null

SMILES CC(C)NC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1

InChI Key InChIKey=GKHIVNAUVKXIIY-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 322155   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6TP0US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataKi:  500nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6TP0US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataKi:  500nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataKi:  500nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataIC50: 1.02E+3nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataIC50: 1.31E+4nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736TZKUS Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataIC50: 1.02E+3nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6TP0US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataIC50: 1.31E+4nMAssay Description:Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6TP0US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataIC50: 1.31E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon Corporation, LLC

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)copy SMILEScopy InChI
Affinity DataIC50: 1.02E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M0B04US Patent