null

SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O

InChI Key InChIKey=HUFOZJXAKZVRNJ-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 149404   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
BETTA PHARMACEUTICALS CO., LTD.

US Patent
LigandPNGBDBM149404(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)copy SMILEScopy InChI
Affinity DataIC50: 145nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514) 1. 2.5 uL-4x Test Compound or 100 nL 100x plus 2.4...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WS8WCBUS Patent
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
BETTA PHARMACEUTICALS CO., LTD.

US Patent
LigandPNGBDBM149404(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)copy SMILEScopy InChI
Affinity DataIC50: 108nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
BETTA PHARMACEUTICALS CO., LTD.

US Patent
LigandPNGBDBM149404(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)copy SMILEScopy InChI
Affinity DataIC50: 16.6nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
BETTA PHARMACEUTICALS CO., LTD.

US Patent
LigandPNGBDBM149404(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)copy SMILEScopy InChI
Affinity DataIC50: 13.7nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
BETTA PHARMACEUTICALS CO., LTD.

US Patent
LigandPNGBDBM149404(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)copy SMILEScopy InChI
Affinity DataIC50: 101nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair