BindingDB

null

SMILES [O-][V]([O-])([O-])=O

InChI Key InChIKey=LSGOVYNHVSXFFJ-UHFFFAOYSA-N

PDB links: 123 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50391109

Tyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 62nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q2KK9G90PubMed PDB

3D Structure (crystal)

Tyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 18nMAssay Description:Inhibition of TCPTP (unknown origin) using pNPP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q2KK9G90PubMed

Tyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shanghai Jiao Tong University (SJTU)

Curated by ChEMBL

BDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)copy SMILEScopy InChI

IC50: 81nMAssay Description:Inhibition of SHP2 (unknown origin) using pNPP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2KK9G90PubMed

Targets 10 ▿
- Tyrosine-protein phosphatase non-receptor type 1 14
- Tyrosine-protein phosphatase non-receptor type 6 12
- Tyrosine-protein phosphatase non-receptor type 11 12
- Receptor-type tyrosine-protein phosphatase F 10
- Tyrosine-protein phosphatase non-receptor type 2 9
- M-phase inducer phosphatase 2 5
- Receptor-type tyrosine-protein phosphatase S 3
- Tyrosyl-DNA phosphodiesterase 1 1
- Tyrosyl-DNA phosphodiesterase 2 1
- Tyrosine-protein phosphatase non-receptor type 1 [1-321] 1
- ...
Publications 25 ▿
- Eur J Med Chem 166: 178-185 (2019) 6
- J Nat Prod 82: 2638-2644 (2019) 6
- Bioorg Med Chem Lett 29: 1187-1193 (2019) 4
- Bioorg Med Chem Lett 22: 7440-3 (2012) 4
- Eur J Med Chem 172: 163-173 (2019) 4
- Bioorg Med Chem Lett 24: 4125-8 (2014) 4
- Eur J Med Chem 164: 408-422 (2019) 3
- Bioorg Med Chem 23: 4891-8 (2015) 3
- Bioorg Med Chem 23: 38-45 (2014) 3
- Eur J Med Chem 144: 692-700 (2018) 3
- Bioorg Med Chem 23: 7079-88 (2015) 3
- Bioorg Med Chem Lett 24: 1889-94 (2014) 3
- Bioorg Med Chem Lett 27: 5154-5157 (2017) 2
- Bioorg Med Chem Lett 30: (2020) 2
- Eur J Med Chem 57: 10-20 (2012) 2
- Bioorg Med Chem 24: 5017-5027 (2016) 2
- Bioorg Med Chem Lett 27: 2166-2170 (2017) 2
- J Enzyme Inhib Med Chem 28: 1067-72 (2013) 1
- Eur J Med Chem 79: 34-46 (2014) 1
- Bioorg Med Chem 20: 2172-9 (2012) 1
- J Nat Prod 83: 323-332 (2020) 1
- J Nat Prod 83: 1394-1399 (2020) 1
- Bioorg Med Chem Lett 26: 87-93 (2016) 1
- J Nat Prod 81: 2091-2100 (2018) 1
- Eur J Med Chem 122: 756-769 (2016) 1
Institutions 22 ▿
- [Jiangnan University] 7
- [Chinese Academy of Sciences, Hebei University, Qilu University of Technology] 6
- [Chinese Academy of Sciences, Hebei University, Qilu University of Technology] 6
- [Chinese Academy of Sciences, Hebei University, Qilu University of Technology] 6
- [Yanbian University, Liaoning Normal University, East China University of Science and Technology, Yanbian University College of Pharmacy] 4
- [Yanbian University, Liaoning Normal University, East China University of Science and Technology, Yanbian University College of Pharmacy] 4
- [Yanbian University, Liaoning Normal University, East China University of Science and Technology, Yanbian University College of Pharmacy] 4
- [Yanbian University, Liaoning Normal University, East China University of Science and Technology, Yanbian University College of Pharmacy] 4
- [Qilu University of Technology (Shandong Academy of Sciences), Nanchang University, Shanghai Jiao Tong University (SJTU)] 3
- [Qilu University of Technology (Shandong Academy of Sciences), Nanchang University, Shanghai Jiao Tong University (SJTU)] 3
- [Qilu University of Technology (Shandong Academy of Sciences), Nanchang University, Shanghai Jiao Tong University (SJTU)] 3
- [Russian Academy of Sciences, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China; China State Institute of Pharmaceutical Industry, Novel Technology Center of Pharmaceutical Chemistry, Shanghai Institute, Shanghai Jiao Tong University] 2
- [Russian Academy of Sciences, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China; China State Institute of Pharmaceutical Industry, Novel Technology Center of Pharmaceutical Chemistry, Shanghai Institute, Shanghai Jiao Tong University] 2
- [Russian Academy of Sciences, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China; China State Institute of Pharmaceutical Industry, Novel Technology Center of Pharmaceutical Chemistry, Shanghai Institute, Shanghai Jiao Tong University] 2
- [Hebei Medical University, Northwest University, Chulalongkorn University, Chungnam National University, University of Innsbruck, Kyungpook National University, Xi'an Jiaotong University, Central Drug Research Institute] 1
- [Hebei Medical University, Northwest University, Chulalongkorn University, Chungnam National University, University of Innsbruck, Kyungpook National University, Xi'an Jiaotong University, Central Drug Research Institute] 1
- [Hebei Medical University, Northwest University, Chulalongkorn University, Chungnam National University, University of Innsbruck, Kyungpook National University, Xi'an Jiaotong University, Central Drug Research Institute] 1
- [Hebei Medical University, Northwest University, Chulalongkorn University, Chungnam National University, University of Innsbruck, Kyungpook National University, Xi'an Jiaotong University, Central Drug Research Institute] 1
- [Hebei Medical University, Northwest University, Chulalongkorn University, Chungnam National University, University of Innsbruck, Kyungpook National University, Xi'an Jiaotong University, Central Drug Research Institute] 1
- [Hebei Medical University, Northwest University, Chulalongkorn University, Chungnam National University, University of Innsbruck, Kyungpook National University, Xi'an Jiaotong University, Central Drug Research Institute] 1
- [Hebei Medical University, Northwest University, Chulalongkorn University, Chungnam National University, University of Innsbruck, Kyungpook National University, Xi'an Jiaotong University, Central Drug Research Institute] 1
- [Hebei Medical University, Northwest University, Chulalongkorn University, Chungnam National University, University of Innsbruck, Kyungpook National University, Xi'an Jiaotong University, Central Drug Research Institute] 1
Affinity: 14 to 4.0E+7 nM▿
- IC50 68
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1