null

SMILES COc1cc(nc(c1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C)N1CCOCC1

InChI Key InChIKey=DCKPXKUYFVTZND-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 202843   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM202843(US10245267, Example 196 | US10709712, Example 196 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB76WPUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM202843(US10245267, Example 196 | US10709712, Example 196 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB76WPUS Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM202843(US10245267, Example 196 | US10709712, Example 196 ...)copy SMILEScopy InChI
Affinity DataIC50: 2.19nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB76WPUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM202843(US10245267, Example 196 | US10709712, Example 196 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.403nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB76WPUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM202843(US10245267, Example 196 | US10709712, Example 196 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.621nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB76WPUS Patent