Found 97 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308460
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(thiophen-3-yl)...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccsc2)c1 |r| Show InChI InChI=1S/C19H19ClN2O5S2/c20-12-2-1-9(18-17(26)16(25)15(24)13(7-23)27-18)5-11(12)6-14-21-22-19(29-14)10-3-4-28-8-10/h1-5,8,13,15-18,23-26H,6-7H2/t13-,15-,16+,17-,18+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.51 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308448
(2-(2-Chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzylo...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cnccn2)c1 |r| Show InChI InChI=1S/C19H19ClN4O5S/c20-11-2-1-9(18-17(28)16(27)15(26)13(8-25)29-18)5-10(11)6-14-23-24-19(30-14)12-7-21-3-4-22-12/h1-5,7,13,15-18,25-28H,6,8H2/t13-,15-,16+,17-,18+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.06 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103019
(US8541380, 97)Show SMILES COc1cc(Cl)c(Cc2nnc(s2)-c2ccco2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C20H21ClN2O7S/c1-28-13-7-11(21)9(6-15-22-23-20(31-15)12-3-2-4-29-12)5-10(13)19-18(27)17(26)16(25)14(8-24)30-19/h2-5,7,14,16-19,24-27H,6,8H2,1H3/t14-,16-,17+,18-,19+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.55 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308450
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)-1,...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccco2)c1 |r| Show InChI InChI=1S/C19H19ClN2O6S/c20-11-4-3-9(18-17(26)16(25)15(24)13(8-23)28-18)6-10(11)7-14-21-22-19(29-14)12-2-1-5-27-12/h1-6,13,15-18,23-26H,7-8H2/t13-,15-,16+,17-,18+/m1/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
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| US Patent
| n/a | n/a | 7.03 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308454
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(5-phenylfuran-...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccc(o2)-c2ccccc2)c1 |r| Show InChI InChI=1S/C25H23ClN2O6S/c26-16-7-6-14(24-23(32)22(31)21(30)19(12-29)34-24)10-15(16)11-20-27-28-25(35-20)18-9-8-17(33-18)13-4-2-1-3-5-13/h1-10,19,21-24,29-32H,11-12H2/t19-,21-,22+,23-,24+/m1/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
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| US Patent
| n/a | n/a | 10.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103015
(US8541380, 93)Show SMILES COc1c(Cc2nnc(s2)-c2ccco2)cc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2ccccc12 |r| Show InChI InChI=1S/C24H24N2O7S/c1-31-22-12(10-18-25-26-24(34-18)16-7-4-8-32-16)9-15(13-5-2-3-6-14(13)22)23-21(30)20(29)19(28)17(11-27)33-23/h2-9,17,19-21,23,27-30H,10-11H2,1H3/t17-,19-,20+,21-,23+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 10.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308436
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(methylthio)-1,...)Show SMILES CSc1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r| Show InChI InChI=1S/C16H19ClN2O5S2/c1-25-16-19-18-11(26-16)5-8-4-7(2-3-9(8)17)15-14(23)13(22)12(21)10(6-20)24-15/h2-4,10,12-15,20-23H,5-6H2,1H3/t10-,12-,13+,14-,15+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 10.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319070
((2S,3R,4R,5S,6R)-2-(3-((6-(1,3,4-thiadiazol-2-yl)p...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)-c2nncs2)c1 |r| Show InChI InChI=1S/C19H19ClN4O5S/c20-12-3-1-9(18-17(28)16(27)15(26)14(7-25)29-18)5-10(12)6-11-2-4-13(23-22-11)19-24-21-8-30-19/h1-5,8,14-18,25-28H,6-7H2/t14-,15-,16+,17-,18+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319048
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(methylthio)pyr...)Show SMILES CSc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C18H21ClN2O5S/c1-27-14-5-3-11(20-21-14)7-10-6-9(2-4-12(10)19)18-17(25)16(24)15(23)13(8-22)26-18/h2-6,13,15-18,22-25H,7-8H2,1H3/t13-,15-,16+,17-,18+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| US Patent
| n/a | n/a | 13.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308459
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(thiophen-2-yl)...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cccs2)c1 |r| Show InChI InChI=1S/C19H19ClN2O5S2/c20-11-4-3-9(18-17(26)16(25)15(24)12(8-23)27-18)6-10(11)7-14-21-22-19(29-14)13-2-1-5-28-13/h1-6,12,15-18,23-26H,7-8H2/t12-,15-,16+,17-,18+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 14.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308440
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-phenyl-1,3,4-th...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccccc2)c1 |r| Show InChI InChI=1S/C21H21ClN2O5S/c22-14-7-6-12(20-19(28)18(27)17(26)15(10-25)29-20)8-13(14)9-16-23-24-21(30-16)11-4-2-1-3-5-11/h1-8,15,17-20,25-28H,9-10H2/t15-,17-,18+,19-,20+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| US Patent
| n/a | n/a | 16.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319044
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(pentyloxy)pyri...)Show SMILES CCCCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C22H29ClN2O6/c1-2-3-4-9-30-18-8-6-15(24-25-18)11-14-10-13(5-7-16(14)23)22-21(29)20(28)19(27)17(12-26)31-22/h5-8,10,17,19-22,26-29H,2-4,9,11-12H2,1H3/t17-,19-,20+,21-,22+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319045
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(hexyloxy)pyrid...)Show SMILES CCCCCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C23H31ClN2O6/c1-2-3-4-5-10-31-19-9-7-16(25-26-19)12-15-11-14(6-8-17(15)24)23-22(30)21(29)20(28)18(13-27)32-23/h6-9,11,18,20-23,27-30H,2-5,10,12-13H2,1H3/t18-,20-,21+,22-,23+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 17.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103018
(US8541380, 96)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2nnc(s2)-c2ccco2)c(Cl)cc1Cl |r| Show InChI InChI=1S/C19H18Cl2N2O6S/c20-10-6-11(21)9(18-17(27)16(26)15(25)13(7-24)29-18)4-8(10)5-14-22-23-19(30-14)12-2-1-3-28-12/h1-4,6,13,15-18,24-27H,5,7H2/t13-,15-,16+,17-,18+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 17.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308451
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(furan-3-yl)-1,...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccoc2)c1 |r| Show InChI InChI=1S/C19H19ClN2O6S/c20-12-2-1-9(18-17(26)16(25)15(24)13(7-23)28-18)5-11(12)6-14-21-22-19(29-14)10-3-4-27-8-10/h1-5,8,13,15-18,23-26H,6-7H2/t13-,15-,16+,17-,18+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 17.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308463
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(5-chlorothioph...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccc(Cl)s2)c1 |r| Show InChI InChI=1S/C19H18Cl2N2O5S2/c20-10-2-1-8(18-17(27)16(26)15(25)11(7-24)28-18)5-9(10)6-14-22-23-19(30-14)12-3-4-13(21)29-12/h1-5,11,15-18,24-27H,6-7H2/t11-,15-,16+,17-,18+/m1/s1 | PDB
UniProtKB/SwissProt
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PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 18.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308465
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(thiazol-4-yl)-...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cscn2)c1 |r| Show InChI InChI=1S/C18H18ClN3O5S2/c19-10-2-1-8(17-16(26)15(25)14(24)12(5-23)27-17)3-9(10)4-13-21-22-18(29-13)11-6-28-7-20-11/h1-3,6-7,12,14-17,23-26H,4-5H2/t12-,14-,15+,16-,17+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 21.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103016
(US8541380, 94)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2nnc(s2)-c2ccco2)c(O)c2ccccc12 |r| Show InChI InChI=1S/C23H22N2O7S/c26-10-16-19(28)20(29)21(30)22(32-16)14-8-11(18(27)13-5-2-1-4-12(13)14)9-17-24-25-23(33-17)15-6-3-7-31-15/h1-8,16,19-22,26-30H,9-10H2/t16-,19-,20+,21-,22+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 24.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM102998
(US8541380, 23)Show SMILES CCCc1ccc(cc1)-c1nnc(Cc2cc(ccc2Cl)C2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r,w:21.22| Show InChI InChI=1S/C24H27ClN2O5S/c1-2-3-13-4-6-14(7-5-13)24-27-26-19(33-24)11-16-10-15(8-9-17(16)25)23-22(31)21(30)20(29)18(12-28)32-23/h4-10,18,20-23,28-31H,2-3,11-12H2,1H3/t18-,20-,21+,22-,23?/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 24.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103013
(US8541380, 91)Show SMILES CC(=O)c1cnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C18H20ClN3O6/c1-8(24)12-6-20-14(22-21-12)5-10-4-9(2-3-11(10)19)18-17(27)16(26)15(25)13(7-23)28-18/h2-4,6,13,15-18,23,25-27H,5,7H2,1H3/t13-,15-,16+,17-,18+/m1/s1 | PDB
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| US Patent
| n/a | n/a | 24.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308442
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(pyridin-2-yl)-...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccccn2)c1 |r| Show InChI InChI=1S/C20H20ClN3O5S/c21-12-5-4-10(19-18(28)17(27)16(26)14(9-25)29-19)7-11(12)8-15-23-24-20(30-15)13-3-1-2-6-22-13/h1-7,14,16-19,25-28H,8-9H2/t14-,16-,17+,18-,19+/m1/s1 | PDB
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| US Patent
| n/a | n/a | 30.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308445
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(2-methylpyridi...)Show SMILES Cc1cc(ccn1)-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r| Show InChI InChI=1S/C21H22ClN3O5S/c1-10-6-12(4-5-23-10)21-25-24-16(31-21)8-13-7-11(2-3-14(13)22)20-19(29)18(28)17(27)15(9-26)30-20/h2-7,15,17-20,26-29H,8-9H2,1H3/t15-,17-,18+,19-,20+/m1/s1 | PDB
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| n/a | n/a | 36.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319039
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-ethoxypyridazin...)Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C19H23ClN2O6/c1-2-27-15-6-4-12(21-22-15)8-11-7-10(3-5-13(11)20)19-18(26)17(25)16(24)14(9-23)28-19/h3-7,14,16-19,23-26H,2,8-9H2,1H3/t14-,16-,17+,18-,19+/m1/s1 | PDB
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| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308464
((2S,3R,4R,5S,6R)-2-(3-((5-(Benzo[b]thiophen-2-yl)-...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cc3ccccc3s2)c1 |r| Show InChI InChI=1S/C23H21ClN2O5S2/c24-14-6-5-12(22-21(30)20(29)19(28)15(10-27)31-22)7-13(14)9-18-25-26-23(33-18)17-8-11-3-1-2-4-16(11)32-17/h1-8,15,19-22,27-30H,9-10H2/t15-,19-,20+,21-,22+/m1/s1 | PDB
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| n/a | n/a | 44.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM102996
(US8541380, 21)Show SMILES OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cccnc2)c1 |r,w:4.11| Show InChI InChI=1S/C20H20ClN3O5S/c21-13-4-3-10(19-18(28)17(27)16(26)14(9-25)29-19)6-12(13)7-15-23-24-20(30-15)11-2-1-5-22-8-11/h1-6,8,14,16-19,25-28H,7,9H2/t14-,16-,17+,18-,19?/m1/s1 | PDB
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| n/a | n/a | 45.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103006
(US8541380, 56)Show SMILES CCCCCCCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C25H35ClN2O6/c1-2-3-4-5-6-7-12-33-21-11-9-18(27-28-21)14-17-13-16(8-10-19(17)26)25-24(32)23(31)22(30)20(15-29)34-25/h8-11,13,20,22-25,29-32H,2-7,12,14-15H2,1H3/t20-,22-,23+,24-,25+/m1/s1 | PDB
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| n/a | n/a | 50.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM102995
(US8541380, 20)Show SMILES OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccncc2)c1 |r,w:4.11| Show InChI InChI=1S/C20H20ClN3O5S/c21-13-2-1-11(19-18(28)17(27)16(26)14(9-25)29-19)7-12(13)8-15-23-24-20(30-15)10-3-5-22-6-4-10/h1-7,14,16-19,25-28H,8-9H2/t14-,16-,17+,18-,19?/m1/s1 | PDB
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| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308453
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(5-methylfuran-...)Show SMILES Cc1ccc(o1)-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r| Show InChI InChI=1S/C20H21ClN2O6S/c1-9-2-5-13(28-9)20-23-22-15(30-20)7-11-6-10(3-4-12(11)21)19-18(27)17(26)16(25)14(8-24)29-19/h2-6,14,16-19,24-27H,7-8H2,1H3/t14-,16-,17+,18-,19+/m1/s1 | PDB
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| US Patent
| n/a | n/a | 58.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319060
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(furan-3-yl)pyr...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)-c2ccoc2)c1 |r| Show InChI InChI=1S/C21H21ClN2O6/c22-15-3-1-11(21-20(28)19(27)18(26)17(9-25)30-21)7-13(15)8-14-2-4-16(24-23-14)12-5-6-29-10-12/h1-7,10,17-21,25-28H,8-9H2/t17-,18-,19+,20-,21+/m1/s1 | PDB
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| US Patent
| n/a | n/a | 61.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319059
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(furan-2-yl)pyr...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)-c2ccco2)c1 |r| Show InChI InChI=1S/C21H21ClN2O6/c22-14-5-3-11(21-20(28)19(27)18(26)17(10-25)30-21)8-12(14)9-13-4-6-15(24-23-13)16-2-1-7-29-16/h1-8,17-21,25-28H,9-10H2/t17-,18-,19+,20-,21+/m1/s1 | PDB
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| n/a | n/a | 64.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319067
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(pyridin-3-yl)p...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)-c2cccnc2)c1 |r| Show InChI InChI=1S/C22H22ClN3O5/c23-16-5-3-12(22-21(30)20(29)19(28)18(11-27)31-22)8-14(16)9-15-4-6-17(26-25-15)13-2-1-7-24-10-13/h1-8,10,18-22,27-30H,9,11H2/t18-,19-,20+,21-,22+/m1/s1 | PDB
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| US Patent
| n/a | n/a | 64.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319040
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-propoxypyridazi...)Show SMILES CCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C20H25ClN2O6/c1-2-7-28-16-6-4-13(22-23-16)9-12-8-11(3-5-14(12)21)20-19(27)18(26)17(25)15(10-24)29-20/h3-6,8,15,17-20,24-27H,2,7,9-10H2,1H3/t15-,17-,18+,19-,20+/m1/s1 | PDB
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| US Patent
| n/a | n/a | 70.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319049
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(ethylthio)pyri...)Show SMILES CCSc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C19H23ClN2O5S/c1-2-28-15-6-4-12(21-22-15)8-11-7-10(3-5-13(11)20)19-18(26)17(25)16(24)14(9-23)27-19/h3-7,14,16-19,23-26H,2,8-9H2,1H3/t14-,16-,17+,18-,19+/m1/s1 | PDB
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| US Patent
| n/a | n/a | 71.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319061
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(thiophen-2-yl)...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)-c2cccs2)c1 |r| Show InChI InChI=1S/C21H21ClN2O5S/c22-14-5-3-11(21-20(28)19(27)18(26)16(10-25)29-21)8-12(14)9-13-4-6-15(24-23-13)17-2-1-7-30-17/h1-8,16,18-21,25-28H,9-10H2/t16-,18-,19+,20-,21+/m1/s1 | PDB
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| US Patent
| n/a | n/a | 71.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM102994
(US8541380, 14)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cnc(s2)-c2ccncc2)c1 |r| Show InChI InChI=1S/C23H21ClN4O5S2/c24-14-2-1-12(21-20(32)19(31)18(30)15(10-29)33-21)7-13(14)8-17-27-28-23(35-17)16-9-26-22(34-16)11-3-5-25-6-4-11/h1-7,9,15,18-21,29-32H,8,10H2/t15-,18-,19+,20-,21+/m1/s1 | PDB
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| US Patent
| n/a | n/a | 72.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319062
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(thiophen-3-yl)...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)-c2ccsc2)c1 |r| Show InChI InChI=1S/C21H21ClN2O5S/c22-15-3-1-11(21-20(28)19(27)18(26)17(9-25)29-21)7-13(15)8-14-2-4-16(24-23-14)12-5-6-30-10-12/h1-7,10,17-21,25-28H,8-9H2/t17-,18-,19+,20-,21+/m1/s1 | PDB
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| US Patent
| n/a | n/a | 75.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319047
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(tetrahydro-2H-...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OC3CCOCC3)nn2)c1 |r| Show InChI InChI=1S/C22H27ClN2O7/c23-16-3-1-12(22-21(29)20(28)19(27)17(11-26)32-22)9-13(16)10-14-2-4-18(25-24-14)31-15-5-7-30-8-6-15/h1-4,9,15,17,19-22,26-29H,5-8,10-11H2/t17-,19-,20+,21-,22+/m1/s1 | PDB
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| US Patent
| n/a | n/a | 77.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308446
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(isoquinolin-3-...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cc3ccccc3cn2)c1 |r| Show InChI InChI=1S/C24H22ClN3O5S/c25-16-6-5-13(23-22(32)21(31)20(30)18(11-29)33-23)7-15(16)9-19-27-28-24(34-19)17-8-12-3-1-2-4-14(12)10-26-17/h1-8,10,18,20-23,29-32H,9,11H2/t18-,20-,21+,22-,23+/m1/s1 | PDB
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| n/a | n/a | 81.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319068
((2S,3R,4R,5S,6R)-2-(3-((6-(benzo[d][1,3]dioxol-5-y...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)-c2ccc3OCOc3c2)c1 |r| Show InChI InChI=1S/C24H23ClN2O7/c25-16-4-1-13(24-23(31)22(30)21(29)20(10-28)34-24)7-14(16)8-15-3-5-17(27-26-15)12-2-6-18-19(9-12)33-11-32-18/h1-7,9,20-24,28-31H,8,10-11H2/t20-,21-,22+,23-,24+/m1/s1 | PDB
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| n/a | n/a | 82.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103014
(US8541380, 92)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2nnc(s2)-c2ccco2)cc2ccccc12 |r| Show InChI InChI=1S/C23H22N2O6S/c26-11-17-19(27)20(28)21(29)22(31-17)15-9-12(8-13-4-1-2-5-14(13)15)10-18-24-25-23(32-18)16-6-3-7-30-16/h1-9,17,19-22,26-29H,10-11H2/t17-,19-,20+,21-,22+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308444
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(6-methylpyridi...)Show SMILES Cc1ccc(cn1)-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r| Show InChI InChI=1S/C21H22ClN3O5S/c1-10-2-3-12(8-23-10)21-25-24-16(31-21)7-13-6-11(4-5-14(13)22)20-19(29)18(28)17(27)15(9-26)30-20/h2-6,8,15,17-20,26-29H,7,9H2,1H3/t15-,17-,18+,19-,20+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319069
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(2,3-dihydroben...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)-c2ccc3OCCOc3c2)c1 |r| Show InChI InChI=1S/C25H25ClN2O7/c26-17-4-1-14(25-24(32)23(31)22(30)21(12-29)35-25)9-15(17)10-16-3-5-18(28-27-16)13-2-6-19-20(11-13)34-8-7-33-19/h1-6,9,11,21-25,29-32H,7-8,10,12H2/t21-,22-,23+,24-,25+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM102997
(US8541380, 22)Show SMILES Cc1ccc(cc1)-c1nnc(Cc2cc(ccc2Cl)C2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r,w:19.20| Show InChI InChI=1S/C22H23ClN2O5S/c1-11-2-4-12(5-3-11)22-25-24-17(31-22)9-14-8-13(6-7-15(14)23)21-20(29)19(28)18(27)16(10-26)30-21/h2-8,16,18-21,26-29H,9-10H2,1H3/t16-,18-,19+,20-,21?/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308452
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(3-methylfuran-...)Show SMILES Cc1ccoc1-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r| Show InChI InChI=1S/C20H21ClN2O6S/c1-9-4-5-28-18(9)20-23-22-14(30-20)7-11-6-10(2-3-12(11)21)19-17(27)16(26)15(25)13(8-24)29-19/h2-6,13,15-17,19,24-27H,7-8H2,1H3/t13-,15-,16+,17-,19+/m1/s1 | PDB
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| n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319042
((2S,3R,4R,5S,6R)-2-(3-((6-butoxypyridazin-3-yl)met...)Show SMILES CCCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C21H27ClN2O6/c1-2-3-8-29-17-7-5-14(23-24-17)10-13-9-12(4-6-15(13)22)21-20(28)19(27)18(26)16(11-25)30-21/h4-7,9,16,18-21,25-28H,2-3,8,10-11H2,1H3/t16-,18-,19+,20-,21+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319041
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-isopropoxypyrid...)Show SMILES CC(C)Oc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C20H25ClN2O6/c1-10(2)28-16-6-4-13(22-23-16)8-12-7-11(3-5-14(12)21)20-19(27)18(26)17(25)15(9-24)29-20/h3-7,10,15,17-20,24-27H,8-9H2,1-2H3/t15-,17-,18+,19-,20+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319046
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(cyclohexyloxy)...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OC3CCCCC3)nn2)c1 |r| Show InChI InChI=1S/C23H29ClN2O6/c24-17-8-6-13(23-22(30)21(29)20(28)18(12-27)32-23)10-14(17)11-15-7-9-19(26-25-15)31-16-4-2-1-3-5-16/h6-10,16,18,20-23,27-30H,1-5,11-12H2/t18-,20-,21+,22-,23+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308457
(((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(1-methyl-1Hpy...)Show SMILES Cn1cccc1-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r| Show InChI InChI=1S/C20H22ClN3O5S/c1-24-6-2-3-13(24)20-23-22-15(30-20)8-11-7-10(4-5-12(11)21)19-18(28)17(27)16(26)14(9-25)29-19/h2-7,14,16-19,25-28H,8-9H2,1H3/t14-,16-,17+,18-,19+/m1/s1 | PDB
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| n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308484
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-heptyl-1,3,4-th...)Show SMILES CCCCCCCc1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r| Show InChI InChI=1S/C22H31ClN2O5S/c1-2-3-4-5-6-7-17-24-25-18(31-17)11-14-10-13(8-9-15(14)23)22-21(29)20(28)19(27)16(12-26)30-22/h8-10,16,19-22,26-29H,2-7,11-12H2,1H3/t16-,19-,20+,21-,22+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308441
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(4-chlorophenyl...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccc(Cl)cc2)c1 |r| Show InChI InChI=1S/C21H20Cl2N2O5S/c22-13-4-1-10(2-5-13)21-25-24-16(31-21)8-12-7-11(3-6-14(12)23)20-19(29)18(28)17(27)15(9-26)30-20/h1-7,15,17-20,26-29H,8-9H2/t15-,17-,18+,19-,20+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319052
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-ethylpyridazin-...)Show SMILES CCc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C19H23ClN2O5/c1-2-12-4-5-13(22-21-12)8-11-7-10(3-6-14(11)20)19-18(26)17(25)16(24)15(9-23)27-19/h3-7,15-19,23-26H,2,8-9H2,1H3/t15-,16-,17+,18-,19+/m1/s1 | PDB
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| n/a | n/a | 131 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319057
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-pentylpyridazin...)Show SMILES CCCCCc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C22H29ClN2O5/c1-2-3-4-5-15-7-8-16(25-24-15)11-14-10-13(6-9-17(14)23)22-21(29)20(28)19(27)18(12-26)30-22/h6-10,18-22,26-29H,2-5,11-12H2,1H3/t18-,19-,20+,21-,22+/m1/s1 | PDB
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| n/a | n/a | 134 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308435
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-methoxy-1,3,4-t...)Show SMILES COc1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r| Show InChI InChI=1S/C16H19ClN2O6S/c1-24-16-19-18-11(26-16)5-8-4-7(2-3-9(8)17)15-14(23)13(22)12(21)10(6-20)25-15/h2-4,10,12-15,20-23H,5-6H2,1H3/t10-,12-,13+,14-,15+/m1/s1 | PDB
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| n/a | n/a | 146 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308437
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(trifluoromethy...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)C(F)(F)F)c1 |r| Show InChI InChI=1S/C16H16ClF3N2O5S/c17-8-2-1-6(14-13(26)12(25)11(24)9(5-23)27-14)3-7(8)4-10-21-22-15(28-10)16(18,19)20/h1-3,9,11-14,23-26H,4-5H2/t9-,11-,12+,13-,14+/m1/s1 | PDB
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| n/a | n/a | 155 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319063
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(5-methylthioph...)Show SMILES Cc1ccc(s1)-c1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C22H23ClN2O5S/c1-11-2-7-18(31-11)16-6-4-14(24-25-16)9-13-8-12(3-5-15(13)23)22-21(29)20(28)19(27)17(10-26)30-22/h2-8,17,19-22,26-29H,9-10H2,1H3/t17-,19-,20+,21-,22+/m1/s1 | PDB
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| n/a | n/a | 168 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319058
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(phenylethynyl)...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)C#Cc2ccccc2)c1 |r| Show InChI InChI=1S/C25H23ClN2O5/c26-20-11-7-16(25-24(32)23(31)22(30)21(14-29)33-25)12-17(20)13-19-10-9-18(27-28-19)8-6-15-4-2-1-3-5-15/h1-5,7,9-12,21-25,29-32H,13-14H2/t21-,22-,23+,24-,25+/m1/s1 | PDB
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| n/a | n/a | 176 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308449
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(pyridazin-4-yl...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccnnc2)c1 |r| Show InChI InChI=1S/C19H19ClN4O5S/c20-12-2-1-9(18-17(28)16(27)15(26)13(8-25)29-18)5-11(12)6-14-23-24-19(30-14)10-3-4-21-22-7-10/h1-5,7,13,15-18,25-28H,6,8H2/t13-,15-,16+,17-,18+/m1/s1 | PDB
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| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103005
(US8541380, 49)Show SMILES COC(=O)c1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C19H21ClN2O7/c1-28-19(27)13-5-3-11(21-22-13)7-10-6-9(2-4-12(10)20)18-17(26)16(25)15(24)14(8-23)29-18/h2-6,14-18,23-26H,7-8H2,1H3/t14-,15-,16+,17-,18+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319038
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-chloropyridazin...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(Cl)nn2)c1 |r| Show InChI InChI=1S/C17H18Cl2N2O5/c18-11-3-1-8(5-9(11)6-10-2-4-13(19)21-20-10)17-16(25)15(24)14(23)12(7-22)26-17/h1-5,12,14-17,22-25H,6-7H2/t12-,14-,15+,16-,17+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308481
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-propyl-1,3,4-th...)Show SMILES CCCc1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r| Show InChI InChI=1S/C18H23ClN2O5S/c1-2-3-13-20-21-14(27-13)7-10-6-9(4-5-11(10)19)18-17(25)16(24)15(23)12(8-22)26-18/h4-6,12,15-18,22-25H,2-3,7-8H2,1H3/t12-,15-,16+,17-,18+/m1/s1 | PDB
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US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319064
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-phenylpyridazin...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)-c2ccccc2)c1 |r| Show InChI InChI=1S/C23H23ClN2O5/c24-17-8-6-14(23-22(30)21(29)20(28)19(12-27)31-23)10-15(17)11-16-7-9-18(26-25-16)13-4-2-1-3-5-13/h1-10,19-23,27-30H,11-12H2/t19-,20-,21+,22-,23+/m1/s1 | PDB
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US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319053
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-propylpyridazin...)Show SMILES CCCc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C20H25ClN2O5/c1-2-3-13-5-6-14(23-22-13)9-12-8-11(4-7-15(12)21)20-19(27)18(26)17(25)16(10-24)28-20/h4-8,16-20,24-27H,2-3,9-10H2,1H3/t16-,17-,18+,19-,20+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308455
((2S,3R,4R,5S,6R)-2-(3-((5-(Benzofuran-2-yl)-1,3,4-...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2cc3ccccc3o2)c1 |r| Show InChI InChI=1S/C23H21ClN2O6S/c24-14-6-5-12(22-21(30)20(29)19(28)17(10-27)32-22)7-13(14)9-18-25-26-23(33-18)16-8-11-3-1-2-4-15(11)31-16/h1-8,17,19-22,27-30H,9-10H2/t17-,19-,20+,21-,22+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308456
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(5-methylisoxaz...)Show SMILES Cc1cc(no1)-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r| Show InChI InChI=1S/C19H20ClN3O6S/c1-8-4-12(23-29-8)19-22-21-14(30-19)6-10-5-9(2-3-11(10)20)18-17(27)16(26)15(25)13(7-24)28-18/h2-5,13,15-18,24-27H,6-7H2,1H3/t13-,15-,16+,17-,18+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319054
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-isopropylpyrida...)Show SMILES CC(C)c1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C20H25ClN2O5/c1-10(2)15-6-4-13(22-23-15)8-12-7-11(3-5-14(12)21)20-19(27)18(26)17(25)16(9-24)28-20/h3-7,10,16-20,24-27H,8-9H2,1-2H3/t16-,17-,18+,19-,20+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103011
(US8541380, 89)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nccnn2)c1 |r| Show InChI InChI=1S/C16H18ClN3O5/c17-10-2-1-8(5-9(10)6-12-18-3-4-19-20-12)16-15(24)14(23)13(22)11(7-21)25-16/h1-5,11,13-16,21-24H,6-7H2/t11-,13-,14+,15-,16+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319065
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(4-fluorophenyl...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)-c2ccc(F)cc2)c1 |r| Show InChI InChI=1S/C23H22ClFN2O5/c24-17-7-3-13(23-22(31)21(30)20(29)19(11-28)32-23)9-14(17)10-16-6-8-18(27-26-16)12-1-4-15(25)5-2-12/h1-9,19-23,28-31H,10-11H2/t19-,20-,21+,22-,23+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319051
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-methylpyridazin...)Show SMILES Cc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C18H21ClN2O5/c1-9-2-4-12(21-20-9)7-11-6-10(3-5-13(11)19)18-17(25)16(24)15(23)14(8-22)26-18/h2-6,14-18,22-25H,7-8H2,1H3/t14-,15-,16+,17-,18+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103017
(US8541380, 95)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2nnc(s2)-c2ccco2)c2ccccc2c1 |r| Show InChI InChI=1S/C23H22N2O6S/c26-11-17-19(27)20(28)21(29)22(31-17)14-8-12-4-1-2-5-15(12)13(9-14)10-18-24-25-23(32-18)16-6-3-7-30-16/h1-9,17,19-22,26-29H,10-11H2/t17-,19-,20+,21-,22+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319066
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(3-methoxypheny...)Show SMILES COc1cccc(c1)-c1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C24H25ClN2O6/c1-32-17-4-2-3-13(11-17)19-8-6-16(26-27-19)10-15-9-14(5-7-18(15)25)24-23(31)22(30)21(29)20(12-28)33-24/h2-9,11,20-24,28-31H,10,12H2,1H3/t20-,21-,22+,23-,24+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308483
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-pentyl-1,3,4-th...)Show SMILES CCCCCc1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r| Show InChI InChI=1S/C20H27ClN2O5S/c1-2-3-4-5-15-22-23-16(29-15)9-12-8-11(6-7-13(12)21)20-19(27)18(26)17(25)14(10-24)28-20/h6-8,14,17-20,24-27H,2-5,9-10H2,1H3/t14-,17-,18+,19-,20+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319055
((2S,3R,4R,5S,6R)-2-(3-((6-butylpyridazin-3-yl)meth...)Show SMILES CCCCc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C21H27ClN2O5/c1-2-3-4-14-6-7-15(24-23-14)10-13-9-12(5-8-16(13)22)21-20(28)19(27)18(26)17(11-25)29-21/h5-9,17-21,25-28H,2-4,10-11H2,1H3/t17-,18-,19+,20-,21+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308482
((2S,3R,4R,5S,6R)-2-(3-((5-Butyl-1,3,4-thiadiazol-2...)Show SMILES CCCCc1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r| Show InChI InChI=1S/C19H25ClN2O5S/c1-2-3-4-14-21-22-15(28-14)8-11-7-10(5-6-12(11)20)19-18(26)17(25)16(24)13(9-23)27-19/h5-7,13,16-19,23-26H,2-4,8-9H2,1H3/t13-,16-,17+,18-,19+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103012
(US8541380, 90)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nncc(n2)-c2ccccc2)c1 |r| Show InChI InChI=1S/C22H22ClN3O5/c23-15-7-6-13(22-21(30)20(29)19(28)17(11-27)31-22)8-14(15)9-18-25-16(10-24-26-18)12-4-2-1-3-5-12/h1-8,10,17,19-22,27-30H,9,11H2/t17-,19-,20+,21-,22+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319043
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-isobutoxypyrida...)Show SMILES CC(C)COc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C21H27ClN2O6/c1-11(2)10-29-17-6-4-14(23-24-17)8-13-7-12(3-5-15(13)22)21-20(28)19(27)18(26)16(9-25)30-21/h3-7,11,16,18-21,25-28H,8-10H2,1-2H3/t16-,18-,19+,20-,21+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308439
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-cyclopentyl-1,3...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)C2CCCC2)c1 |r| Show InChI InChI=1S/C20H25ClN2O5S/c21-13-6-5-11(19-18(27)17(26)16(25)14(9-24)28-19)7-12(13)8-15-22-23-20(29-15)10-3-1-2-4-10/h5-7,10,14,16-19,24-27H,1-4,8-9H2/t14-,16-,17+,18-,19+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103000
(US8541380, 25)Show SMILES CC1CCC(Cc2nnc(Cc3cc(ccc3Cl)C3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)s2)CC1 |r,w:18.18,wU:20.21,25.26,wD:23.24,27.29,(9.5,5.36,;8.73,4.03,;9.5,2.7,;8.73,1.36,;7.19,1.36,;6.42,.03,;4.88,.03,;3.97,1.27,;2.51,.8,;2.51,-.74,;1.17,-1.51,;-.16,-.74,;-1.49,-1.51,;-2.83,-.74,;-2.83,.8,;-1.49,1.57,;-.16,.8,;1.17,1.57,;-4.16,-1.51,;-5.5,-.74,;-6.83,-1.51,;-8.16,-.74,;-9.5,-1.51,;-6.83,-3.05,;-8.16,-3.82,;-5.5,-3.82,;-5.5,-5.36,;-4.16,-3.05,;-2.83,-3.82,;3.97,-1.22,;6.42,2.7,;7.19,4.03,)| Show InChI InChI=1S/C23H31ClN2O5S/c1-12-2-4-13(5-3-12)8-18-25-26-19(32-18)10-15-9-14(6-7-16(15)24)23-22(30)21(29)20(28)17(11-27)31-23/h6-7,9,12-13,17,20-23,27-30H,2-5,8,10-11H2,1H3/t12?,13?,17-,20-,21+,22-,23?/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103010
(US8541380, 88)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc3ccccc3n2)c1 |r| Show InChI InChI=1S/C20H20ClN3O5/c21-12-6-5-10(20-19(28)18(27)17(26)15(9-25)29-20)7-11(12)8-16-22-13-3-1-2-4-14(13)23-24-16/h1-7,15,17-20,25-28H,8-9H2/t15-,17-,18+,19-,20+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103009
(US8541380, 87)Show SMILES Cc1ccc2nc(Cc3cc(ccc3Cl)[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)nnc2c1 |r| Show InChI InChI=1S/C21H22ClN3O5/c1-10-2-5-14-15(6-10)24-25-17(23-14)8-12-7-11(3-4-13(12)22)21-20(29)19(28)18(27)16(9-26)30-21/h2-7,16,18-21,26-29H,8-9H2,1H3/t16-,18-,19+,20-,21+/m1/s1 | PDB
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US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM102999
(US8541380, 24)Show SMILES OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)C2CCCCC2)c1 |r,w:4.11| Show InChI InChI=1S/C21H27ClN2O5S/c22-14-7-6-12(20-19(28)18(27)17(26)15(10-25)29-20)8-13(14)9-16-23-24-21(30-16)11-4-2-1-3-5-11/h6-8,11,15,17-20,25-28H,1-5,9-10H2/t15-,17-,18+,19-,20?/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103001
(US8541380, 26)Show SMILES CC(Cc1nnc(Cc2cc(ccc2Cl)C2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1)c1ccccc1 |r,w:15.15| Show InChI InChI=1S/C24H27ClN2O5S/c1-13(14-5-3-2-4-6-14)9-19-26-27-20(33-19)11-16-10-15(7-8-17(16)25)24-23(31)22(30)21(29)18(12-28)32-24/h2-8,10,13,18,21-24,28-31H,9,11-12H2,1H3/t13?,18-,21-,22+,23-,24?/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308447
(((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(quinolin-2-yl...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccc3ccccc3n2)c1 |r| Show InChI InChI=1S/C24H22ClN3O5S/c25-15-7-5-13(23-22(32)21(31)20(30)18(11-29)33-23)9-14(15)10-19-27-28-24(34-19)17-8-6-12-3-1-2-4-16(12)26-17/h1-9,18,20-23,29-32H,10-11H2/t18-,20-,21+,22-,23+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103007
(US8541380, 83)Show SMILES Cc1cc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)n[nH]c1=O |r| Show InChI InChI=1S/C18H21ClN2O6/c1-8-4-11(20-21-18(8)26)6-10-5-9(2-3-12(10)19)17-16(25)15(24)14(23)13(7-22)27-17/h2-5,13-17,22-25H,6-7H2,1H3,(H,21,26)/t13-,14-,15+,16-,17+/m1/s1 | PDB
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US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308443
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(6-methylpyridi...)Show SMILES Cc1cccc(n1)-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r| Show InChI InChI=1S/C21H22ClN3O5S/c1-10-3-2-4-14(23-10)21-25-24-16(31-21)8-12-7-11(5-6-13(12)22)20-19(29)18(28)17(27)15(9-26)30-20/h2-7,15,17-20,26-29H,8-9H2,1H3/t15-,17-,18+,19-,20+/m1/s1 | PDB
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US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319072
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-morpholinopyrid...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)N2CCOCC2)c1 |r| Show InChI InChI=1S/C21H26ClN3O6/c22-15-3-1-12(21-20(29)19(28)18(27)16(11-26)31-21)9-13(15)10-14-2-4-17(24-23-14)25-5-7-30-8-6-25/h1-4,9,16,18-21,26-29H,5-8,10-11H2/t16-,18-,19+,20-,21+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308462
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(3-chlorothioph...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2sccc2Cl)c1 |r| Show InChI InChI=1S/C19H18Cl2N2O5S2/c20-10-2-1-8(17-16(27)15(26)14(25)12(7-24)28-17)5-9(10)6-13-22-23-19(30-13)18-11(21)3-4-29-18/h1-5,12,14-17,24-27H,6-7H2/t12-,14-,15+,16-,17+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103002
(US8541380, 27)Show SMILES OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(\C=C\c3ccccc3)s2)c1 |r,w:4.11| Show InChI InChI=1S/C23H23ClN2O5S/c24-16-8-7-14(23-22(30)21(29)20(28)17(12-27)31-23)10-15(16)11-19-26-25-18(32-19)9-6-13-4-2-1-3-5-13/h1-10,17,20-23,27-30H,11-12H2/b9-6+/t17-,20-,21+,22-,23?/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308438
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(2,2,2-trifluor...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(CC(F)(F)F)s2)c1 |r| Show InChI InChI=1S/C17H18ClF3N2O5S/c18-9-2-1-7(16-15(27)14(26)13(25)10(6-24)28-16)3-8(9)4-11-22-23-12(29-11)5-17(19,20)21/h1-3,10,13-16,24-27H,4-6H2/t10-,13-,14+,15-,16+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50308461
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(3-methylthioph...)Show SMILES Cc1ccsc1-c1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)s1 |r| Show InChI InChI=1S/C20H21ClN2O5S2/c1-9-4-5-29-19(9)20-23-22-14(30-20)7-11-6-10(2-3-12(11)21)18-17(27)16(26)15(25)13(8-24)28-18/h2-6,13,15-18,24-27H,7-8H2,1H3/t13-,15-,16+,17-,18+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319056
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-isobutylpyridaz...)Show SMILES CC(C)Cc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C21H27ClN2O5/c1-11(2)7-14-4-5-15(24-23-14)9-13-8-12(3-6-16(13)22)21-20(28)19(27)18(26)17(10-25)29-21/h3-6,8,11,17-21,25-28H,7,9-10H2,1-2H3/t17-,18-,19+,20-,21+/m1/s1 | PDB
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Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319074
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(pyrrolidin-1-y...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(nn2)N2CCCC2)c1 |r| Show InChI InChI=1S/C21H26ClN3O5/c22-15-5-3-12(21-20(29)19(28)18(27)16(11-26)30-21)9-13(15)10-14-4-6-17(24-23-14)25-7-1-2-8-25/h3-6,9,16,18-21,26-29H,1-2,7-8,10-11H2/t16-,18-,19+,20-,21+/m1/s1 | PDB
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| n/a | n/a | 1.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103008
(CHEMBL1082417 | US8541380, 185)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(Nc3ccccc3)nn2)c1 |r| Show InChI InChI=1S/C23H24ClN3O5/c24-17-8-6-13(23-22(31)21(30)20(29)18(12-28)32-23)10-14(17)11-16-7-9-19(27-26-16)25-15-4-2-1-3-5-15/h1-10,18,20-23,28-31H,11-12H2,(H,25,27)/t18-,20-,21+,22-,23+/m1/s1 | PDB
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| n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103004
(US8541380, 36)Show SMILES OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c1cccc(Cc2nnc(s2)-c2cccnc2)c1 |r,w:4.11| Show InChI InChI=1S/C20H21N3O5S/c24-10-14-16(25)17(26)18(27)19(28-14)12-4-1-3-11(7-12)8-15-22-23-20(29-15)13-5-2-6-21-9-13/h1-7,9,14,16-19,24-27H,8,10H2/t14-,16-,17+,18-,19?/m1/s1 | PDB
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| n/a | n/a | 1.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM103003
(US8541380, 35)Show SMILES OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c1cccc(Cc2nnc(s2)-c2ccccc2)c1 |r,w:4.11| Show InChI InChI=1S/C21H22N2O5S/c24-11-15-17(25)18(26)19(27)20(28-15)14-8-4-5-12(9-14)10-16-22-23-21(29-16)13-6-2-1-3-7-13/h1-9,15,17-20,24-27H,10-11H2/t15-,17-,18+,19-,20?/m1/s1 | PDB
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| n/a | n/a | 1.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319075
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-methyl-6-(methy...)Show SMILES CSc1nnc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1C |r| Show InChI InChI=1S/C19H23ClN2O5S/c1-9-5-12(21-22-19(9)28-2)7-11-6-10(3-4-13(11)20)18-17(26)16(25)15(24)14(8-23)27-18/h3-6,14-18,23-26H,7-8H2,1-2H3/t14-,15-,16+,17-,18+/m1/s1 | PDB
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| n/a | n/a | 1.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319071
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(5-methyloxazol...)Show SMILES Cc1cnc(o1)-c1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r| Show InChI InChI=1S/C21H22ClN3O6/c1-10-8-23-21(30-10)15-5-3-13(24-25-15)7-12-6-11(2-4-14(12)22)20-19(29)18(28)17(27)16(9-26)31-20/h2-6,8,16-20,26-29H,7,9H2,1H3/t16-,17-,18+,19-,20+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50319050
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-(phenylthio)pyr...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(Sc3ccccc3)nn2)c1 |r| Show InChI InChI=1S/C23H23ClN2O5S/c24-17-8-6-13(23-22(30)21(29)20(28)18(12-27)31-23)10-14(17)11-15-7-9-19(26-25-15)32-16-4-2-1-3-5-16/h1-10,18,20-23,27-30H,11-12H2/t18-,20-,21+,22-,23+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
US Patent
| Assay Description
Inhibition assay using hSGLT2. |
US Patent US8541380 (2013)
BindingDB Entry DOI: 10.7270/Q2T43RQ3 |
More data for this
Ligand-Target Pair | |
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