88 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Arena Pharmaceuticals
Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes For Biomedical Research
Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Askat
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Jagiellonian University Medical College
Discovery of Novel Seven-Membered Prostacyclin Analogues as Potent and Selective Prostaglandin FP and EP3 Dual Agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ono Pharmaceutical
Identification and biological activity of 6-alkyl-substituted 3-methyl-pyridine-2-carbonyl amino dimethyl-benzoic acid EP4 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eli Lilly
Structural optimization and structure-functional selectivity relationship studies of G protein-biased EP2 receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ono Pharmaceutical
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Jagiellonian University Medical College
Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eli Lilly
Discovery of highly potent dual EP(2) and EP(3) agonists with subtype selectivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ono Pharmaceutical
Discovery and characterization of a potent and selective EP4 receptor antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eli Lilly
A selective prostaglandin E2 receptor subtype 2 (EP2) antagonist increases the macrophage-mediated clearance of amyloid-beta plaques.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Amgen
Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes For Biomedical Research
Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Canada
Synthesis and evaluation of a gamma-lactam as a highly selective EP2 and EP4 receptor agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Emd-Serono Research Institute
Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Centre For Therapeutic Research
Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Emd-Serono Research Institute
Discovery of novel prostaglandin analogs of PGE2 as potent and selective EP2 and EP4 receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Emd-Serono Research Institute
Comparison between two classes of selective EP(3) antagonists and their biological activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Centre For Therapeutic Research
Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP(3) antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Centre For Therapeutic Research
Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Fujisawa Pharmaceutical
Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Centre For Therapeutic Research
Synthesis, pharmacophore modeling and in vitro activity of 10,11-dihydrodibenzo[b,f]oxepine-4-carboxamide derivatives as novel and potent antagonists of the prostaglandin EP4 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Rottapharm Madaus
The identification of substituted benzothiophene derivatives as PGE(2) subtype 4 receptor antagonists: From acid to non-acid.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Centre For Therapeutic Research
Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Centre For Therapeutic Research
3-Urea-1-(phenylmethyl)-pyridones as novel, potent, and selective EP3 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Canada
1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Decode Chemistry
Heterocyclic 1,7-disubstituted indole sulfonamides are potent and selective human EP3 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Decode Chemistry
The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Centre For Therapeutic Research
Structure-activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Decode Chemistry
7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes of Biomedical Research
Discovery of novel aminothiadiazole amides as selective EP(3) receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP(1) receptor antagonist for the treatment of inflammatory pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Discovery of potent and selective DP1 receptor antagonists in the azaindole series.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Centre For Therapeutic Research
3-Acrylamide-4-aryloxyindoles: synthesis, biological evaluation and metabolic stability of potent and selective EP3 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Decode Chemistry
Peri-substituted hexahydro-indolones as novel, potent and selective human EP3 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Decode Chemistry
2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes of Biomedical Research
Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Canada
Identification of an indole series of prostaglandin D2 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Canada
Metabolism investigation leading to novel drug design: orally active prostacyclin mimetics. Part 4.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Fujisawa Pharmaceutical
Discovery of diphenyloxazole and Ndelta-Z-ornithine derivatives as highly potent and selective human prostaglandin EP(4) receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Fujisawa Pharmaceutical
Lactams as EP4 prostanoid receptor agonists. 3. Discovery of N-ethylbenzoic acid 2-pyrrolidinones as subtype selective agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Roche Palo Alto
Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Roche Palo Alto
Structure-activity relationship of triaryl propionic acid analogues on the human EP3 prostanoid receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Centre For Therapeutic Research
Structure-activity relationship of biaryl acylsulfonamide analogues on the human EP(3) prostanoid receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Centre For Therapeutic Research
Synthesis and biological evaluation of prostaglandin-F alkylphosphinic acid derivatives as bone anabolic agents for the treatment of osteoporosis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Procter & Gamble Pharmaceuticals
Design and synthesis of a highly selective EP2-receptor agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Minase Research Institute
Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Canada
Design and synthesis of 13,14-dihydro prostaglandin F(1alpha) analogues as potent and selective ligands for the human FP receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Procter and Gamble Pharmaceuticals
New class of biphenylene dibenzazocinones as potent ligands for the human EP1 prostanoid receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Frosst Centre For Therapeutic Research
Difluoromethylene at the ?-Lactam ?-Position Improves 11-Deoxy-8-aza-PGE![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Cayman Chemical
Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ube Industries
Discovery of substituted-2,4-dimethyl-(naphthalene-4-carbonyl)amino-benzoic acid as potent and selective EP4 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eli Lilly
Hit-to-lead optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as a novel class of EP1 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Asahi Kasei Pharma
Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Asahi Kasei Pharma
Carbocyclic potential DNA minor groove binders and their biological evaluation.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Medical University
Synthesis of 4-[2-(3,4-dimethoxybenzyl)cyclopentyl]-1,2-dimethoxybenzene Derivatives and Evaluations of Their Carbonic Anhydrase Isoenzymes Inhibitory Effects.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Atat£Rk University
Ring Size effect in the PKC inhibitory activities of perhydroazepine analogs of balanol.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Sphinx Laboratories
Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Upjohn