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Patent code US9447091

Compile Data Set for Download or QSAR
Found 40 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247344
PNG
(US9447091, 131)
Show SMILES CC(=O)Nc1cc(cc(c1)-n1cnc2cc(cnc12)-c1cnn(C)c1)-c1ccc(F)cc1F
Show InChI InChI=1S/C24H18F2N6O/c1-14(33)30-19-5-15(21-4-3-18(25)8-22(21)26)6-20(9-19)32-13-28-23-7-16(10-27-24(23)32)17-11-29-31(2)12-17/h3-13H,1-2H3,(H,30,33)
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n/an/a 1.30n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247340
PNG
(US9447091, 112)
Show SMILES CC(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-c1cn(CCC(C)(C)O)nn1)-n1cccc1
Show InChI InChI=1S/C26H27N7O2/c1-18(34)28-20-13-21(31-9-4-5-10-31)15-22(14-20)33-17-27-23-12-19(6-7-25(23)33)24-16-32(30-29-24)11-8-26(2,3)35/h4-7,9-10,12-17,35H,8,11H2,1-3H3,(H,28,34)
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247357
PNG
(US9447091, 241)
Show SMILES Cn1cc(cn1)-c1ccc2n(cnc2c1)-c1cc(NC(=O)Cn2cncn2)cc(c1)-c1ccc(F)cc1F
Show InChI InChI=1S/C27H20F2N8O/c1-35-12-19(11-32-35)17-2-5-26-25(8-17)31-16-37(26)22-7-18(23-4-3-20(28)9-24(23)29)6-21(10-22)34-27(38)13-36-15-30-14-33-36/h2-12,14-16H,13H2,1H3,(H,34,38)
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247361
PNG
(US9447091, 220)
Show SMILES CC(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-c1cnn(CCC(C)(C)O)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H28FN5O2/c1-19(36)33-25-12-22(20-4-7-24(30)8-5-20)13-26(15-25)35-18-31-27-14-21(6-9-28(27)35)23-16-32-34(17-23)11-10-29(2,3)37/h4-9,12-18,37H,10-11H2,1-3H3,(H,33,36)
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247334
PNG
(US9447091, 49)
Show SMILES CCS(=O)(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-c1cn(CCN2CCOCC2)nn1)-c1ccc(F)cc1F
Show InChI InChI=1S/C29H29F2N7O3S/c1-2-42(39,40)34-23-13-21(25-5-4-22(30)16-26(25)31)14-24(17-23)38-19-32-27-15-20(3-6-29(27)38)28-18-37(35-33-28)8-7-36-9-11-41-12-10-36/h3-6,13-19,34H,2,7-12H2,1H3
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247328
PNG
(US9447091, 22)
Show SMILES CC(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-c1cnco1)-c1ccc(F)cc1F
Show InChI InChI=1S/C24H16F2N4O2/c1-14(31)29-18-6-16(20-4-3-17(25)9-21(20)26)7-19(10-18)30-12-28-22-8-15(2-5-23(22)30)24-11-27-13-32-24/h2-13H,1H3,(H,29,31)
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247354
PNG
(US9447091, 190)
Show SMILES COc1ccc(c(F)c1)-c1cc(NC(C)=O)cc(c1)-n1cnc2cc(ccc12)-c1cnn(C)c1
Show InChI InChI=1S/C26H22FN5O2/c1-16(33)30-20-8-18(23-6-5-22(34-3)12-24(23)27)9-21(11-20)32-15-28-25-10-17(4-7-26(25)32)19-13-29-31(2)14-19/h4-15H,1-3H3,(H,30,33)
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247333
PNG
(US9447091, 47)
Show SMILES CC(C)(O)CCn1cc(nn1)-c1ccc2n(cnc2c1)-c1cc(NS(=O)(=O)C2CC2)cc(c1)-c1ccc(F)cc1F
Show InChI InChI=1S/C29H28F2N6O3S/c1-29(2,38)9-10-36-16-27(33-35-36)18-3-8-28-26(13-18)32-17-37(28)22-12-19(24-7-4-20(30)14-25(24)31)11-21(15-22)34-41(39,40)23-5-6-23/h3-4,7-8,11-17,23,34,38H,5-6,9-10H2,1-2H3
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247348
PNG
(US9447091, 152)
Show SMILES CC(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-n1cccn1)-c1c(F)cccc1F
Show InChI InChI=1S/C24H17F2N5O/c1-15(32)29-17-10-16(24-20(25)4-2-5-21(24)26)11-19(12-17)30-14-27-22-13-18(6-7-23(22)30)31-9-3-8-28-31/h2-14H,1H3,(H,29,32)
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247360
PNG
(US9447091, 281)
Show SMILES Cn1cc(cn1)-c1ccc2n(cnc2c1)-c1cc(Nc2nccs2)cc(c1)-c1ccc(F)cc1F
Show InChI InChI=1S/C26H18F2N6S/c1-33-14-18(13-31-33)16-2-5-25-24(10-16)30-15-34(25)21-9-17(22-4-3-19(27)11-23(22)28)8-20(12-21)32-26-29-6-7-35-26/h2-15H,1H3,(H,29,32)
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247363
PNG
(US9447091, 294)
Show SMILES CS(=O)(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-c1cnn(CCN2CCOCC2)c1)-c1ncccc1F
Show InChI InChI=1S/C28H28FN7O3S/c1-40(37,38)33-23-13-21(28-25(29)3-2-6-30-28)14-24(16-23)36-19-31-26-15-20(4-5-27(26)36)22-17-32-35(18-22)8-7-34-9-11-39-12-10-34/h2-6,13-19,33H,7-12H2,1H3
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247336
PNG
(US9447091, 70)
Show SMILES CC(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-n1cccn1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H18FN5O/c1-16(31)28-20-11-18(17-3-5-19(25)6-4-17)12-22(13-20)29-15-26-23-14-21(7-8-24(23)29)30-10-2-9-27-30/h2-15H,1H3,(H,28,31)
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US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247356
PNG
(US9447091, 217)
Show SMILES CNS(=O)(=O)N(C)c1cc(cc(c1)-n1cnc2cc(cnc12)-c1cnn(c1)C(C)C)-c1ccc(F)cc1F
Show InChI InChI=1S/C26H25F2N7O2S/c1-16(2)35-14-19(13-32-35)18-9-25-26(30-12-18)34(15-31-25)22-8-17(23-6-5-20(27)10-24(23)28)7-21(11-22)33(4)38(36,37)29-3/h5-16,29H,1-4H3
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247327
PNG
(US9447091, 5)
Show SMILES Cn1cc(cn1)-c1ccc2n(cnc2c1)-c1cc(NS(=O)(=O)C2CC2)cc(c1)-c1ccc(F)cc1F
Show InChI InChI=1S/C26H21F2N5O2S/c1-32-14-18(13-30-32)16-2-7-26-25(10-16)29-15-33(26)21-9-17(23-6-3-19(27)11-24(23)28)8-20(12-21)31-36(34,35)22-4-5-22/h2-3,6-15,22,31H,4-5H2,1H3
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247358
PNG
(US9447091, 244)
Show SMILES Cn1cc(cn1)-c1cnc2n(cnc2c1)-c1cc(NS(=O)(=O)NC2CC2)cc(c1)-c1ccc(F)cc1F
Show InChI InChI=1S/C25H21F2N7O2S/c1-33-13-17(12-30-33)16-8-24-25(28-11-16)34(14-29-24)21-7-15(22-5-2-18(26)9-23(22)27)6-20(10-21)32-37(35,36)31-19-3-4-19/h2,5-14,19,31-32H,3-4H2,1H3
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Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247345
PNG
(US9447091, 133)
Show SMILES CCS(=O)(=O)Nc1cc(cc(c1)-n1cnc2cc(cnc12)-c1cnn(C)c1)-c1ccc(F)cc1F
Show InChI InChI=1S/C24H20F2N6O2S/c1-3-35(33,34)30-19-6-15(21-5-4-18(25)9-22(21)26)7-20(10-19)32-14-28-23-8-16(11-27-24(23)32)17-12-29-31(2)13-17/h4-14,30H,3H2,1-2H3
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US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247353
PNG
(US9447091, 178)
Show SMILES CC(=O)Nc1cc(cc(c1)-n1cnc2cc(cnc12)-c1ccc(F)nc1)-c1ccc(F)cc1F
Show InChI InChI=1S/C25H16F3N5O/c1-14(34)32-19-6-16(21-4-3-18(26)9-22(21)27)7-20(10-19)33-13-31-23-8-17(12-30-25(23)33)15-2-5-24(28)29-11-15/h2-13H,1H3,(H,32,34)
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247331
PNG
(US9447091, 30)
Show SMILES CCS(=O)(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-n1cccn1)-c1ccc(F)cc1F
Show InChI InChI=1S/C24H19F2N5O2S/c1-2-34(32,33)29-18-10-16(21-6-4-17(25)12-22(21)26)11-20(13-18)30-15-27-23-14-19(5-7-24(23)30)31-9-3-8-28-31/h3-15,29H,2H2,1H3
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247338
PNG
(US9447091, 82)
Show SMILES CN(C)CCn1cc(cn1)-c1ccc2n(cnc2c1)-c1cc(NC(C)=O)cc(c1)-c1ccc(C)o1
Show InChI InChI=1S/C27H28N6O2/c1-18-5-8-27(35-18)21-11-23(30-19(2)34)14-24(12-21)33-17-28-25-13-20(6-7-26(25)33)22-15-29-32(16-22)10-9-31(3)4/h5-8,11-17H,9-10H2,1-4H3,(H,30,34)
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n/an/a 16n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247364
PNG
(US9447091, 319)
Show SMILES CN1CCC(CC1)C(=O)Nc1cc(cc(c1)-n1cnc2cc(cnc12)-c1cnn(C)c1)-c1ccc(F)cc1F
Show InChI InChI=1S/C29H27F2N7O/c1-36-7-5-18(6-8-36)29(39)35-23-9-19(25-4-3-22(30)12-26(25)31)10-24(13-23)38-17-33-27-11-20(14-32-28(27)38)21-15-34-37(2)16-21/h3-4,9-18H,5-8H2,1-2H3,(H,35,39)
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n/an/a 18n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247355
PNG
(US9447091, 204)
Show SMILES CC(C)n1cc(cn1)-c1ccc2n(cnc2c1)-c1cc(NS(=O)(=O)C2CC2)cc(c1)-c1ccc(F)cc1F
Show InChI InChI=1S/C28H25F2N5O2S/c1-17(2)35-15-20(14-32-35)18-3-8-28-27(11-18)31-16-34(28)23-10-19(25-7-4-21(29)12-26(25)30)9-22(13-23)33-38(36,37)24-5-6-24/h3-4,7-17,24,33H,5-6H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247330
PNG
(US9447091, 26)
Show SMILES Fc1ccc(c(F)c1)-c1cc(NS(=O)(=O)c2ccccc2)cc(c1)-n1cnc2cc(ccc12)-c1cnco1
Show InChI InChI=1S/C28H18F2N4O3S/c29-20-7-8-24(25(30)13-20)19-10-21(33-38(35,36)23-4-2-1-3-5-23)14-22(11-19)34-16-32-26-12-18(6-9-27(26)34)28-15-31-17-37-28/h1-17,33H
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n/an/a 21n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247350
PNG
(US9447091, 158)
Show SMILES COc1ccc(cn1)-c1cc(NC(C)=O)cc(c1)-n1cnc2cc(ccc12)-c1cnn(C)c1
Show InChI InChI=1S/C25H22N6O2/c1-16(32)29-21-8-19(18-5-7-25(33-3)26-12-18)9-22(11-21)31-15-27-23-10-17(4-6-24(23)31)20-13-28-30(2)14-20/h4-15H,1-3H3,(H,29,32)
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n/an/a 22n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247335
PNG
(US9447091, 69)
Show SMILES COc1ccc(cn1)-c1ccc2n(cnc2c1)-c1cc(NC(C)=O)cc(c1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H21FN4O2/c1-17(33)31-23-11-21(18-3-7-22(28)8-4-18)12-24(14-23)32-16-30-25-13-19(5-9-26(25)32)20-6-10-27(34-2)29-15-20/h3-16H,1-2H3,(H,31,33)
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n/an/a 22n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247362
PNG
(US9447091, 289)
Show SMILES Fc1ccc(c(F)c1)-c1cc(NS(=O)(=O)C2CC2)cc(c1)-n1cnc2cc(ccc12)-c1ccc(=O)[nH]c1
Show InChI InChI=1S/C27H20F2N4O3S/c28-19-3-6-23(24(29)12-19)18-9-20(32-37(35,36)22-4-5-22)13-21(10-18)33-15-31-25-11-16(1-7-26(25)33)17-2-8-27(34)30-14-17/h1-3,6-15,22,32H,4-5H2,(H,30,34)
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n/an/a 32n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247337
PNG
(US9447091, 72)
Show SMILES CCS(=O)(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-n1cccn1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H20FN5O2S/c1-2-33(31,32)28-20-12-18(17-4-6-19(25)7-5-17)13-22(14-20)29-16-26-23-15-21(8-9-24(23)29)30-11-3-10-27-30/h3-16,28H,2H2,1H3
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n/an/a 32n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247332
PNG
(US9447091, 38)
Show SMILES Fc1ccc(c(F)c1)-c1cc(NC(=O)NC2CCCC2)cc(c1)-n1cnc2cc(ccc12)-n1cccn1
Show InChI InChI=1S/C28H24F2N6O/c29-19-6-8-24(25(30)14-19)18-12-21(34-28(37)33-20-4-1-2-5-20)15-23(13-18)35-17-31-26-16-22(7-9-27(26)35)36-11-3-10-32-36/h3,6-17,20H,1-2,4-5H2,(H2,33,34,37)
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n/an/a 33n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247329
PNG
(US9447091, 25)
Show SMILES CC(C)S(=O)(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-c1cnco1)-c1ccc(F)cc1F
Show InChI InChI=1S/C25H20F2N4O3S/c1-15(2)35(32,33)30-19-7-17(21-5-4-18(26)10-22(21)27)8-20(11-19)31-13-29-23-9-16(3-6-24(23)31)25-12-28-14-34-25/h3-15,30H,1-2H3
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n/an/a 34n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247339
PNG
(US9447091, 83)
Show SMILES CC(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-c1cnn(CCN2CCOCC2)c1)-c1ccc(C)o1
Show InChI InChI=1S/C29H30N6O3/c1-20-3-6-29(38-20)23-13-25(32-21(2)36)16-26(14-23)35-19-30-27-15-22(4-5-28(27)35)24-17-31-34(18-24)8-7-33-9-11-37-12-10-33/h3-6,13-19H,7-12H2,1-2H3,(H,32,36)
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n/an/a 37n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247366
PNG
(US9447091, 259)
Show SMILES Fc1ccc(c(F)c1)-c1cc(NC(=O)CN2CCCCC2)cc(c1)-n1cnc2cc(ccc12)-n1cccn1
Show InChI InChI=1S/C29H26F2N6O/c30-21-5-7-25(26(31)15-21)20-13-22(34-29(38)18-35-10-2-1-3-11-35)16-24(14-20)36-19-32-27-17-23(6-8-28(27)36)37-12-4-9-33-37/h4-9,12-17,19H,1-3,10-11,18H2,(H,34,38)
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n/an/a 45n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247347
PNG
(US9447091, 142)
Show SMILES CC(C)S(=O)(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-c1cnn(CCN2CCOCC2)c1)-c1cc(F)ccc1F
Show InChI InChI=1S/C31H32F2N6O3S/c1-21(2)43(40,41)36-26-13-23(28-16-25(32)4-5-29(28)33)14-27(17-26)39-20-34-30-15-22(3-6-31(30)39)24-18-35-38(19-24)8-7-37-9-11-42-12-10-37/h3-6,13-21,36H,7-12H2,1-2H3
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n/an/a 48n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247352
PNG
(US9447091, 170)
Show SMILES CC(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-c1ccc(F)nc1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H18F2N4O/c1-16(33)31-22-10-20(17-2-6-21(27)7-3-17)11-23(13-22)32-15-30-24-12-18(4-8-25(24)32)19-5-9-26(28)29-14-19/h2-15H,1H3,(H,31,33)
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n/an/a 59n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247342
PNG
(US9447091, 123)
Show SMILES O=C(NCc1ccco1)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-n1cccn1)-n1cccn1
Show InChI InChI=1S/C25H20N8O2/c34-25(26-16-22-4-1-11-35-22)30-18-12-20(14-21(13-18)33-10-3-8-29-33)31-17-27-23-15-19(5-6-24(23)31)32-9-2-7-28-32/h1-15,17H,16H2,(H2,26,30,34)
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n/an/a 61n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247349
PNG
(US9447091, 155)
Show SMILES CC(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-c1cnn(C)c1)-n1cncn1
Show InChI InChI=1S/C21H18N8O/c1-14(30)26-17-6-18(8-19(7-17)29-12-22-11-25-29)28-13-23-20-5-15(3-4-21(20)28)16-9-24-27(2)10-16/h3-13H,1-2H3,(H,26,30)
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n/an/a 62n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247343
PNG
(US9447091, 127)
Show SMILES CC(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)-c1cnn(CC2CC2)c1)-n1cccn1
Show InChI InChI=1S/C25H23N7O/c1-17(33)29-21-10-22(12-23(11-21)32-8-2-7-27-32)31-16-26-24-9-19(5-6-25(24)31)20-13-28-30(15-20)14-18-3-4-18/h2,5-13,15-16,18H,3-4,14H2,1H3,(H,29,33)
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247365
PNG
(US9447091, 322)
Show SMILES OC1CCN(C1)c1ccc2n(cnc2c1)-c1cc(NS(=O)(=O)C2CC2)cc(c1)C1=CC=C(F)CC1F |t:33,35|
Show InChI InChI=1S/C26H26F2N4O3S/c27-17-1-5-23(24(28)11-17)16-9-18(30-36(34,35)22-3-4-22)12-20(10-16)32-15-29-25-13-19(2-6-26(25)32)31-8-7-21(33)14-31/h1-2,5-6,9-10,12-13,15,21-22,24,30,33H,3-4,7-8,11,14H2
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n/an/a 65.8n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247341
PNG
(US9447091, 119)
Show SMILES Cn1cc(cn1)-c1ccc2n(cnc2c1)-c1cc(NS(=O)(=O)N2CCCCC2)cc(c1)-n1cccn1
Show InChI InChI=1S/C25H26N8O2S/c1-30-17-20(16-28-30)19-6-7-25-24(12-19)26-18-32(25)22-13-21(14-23(15-22)33-11-5-8-27-33)29-36(34,35)31-9-3-2-4-10-31/h5-8,11-18,29H,2-4,9-10H2,1H3
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ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247359
PNG
(US9447091, 280)
Show SMILES Cn1cc(cn1)-c1ccc2n(cnc2c1)-c1cc(Nc2ncccn2)cc(c1)-c1ccc(F)cc1F
Show InChI InChI=1S/C27H19F2N7/c1-35-15-19(14-33-35)17-3-6-26-25(11-17)32-16-36(26)22-10-18(23-5-4-20(28)12-24(23)29)9-21(13-22)34-27-30-7-2-8-31-27/h2-16H,1H3,(H,30,31,34)
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UniProtKB/SwissProt

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n/an/a 90n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247351
PNG
(US9447091, 169)
Show SMILES CC(=O)Nc1cc(cc(c1)-n1cnc2cc(ccc12)C1=NCCN1)-c1ccc(F)cc1F |t:22|
Show InChI InChI=1S/C24H19F2N5O/c1-14(32)30-18-8-16(20-4-3-17(25)11-21(20)26)9-19(12-18)31-13-29-22-10-15(2-5-23(22)31)24-27-6-7-28-24/h2-5,8-13H,6-7H2,1H3,(H,27,28)(H,30,32)
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n/an/a 94n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM247346
PNG
(US9447091, 134)
Show SMILES Cn1cc(cn1)-c1cnc2n(cnc2c1)-c1cc(NS(=O)(=O)c2ccccc2)cc(c1)-c1ccc(F)cc1F
Show InChI InChI=1S/C28H20F2N6O2S/c1-35-16-20(15-33-35)19-11-27-28(31-14-19)36(17-32-27)23-10-18(25-8-7-21(29)12-26(25)30)9-22(13-23)34-39(37,38)24-5-3-2-4-6-24/h2-17,34H,1H3
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n/an/a 98n/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Compounds were screened in the TR-FRET assay with FGFR1 kinase. 5 ng of FGFR1 [Upstate, USA] kinase was used for assay. The compound was incubated wi...

US Patent US9447091 (2016)


BindingDB Entry DOI: 10.7270/Q2TM792J
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%