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Patent code US8618107

Compile Data Set for Download or QSAR
Found 64 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111938
PNG
(US8618107, 104)
Show SMILES Cn1cc(cc(Nc2ccncn2)c1=O)-c1cccc(N2CCc3c4CCCCc4sc3C2=O)c1CO
Show InChI InChI=1S/C28H27N5O3S/c1-32-14-17(13-22(27(32)35)31-25-9-11-29-16-30-25)18-6-4-7-23(21(18)15-34)33-12-10-20-19-5-2-3-8-24(19)37-26(20)28(33)36/h4,6-7,9,11,13-14,16,34H,2-3,5,8,10,12,15H2,1H3,(H,29,30,31)
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US Patent
n/an/a 0.870n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111953
PNG
(US8618107, 212)
Show SMILES CN1CCN(CC1)c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CCCCc5sc4C3=O)c2CO)nc1
Show InChI InChI=1S/C34H37FN6O3S/c1-38-11-13-40(14-12-38)23-7-8-31(36-18-23)37-28-15-21(19-39(2)33(28)43)26-16-22(35)17-29(27(26)20-42)41-10-9-25-24-5-3-4-6-30(24)45-32(25)34(41)44/h7-8,15-19,42H,3-6,9-14,20H2,1-2H3,(H,36,37)
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n/an/a 1n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111940
PNG
(US8618107, 106)
Show SMILES Cn1cc(cc(Nc2cc(n[nH]2)C2CC2)c1=O)-c1cccc(N2CCn3c4CCCCc4cc3C2=O)c1CO
Show InChI InChI=1S/C30H32N6O3/c1-34-16-20(13-24(29(34)38)31-28-15-23(32-33-28)18-9-10-18)21-6-4-8-26(22(21)17-37)36-12-11-35-25-7-3-2-5-19(25)14-27(35)30(36)39/h4,6,8,13-16,18,37H,2-3,5,7,9-12,17H2,1H3,(H2,31,32,33)
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n/an/a 1n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111975
PNG
(US8618107, 287)
Show SMILES CN1CCCC1c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CC(C)(C)Cc5sc4C3=O)c2CO)nc1
Show InChI InChI=1S/C35H38FN5O3S/c1-35(2)15-25-23-9-11-41(34(44)32(23)45-30(25)16-35)29-14-22(36)13-24(26(29)19-42)21-12-27(33(43)40(4)18-21)38-31-8-7-20(17-37-31)28-6-5-10-39(28)3/h7-8,12-14,17-18,28,42H,5-6,9-11,15-16,19H2,1-4H3,(H,37,38)
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n/an/a 1.40n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111978
PNG
(US8618107, 291)
Show SMILES CN1CCC[C@@H]1c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)nc1 |r|
Show InChI InChI=1S/C35H39FN6O3/c1-35(2)16-22-13-30-34(45)42(11-10-41(30)31(22)17-35)29-15-24(36)14-25(26(29)20-43)23-12-27(33(44)40(4)19-23)38-32-8-7-21(18-37-32)28-6-5-9-39(28)3/h7-8,12-15,18-19,28,43H,5-6,9-11,16-17,20H2,1-4H3,(H,37,38)/t28-/m1/s1
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n/an/a 1.74n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111935
PNG
(US8618107, 101)
Show SMILES CN1CCn2nc(Nc3cc(n[nH]c3=O)-c3cccc(N4CCn5c6CCCCc6cc5C4=O)c3C)cc2C1
Show InChI InChI=1S/C29H32N8O2/c1-18-21(22-16-23(28(38)32-31-22)30-27-15-20-17-34(2)10-13-37(20)33-27)7-5-9-24(18)36-12-11-35-25-8-4-3-6-19(25)14-26(35)29(36)39/h5,7,9,14-16H,3-4,6,8,10-13,17H2,1-2H3,(H,32,38)(H,30,31,33)
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n/an/a 2n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111956
PNG
(US8618107, 268)
Show SMILES CN(C)CCOc1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CCCCc5sc4C3=O)c2CO)nc1
Show InChI InChI=1S/C33H36FN5O4S/c1-37(2)12-13-43-22-8-9-30(35-17-22)36-27-14-20(18-38(3)32(27)41)25-15-21(34)16-28(26(25)19-40)39-11-10-24-23-6-4-5-7-29(23)44-31(24)33(39)42/h8-9,14-18,40H,4-7,10-13,19H2,1-3H3,(H,35,36)
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n/an/a 2n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111951
PNG
(US8618107, 197)
Show SMILES CN1CCN(CC1)c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCn4c5CCCCc5cc4C3=O)c2CO)nc1
Show InChI InChI=1S/C34H38FN7O3/c1-38-9-11-40(12-10-38)25-7-8-32(36-19-25)37-28-15-23(20-39(2)33(28)44)26-17-24(35)18-30(27(26)21-43)42-14-13-41-29-6-4-3-5-22(29)16-31(41)34(42)45/h7-8,15-20,43H,3-6,9-14,21H2,1-2H3,(H,36,37)
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n/an/a 2n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111949
PNG
(US8618107, 131)
Show SMILES CCn1cc(Nc2nc(cn(C)c2=O)-c2cccc(N3CCc4c5CC(C)(C)Cc5sc4C3=O)c2CO)cn1
Show InChI InChI=1S/C29H32N6O3S/c1-5-34-14-17(13-30-34)31-26-28(38)33(4)15-22(32-26)18-7-6-8-23(21(18)16-36)35-10-9-19-20-11-29(2,3)12-24(20)39-25(19)27(35)37/h6-8,13-15,36H,5,9-12,16H2,1-4H3,(H,31,32)
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n/an/a 2n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111976
PNG
(US8618107, 288)
Show SMILES CN1CCCC1c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CCCCc5sc4C3=O)c2CO)nc1
Show InChI InChI=1S/C34H36FN5O3S/c1-38-12-5-7-28(38)20-9-10-31(36-17-20)37-27-14-21(18-39(2)33(27)42)25-15-22(35)16-29(26(25)19-41)40-13-11-24-23-6-3-4-8-30(23)44-32(24)34(40)43/h9-10,14-18,28,41H,3-8,11-13,19H2,1-2H3,(H,36,37)
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n/an/a 2.10n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111982
PNG
(US8618107, 295)
Show SMILES CN1CCC(CC1)c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CC(C)(C)Cc5sc4C3=O)c2CO)nc1
Show InChI InChI=1S/C36H40FN5O3S/c1-36(2)16-27-25-9-12-42(35(45)33(25)46-31(27)17-36)30-15-24(37)14-26(28(30)20-43)23-13-29(34(44)41(4)19-23)39-32-6-5-22(18-38-32)21-7-10-40(3)11-8-21/h5-6,13-15,18-19,21,43H,7-12,16-17,20H2,1-4H3,(H,38,39)
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n/an/a 2.20n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111964
PNG
(US8618107, 276)
Show SMILES Cc1cc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)[nH]n1
Show InChI InChI=1S/C29H31FN6O3/c1-16-7-26(33-32-16)31-22-8-18(14-34(4)27(22)38)20-10-19(30)11-23(21(20)15-37)36-6-5-35-24(28(36)39)9-17-12-29(2,3)13-25(17)35/h7-11,14,37H,5-6,12-13,15H2,1-4H3,(H2,31,32,33)
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n/an/a 2.20n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111962
PNG
(US8618107, 274)
Show SMILES Cn1cc(cc(Nc2ccc(CN3CCOCC3)cn2)c1=O)-c1cc(F)cc(N2CCn3c4CC(C)(C)Cc4cc3C2=O)c1CO
Show InChI InChI=1S/C35H39FN6O4/c1-35(2)16-23-13-30-34(45)42(7-6-41(30)31(23)17-35)29-15-25(36)14-26(27(29)21-43)24-12-28(33(44)39(3)20-24)38-32-5-4-22(18-37-32)19-40-8-10-46-11-9-40/h4-5,12-15,18,20,43H,6-11,16-17,19,21H2,1-3H3,(H,37,38)
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n/an/a 2.34n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111966
PNG
(US8618107, 278)
Show SMILES CN1CCC(CC1)c1ccc(Nc2nc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CC(C)(C)Cc5sc4C3=O)c2CO)cc1
Show InChI InChI=1S/C36H40FN5O3S/c1-36(2)17-27-25-11-14-42(34(44)32(25)46-31(27)18-36)30-16-23(37)15-26(28(30)20-43)29-19-41(4)35(45)33(39-29)38-24-7-5-21(6-8-24)22-9-12-40(3)13-10-22/h5-8,15-16,19,22,43H,9-14,17-18,20H2,1-4H3,(H,38,39)
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n/an/a 2.60n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111954
PNG
(US8618107, 265)
Show SMILES Cn1cc(cc(Nc2ccc(cn2)C2CCN(CC2)C2COC2)c1=O)-c1cc(F)cc(N2CCn3c4CCCCc4cc3C2=O)c1CO
Show InChI InChI=1S/C37H41FN6O4/c1-41-19-26(14-31(36(41)46)40-35-7-6-25(18-39-35)23-8-10-42(11-9-23)28-21-48-22-28)29-16-27(38)17-33(30(29)20-45)44-13-12-43-32-5-3-2-4-24(32)15-34(43)37(44)47/h6-7,14-19,23,28,45H,2-5,8-13,20-22H2,1H3,(H,39,40)
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n/an/a 2.80n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111972
PNG
(US8618107, 284)
Show SMILES CCN1CCc2nc(Nc3cc(cn(C)c3=O)-c3cc(F)cc(N4CCn5c6CC(C)(C)Cc6cc5C4=O)c3CO)ccc2C1
Show InChI InChI=1S/C35H39FN6O3/c1-5-40-9-8-27-21(19-40)6-7-32(37-27)38-28-12-23(18-39(4)33(28)44)25-14-24(36)15-29(26(25)20-43)42-11-10-41-30(34(42)45)13-22-16-35(2,3)17-31(22)41/h6-7,12-15,18,43H,5,8-11,16-17,19-20H2,1-4H3,(H,37,38)
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n/an/a 2.80n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111948
PNG
(US8618107, 123)
Show SMILES Cn1cc(cc(Nc2cc(n[nH]2)C2CC2)c1=O)-c1cccc(N2CCc3c4CCCCc4sc3C2=O)c1CO
Show InChI InChI=1S/C30H31N5O3S/c1-34-15-18(13-24(29(34)37)31-27-14-23(32-33-27)17-9-10-17)19-6-4-7-25(22(19)16-36)35-12-11-21-20-5-2-3-8-26(20)39-28(21)30(35)38/h4,6-7,13-15,17,36H,2-3,5,8-12,16H2,1H3,(H2,31,32,33)
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n/an/a 3n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111983
PNG
(US8618107, 296)
Show SMILES CN(C)CCOc1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CC(C)(C)Cc5sc4C3=O)c2CO)nc1
Show InChI InChI=1S/C34H38FN5O4S/c1-34(2)15-25-23-8-9-40(33(43)31(23)45-29(25)16-34)28-14-21(35)13-24(26(28)19-41)20-12-27(32(42)39(5)18-20)37-30-7-6-22(17-36-30)44-11-10-38(3)4/h6-7,12-14,17-18,41H,8-11,15-16,19H2,1-5H3,(H,36,37)
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n/an/a 3n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111994
PNG
(US8618107, 308)
Show SMILES CN1CCC(C1)c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CCCCc5sc4C3=O)c2CO)nc1
Show InChI InChI=1S/C34H36FN5O3S/c1-38-11-9-21(17-38)20-7-8-31(36-16-20)37-28-13-22(18-39(2)33(28)42)26-14-23(35)15-29(27(26)19-41)40-12-10-25-24-5-3-4-6-30(24)44-32(25)34(40)43/h7-8,13-16,18,21,41H,3-6,9-12,17,19H2,1-2H3,(H,36,37)
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n/an/a 3.30n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111987
PNG
(US8618107, 300)
Show SMILES COc1nccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)n1
Show InChI InChI=1S/C30H31FN6O4/c1-30(2)13-17-10-24-28(40)37(8-7-36(24)25(17)14-30)23-12-19(31)11-20(21(23)16-38)18-9-22(27(39)35(3)15-18)33-26-5-6-32-29(34-26)41-4/h5-6,9-12,15,38H,7-8,13-14,16H2,1-4H3,(H,32,33,34)
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n/an/a 3.40n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111965
PNG
(US8618107, 277)
Show SMILES CC(C)N(C)Cc1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CCCCc5sc4C3=O)c2CO)nc1
Show InChI InChI=1S/C34H38FN5O3S/c1-20(2)38(3)17-21-9-10-31(36-16-21)37-28-13-22(18-39(4)33(28)42)26-14-23(35)15-29(27(26)19-41)40-12-11-25-24-7-5-6-8-30(24)44-32(25)34(40)43/h9-10,13-16,18,20,41H,5-8,11-12,17,19H2,1-4H3,(H,36,37)
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n/an/a 3.40n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111974
PNG
(US8618107, 286)
Show SMILES CN(C)CCN(C)c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CCCCc5sc4C3=O)c2CO)nc1
Show InChI InChI=1S/C34H39FN6O3S/c1-38(2)13-14-39(3)23-9-10-31(36-18-23)37-28-15-21(19-40(4)33(28)43)26-16-22(35)17-29(27(26)20-42)41-12-11-25-24-7-5-6-8-30(24)45-32(25)34(41)44/h9-10,15-19,42H,5-8,11-14,20H2,1-4H3,(H,36,37)
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n/an/a 3.40n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111973
PNG
(US8618107, 285)
Show SMILES CCN1CCn2nc(Nc3cc(cn(C)c3=O)-c3cc(F)cc(N4CCn5c6CC(C)(C)Cc6cc5C4=O)c3CO)cc2C1
Show InChI InChI=1S/C33H38FN7O3/c1-5-38-6-9-41-23(18-38)14-30(36-41)35-26-10-21(17-37(4)31(26)43)24-12-22(34)13-27(25(24)19-42)40-8-7-39-28(32(40)44)11-20-15-33(2,3)16-29(20)39/h10-14,17,42H,5-9,15-16,18-19H2,1-4H3,(H,35,36)
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n/an/a 3.60n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111955
PNG
(US8618107, 267)
Show SMILES CN1CCC(CC1)c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CCCCc5sc4C3=O)c2CO)nc1
Show InChI InChI=1S/C35H38FN5O3S/c1-39-12-9-21(10-13-39)22-7-8-32(37-18-22)38-29-15-23(19-40(2)34(29)43)27-16-24(36)17-30(28(27)20-42)41-14-11-26-25-5-3-4-6-31(25)45-33(26)35(41)44/h7-8,15-19,21,42H,3-6,9-14,20H2,1-2H3,(H,37,38)
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n/an/a 3.80n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111952
PNG
(US8618107, 210)
Show SMILES Cn1cc(cc(Nc2ccc(cn2)N2CCN(CC2)C2COC2)c1=O)-c1cc(F)cc(N2CCn3c4CCCCc4cc3C2=O)c1CO
Show InChI InChI=1S/C36H40FN7O4/c1-40-19-24(14-30(35(40)46)39-34-7-6-26(18-38-34)41-8-10-42(11-9-41)27-21-48-22-27)28-16-25(37)17-32(29(28)20-45)44-13-12-43-31-5-3-2-4-23(31)15-33(43)36(44)47/h6-7,14-19,27,45H,2-5,8-13,20-22H2,1H3,(H,38,39)
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n/an/a 3.90n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111958
PNG
(US8618107, 270)
Show SMILES CN(C)CCN(C)c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CC(C)(C)Cc5sc4C3=O)c2CO)nc1
Show InChI InChI=1S/C35H41FN6O3S/c1-35(2)16-26-24-9-10-42(34(45)32(24)46-30(26)17-35)29-15-22(36)14-25(27(29)20-43)21-13-28(33(44)41(6)19-21)38-31-8-7-23(18-37-31)40(5)12-11-39(3)4/h7-8,13-15,18-19,43H,9-12,16-17,20H2,1-6H3,(H,37,38)
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n/an/a 4n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111970
PNG
(US8618107, 282)
Show SMILES CN1CCC(CC1)c1ccc(Nc2nc(cn(C)c2=O)-c2cc(F)cc(N3CCn4c5CCCCc5cc4C3=O)c2CO)cc1
Show InChI InChI=1S/C35H39FN6O3/c1-39-13-11-23(12-14-39)22-7-9-26(10-8-22)37-33-35(45)40(2)20-29(38-33)27-18-25(36)19-31(28(27)21-43)42-16-15-41-30-6-4-3-5-24(30)17-32(41)34(42)44/h7-10,17-20,23,43H,3-6,11-16,21H2,1-2H3,(H,37,38)
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n/an/a 4n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111957
PNG
(US8618107, 269)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CCCCc5sc4C3=O)c2CO)nc1
Show InChI InChI=1S/C35H39FN6O3S/c1-3-40-12-14-41(15-13-40)24-8-9-32(37-19-24)38-29-16-22(20-39(2)34(29)44)27-17-23(36)18-30(28(27)21-43)42-11-10-26-25-6-4-5-7-31(25)46-33(26)35(42)45/h8-9,16-20,43H,3-7,10-15,21H2,1-2H3,(H,37,38)
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n/an/a 4n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111968
PNG
(US8618107, 280)
Show SMILES Cn1cc(cc(Nc2ccc3CN(CCc3n2)C2COC2)c1=O)-c1cc(F)cc(N2CCc3c4CC(C)(C)Cc4sc3C2=O)c1CO
Show InChI InChI=1S/C36H38FN5O4S/c1-36(2)13-26-24-6-9-42(35(45)33(24)47-31(26)14-36)30-12-22(37)11-25(27(30)17-43)21-10-29(34(44)40(3)15-21)39-32-5-4-20-16-41(23-18-46-19-23)8-7-28(20)38-32/h4-5,10-12,15,23,43H,6-9,13-14,16-19H2,1-3H3,(H,38,39)
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n/an/a 4.20n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111984
PNG
(US8618107, 297)
Show SMILES CN(C)CCOc1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCn4c5CCCCc5cc4C3=O)c2CO)nc1
Show InChI InChI=1S/C33H37FN6O4/c1-37(2)12-13-44-24-8-9-31(35-18-24)36-27-14-22(19-38(3)32(27)42)25-16-23(34)17-29(26(25)20-41)40-11-10-39-28-7-5-4-6-21(28)15-30(39)33(40)43/h8-9,14-19,41H,4-7,10-13,20H2,1-3H3,(H,35,36)
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n/an/a 4.20n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111959
PNG
(US8618107, 271)
Show SMILES CN1CC(C1)c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)nc1
Show InChI InChI=1S/C34H37FN6O3/c1-34(2)13-21-10-29-33(44)41(8-7-40(29)30(21)14-34)28-12-24(35)11-25(26(28)19-42)22-9-27(32(43)39(4)18-22)37-31-6-5-20(15-36-31)23-16-38(3)17-23/h5-6,9-12,15,18,23,42H,7-8,13-14,16-17,19H2,1-4H3,(H,36,37)
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n/an/a 4.70n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111967
PNG
(US8618107, 279)
Show SMILES CN1CCn2nc(Nc3cc(cn(C)c3=O)-c3cc(F)cc(N4CCc5c6CC(C)(C)Cc6sc5C4=O)c3CO)cc2C1
Show InChI InChI=1S/C32H35FN6O3S/c1-32(2)13-23-21-5-6-38(31(42)29(21)43-27(23)14-32)26-11-19(33)10-22(24(26)17-40)18-9-25(30(41)37(4)15-18)34-28-12-20-16-36(3)7-8-39(20)35-28/h9-12,15,40H,5-8,13-14,16-17H2,1-4H3,(H,34,35)
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n/an/a 4.90n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111990
PNG
(US8618107, 303)
Show SMILES Cn1cc(cc(Nc2ccc(cn2)C2CCN(CC2)C2COC2)c1=O)-c1cc(F)cc(N2CCc3c4CCCCc4sc3C2=O)c1CO
Show InChI InChI=1S/C37H40FN5O4S/c1-41-18-24(14-31(36(41)45)40-34-7-6-23(17-39-34)22-8-11-42(12-9-22)26-20-47-21-26)29-15-25(38)16-32(30(29)19-44)43-13-10-28-27-4-2-3-5-33(27)48-35(28)37(43)46/h6-7,14-18,22,26,44H,2-5,8-13,19-21H2,1H3,(H,39,40)
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n/an/a 4.90n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111977
PNG
(US8618107, 289)
Show SMILES Cn1cc(cc(Nc2ccc(cn2)N2CCOCC2)c1=O)-c1cc(F)cc(N2CCc3c4CCCCc4sc3C2=O)c1CO
Show InChI InChI=1S/C33H34FN5O4S/c1-37-18-20(14-27(32(37)41)36-30-7-6-22(17-35-30)38-10-12-43-13-11-38)25-15-21(34)16-28(26(25)19-40)39-9-8-24-23-4-2-3-5-29(23)44-31(24)33(39)42/h6-7,14-18,40H,2-5,8-13,19H2,1H3,(H,35,36)
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n/an/a 5n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111950
PNG
(US8618107, 149)
Show SMILES Cn1cc(cc(Nc2cc3COCCn3n2)c1=O)-c1cc(F)cc(N2CCn3c4CCCCc4cc3C2=O)c1CO
Show InChI InChI=1S/C30H31FN6O4/c1-34-15-19(10-24(29(34)39)32-28-14-21-17-41-9-8-37(21)33-28)22-12-20(31)13-26(23(22)16-38)36-7-6-35-25-5-3-2-4-18(25)11-27(35)30(36)40/h10-15,38H,2-9,16-17H2,1H3,(H,32,33)
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n/an/a 5n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111945
PNG
(US8618107, 113)
Show SMILES CN1CCN(CC1)c1ccc(Nc2cc(cn(C)c2=O)-c2cccc(N3CCn4c5CCCCc5cc4C3=O)c2CO)nc1
Show InChI InChI=1S/C34H39N7O3/c1-37-12-14-39(15-13-37)25-10-11-32(35-20-25)36-28-18-24(21-38(2)33(28)43)26-7-5-9-30(27(26)22-42)41-17-16-40-29-8-4-3-6-23(29)19-31(40)34(41)44/h5,7,9-11,18-21,42H,3-4,6,8,12-17,22H2,1-2H3,(H,35,36)
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n/an/a 5n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111997
PNG
(US8618107, 311)
Show SMILES Cn1cc(cc(Nc2ccc(cn2)N2CCN(CC2)C2COC2)c1=O)-c1cccc(N2CCn3c4CC(C)(C)Cc4cc3C2=O)c1CO
Show InChI InChI=1S/C37H43N7O4/c1-37(2)17-24-16-32-36(47)44(14-13-43(32)33(24)18-37)31-6-4-5-28(29(31)21-45)25-15-30(35(46)40(3)20-25)39-34-8-7-26(19-38-34)41-9-11-42(12-10-41)27-22-48-23-27/h4-8,15-16,19-20,27,45H,9-14,17-18,21-23H2,1-3H3,(H,38,39)
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n/an/a 5.20n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111969
PNG
(US8618107, 281)
Show SMILES CN1CCC(CC1)c1ccc(Nc2nc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CCCCc5sc4C3=O)c2CO)cc1
Show InChI InChI=1S/C35H38FN5O3S/c1-39-14-11-22(12-15-39)21-7-9-24(10-8-21)37-33-35(44)40(2)19-29(38-33)27-17-23(36)18-30(28(27)20-42)41-16-13-26-25-5-3-4-6-31(25)45-32(26)34(41)43/h7-10,17-19,22,42H,3-6,11-16,20H2,1-2H3,(H,37,38)
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n/an/a 5.20n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111985
PNG
(US8618107, 298)
Show SMILES CN1CC(C1)c1ccc(Nc2nc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CC(C)(C)Cc5sc4C3=O)c2CO)cc1
Show InChI InChI=1S/C34H36FN5O3S/c1-34(2)13-25-23-9-10-40(32(42)30(23)44-29(25)14-34)28-12-21(35)11-24(26(28)18-41)27-17-39(4)33(43)31(37-27)36-22-7-5-19(6-8-22)20-15-38(3)16-20/h5-8,11-12,17,20,41H,9-10,13-16,18H2,1-4H3,(H,36,37)
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n/an/a 5.30n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111946
PNG
(US8618107, 116)
Show SMILES Cn1cc(nc(Nc2cnn(CCO)c2)c1=O)-c1cccc(N2CCc3c4CCCCc4sc3C2=O)c1CO
Show InChI InChI=1S/C28H30N6O4S/c1-32-15-22(31-26(28(32)38)30-17-13-29-33(14-17)11-12-35)18-6-4-7-23(21(18)16-36)34-10-9-20-19-5-2-3-8-24(19)39-25(20)27(34)37/h4,6-7,13-15,35-36H,2-3,5,8-12,16H2,1H3,(H,30,31)
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n/an/a 6n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111942
PNG
(US8618107, 108)
Show SMILES CC(=O)N1CCn2nc(Nc3cc(cn(C)c3=O)-c3cccc(N4CCn5c6CCCCc6cc5C4=O)c3CO)cc2C1
Show InChI InChI=1S/C32H35N7O4/c1-20(41)36-10-13-39-23(18-36)16-30(34-39)33-26-14-22(17-35(2)31(26)42)24-7-5-9-28(25(24)19-40)38-12-11-37-27-8-4-3-6-21(27)15-29(37)32(38)43/h5,7,9,14-17,40H,3-4,6,8,10-13,18-19H2,1-2H3,(H,33,34)
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n/an/a 6.10n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111988
PNG
(US8618107, 301)
Show SMILES Cn1cc(cc(Nc2ccc(cn2)N2CCNCC2)c1=O)-c1cccc(N2CCn3c4CCCCc4cc3C2=O)c1CO
Show InChI InChI=1S/C33H37N7O3/c1-37-20-23(17-27(32(37)42)36-31-10-9-24(19-35-31)38-13-11-34-12-14-38)25-6-4-8-29(26(25)21-41)40-16-15-39-28-7-3-2-5-22(28)18-30(39)33(40)43/h4,6,8-10,17-20,34,41H,2-3,5,7,11-16,21H2,1H3,(H,35,36)
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n/an/a 6.10n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111943
PNG
(US8618107, 109)
Show SMILES Cn1cc(cc(Nc2ccncn2)c1=O)-c1cccc(N2CCn3c4CCCCc4cc3C2=O)c1CO
Show InChI InChI=1S/C28H28N6O3/c1-32-15-19(13-22(27(32)36)31-26-9-10-29-17-30-26)20-6-4-8-24(21(20)16-35)34-12-11-33-23-7-3-2-5-18(23)14-25(33)28(34)37/h4,6,8-10,13-15,17,35H,2-3,5,7,11-12,16H2,1H3,(H,29,30,31)
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n/an/a 6.20n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111961
PNG
(US8618107, 273)
Show SMILES Cn1cc(cc(Nc2ccc(cn2)N2CCN(CCF)CC2)c1=O)-c1cc(F)cc(N2CCn3c4CC(C)(C)Cc4cc3C2=O)c1CO
Show InChI InChI=1S/C36H41F2N7O3/c1-36(2)18-23-15-31-35(48)45(13-12-44(31)32(23)19-36)30-17-25(38)16-27(28(30)22-46)24-14-29(34(47)41(3)21-24)40-33-5-4-26(20-39-33)43-10-8-42(7-6-37)9-11-43/h4-5,14-17,20-21,46H,6-13,18-19,22H2,1-3H3,(H,39,40)
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n/an/a 6.35n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111960
PNG
(US8618107, 272)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CC(C)(C)Cc5sc4C3=O)c2CO)nc1
Show InChI InChI=1S/C36H41FN6O3S/c1-5-41-10-12-42(13-11-41)24-6-7-32(38-19-24)39-29-14-22(20-40(4)34(29)45)26-15-23(37)16-30(28(26)21-44)43-9-8-25-27-17-36(2,3)18-31(27)47-33(25)35(43)46/h6-7,14-16,19-20,44H,5,8-13,17-18,21H2,1-4H3,(H,38,39)
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n/an/a 6.40n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111947
PNG
(US8618107, 119)
Show SMILES Cn1nc(Nc2cc(nn(C)c2=O)-c2cccc(N3CCc4c5CCCCc5sc4C3=O)c2CO)cc1C(C)(C)O
Show InChI InChI=1S/C30H34N6O4S/c1-30(2,40)25-15-26(33-34(25)3)31-22-14-21(32-35(4)28(22)38)17-9-7-10-23(20(17)16-37)36-13-12-19-18-8-5-6-11-24(18)41-27(19)29(36)39/h7,9-10,14-15,37,40H,5-6,8,11-13,16H2,1-4H3,(H,31,33)
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n/an/a 7n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111993
PNG
(US8618107, 307)
Show SMILES CN1CCN(CC1)c1ccc(Nc2cc(nn(C)c2=O)-c2cccc(N3CCn4c5CCCCc5cc4C3=O)c2CO)nc1
Show InChI InChI=1S/C33H38N8O3/c1-37-12-14-39(15-13-37)23-10-11-31(34-20-23)35-27-19-26(36-38(2)32(27)43)24-7-5-9-29(25(24)21-42)41-17-16-40-28-8-4-3-6-22(28)18-30(40)33(41)44/h5,7,9-11,18-20,42H,3-4,6,8,12-17,21H2,1-2H3,(H,34,35)
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n/an/a 7.10n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111944
PNG
(US8618107, 110)
Show SMILES Cn1cc(cc(Nc2cc3COCCn3n2)c1=O)-c1cccc(N2CCn3c4CCCCc4cc3C2=O)c1CO
Show InChI InChI=1S/C30H32N6O4/c1-33-16-20(13-24(29(33)38)31-28-15-21-18-40-12-11-36(21)32-28)22-6-4-8-26(23(22)17-37)35-10-9-34-25-7-3-2-5-19(25)14-27(34)30(35)39/h4,6,8,13-16,37H,2-3,5,7,9-12,17-18H2,1H3,(H,31,32)
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n/an/a 7.70n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111991
PNG
(US8618107, 304)
Show SMILES Cn1cc(cc(Nc2ccc(cn2)N2CCN(CC2)C2COC2)c1=O)-c1cc(F)cc(N2CCn3c4CC(C)(C)Cc4cc3C2=O)c1CO
Show InChI InChI=1S/C37H42FN7O4/c1-37(2)16-23-13-32-36(48)45(11-10-44(32)33(23)17-37)31-15-25(38)14-28(29(31)20-46)24-12-30(35(47)41(3)19-24)40-34-5-4-26(18-39-34)42-6-8-43(9-7-42)27-21-49-22-27/h4-5,12-15,18-19,27,46H,6-11,16-17,20-22H2,1-3H3,(H,39,40)
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n/an/a 7.80n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111971
PNG
(US8618107, 283)
Show SMILES CN1CCc2cc(Nc3nc(cn(C)c3=O)-c3cc(F)cc(N4CCn5c6CCCCc6cc5C4=O)c3CO)ccc2C1
Show InChI InChI=1S/C33H35FN6O3/c1-37-10-9-20-13-24(8-7-22(20)17-37)35-31-33(43)38(2)18-27(36-31)25-15-23(34)16-29(26(25)19-41)40-12-11-39-28-6-4-3-5-21(28)14-30(39)32(40)42/h7-8,13-16,18,41H,3-6,9-12,17,19H2,1-2H3,(H,35,36)
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n/an/a 8.10n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111986
PNG
(US8618107, 299)
Show SMILES Cn1cc(cc(Nc2ccc(cn2)C2CCN(CC2)C2COC2)c1=O)-c1cc(F)cc(N2CCc3c4CC(C)(C)Cc4sc3C2=O)c1CO
Show InChI InChI=1S/C38H42FN5O4S/c1-38(2)15-29-27-8-11-44(37(47)35(27)49-33(29)16-38)32-14-25(39)13-28(30(32)19-45)24-12-31(36(46)42(3)18-24)41-34-5-4-23(17-40-34)22-6-9-43(10-7-22)26-20-48-21-26/h4-5,12-14,17-18,22,26,45H,6-11,15-16,19-21H2,1-3H3,(H,40,41)
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n/an/a 8.70n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111980
PNG
(US8618107, 293)
Show SMILES CN1CC(C1)Oc1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCn4c5CCCCc5cc4C3=O)c2CO)nc1
Show InChI InChI=1S/C33H35FN6O4/c1-37-17-24(18-37)44-23-7-8-31(35-15-23)36-27-11-21(16-38(2)32(27)42)25-13-22(34)14-29(26(25)19-41)40-10-9-39-28-6-4-3-5-20(28)12-30(39)33(40)43/h7-8,11-16,24,41H,3-6,9-10,17-19H2,1-2H3,(H,35,36)
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n/an/a 9.80n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111989
PNG
(US8618107, 302)
Show SMILES CCn1nc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)cc1C
Show InChI InChI=1S/C31H35FN6O3/c1-6-38-18(2)9-28(34-38)33-24-10-20(16-35(5)29(24)40)22-12-21(32)13-25(23(22)17-39)37-8-7-36-26(30(37)41)11-19-14-31(3,4)15-27(19)36/h9-13,16,39H,6-8,14-15,17H2,1-5H3,(H,33,34)
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n/an/a 9.90n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111939
PNG
(US8618107, 105)
Show SMILES Cn1cc(cc(Nc2ccncn2)c1=O)-c1cccc(N2CCc3c4CC(C)(C)Cc4sc3C2=O)c1CO
Show InChI InChI=1S/C29H29N5O3S/c1-29(2)12-20-19-8-10-34(28(37)26(19)38-24(20)13-29)23-6-4-5-18(21(23)15-35)17-11-22(27(36)33(3)14-17)32-25-7-9-30-16-31-25/h4-7,9,11,14,16,35H,8,10,12-13,15H2,1-3H3,(H,30,31,32)
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n/an/a 10n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111941
PNG
(US8618107, 107)
Show SMILES Cn1cc(cc(Nc2ccc(cn2)N2CCOCC2)c1=O)-c1cccc(N2CCn3c4CCCCc4cc3C2=O)c1CO
Show InChI InChI=1S/C33H36N6O4/c1-36-20-23(17-27(32(36)41)35-31-10-9-24(19-34-31)37-13-15-43-16-14-37)25-6-4-8-29(26(25)21-40)39-12-11-38-28-7-3-2-5-22(28)18-30(38)33(39)42/h4,6,8-10,17-20,40H,2-3,5,7,11-16,21H2,1H3,(H,34,35)
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n/an/a 10.1n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111979
PNG
(US8618107, 292)
Show SMILES Cn1cc(cc(Nc2ccc3CN(CCc3n2)C2COC2)c1=O)-c1cc(F)cc(N2CCn3c4CC(C)(C)Cc4cc3C2=O)c1CO
Show InChI InChI=1S/C36H39FN6O4/c1-36(2)14-22-11-31-35(46)43(9-8-42(31)32(22)15-36)30-13-24(37)12-26(27(30)18-44)23-10-29(34(45)40(3)16-23)39-33-5-4-21-17-41(25-19-47-20-25)7-6-28(21)38-33/h4-5,10-13,16,25,44H,6-9,14-15,17-20H2,1-3H3,(H,38,39)
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n/an/a 11.6n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111981
PNG
(US8618107, 294)
Show SMILES CN1CCC(CC1)c1ccc(Nc2nc(cn(C)c2=O)-c2cc(F)cc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)cc1
Show InChI InChI=1S/C36H41FN6O3/c1-36(2)18-24-15-31-34(45)43(14-13-42(31)32(24)19-36)30-17-25(37)16-27(28(30)21-44)29-20-41(4)35(46)33(39-29)38-26-7-5-22(6-8-26)23-9-11-40(3)12-10-23/h5-8,15-17,20,23,44H,9-14,18-19,21H2,1-4H3,(H,38,39)
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n/an/a 16n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111963
PNG
(US8618107, 275)
Show SMILES CN1CCN(CC1)c1ccc(Nc2cc(cn(C)c2=O)-c2cccc(N3CCc4c(cc5CCCCn45)C3=O)c2CO)nc1
Show InChI InChI=1S/C34H39N7O3/c1-37-14-16-39(17-15-37)25-9-10-32(35-20-25)36-29-18-23(21-38(2)34(29)44)26-7-5-8-30(28(26)22-42)41-13-11-31-27(33(41)43)19-24-6-3-4-12-40(24)31/h5,7-10,18-21,42H,3-4,6,11-17,22H2,1-2H3,(H,35,36)
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n/an/a 16.3n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111995
PNG
(US8618107, 309)
Show SMILES Cn1cc(cc(Nc2cc3COCCn3n2)c1=O)-c1cccc(N2CCc3c(cc4CCCCn34)C2=O)c1CO
Show InChI InChI=1S/C30H32N6O4/c1-33-16-19(13-25(30(33)39)31-28-15-21-18-40-12-11-36(21)32-28)22-6-4-7-26(24(22)17-37)35-10-8-27-23(29(35)38)14-20-5-2-3-9-34(20)27/h4,6-7,13-16,37H,2-3,5,8-12,17-18H2,1H3,(H,31,32)
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n/an/a 16.5n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111996
PNG
(US8618107, 310)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(cn(C)c2=O)-c2cccc(N3CCc4c(cc5CCCCn45)C3=O)c2CO)nc1
Show InChI InChI=1S/C35H41N7O3/c1-3-39-15-17-40(18-16-39)26-10-11-33(36-21-26)37-30-19-24(22-38(2)35(30)45)27-8-6-9-31(29(27)23-43)42-14-12-32-28(34(42)44)20-25-7-4-5-13-41(25)32/h6,8-11,19-22,43H,3-5,7,12-18,23H2,1-2H3,(H,36,37)
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n/an/a 16.6n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111992
PNG
(US8618107, 305)
Show SMILES Cn1cc(nc(Nc2ccc(cc2)C2CCN(CC2)C2COC2)c1=O)-c1cccc(N2CCc3c4CCCCc4sc3C2=O)c1CO
Show InChI InChI=1S/C37H41N5O4S/c1-40-19-31(39-35(37(40)45)38-25-11-9-23(10-12-25)24-13-16-41(17-14-24)26-21-46-22-26)27-6-4-7-32(30(27)20-43)42-18-15-29-28-5-2-3-8-33(28)47-34(29)36(42)44/h4,6-7,9-12,19,24,26,43H,2-3,5,8,13-18,20-22H2,1H3,(H,38,39)
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n/an/a 17.1n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111936
PNG
(US8618107, 102)
Show SMILES CN1CCn2nc(Nc3cc(n[nH]c3=O)-c3cccc(N4CCn5c(cc6ccccc56)C4=O)c3C)cc2C1
Show InChI InChI=1S/C29H28N8O2/c1-18-21(22-16-23(28(38)32-31-22)30-27-15-20-17-34(2)10-13-37(20)33-27)7-5-9-24(18)36-12-11-35-25-8-4-3-6-19(25)14-26(35)29(36)39/h3-9,14-16H,10-13,17H2,1-2H3,(H,32,38)(H,30,31,33)
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n/an/a 22.9n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111998
PNG
(US8618107, 312)
Show SMILES Cn1cc(cc(Nc2ccc(cn2)N2CCN(CC2)C2COC2)c1=O)-c1cccc(N2CCc3c4CC(C)(C)Cc4sc3C2=O)c1CO
Show InChI InChI=1S/C37H42N6O4S/c1-37(2)16-28-27-9-10-43(36(46)34(27)48-32(28)17-37)31-6-4-5-26(29(31)20-44)23-15-30(35(45)40(3)19-23)39-33-8-7-24(18-38-33)41-11-13-42(14-12-41)25-21-47-22-25/h4-8,15,18-19,25,44H,9-14,16-17,20-22H2,1-3H3,(H,38,39)
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n/an/a 43n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM111937
PNG
(US8618107, 103)
Show SMILES CN1CCn2nc(Nc3cc(nn(C)c3=O)-c3cccc(N4Cc5c(sc6ccccc56)C4=O)c3C)cc2C1
Show InChI InChI=1S/C29H27N7O2S/c1-17-19(8-6-9-24(17)35-16-21-20-7-4-5-10-25(20)39-27(21)29(35)38)22-14-23(28(37)34(3)31-22)30-26-13-18-15-33(2)11-12-36(18)32-26/h4-10,13-14H,11-12,15-16H2,1-3H3,(H,30,32)
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n/an/a 3.20E+3n/an/an/an/a7.5n/a



Gilead Connecticut, Inc.; Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...


US Patent US8618107 (2013)


BindingDB Entry DOI: 10.7270/Q2T72G3C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%