null

SMILES Cc1ccc(cc1-c1ccnc(c1)N1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=LZHLFLLBTSFGEX-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 202717   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202717(US10245267, Example 63 | US10709712, Example 63 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.55nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202717(US10245267, Example 63 | US10709712, Example 63 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.440nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202717(US10245267, Example 63 | US10709712, Example 63 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.510nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202717(US10245267, Example 63 | US10709712, Example 63 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202717(US10245267, Example 63 | US10709712, Example 63 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent