PMID

Data

Article Title

Organization

Preparation of biotinylated allosamidins with strong chitinase inhibitory activities.

University of Tokyo

Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase.

Kitasato University

Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting.

The Scripps Research Institute

Bisdionin C-a rationally designed, submicromolar inhibitor of family 18 chitinases.

TBA

Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus.

The Skaggs Institute For Chemical Biology

NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin.

Kitasato University

Computer-aided rational molecular design of argifin-derivatives with increased inhibitory activity against chitinase B from Serratia marcescens.

Kitasato University

Argifin; efficient solid phase total synthesis and evaluation of analogues of acyclic peptide.

Kitasato University

Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens.

Kitasato University

An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential.

University of Dundee

Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase.

Oncoarendi Therapeutics

A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors.

Dalian University of Technology

Development of Dual Chitinase Inhibitors as Potential New Treatment for Respiratory System Diseases.

Oncoarendi Therapeutics

Exploiting the Polypharmacology of ß-Carbolines to Disrupt O. volvulus Molting.

The Scripps Research Institute

Druggability Assessment of Targets Used in Kinetic Target-Guided Synthesis.

University of Groningen

Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma.

Oncoarendi Therapeutics

Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor.

University of Edinburgh

Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.

University of Dundee

Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.

University of Dundee

Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.

University of Dundee