BindingDB

null

SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccc(Cl)cc2Cl)c2ccccc12

InChI Key InChIKey=JCSGFHVFHSKIJH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 8296

Glycogen synthase kinase-3 beta(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL

BDBM8296(3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)copy SMILEScopy InChI

IC50: 11nMAssay Description:Inhibition of GSK3beta (unknown origin) pre-incubated for 30 mins followed by ULight-GS (Ser641/pSer657) peptide substrate addition and measured afte...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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PC cid PC sid Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q26W9FHZPubMed

Glycogen synthase kinase-3 beta(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL

BDBM8296(3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)copy SMILEScopy InChI

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q26W9FHZPubMed

Targets 9 ▿
- Glycogen synthase kinase-3 beta 21
- Glycogen synthase kinase-3 alpha 5
- Glycogen synthase kinase-3 3
- Orotidine 5'-phosphate decarboxylase 1
- Cyclin-dependent kinase 1 1
- POsterior Segregation 1
- Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3 1
- Zinc finger protein mex-5 1
- Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2 1
Publications 19 ▿
- ACS Med Chem Lett 6: 548-52 (2015) 2
- Eur J Med Chem 163: 394-402 (2019) 2
- J Med Chem 53: 994-1003 (2010) 2
- Trends Pharmacol Sci 25: 471-80 (2004) 2
- Eur J Med Chem 175: 309-329 (2019) 1
- PubChem Bioassay (2009) 1
- Bioorg Med Chem Lett 13: 3049-53 (2003) 1
- PubChem Bioassay (2009) 1
- Eur J Med Chem 125: 464-477 (2017) 1
- Chem Biol 7: 793-803 (2000) 1
- Bioorg Med Chem Lett 14: 3245-50 (2004) 1
- Eur J Med Chem 44: 2361-71 (2009) 1
- Bioorg Med Chem 27: 1804-1817 (2019) 1
- J Med Chem 55: 9107-19 (2012) 1
- J Med Chem 61: 7640-7656 (2018) 1
- J Med Chem 52: 1853-63 (2009) 1
- Bioorg Med Chem 18: 6785-95 (2010) 1
- PubChem Bioassay (2011) 1
- Bioorg Med Chem Lett 24: 1532-7 (2014) 1
Institutions 16 ▿
- [Alma Mater Studiorum-University of Bologna] 3
- [Peking University, Johnson & Johnson Pharmaceutical Research & Development, The Rockefeller University, Broad Institute, University of Cambridge] 2
- [Peking University, Johnson & Johnson Pharmaceutical Research & Development, The Rockefeller University, Broad Institute, University of Cambridge] 2
- [Peking University, Johnson & Johnson Pharmaceutical Research & Development, The Rockefeller University, Broad Institute, University of Cambridge] 2
- [Peking University, Johnson & Johnson Pharmaceutical Research & Development, The Rockefeller University, Broad Institute, University of Cambridge] 2
- [Peking University, Johnson & Johnson Pharmaceutical Research & Development, The Rockefeller University, Broad Institute, University of Cambridge] 2
- [Sterling Road, Eberhard Karls Universit£t T£bingen, University of Illinois at Chicago, University of Rostock, Northwestern University, Jamia Hamdard (Hamdard University), AstraZeneca, The Scripps Research Institute Molecular Screening Center, SmithKline Beecham Pharmaceuticals, Lomonosov Moscow State University] 1
- [Sterling Road, Eberhard Karls Universit£t T£bingen, University of Illinois at Chicago, University of Rostock, Northwestern University, Jamia Hamdard (Hamdard University), AstraZeneca, The Scripps Research Institute Molecular Screening Center, SmithKline Beecham Pharmaceuticals, Lomonosov Moscow State University] 1
- [Sterling Road, Eberhard Karls Universit£t T£bingen, University of Illinois at Chicago, University of Rostock, Northwestern University, Jamia Hamdard (Hamdard University), AstraZeneca, The Scripps Research Institute Molecular Screening Center, SmithKline Beecham Pharmaceuticals, Lomonosov Moscow State University] 1
- [Sterling Road, Eberhard Karls Universit£t T£bingen, University of Illinois at Chicago, University of Rostock, Northwestern University, Jamia Hamdard (Hamdard University), AstraZeneca, The Scripps Research Institute Molecular Screening Center, SmithKline Beecham Pharmaceuticals, Lomonosov Moscow State University] 1
- [Sterling Road, Eberhard Karls Universit£t T£bingen, University of Illinois at Chicago, University of Rostock, Northwestern University, Jamia Hamdard (Hamdard University), AstraZeneca, The Scripps Research Institute Molecular Screening Center, SmithKline Beecham Pharmaceuticals, Lomonosov Moscow State University] 1
- [Sterling Road, Eberhard Karls Universit£t T£bingen, University of Illinois at Chicago, University of Rostock, Northwestern University, Jamia Hamdard (Hamdard University), AstraZeneca, The Scripps Research Institute Molecular Screening Center, SmithKline Beecham Pharmaceuticals, Lomonosov Moscow State University] 1
- [Sterling Road, Eberhard Karls Universit£t T£bingen, University of Illinois at Chicago, University of Rostock, Northwestern University, Jamia Hamdard (Hamdard University), AstraZeneca, The Scripps Research Institute Molecular Screening Center, SmithKline Beecham Pharmaceuticals, Lomonosov Moscow State University] 1
- [Sterling Road, Eberhard Karls Universit£t T£bingen, University of Illinois at Chicago, University of Rostock, Northwestern University, Jamia Hamdard (Hamdard University), AstraZeneca, The Scripps Research Institute Molecular Screening Center, SmithKline Beecham Pharmaceuticals, Lomonosov Moscow State University] 1
- [Sterling Road, Eberhard Karls Universit£t T£bingen, University of Illinois at Chicago, University of Rostock, Northwestern University, Jamia Hamdard (Hamdard University), AstraZeneca, The Scripps Research Institute Molecular Screening Center, SmithKline Beecham Pharmaceuticals, Lomonosov Moscow State University] 1
- [Sterling Road, Eberhard Karls Universit£t T£bingen, University of Illinois at Chicago, University of Rostock, Northwestern University, Jamia Hamdard (Hamdard University), AstraZeneca, The Scripps Research Institute Molecular Screening Center, SmithKline Beecham Pharmaceuticals, Lomonosov Moscow State University] 1
Affinity: 7 to 6.0E+4 nM▿
- Ki 3
- IC50 29
- EC50 4
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1