PMID

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Article Title

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Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain.

University of Tsukuba

Novel diazabicycloalkane delta opioid agonists.

Istituto Di Farmacologia Traslazionale

Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14ß-dihydroxy-4,5a-epoxy-6a-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.

Virginia Commonwealth University

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: part 3, novel propellane derivatives with pentacyclic skeletons.

Kitasato University

Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associatedµ opioid receptor (MOR-1) splice variants.

Memorial Sloan-Kettering Cancer Center

Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists.

Toray Industries

Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase.

University of Washington

Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.

Smithkline Beecham

Pyrrolomorphinans as delta opioid receptor antagonists. The role of steric hindrance in conferring selectivity.

University of Minnesota

7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors.

University of Minnesota

Arylacetamide-derived fluorescent probes: synthesis, biological evaluation, and direct fluorescent labeling of kappa opioid receptors in mouse microglial cells.

University of Minnesota

Benzofuro[2,3-c]pyridin-6-ols: synthesis, affinity for opioid-receptor subtypes, and antinociceptive activity.

Ciba-Geigy

 

Pyrrolooctahydroisoquinolines as potent and selective opioid receptor ligands: SAR analysis and docking studies

TBA

Synthesis and biological evaluation of dibenz[b,f][1,5]oxazocine derivatives for agonist activity at κ-opioid receptor.

Indian Institute of Chemical Biology

 

6N-Cinnamoyl-β-naltrexamine and its p-nitro derivative. High efficacy κ-opioid agonists with weak antagonist actions

TBA

Synthesis and structure-activity relationships of an orally available and long-acting analgesic peptide, N(alpha)-amidino-Tyr-D-Arg-Phe-MebetaAla-OH (ADAMB).

Daiichi Fine Chemical

Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues.

Virginia Commonwealth University

Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit ?-Arrestin-2.

Memorial Sloan Kettering Cancer Center

Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14?-dihydroxy-4,5?-epoxy-6?-[(4'-pyridyl)carboxamido]morphinan (NAP) Derivatives as ?/? Opioid Receptor Dual Selective Ligands.

Virginia Commonwealth University

7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands.

University of Minnesota

Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators.

Virginia Commonwealth University

Novel 6?-acylaminomorphinans with analgesic activity.

Semmelweis University

Synthesis and biological evaluation of novel delta (?) opioid receptor ligands with diazatricyclodecane skeletons.

C.N.R. Istituto Di Farmacologia Traslazionale

Structure activity relationship studies of 17-cyclopropylmethyl-3,14?-dihydroxy-4,5?-epoxy-6?-(isoquinoline-3'-carboxamido)morphinan (NAQ) analogues as potent opioid receptor ligands: preliminary results on the role of electronic characteristics for affinity and function.

Virginia Commonwealth University

Access to 7?-analogs of codeine with mixed ?/? agonist activity via 6,7-?-epoxide opening.

University of Texas At Austin

Selective kappa-opioid agonists: synthesis and structure-activity relationships of piperidines incorporating on oxo-containing acyl group.

Smithkline Beecham Farmaceutici

Synthesis and structure-activity relationships of dynorphin A-(1-8) amide analogues.

Eisai

Naphtho and benzo analogues of the kappa opioid agonist trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] benzeneacetamide.

University of Notre Dame

Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents.

Hazara University