33 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
ß-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
F. Hoffmann-La Roche
Non-peptide renin inhibitors containing 2-(((3-phenylpropyl)phosphoryl)oxy)alkanoic acid moieties as P2-P3 replacements.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
E. Merck Darmstadt
Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Parke-Davis Pharmaceutical Research Division of Warner-Lambert
Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Sharp and Dohme Research Laboratories
Substrate analogue renin inhibitors containing replacements of histidine in P2 or isosteres of the amide bond between P3 and P2 sites.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
E. Merck Darmstadt
Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Kissei Pharmaceutical
Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
The sulfonimidamide as a novel transition state analog for aspartic acid and metallo proteases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Kansas
Peptidomimetic inhibitors of human immunodeficiency virus protease (HIV-PR): Design, enzyme binding and selectivity, antiviral efficacy, and cell permeability properties![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Novel low molecular renin inhibitors which show good oral blood pressure lowering effects in marmosets![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
MDL 74147, a novel selective and soluble inhibitor of human renin. Synthesis, structure-activity relationship, species and protease selectivities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Miraziridine A: natures blueprint towards protease class-spanning inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institut FüR Biochemie
Designing non-peptide peptidomimetics in the 21st century: inhibitors targeting conformational ensembles.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Wisconsin-Madison
Simplified pepstatins: synthesis and evaluation of N-terminally modified analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute of Pharmaceutical Chemistry and Institute of Pharmaceutical Technology
Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effect of structure in subsite P3 on inhibition of pepsin.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effects of structure on inhibition of pepsin and renin.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synthesis of analogues of pepstatin. Effect of structure in subsites P1', P2', and P2 on inhibition of porcine pepsin.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Pepstatin-derived inhibitors of aspartic proteinases. A close look at an apparent transition-state analogue inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Wisconsin
Synthetic and enzyme inhibition studies of pepstatin analogues containing hydroxyethylene and ketomethylene dipeptide isosteres.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Inhibition of aspartic proteinases by peptides containing lysine and ornithine side-chain analogues of statine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Renin inhibitors containing new P1-P1' dipeptide mimetics with heterocycles in P1'.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
E. Merck Darmstadt