100 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eli Lilly
Synthesis and binding monitoring of a new nanomolar PAMAM-based matrix metalloproteinases inhibitor (MMPIs).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Florence
Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Takeda Pharmaceutical
Robust design of some selective matrix metalloproteinase-2 inhibitors over matrix metalloproteinase-9 through in silico/fragment-based lead identification and de novo lead modification: Syntheses and biological assays.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Jadavpur University
Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Minnesota
Imidazopyridines as a source of biological activity and their pharmacological potentials-Infrared and Raman spectroscopic evidence of their content in pharmaceuticals and plant materials.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wroclaw University of Economics
A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹8F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University Medical Center Groningen
Targeting matrix metalloproteinases: exploring the dynamics of the s1' pocket in the design of selective, small molecule inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universidad Ceu San Pablo
Investigating the selectivity of metalloenzyme inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of California San Diego
Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Lille
Discovery of a New Class of Potent MMP Inhibitors by Structure-Based Optimization of the Arylsulfonamide Scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Florence
Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Second Military Medical University
Synthesis and preliminary evaluation in tumor bearing mice of new (18)F-labeled arylsulfone matrix metalloproteinase inhibitors as tracers for positron emission tomography.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Cea
Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pomona College
A one-pot synthesis and biological activity of ageladine A and analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Macquarie University
Natural products as a gold mine for selective matrix metalloproteinases inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
East China University of Science and Technology
Discovery and evaluation of a non-Zn chelating, selective matrix metalloproteinase 13 (MMP-13) inhibitor for potential intra-articular treatment of osteoarthritis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Alantos Pharmaceuticals
Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Panthera Biopharma
Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
P. Angeletti S.P.A. (Merck Research Laboratories)
Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Florida
Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic matrix metalloproteinase-2 selective inhibitor--synthesis and pharmacodynamic and pharmacokinetic analysis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Hebrew University of Jerusalem
Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Research and Development
Synthesis and evaluation of novel heterocyclic MMP inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
North Dakota State University
Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
F. Hoffmann-La Roche
Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
In silico scaffold evaluation and solid phase approach to identify new gelatinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Colosseum Combinatorial Chemistry Centre For Technology (C4T Scarl)
Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Astrazeneca
Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Boehringer Ingelheim Pharmaceuticals
Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Instituto Superior T£Cnico
Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Tokyo
Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Protera
The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Schering-Plough Research Institute
Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Synthesis of novel ageladine A analogs showing more potent matrix metalloproteinase (MMP)-12 inhibitory activity than the natural product.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Kyorin Pharmaceutical
The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Gsk Medicines Research Centre
Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Research
N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Research
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Athens
Identification of MMP-12 inhibitors by using biosensor-based screening of a fragment library.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Uppsala University
Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Platinum complexes can inhibit matrix metalloproteinase activity: platinum-diethyl[(methylsulfinyl)methyl]phosphonate complexes as inhibitors of matrix metalloproteinases 2, 3, 9, and 12.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Università
Synthesis and structure-activity relationship of a novel, non-hydroxamate series of TNF-alpha converting enzyme inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Pharmaceutical Research Institute
Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Kyorin Pharmaceutical
Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Pharmaceutical Research Institute
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Pharmaceutical Research Institute
Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Chinese Academy of Sciences
Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Synthesis and evaluation of novel oxazoline MMP inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
North Dakota State University
3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Chinese Academy of Sciences
Development of a water-soluble matrix metalloproteinase inhibitor as an intra-arterial infusion drug for prevention of restenosis after angioplasty.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Cardiovascular Center Research Institute
Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Dupont Pharmaceuticals
Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
UniversitäT Bielefeld
2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
F. Hoffmann-La Roche
Synthesis and Structural/Functional Characterization of Selective M14 Metallocarboxypeptidase Inhibitors Based on Phosphinic Pseudopeptide Scaffold: Implications on the Design of Specific Optical Probes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universitat Aut£Noma De Barcelona
Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
School of Pharmaceutical Sciences & The Fifth Affiliated Hospital
Recent developments in the synthesis and applications of phosphinic peptide analogs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wroclaw University of Technology
Matrix metalloproteinase-12 inhibitors: synthesis, structure-activity relationships and intestinal absorption of novel sugar-based biphenylsulfonamide carboxylates.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Pisa
Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline Pharmaceuticals
Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Nestl�
Synthesis of radioiodinated probes targeted toward matrix metalloproteinase-12.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Kobe Pharmaceutical University
Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Graz University of Technology
HTS by NMR for the Identification of Potent and Selective Inhibitors of Metalloenzymes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of California-Riverside
A pentanoic acid derivative targeting matrix metalloproteinase-2 (MMP-2) induces apoptosis in a chronic myeloid leukemia cell line.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Jadavpur University
Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Florence
Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Scripps Florida
Design, synthesis and pharmacological evaluation of conformationally restricted N-arylsulfonyl-3-aminoalkoxy indoles as a potential 5-HT6 receptor ligands.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Suven Life Sciences
Pharmacologic characterization of the human 5-hydroxytryptamine2B receptor: evidence for species differences.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Eli Lilly
Development of a radioligand binding assay for 5-HT4 receptors in guinea-pig and rat brain.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Glaxo Group Research
Characterization of (+/-)(-)[3H]epibatidine binding to nicotinic cholinergic receptors in rat and human brain.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Georgetown University