null

SMILES: Cc1c(ccc(F)c1[N+]#[C-])C1CN2CCN(CC2CCO1)C(=O)Cc1ccc(nc1)-n1cnnn1

InChI Key: InChIKey=YYLKTLHBSVNPLY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 196064   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM196064 (US9206199, 169 | US9206199, 170 | US9206199, 171) Show SMILES Cc1c(ccc(F)c1[N+]#[C-])C1CN2CCN(CC2CCO1)C(=O)Cc1ccc(nc1)-n1cnnn1 Show InChI InChI=1S/C24H25FN8O2/c1-16-19(4-5-20(25)24(16)26-2)21-14-31-8-9-32(13-18(31)7-10-35-21)23(34)11-17-3-6-22(27-12-17)33-15-28-29-30-33/h3-6,12,15,18,21H,7-11,13-14H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...				US Patent US9206199 (2015) BindingDB Entry DOI: 10.7270/Q2VH5MND
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM196064 (US9206199, 169 | US9206199, 170 | US9206199, 171) Show SMILES Cc1c(ccc(F)c1[N+]#[C-])C1CN2CCN(CC2CCO1)C(=O)Cc1ccc(nc1)-n1cnnn1 Show InChI InChI=1S/C24H25FN8O2/c1-16-19(4-5-20(25)24(16)26-2)21-14-31-8-9-32(13-18(31)7-10-35-21)23(34)11-17-3-6-22(27-12-17)33-15-28-29-30-33/h3-6,12,15,18,21H,7-11,13-14H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...				US Patent US9206199 (2015) BindingDB Entry DOI: 10.7270/Q2VH5MND
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM196064 (US9206199, 169 | US9206199, 170 | US9206199, 171) Show SMILES Cc1c(ccc(F)c1[N+]#[C-])C1CN2CCN(CC2CCO1)C(=O)Cc1ccc(nc1)-n1cnnn1 Show InChI InChI=1S/C24H25FN8O2/c1-16-19(4-5-20(25)24(16)26-2)21-14-31-8-9-32(13-18(31)7-10-35-21)23(34)11-17-3-6-22(27-12-17)33-15-28-29-30-33/h3-6,12,15,18,21H,7-11,13-14H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...				US Patent US9206199 (2015) BindingDB Entry DOI: 10.7270/Q2VH5MND
					More data for this Ligand-Target Pair