90 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
SAR exploration at the C-3 position of tetrahydro-ß-carboline sstr3 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Treating pain with somatostatin receptor subtype 4 agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Therachem Research Medilab (India)
Investigation of Cardiovascular Effects of Tetrahydro-ß-carboline sstr3 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Missouri
Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst 1 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes For Biomedical Research
Identification and SAR of potent and selective non-peptide obeline somatostatin sst1 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes For Biomedical Research
The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
N-Methylated sst2 Selective Somatostatin Cyclic Peptide Analogue as a Potent Candidate for Treating Neurogenic Inflammation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Firenze
Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Clayton Foundation Laboratories For Peptide Biology
Highly potent 4-amino-indolo[2,3-c]azepin-3-one-containing somatostatin mimetics with a range of sst receptor selectivities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vrije Universiteit Brussel
Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Berne
Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Salk Institute
Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Salk Institute
Novel sst5-selective somatostatin dicarba-analogues: synthesis and conformation-affinity relationships.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Firenze
Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from rat pituitary cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of California San Diego
N-terminal sugar conjugation and C-terminal Thr-for-Thr(ol) exchange in radioiodinated Tyr3-octreotide: effect on cellular ligand trafficking in vitro and tumor accumulation in vivo.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Technische Universit£T M£Nchen
Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSST2 and hSST4. An unexpected effect of the chirality of Trp8 on NMR spectra in methanol.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Pennsylvania
Novel sst(4)-selective somatostatin (SRIF) agonists. 2. Analogues with beta-methyl-3-(2-naphthyl)alanine substitutions at position 8.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Salk Institute
Novel sst(4)-selective somatostatin (SRIF) agonists. 1. Lead identification using a betide scan.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Salk Institute
2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Tulane University Health Sciences Center
Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institut Henri Beaufour
Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Pennsylvania
Potent antagonists of somatostatin: synthesis and biology.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Tulane University School of Medicine
Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Northeast Louisiana University
Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Lanthionine-somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of California San Diego
Synthesis of substituted imidazopyrazines as ligands for the human somatostatin receptor subtype 5.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institut Henri Beaufour
N-imidazolebenzyl-histidine substitution in somatostatin and in its octapeptide analogue modulates receptor selectivity and function.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Salk Institute
Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Shandong University School of Medicine
Biological diversity from a structurally diverse library: systematically scanning conformational space using a pyranose scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Alchemia
Synthesis and anti-tumor activities of methyl 2-O-aryl-6-O-aryl'-D-glucopyranosides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ocean University of China
Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
F. Hoffmann-La Roche
Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Amgen
Discovery of the first nonpeptidic, small-molecule, highly selective somatostatin receptor subtype 5 antagonists: a chemogenomics approach.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
F. Hoffmann-La Roche
New sst4/5-selective somatostatin peptidomimetics based on a constrained tryptophan scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vrije Universiteit Brussel
Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Salk Institute
Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Salk Institute
Novel sst(4)-selective somatostatin (SRIF) agonists. 4. Three-dimensional consensus structure by NMR.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Salk Institute
Novel sst(4)-selective somatostatin (SRIF) agonists. 3. Analogues amenable to radiolabeling.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Salk Institute
Effects of heterocyclic aromatic substituents on binding affinities at two distinct sites of somatostatin receptors. Correlation with the electrostatic potential of the substituents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Pennsylvania
Human somatostatin receptor specificity of backbone-cyclic analogues containing novel sulfur building units.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Hebrew University
Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Salk Institute
N-Methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Tulane University Health Sciences Center
Optimization of a somatostatin mimetic via constrained amino acid and backbone incorporation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of California
Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Tarveda Therapeutics
Highly potent cyclic disulfide antagonists of somatostatin.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Tulane University School of Medicine
Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Design, synthesis, and biological activities of potent and selective somatostatin analogues incorporating novel peptoid residues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of California San Diego
Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity. A new route to ether synthesis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Pennsylvania
Ligand design for somatostatin receptor isoforms 4 and 5.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National University of Ireland Galway
Non-iminosugar glucocerebrosidase small molecule chaperones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Human Genome Research Institute
[DOTA]Somatostatin-14 analogs and their (111)In-radioligands: effects of decreasing ring-size on sst1-5 profile, stability and tumor targeting.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Inrastes
A tetradecapeptide somatostatin dicarba-analog: Synthesis, structural impact and biological activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute For Research In Biomedicine (Irb Barcelona)
A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Pharma
Peptide folding induces high and selective affinity of a linear and small beta-peptide to the human somatostatin receptor 4.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eth Zurich
Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck
Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Takeda Pharmaceutical
Novel biphenyl bis-sulfonamides as acetyl and butyrylcholinesterase inhibitors: Synthesis, biological evaluation and molecular modeling studies.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Government College University
Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
China Pharmaceutical University
Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Northeastern University
Synthesis, antioxidant and anticholinesterase activities of novel coumarylthiazole derivatives.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Bezmialem Vakif University
Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Pfizer
Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Wyeth Research