Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM111965'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM111965 (US8618107, 277) Show SMILES CC(C)N(C)Cc1ccc(Nc2cc(cn(C)c2=O)-c2cc(F)cc(N3CCc4c5CCCCc5sc4C3=O)c2CO)nc1 Show InChI InChI=1S/C34H38FN5O3S/c1-20(2)38(3)17-21-9-10-31(36-16-21)37-28-13-22(18-39(4)33(28)42)26-14-23(35)15-29(27(26)19-41)40-12-11-25-24-7-5-6-8-30(24)44-32(25)34(40)43/h9-10,13-16,18,20,41H,5-8,11-12,17,19H2,1-4H3,(H,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	7.5	n/a
Gilead Connecticut, Inc.; Genentech, Inc. US Patent					Assay Description A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...				US Patent US8618107 (2013) BindingDB Entry DOI: 10.7270/Q2T72G3C
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