2C1)c1ccc2C(=O)OCCc2c1 |r|
Show InChI InChI=1S/C24H25N7O4/c32-23(9-16-1-4-22(25-11-16)31-15-26-27-28-31)30-7-6-29-13-21(35-14-19(29)12-30)18-2-3-20-17(10-18)5-8-34-24(20)33/h1-4,10-11,15,19,21H,5-9,12-14H2/t19-,21-/m0/s1
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n/an/a 60n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196103
PNG
(US9206199, 7 | US9206199, 8)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])C1CN2CCN(CC2CO1)C(=O)Cc1ccc(nc1)-n1cnnn1
Show InChI InChI=1S/C23H23FN8O2/c1-15-18(4-5-19(24)23(15)25-2)20-12-30-7-8-31(11-17(30)13-34-20)22(33)9-16-3-6-21(26-10-16)32-14-27-28-29-32/h3-6,10,14,17,20H,7-9,11-13H2,1H3
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n/an/a 70n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196105
PNG
(US9206199, 13 | US9206199, 14 | US9206199, 9)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])C1CN2CCN(CC2CO1)C(=O)Cc1cnc(nc1)-n1cnnn1
Show InChI InChI=1S/C22H22FN9O2/c1-14-17(3-4-18(23)21(14)24-2)19-11-30-5-6-31(10-16(30)12-34-19)20(33)7-15-8-25-22(26-9-15)32-13-27-28-29-32/h3-4,8-9,13,16,19H,5-7,10-12H2,1H3
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n/an/a 30n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196106
PNG
(US9206199, 11)
Show SMILES Fc1ccc(C2CN3CCN(CC3CO2)C(=O)Cc2ccc(nc2)-n2cnnn2)c(F)c1[N+]#[C-]
Show InChI InChI=1S/C22H20F2N8O2/c1-25-22-17(23)4-3-16(21(22)24)18-11-30-6-7-31(10-15(30)12-34-18)20(33)8-14-2-5-19(26-9-14)32-13-27-28-29-32/h2-5,9,13,15,18H,6-8,10-12H2
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n/an/a 90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM196105
PNG
(US9206199, 13 | US9206199, 14 | US9206199, 9)
Show SMILES Cc1c(ccc(F)c1[N+]#[C-])C1CN2CCN(CC2CO1)C(=O)Cc1cnc(nc1)-n1cnnn1
Show InChI InChI=1S/C22H22FN9O2/c1-14-17(3-4-18(23)21(14)24-2)19-11-30-5-6-31(10-16(30)12-34-19)20(33)7-15-8-25-22(26-9-15)32-13-27-28-29-32/h3-4,8-9,13,16,19H,5-7,10-12H2,1H3
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n/an/a 80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195916
PNG
(US9206199, 15)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1cnc(nc1)-n1cnnn1 |r|
Show InChI InChI=1S/C23H24N8O4/c1-14-17(2-3-18-19(14)12-35-22(18)33)20-10-29-4-5-30(9-16(29)11-34-20)21(32)6-15-7-24-23(25-8-15)31-13-26-27-28-31/h2-3,7-8,13,16,20H,4-6,9-12H2,1H3/t16-,20+/m0/s1
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n/an/a 140n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195917
PNG
(US9206199, 18)
Show SMILES Cc1c(cccc1[C@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1cnc(nc1)-n1cnnn1)[N+]#[C-] |r|
Show InChI InChI=1S/C22H23N9O2/c1-15-18(4-3-5-19(15)23-2)20-12-29-6-7-30(11-17(29)13-33-20)21(32)8-16-9-24-22(25-10-16)31-14-26-27-28-31/h3-5,9-10,14,17,20H,6-8,11-13H2,1H3/t17-,20+/m0/s1
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n/an/a 320n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 217 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%