BindingDB

null

SMILES Cc1cccc(CCN2CCC(CC2)C(=O)c2ccc(NS(C)(=O)=O)cc2)n1

InChI Key InChIKey=SRUISGSHWFJION-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50117930

Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£ di Napoli "Federico II"

Curated by ChEMBL

BDBM50117930((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)copy SMILEScopy InChI

IC50: 27nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article
BindingDB Entry DOI: 10.7270/Q2154MD0PubMed

Targets 2 ▿
- Potassium voltage-gated channel subfamily H member 2 29
- Voltage-dependent L-type calcium channel subunit alpha-1C 1
Publications 24 ▿
- J Med Chem 50: 2931-41 (2007) 2
- J Med Chem 52: 1630-8 (2009) 1
- J Med Chem 63: 4506-4516 (2020) 1
- J Med Chem 57: 4640-60 (2014) 1
- Bioorg Med Chem Lett 15: 2886-90 (2005) 1
- Eur J Med Chem 46: 618-30 (2011) 1
- Eur J Med Chem 92: 221-35 (2015) 1
- J Med Chem 62: 4638-4655 (2019) 1
- J Med Chem 45: 3844-53 (2002) 1
- Eur J Med Chem 162: 161-175 (2019) 1
- Bioorg Med Chem 24: 2954-2963 (2016) 1
- Eur J Med Chem 183: (2019) 1
- Bioorg Med Chem Lett 14: 4771-7 (2004) 1
- J Med Chem 52: 4266-76 (2009) 1
- Bioorg Med Chem 16: 6252-60 (2008) 1
- Eur J Med Chem 175: 107-113 (2019) 1
- Eur J Med Chem 43: 2479-88 (2008) 1
- Eur J Med Chem 44: 1926-32 (2009) 1
- J Med Chem 60: 9205-9221 (2017) 1
- Eur J Med Chem 101: 627-39 (2015) 1
- J Med Chem 57: 4543-57 (2014) 1
- J Appl Toxicol 32: 858-66 (2012) 1
- Eur J Med Chem 117: 256-68 (2016) 1
- Bioorg Med Chem Lett 13: 2773-5 (2003) 1
Institutions 23 ▿
- [Pfizer Global Research and Development, Universit£ Lille Nord de France] 2
- [Pfizer Global Research and Development, Universit£ Lille Nord de France] 2
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
- [Saint Petersburg State University, Jagiellonian University Collegium Medicum, Korea Institute of Science and Technology (KIST), China Pharmaceutical University, Korea Advanced Institute of Science and Technology (KAIST) , Jagiellonian University, Hoffmann-La Roche, CASMedChem Laboratory, Reverse proteomics research institute, University of Zurich, Universit£ di Pisa, Ghent University, Academy of Scientific and Innovative Research (AcSIR), Adamed Ltd., Universit£ di Napoli "Federico II", Takeda Pharmaceutical Company Ltd., University of Sharjah, Gedeon Richter Ltd, AstraZeneca, TCG Lifesciences Ltd., University of Bologna] 1
Affinity: 1.2 to 4.4E+5 nM▿
- Ki 2
- IC50 27
- EC50 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1