null

SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O

InChI Key InChIKey=HUFOZJXAKZVRNJ-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 149404   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuxi AppTec

Curated by ChEMBL
LigandPNGBDBM149404(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of EGFR T790M/exon 19 deletion mutant phosphorylation in human PC9-DRH cells preincubated for 2 hrs followed by EGF stimulation for 10 min...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuxi AppTec

Curated by ChEMBL
LigandPNGBDBM149404(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Inhibition of EGFR exon 19 deletion mutant phosphorylation in human PC9 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandw...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuxi AppTec

Curated by ChEMBL
LigandPNGBDBM149404(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by s...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-3(Homo sapiens (Human))
Wuxi AppTec

Curated by ChEMBL
LigandPNGBDBM149404(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2CJZPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuxi AppTec

Curated by ChEMBL
LigandPNGBDBM149404(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A549 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by san...More data for this Ligand-Target Pair