null

SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F

InChI Key InChIKey=CLGRAWDGLMENOD-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50335231   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50335231(3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...)copy SMILEScopy InChI
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of JAK3 in human CTLL2 cells assessed as reduction in IL2-induced STAT5 phosphorylation preincubated for 2 hrs followed by IL2 stimulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3PFPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50335231(3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...)copy SMILEScopy InChI
Affinity DataIC50: 685nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 1 mM ATP by HTRF assa...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3PFPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50335231(3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3PFPPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50335231(3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...)copy SMILEScopy InChI
Affinity DataEC50:  1.04E+3nMAssay Description:Inhibition of JAK3 in human CTLL2 cells assessed as reduction in IL15-induced STAT5 phosphorylation preincubated for 2 hrs followed by IL15 stimulati...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3PFPPubMed