BindingDB

null

SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1

InChI Key InChIKey=DXDRHHKMWQZJHT-FPYGCLRLSA-N

PDB links: 5 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50042944

Amine oxidase [flavin-containing] B(Rattus norvegicus (rat))
North-West University

Curated by ChEMBL

BDBM50042944((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...)copy SMILEScopy InChI

IC50: 4.72E+4nMAssay Description:Displacement of [14C]-beta-PEA from rat MAO-B after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q29K4F4ZPubMed

Amine oxidase [flavin-containing] A(Rattus norvegicus (rat))
North-West University

Curated by ChEMBL

BDBM50042944((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...)copy SMILEScopy InChI

IC50: 1.39E+4nMAssay Description:Displacement of [14C]-5HT from rat MAO-A after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Purchase CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q29K4F4ZPubMed

Targets 30 ▿
- Neuraminidase 5
- Beta-secretase 1 3
- Integrase 2
- Polyunsaturated fatty acid 5-lipoxygenase 2
- Tyrosine-protein phosphatase non-receptor type 1 2
- Amine oxidase [flavin-containing] A 2
- Aldo-keto reductase family 1 member B1 2
- NACHT, LRR and PYD domains-containing protein 3 2
- Estrogen receptor 1
- Tyrosyl-DNA phosphodiesterase 1 1
- Amine oxidase [flavin-containing] B 1
- Amyloid-beta precursor protein 1
- Collagenase 3 1
- Bcl-2-like protein 11 1
- Matrix metalloproteinase-9 1
- 17-beta-hydroxysteroid dehydrogenase type 2 1
- 17-beta-hydroxysteroid dehydrogenase type 1 1
- Neuronal acetylcholine receptor subunit alpha-7 1
- Aromatase 1
- Xanthine dehydrogenase/oxidase 1
- Protein disulfide-isomerase 1
- Proteasome subunit beta type-5 1
- 72 kDa type IV collagenase 1
- Prostaglandin G/H synthase 1/2 1
- Estrogen receptor beta 1
- Stromelysin-1 1
- Interstitial collagenase 1
- Sialidase 1
- Probable global transcription activator SNF2L2 1
- Matrilysin 1
Publications 21 ▿
- Bioorg Med Chem Lett 21: 294-8 (2011) 6
- J Nat Prod 80: 965-974 (2017) 5
- Bioorg Med Chem Lett 23: 4985-9 (2013) 2
- J Med Chem 36: 3904-9 (1994) 2
- Bioorg Med Chem Lett 30: (2020) 1
- Bioorg Med Chem 20: 1251-8 (2012) 1
- Eur J Med Chem 167: 291-311 (2019) 1
- Eur J Med Chem 86: 724-39 (2014) 1
- Bioorg Med Chem Lett 26: 4599-4605 (2016) 1
- Bioorg Med Chem Lett 27: 3602-3606 (2017) 1
- J Enzyme Inhib Med Chem 26: 643-8 (2011) 1
- Bioorg Med Chem Lett 27: 3123-3126 (2017) 1
- Bioorg Med Chem 26: 1653-1664 (2018) 1
- Eur J Med Chem 66: 22-31 (2013) 1
- J Med Chem 41: 3948-60 (1998) 1
- PubChem Bioassay (2010) 1
- J Nat Prod 69: 1572-6 (2006) 1
- Bioorg Med Chem Lett 19: 5155-7 (2009) 1
- J Med Chem 45: 841-52 (2002) 1
- Bioorg Med Chem 28: (2020) 1
- PubChem Bioassay (2013) 1
Institutions 18 ▿
- [Chosun University] 6
- [University of Basel] 5
- [North-West University] 3
- [Soochow University, Sun Yat-sen University, Tokushima Bunri University] 2
- [Soochow University, Sun Yat-sen University, Tokushima Bunri University] 2
- [Soochow University, Sun Yat-sen University, Tokushima Bunri University] 2
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
Affinity: 8 to 3.5E+5 nM▿
- Ki 1
- IC50 38
- EC50 3
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1