BindingDB

null

SMILES CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1

InChI Key InChIKey=BMGQWWVMWDBQGC-IIFHNQTCSA-N

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326053

Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vichem Chemie Research Ltd

Curated by ChEMBL

BDBM50326053(CHEMBL608533 | PKC-412)copy SMILEScopy InChI

IC50: 30nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin)More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid PDB Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q27947ZVPubMed

Targets 386 ▿
- Receptor-type tyrosine-protein kinase FLT3 26
- Tyrosine-protein kinase ABL1 23
- Epidermal growth factor receptor 23
- Mast/stem cell growth factor receptor Kit 15
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 13
- Proto-oncogene tyrosine-protein kinase receptor Ret 7
- Ribosomal protein S6 kinase alpha-2 6
- Ribosomal protein S6 kinase alpha-1 6
- Ephrin type-A receptor 6 6
- Mitogen-activated protein kinase 14 6
- Ribosomal protein S6 kinase alpha-6 6
- Ribosomal protein S6 kinase alpha-4 6
- Ribosomal protein S6 kinase alpha-5 6
- Hepatocyte growth factor receptor 5
- Non-receptor tyrosine-protein kinase TYK2 5
- Myosin light chain kinase, smooth muscle 5
- Tyrosine-protein kinase JAK1 5
- Serine/threonine-protein kinase B-raf 5
- Fibroblast growth factor receptor 3 5
- AP2-associated protein kinase 1 4
- Dual specificity protein kinase CLK1 4
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 4
- Tyrosine-protein kinase receptor TYRO3 4
- Death-associated protein kinase 3 4
- Dual specificity protein kinase CLK4 4
- Dual specificity protein kinase CLK3 4
- Dual specificity protein kinase CLK2 4
- Calcium/calmodulin-dependent protein kinase type II subunit gamma 4
- Aspartyl/asparaginyl beta-hydroxylase 4
- Mitogen-activated protein kinase kinase kinase 11 4
- Casein kinase I isoform epsilon 4
- Vascular endothelial growth factor receptor 2 4
- Aurora kinase A 4
- Glycogen synthase kinase-3 alpha 4
- Glycogen synthase kinase-3 beta 4
- Tyrosine-protein kinase Tec 3
- BMP-2-inducible protein kinase 3
- Cyclin-dependent kinase 11B 3
- Cyclin-dependent kinase 11A 3
- LIM domain kinase 1 3
- LIM domain kinase 2 3
- ALK tyrosine kinase receptor 3
- NUAK family SNF1-like kinase 2 3
- Calcium/calmodulin-dependent protein kinase type 1 3
- NUAK family SNF1-like kinase 1 3
- Calcium/calmodulin-dependent protein kinase type II subunit beta 3
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 3
- Serine/threonine-protein kinase PAK 1 3
- Protein kinase C theta type 3
- Serine/threonine-protein kinase PAK 2 3
- Serine/threonine-protein kinase PAK 3 3
- Dual specificity mitogen-activated protein kinase kinase 2 3
- Serine/threonine-protein kinase PAK 4 3
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 3
- Serine/threonine-protein kinase tousled-like 2 3
- Dual specificity mitogen-activated protein kinase kinase 3 3
- Serine/threonine-protein kinase PAK 5 3
- Serine/threonine-protein kinase PAK 6 3
- Serine/threonine-protein kinase tousled-like 1 3
- Tyrosine-protein kinase JAK3 3
- Tyrosine-protein kinase JAK2 3
- Dual specificity mitogen-activated protein kinase kinase 1 3
- Dual specificity mitogen-activated protein kinase kinase 6 3
- Dual specificity mitogen-activated protein kinase kinase 4 3
- Tyrosine-protein kinase ZAP-70 3
- Casein kinase I isoform gamma-3 3
- Casein kinase I isoform gamma-2 3
- Casein kinase I isoform gamma-1 3
- Ephrin type-A receptor 1 3
- Ephrin type-A receptor 3 3
- Ephrin type-A receptor 2 3
- Ephrin type-A receptor 5 3
- Tyrosine-protein kinase BTK 3
- Ephrin type-A receptor 4 3
- Tyrosine-protein kinase receptor UFO 3
- Insulin-like growth factor 1 receptor 3
- Activin receptor type-1 3
- Myosin light chain kinase 2, skeletal/cardiac muscle 3
- Tyrosine-protein kinase Srms 3
- Wee1-like protein kinase 3
- Ankyrin repeat and protein kinase domain-containing protein 1 3
- Tyrosine-protein kinase Lyn 3
- Focal adhesion kinase 1 3
- Cyclin-dependent kinase 2 3
- Tyrosine-protein kinase TXK 3
- Ephrin type-A receptor 8 3
- Death-associated protein kinase 2 3
- Death-associated protein kinase 1 3
- Serine/threonine-protein kinase D2 3
- Serine/threonine-protein kinase D3 3
- TGF-beta receptor type-2 3
- Serine/threonine-protein kinase D1 3
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 3
- Cyclin-dependent kinase 9 3
- Cyclin-dependent kinase 8 3
- Serine/threonine-protein kinase pim-3 3
- Cyclin-dependent kinase 7 3
- Serine/threonine-protein kinase pim-1 3
- Cyclin-dependent kinase 5 3
- Serine/threonine-protein kinase pim-2 3
- Cyclin-dependent kinase 3 3
- Serine/threonine-protein kinase 36 3
- Testis-specific serine/threonine-protein kinase 1 3
- Cyclin-dependent kinase 16 3
- Protein kinase C epsilon type 3
- Cyclin-dependent kinase 17 3
- Bone morphogenetic protein receptor type-2 3
- Cyclin-dependent kinase 19 3
- Protein-tyrosine kinase 6 3
- Casein kinase II subunit alpha 3
- Cyclin-dependent kinase 14 3
- Leukocyte tyrosine kinase receptor 3
- Cytoplasmic tyrosine-protein kinase BMX 3
- Tyrosine-protein kinase ABL2 3
- Atypical kinase COQ8B, mitochondrial 3
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 3
- cGMP-dependent protein kinase 2 3
- cGMP-dependent protein kinase 1 3
- Serine/threonine-protein kinase SIK2 3
- Tyrosine-protein kinase Fes/Fps 3
- Serine/threonine-protein kinase SIK1 3
- 3-phosphoinositide-dependent protein kinase 1 3
- Mitogen-activated protein kinase 1 3
- Serine/threonine-protein kinase 3 3
- Discoidin domain-containing receptor 2 3
- Mitogen-activated protein kinase 3 3
- Mitogen-activated protein kinase 4 3
- Serine/threonine-protein kinase 4 3
- Mitogen-activated protein kinase 9 3
- SRSF protein kinase 2 3
- Mitogen-activated protein kinase 6 3
- Mitogen-activated protein kinase 7 3
- Mitogen-activated protein kinase 8 3
- Calcium/calmodulin-dependent protein kinase type IV 3
- Tyrosine-protein kinase SYK 3
- Serine/threonine-protein kinase RIO1 3
- Serine/threonine-protein kinase LATS1 3
- Serine/threonine-protein kinase RIO3 3
- Serine/threonine-protein kinase 32B 3
- Serine/threonine-protein kinase 32C 3
- Insulin receptor 3
- Tyrosine-protein kinase HCK 3
- Vascular endothelial growth factor receptor 3 3
- Vascular endothelial growth factor receptor 1 3
- Serine/threonine-protein kinase PLK1 3
- Insulin receptor-related protein 3
- Serine/threonine-protein kinase PLK3 3
- Serine/threonine-protein kinase PLK4 3
- Serine/threonine-protein kinase BRSK1 3
- Serine/threonine-protein kinase LATS2 3
- Citron Rho-interacting kinase 3
- Platelet-derived growth factor receptor alpha 3
- Serine/threonine-protein kinase BRSK2 3
- Serine/threonine-protein kinase Chk1 3
- cAMP-dependent protein kinase catalytic subunit PRKX 3
- SRSF protein kinase 1 3
- Tyrosine-protein kinase Yes 3
- Serine/threonine-protein kinase MRCK beta 3
- Serine/threonine-protein kinase MRCK gamma 3
- Casein kinase II subunit alpha' 3
- Dual specificity tyrosine-phosphorylation-regulated kinase 2 3
- Serine/threonine-protein kinase STK11 3
- Cyclin-G-associated kinase 3
- Tyrosine-protein kinase FRK 3
- Receptor tyrosine-protein kinase erbB-2 3
- Serine/threonine-protein kinase Nek9 3
- Serine/threonine-protein kinase Nek7 3
- Serine/threonine-protein kinase Nek6 3
- Serine/threonine-protein kinase Nek5 3
- Serine/threonine-protein kinase Nek2 3
- Serine/threonine-protein kinase Nek1 3
- Serine/threonine-protein kinase receptor R3 3
- MAP/microtubule affinity-regulating kinase 3 3
- MAP kinase-interacting serine/threonine-protein kinase 2 3
- MAP kinase-interacting serine/threonine-protein kinase 1 3
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 3
- MAP/microtubule affinity-regulating kinase 4 3
- Serine/threonine-protein kinase 10 3
- Serine/threonine-protein kinase 38-like 3
- Dual specificity protein kinase TTK 3
- Myosin-IIIb 3
- Myosin-IIIa 3
- Tyrosine-protein kinase ITK/TSK 3
- Myotonin-protein kinase 3
- Protein kinase C eta type 3
- Bone morphogenetic protein receptor type-1A 3
- Receptor-interacting serine/threonine-protein kinase 1 3
- Tyrosine-protein kinase Blk 3
- Receptor-interacting serine/threonine-protein kinase 2 3
- Serine/threonine-protein kinase 16 3
- Non-receptor tyrosine-protein kinase TNK1 3
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 3
- Serine/threonine-protein kinase NLK 3
- Casein kinase I isoform delta 3
- Cyclin-dependent kinase 18 [3-474] 3
- RAF proto-oncogene serine/threonine-protein kinase 3
- Serine/threonine-protein kinase 26 3
- Serine/threonine-protein kinase 24 3
- Dual specificity testis-specific protein kinase 1 3
- Serine/threonine-protein kinase 25 3
- Ephrin type-B receptor 3 3
- Serine/threonine-protein kinase 33 3
- Ephrin type-B receptor 4 3
- Ephrin type-B receptor 1 3
- Ephrin type-B receptor 2 3
- MAP kinase-activated protein kinase 2 3
- Platelet-derived growth factor receptor beta 3
- Epithelial discoidin domain-containing receptor 1 3
- MAP kinase-activated protein kinase 5 3
- Muscle, skeletal receptor tyrosine-protein kinase 3
- Tyrosine-protein kinase Fer 3
- 5'-AMP-activated protein kinase catalytic subunit alpha-2 3
- Tyrosine-protein kinase receptor Tie-1 3
- Calcium/calmodulin-dependent protein kinase type II subunit delta 3
- Proto-oncogene tyrosine-protein kinase ROS 3
- Serine/threonine-protein kinase TAO1 3
- Calcium/calmodulin-dependent protein kinase kinase 1 3
- Serine/threonine-protein kinase DCLK1 3
- Calcium/calmodulin-dependent protein kinase kinase 2 3
- Serine/threonine-protein kinase DCLK2 3
- Serine/threonine-protein kinase DCLK3 3
- Angiopoietin-1 receptor 3
- Serine/threonine-protein kinase TNNI3K 3
- Interferon-induced, double-stranded RNA-activated protein kinase 3
- Mitogen-activated protein kinase kinase kinase kinase 3 3
- Mitogen-activated protein kinase kinase kinase kinase 1 3
- Serine/threonine-protein kinase MRCK alpha 3
- Mitogen-activated protein kinase kinase kinase kinase 4 3
- Mitogen-activated protein kinase kinase kinase kinase 5 3
- Mitogen-activated protein kinase 15 3
- 5'-AMP-activated protein kinase catalytic subunit alpha-1 3
- Activin receptor type-1B 3
- Myosin light chain kinase family member 4 3
- Mitogen-activated protein kinase kinase kinase 9 3
- RAC-gamma serine/threonine-protein kinase 3
- Mitogen-activated protein kinase kinase kinase 5 3
- Interleukin-1 receptor-associated kinase 3 3
- Mitogen-activated protein kinase kinase kinase 4 3
- RAC-alpha serine/threonine-protein kinase 3
- Proto-oncogene tyrosine-protein kinase Src 3
- Activin receptor type-2B 3
- Activin receptor type-2A 3
- BDNF/NT-3 growth factors receptor 3
- Serine/threonine-protein kinase 17A 3
- Tyrosine-protein kinase Lck 3
- Serine/threonine-protein kinase 17B 3
- Protein kinase C delta type 3
- NT-3 growth factor receptor 3
- Protein-tyrosine kinase 2-beta 3
- High affinity nerve growth factor receptor 3
- Tyrosine-protein kinase Mer 3
- Serine/threonine-protein kinase N2 3
- cAMP-dependent protein kinase catalytic subunit beta 3
- Serine/threonine-protein kinase N1 3
- Ribosomal protein S6 kinase alpha-3 3
- Calcium/calmodulin-dependent protein kinase type 1D 3
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 3
- STE20-like serine/threonine-protein kinase 3
- Fibroblast growth factor receptor 4 3
- Tyrosine-protein kinase Fgr 3
- Aurora kinase B 3
- Mitogen-activated protein kinase kinase kinase 20 3
- Fibroblast growth factor receptor 1 3
- Fibroblast growth factor receptor 2 3
- Atypical kinase COQ8A, mitochondrial 3
- Aurora kinase C 3
- Mitogen-activated protein kinase 12 3
- Mitogen-activated protein kinase 11 3
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 3
- RAC-beta serine/threonine-protein kinase 3
- Mitogen-activated protein kinase 10 3
- Tyrosine-protein kinase Fyn 3
- Tyrosine-protein kinase CSK 3
- Macrophage colony-stimulating factor 1 receptor 3
- Maternal embryonic leucine zipper kinase 3
- Serine/threonine-protein kinase MARK1 3
- Serine/threonine-protein kinase MARK2 3
- TRAF2 and NCK-interacting protein kinase 3
- Mitogen-activated protein kinase kinase kinase 10 3
- Receptor tyrosine-protein kinase erbB-4 2
- Rhodopsin kinase GRK1 2
- Serine/threonine-protein kinase 38 2
- Cyclin-dependent kinase 4 2
- Serine/threonine-protein kinase TAO3 2
- Serine/threonine-protein kinase 35 2
- Uncharacterized serine/threonine-protein kinase SBK3 2
- Receptor tyrosine-protein kinase erbB-3 2
- Mitogen-activated protein kinase kinase kinase kinase 2 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 2
- Casein kinase I isoform alpha-like 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 2
- Cyclin-dependent kinase 15 2
- Mitogen-activated protein kinase kinase kinase 6 2
- Macrophage-stimulating protein receptor 2
- Interleukin-1 receptor-associated kinase 1 2
- Mitogen-activated protein kinase kinase kinase 7 2
- Mitogen-activated protein kinase kinase kinase 2 2
- Cyclin-dependent kinase-like 3 2
- Mitogen-activated protein kinase kinase kinase 1 2
- Cyclin-dependent kinase-like 2 2
- Serine/threonine-protein kinase SIK3 [59-1321] 2
- Mitogen-activated protein kinase kinase kinase 3 2
- Homeodomain-interacting protein kinase 4 2
- Homeodomain-interacting protein kinase 3 2
- Serine/threonine-protein kinase ICK 2
- Cyclin-dependent kinase-like 5 2
- Microtubule-associated serine/threonine-protein kinase 1 2
- Megakaryocyte-associated tyrosine-protein kinase 2
- Leucine-rich repeat serine/threonine-protein kinase 2 2
- Rho-associated protein kinase 2 2
- Rho-associated protein kinase 1 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2
- Serine/threonine-protein kinase ULK1 2
- Serine/threonine-protein kinase ULK2 2
- Serine/threonine-protein kinase ULK3 2
- Mitogen-activated protein kinase kinase kinase 19 2
- Mitogen-activated protein kinase kinase kinase 15 2
- SRSF protein kinase 3 2
- G protein-coupled receptor kinase 4 2
- Bone morphogenetic protein receptor type-1B 2
- Homeodomain-interacting protein kinase 2 2
- Homeodomain-interacting protein kinase 1 2
- Receptor-interacting serine/threonine-protein kinase 4 2
- Serine/threonine-protein kinase TBK1 2
- Ribosomal protein S6 kinase beta-1 2
- Hormonally up-regulated neu tumor-associated kinase 2
- Calcium/calmodulin-dependent protein kinase type 1G 2
- Serine/threonine-protein kinase RIO2 2
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 2
- Serine/threonine-protein kinase OSR1 2
- Serine/threonine-protein kinase PLK2 2
- Inhibitor of nuclear factor kappa-B kinase subunit beta 2
- Serine/threonine-protein kinase NIM1 2
- Serine/threonine-protein kinase MAK 2
- Serine/threonine-protein kinase/endoribonuclease IRE1 2
- Mitogen-activated protein kinase 13 2
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 2
- Wee1-like protein kinase 2 2
- Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma 2
- Casein kinase I isoform alpha 2
- Misshapen-like kinase 1 2
- cAMP-dependent protein kinase catalytic subunit alpha 2
- eIF-2-alpha kinase GCN2 2
- Serine/threonine-protein kinase Chk2 2
- Activated CDC42 kinase 1 2
- Ephrin type-B receptor 6 2
- Rhodopsin kinase GRK7 2
- Mitogen-activated protein kinase kinase kinase 13 2
- STE20/SPS1-related proline-alanine-rich protein kinase 2
- Phosphatidylinositol 4-kinase beta 2
- Calcium-dependent protein kinase 1 1
- Serine/threonine-protein kinase Nek11 1
- Peripheral plasma membrane protein CASK 1
- Serine/threonine-protein kinase mTOR 1
- Eukaryotic translation initiation factor 2-alpha kinase 1 1
- Dual serine/threonine and tyrosine protein kinase 1
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 1
- Tubulin alpha-1A chain 1
- Poly [ADP-ribose] polymerase tankyrase-2 1
- Serine/threonine-protein kinase PknB 1
- SNF-related serine/threonine-protein kinase 1
- Serine/threonine-protein kinase PRP4 homolog 1
- Serine/threonine-protein kinase TAO2 1
- Cyclin-dependent kinase-like 1 [2-358] 1
- Cyclin-dependent kinase 2 homolog 1
- Serine/threonine-protein kinase 32A 1
- Cyclin-dependent kinase 13 1
- Protein kinase C iota type 1
- Interleukin-1 receptor-associated kinase 4 1
- Transient receptor potential cation channel subfamily M member 6 1
- Serine/threonine-protein kinase Nek4 1
- U4/U6 small nuclear ribonucleoprotein Prp4 1
- Serine/threonine-protein kinase Nek3 1
- Platelet-derived growth factor receptor alpha/beta 1
- Serine/threonine-protein kinase VRK2 1
- Protein kinase C alpha type 1
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1
- Serine/threonine-protein kinase SBK1 1
- Protein delta homolog 1 1
- Dual specificity mitogen-activated protein kinase kinase 7 1
- Dual specificity mitogen-activated protein kinase kinase 5 1
- Mitogen-activated protein kinase kinase kinase 12 1
- Serine/threonine-protein kinase Sgk3 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 4 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 3 1
- Myosin light chain kinase 3 1
- ...
Publications 9 ▿
- Nat Biotechnol 29: 1046-51 (2011) 442
- Blood 114: 2984-92 (2009) 360
- Nat Biotechnol 26: 127-32 (2008) 318
- Eur J Med Chem 100: 151-61 (2015) 3
- J Med Chem 62: 2428-2446 (2019) 3
- J Med Chem 62: 11135-11150 (2019) 2
- Eur J Med Chem 178: 468-483 (2019) 2
- J Med Chem 56: 8032-48 (2013) 2
- Eur J Med Chem 184: (2019) 1
Institutions 6 ▿
- [Ambit Biosciences] 1120
- [National Health Research Institutes] 5
- [Technische Universit£t Darmstadt] 3
- [Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Califia Bio Inc.] 2
- [Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Califia Bio Inc.] 2
- [Vichem Chemie Research Ltd] 1
Affinity: 1 to 1.2E+4 nM▿
- IC50 27
- Kd 1126
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 2
Catalog Cmpds: 1