51 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vanderbilt University Medical Center
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Copenhagen
Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Massachusetts General Hospital
Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Massachusetts General Hospital
Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vanderbilt University Medical Center
Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Sanford-Burnham Medical Research Institute
Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Sanford-Burnham Medical Research Institute
¿-amino-ß-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Insa De Rouen and Universit£
Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vanderbilt University Medical Center
A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universite Paris Descartes
Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Virtual screening workflow development guided by the"receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Royal Danish School of Pharmacy
Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vanderbilt University Medical Center
Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkin![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vanderbilt University Medical Center
An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Evotec (Uk)
Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vanderbilt University Medical Center
Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA)![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Université
Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Danish University of Pharmaceutical Sciences
Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Faust Pharmaceuticals
Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Università
Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Taisho Pharmaceutical
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eli Lilly
Binding of beta-carbolines at 5-HT(2) serotonin receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Virginia Commonwealth University
Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Royal Danish School of Pharmacy
Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Royal Danish School of Pharmacy
(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Pharma
alpha-substituted quisqualic acid analogs: new metabotropic glutamate receptor group II selective antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Georgetown University Medical Center
Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vanderbilt University School of Medicine
Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vanderbilt University
Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Paris
Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Prexton Therapeutics
Synthesis and anticholinergic activity of 4-hydroxycoumarin derivatives containing substituted benzyl-1,2,3-triazole moiety.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Tehran University of Medical Sciences
Design, synthesis and biological evaluation of pazopanib derivatives as antitumor agents.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Shandong Institute of Pharmaceutical Industry