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SMILES Brc1cccc(Nc2ncnc3ccc(NC(=O)C=C)cc23)c1

InChI Key InChIKey=HTUBKQUPEREOGA-UHFFFAOYSA-N

PDB links: 4 PDB IDs match this monomer. 2 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 4567   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£ degli Studi di Parma

Curated by ChEMBL
LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured at 1 hr by Western blot...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£ degli Studi di Parma

Curated by ChEMBL
LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)copy SMILEScopy InChI
Affinity DataIC50: 1.69nMAssay Description:Inhibition of human recombinant EGFR expressed in insect cells by time-resolved fluorometryMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£ degli Studi di Parma

Curated by ChEMBL
LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)copy SMILEScopy InChI
Affinity DataIC50: 152nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cells after 8 hrs by western blotMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£ degli Studi di Parma

Curated by ChEMBL
LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cells after 1 hr by western blotMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£ degli Studi di Parma

Curated by ChEMBL
LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured after 8 hrs by Western ...More data for this Ligand-Target Pair