BindingDB

null

SMILES N[C@H]1C[C@@H]1c1ccccc1

InChI Key InChIKey=AELCINSCMGFISI-BDAKNGLRSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50236898

Amine oxidase [flavin-containing] A(Homo sapiens (Human))
University of Freiburg

Curated by ChEMBL

BDBM50236898((1S,2R)-(+)-2-phenylcyclopropylamine | CHEMBL25799...)copy SMILEScopy InChI

IC50: 3.40E+3nMAssay Description:Inhibition of MAO-A (unknown origin) using beetle luciferin derived luminogenic substrate preincubated for 15 mins followed by substrate addition mea...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q20V8GGBPubMed

Lysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Freiburg

Curated by ChEMBL

BDBM50236898((1S,2R)-(+)-2-phenylcyclopropylamine | CHEMBL25799...)copy SMILEScopy InChI

IC50: 6.30E+3nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q20V8GGBPubMed

Lysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Freiburg

Curated by ChEMBL

BDBM50236898((1S,2R)-(+)-2-phenylcyclopropylamine | CHEMBL25799...)copy SMILEScopy InChI

IC50: 6.50E+3nMAssay Description:Inhibition of GST-tagged LSD1 (2 to 852 residues) (unknown origin) expressed in baculovirus infected sf9 cells preincubated for 15 mins followed by H...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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PC cid PC sid Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q20V8GGBPubMed

Targets 10 ▿
- Lysine-specific histone demethylase 1A 17
- Amine oxidase [flavin-containing] A 9
- Amine oxidase [flavin-containing] B 8
- Alpha-1A adrenergic receptor 2
- REST corepressor 1 1
- Serine protease 1 1
- Cytochrome P450 2C19 1
- Trace amine-associated receptor 1 1
- Bile salt export pump 1
- Cytochrome P450 2B6 1
Publications 17 ▿
- Bioorg Med Chem 19: 3709-16 (2011) 4
- J Med Chem 54: 8236-50 (2011) 3
- Medchemcomm 5: 1863-1870 (2014) 3
- Eur J Med Chem 144: 52-67 (2018) 3
- J Med Chem 59: 253-63 (2016) 3
- J Med Chem 59: 1531-44 (2016) 3
- Chem Biol Drug Des 85: 659-71 (2015) 3
- Mol Pharmacol 13: 454-73 (1977) 2
- Bioorg Med Chem 16: 7148-66 (2008) 2
- J Med Chem 51: 2158-69 (2008) 2
- J Med Chem 52: 4551-73 (2009) 1
- Drug Metab Dispos 40: 2332-41 (2012) 1
- Bioorg Med Chem 26: 4871-4880 (2018) 1
- Bioorg Med Chem 16: 7415-23 (2008) 1
- Eur J Med Chem 125: 940-951 (2017) 1
- Bioorg Med Chem 19: 3702-8 (2011) 1
- J Med Chem 45: 2770-80 (2002) 1
Institutions 16 ▿
- [Kyoto Prefectural University of Medicine] 6
- [University of Southampton] 4
- [Medical University of South Carolina, China Pharmaceutical University, University of Freiburg, Baylor College of Medicine] 3
- [Medical University of South Carolina, China Pharmaceutical University, University of Freiburg, Baylor College of Medicine] 3
- [Medical University of South Carolina, China Pharmaceutical University, University of Freiburg, Baylor College of Medicine] 3
- [Medical University of South Carolina, China Pharmaceutical University, University of Freiburg, Baylor College of Medicine] 3
- [Universität Münster, TBA, Saarland University] 2
- [Universität Münster, TBA, Saarland University] 2
- [Universität Münster, TBA, Saarland University] 2
- [Johns Hopkins University, Fudan University, RTI International, AstraZeneca, Harvard University, Nagoya City University, Zhengzhou University] 1
- [Johns Hopkins University, Fudan University, RTI International, AstraZeneca, Harvard University, Nagoya City University, Zhengzhou University] 1
- [Johns Hopkins University, Fudan University, RTI International, AstraZeneca, Harvard University, Nagoya City University, Zhengzhou University] 1
- [Johns Hopkins University, Fudan University, RTI International, AstraZeneca, Harvard University, Nagoya City University, Zhengzhou University] 1
- [Johns Hopkins University, Fudan University, RTI International, AstraZeneca, Harvard University, Nagoya City University, Zhengzhou University] 1
- [Johns Hopkins University, Fudan University, RTI International, AstraZeneca, Harvard University, Nagoya City University, Zhengzhou University] 1
- [Johns Hopkins University, Fudan University, RTI International, AstraZeneca, Harvard University, Nagoya City University, Zhengzhou University] 1
Affinity: 8.5 to 1.3E+7 nM▿
- Ki 9
- IC50 31
- Kd 1
- EC50 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1