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SMILES: Cc1nc(ccc1CC(=O)N1CCN2C[C@@H](OC[C@@H]2C1)c1cccc([N+]#[C-])c1C)-n1cnnn1

InChI Key: InChIKey=BJADLHSHKJKDPK-SIKLNZKXSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 195987   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM195987
PNG
(US9206199, 92)
Show SMILES Cc1nc(ccc1CC(=O)N1CCN2C[C@@H](OC[C@@H]2C1)c1cccc([N+]#[C-])c1C)-n1cnnn1 |r|
Show InChI InChI=1S/C24H26N8O2/c1-16-20(5-4-6-21(16)25-3)22-13-30-9-10-31(12-19(30)14-34-22)24(33)11-18-7-8-23(27-17(18)2)32-15-26-28-29-32/h4-8,15,19,22H,9-14H2,1-2H3/t19-,22+/m0/s1
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PC cid
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US Patent
n/an/a 200n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...

US Patent US9206199 (2015)


BindingDB Entry DOI: 10.7270/Q2VH5MND
More data for this
Ligand-Target Pair