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SMILES [H][C@@]12CN(C[C@]1([H])CN(C2)c1nc(Nc2cnn(C)c2)c2ncn(C(C)C)c2n1)C(=O)C=C
InChI Key InChIKey=VLUFVWDZAMAWPX-GASCZTMLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50450879
Affinity DataKi: 85nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 805nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A549 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by san...More data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by s...More data for this Ligand-Target Pair