43 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Quinolone antibacterials: synthesis and biological activity of carbon isosteres of the 1-piperazinyl and 3-amino-1-pyrrolidinyl side chains.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Warner-Lambert
7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Warner-Lambert
Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Dainippon Pharmaceutical
Fine Tuning of physico-chemical parameters to optimise a new series of novobiocin analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Aventis Pharma
DNA gyrase inhibitory activity of ellagic acid derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
R. W. Johnson Pharmaceutical Research Institute
Discovery of WQ-3810: Design, synthesis, and evaluation of 7-(3-alkylaminoazetidin-1-yl)fluoro-quinolones as orally active antibacterial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wakunaga Pharmaceutical
Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Astrazeneca
Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Ljubljana
Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medical University
Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Hawaii At Hilo
Chiral DNA gyrase inhibitors. 3. Probing the chiral preference of the active site of DNA gyrase. Synthesis of 10-fluoro-6-methyl-6,7-dihydro-9-piperazinyl- 2H-benzo[a]quinolizin-20-one-3-carboxylic acid analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Kansas
DNA gyrase from the albicidin producer Xanthomonas albilineans has multiple-antibiotic-resistance and unusual enzymatic properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Queensland
3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Achillion Pharmaceuticals
Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Achillion Pharmaceuticals
Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Morphochem
Identification of an ethyl 5,6-dihydropyrazolo[1,5-c]quinazoline-1-carboxylate as a catalytic inhibitor of DNA gyrase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Iowa
Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes For Biomedical Research
Discovery and development of novel rhodanine derivatives targeting enoyl-acyl carrier protein reductase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Nanjing University
Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medical University of Gdansk
Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Angelini
1,2,4-Triazole-quinoline/quinolone hybrids as potential anti-bacterial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Henan University of Chinese Medicine
Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vertex Pharmaceuticals
Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: design, synthesis and evaluation as antibacterial agent.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Jishou University
Synthesis and antibacterial activity of a novel series of DNA gyrase inhibitors: 5-[(E)-2-arylvinyl]pyrazoles.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Dainippon Pharmaceutical
Synthesis and antibacterial activity of a novel series of potent DNA gyrase inhibitors. Pyrazole derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Dainippon Pharmaceutical
Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Procter & Gamble Pharmaceuticals
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Warner-Lambert
Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Sanofi R&D
Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Iowa