29 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Acyclic tethers mimicking subunits of polysaccharide ligands: selectin antagonists.
Institut De Recherches Cliniques De Montr£Al (Ircm)
Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.
Pfizer
A new approach to explore the binding space of polysaccharide-based ligands: selectin antagonists.
TBA
Rational design of novel, potent small molecule pan-selectin antagonists.
Revotar Biopharmaceuticals
Development of potent non-carbohydrate imidazole-based small molecule selectin inhibitors with antiinflammatory activity.
Ontogen
Novel synthetic inhibitors of selectin-mediated cell adhesion: synthesis of 1,6-bis[3-(3-carboxymethylphenyl)-4-(2-alpha-D- mannopyranosyloxy)phenyl]hexane (TBC1269).
Texas Biotechnology
Studies on selectin blockers. 7. Structure-activity relationships of sialyl Lewis X mimetics based on modified Ser-Glu dipeptides.
Kanebo
Sulfated galactocerebrosides as potential antiinflammatory agents.
Bristol-Myers Squibb Pharmaceutical Research Institute
Studies on selectin blocker. 1. Structure-activity relationships of sialyl Lewis X analogs.
Institute of Cancer Research
Studies on selectin blocker. 3. Investigation of the carbohydrate ligand sialyl Lewis X recognition site of P-selectin.
Kanebo
Studies on selectin blockers. 2. Novel selectin blocker as potential therapeutics for inflammatory disorders.
New Drug Research Laboratory
Rational design and synthesis of small molecule, non-oligosaccharide selectin inhibitors: (alpha-D-mannopyranosyloxy)biphenyl-substituted carboxylic acids.
Texas Biotechnology
Design and synthesis of a new sialyl Lewis X mimetic: how selective are the selectin receptors?
Universit£
Synthesis of sialyl Lewis X mimetics using the Ugi four-component reaction.
Scripps Research Institute
Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.
Pfizer
Synthesis of fluorinated C-mannopeptides as sialyl Lewisx mimics for E- and P-selectin inhibition.
Universit£
Isolation and structure determination of sulfonoquinovosyl dipalmitoyl glyceride, a P-selectin receptor inhibitor from the alga Dictyochloris fragrans.
Bristol-Myers Squibb Pharmaceutical Research Institute
2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists.
Wyeth Research
Quinic acid derivatives as sialyl Lewis(x)-mimicking selectin inhibitors: design, synthesis, and crystal structure in complex with E-selectin.
Wyeth
Sialyl Lewis(x) analogs based on a quinic acid scaffold as the fucose mimic.
National Chemical Engineering Institute In Paris
Drug design, synthesis, and evaluation of a non-sugar-based selectin antagonist.
Organon K.K.
Cinnamamide: An insight into the pharmacological advances and structure-activity relationships.
National Institute of Pharmaceutical Education and Research (NIPER)
Selectin-ligand interactions revealed by molecular dynamics simulation in solution.
Kanebo